SI3348556T1 - Heteroarilni amidi kot inhibitorji proteinske agregacije - Google Patents

Heteroarilni amidi kot inhibitorji proteinske agregacije

Info

Publication number: SI3348556T1
Authority: SI; Slovenia
Prior art keywords: inhibitors; protein aggregation; heteroaryl amides; heteroaryl; amides
Prior art date: 2014-01-29

Application number

SI201531297T

Other languages

English (en)

Inventor

Emily M. Stocking

Wolfgang Wrasidlo

Original Assignee

UCB Biopharma SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-01-29

Filing date

2015-01-28

Publication date

2020-10-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52484559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3348556(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-01-28 Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL

2020-10-30 Publication of SI3348556T1 publication Critical patent/SI3348556T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SI201531297T 2014-01-29 2015-01-28 Heteroarilni amidi kot inhibitorji proteinske agregacije SI3348556T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201461933246P	2014-01-29	2014-01-29
US201462078895P	2014-11-12	2014-11-12
EP18156929.4A EP3348556B1 (en)	2014-01-29	2015-01-28	Heteroaryl amides as inhibitors of protein aggregation

Publications (1)

Publication Number	Publication Date
SI3348556T1 true SI3348556T1 (sl)	2020-10-30

Family

ID=52484559

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI201531297T SI3348556T1 (sl)	2014-01-29	2015-01-28	Heteroarilni amidi kot inhibitorji proteinske agregacije
SI201530252T SI3099684T1 (sl)	2014-01-29	2015-01-28	Heteroaril amidi kot inhibitorji proteinske agregacije

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SI201530252T SI3099684T1 (sl)	2014-01-29	2015-01-28	Heteroaril amidi kot inhibitorji proteinske agregacije

Country Status (38)

Country	Link
US (3)	US9738635B2 (sl)
EP (2)	EP3099684B8 (sl)
JP (2)	JP6619741B2 (sl)
KR (1)	KR102383038B1 (sl)
CN (2)	CN111039939B (sl)
AP (1)	AP2016009347A0 (sl)
AU (1)	AU2015211119B2 (sl)
BR (2)	BR112016017344B1 (sl)
CA (1)	CA2937967C (sl)
CL (1)	CL2016001918A1 (sl)
CR (1)	CR20160394A (sl)
CY (2)	CY1120348T1 (sl)
DK (2)	DK3099684T3 (sl)
EA (1)	EA032374B1 (sl)
EC (1)	ECSP16070327A (sl)
ES (2)	ES2808978T3 (sl)
HK (1)	HK1231470A1 (sl)
HR (2)	HRP20180813T1 (sl)
HU (2)	HUE050964T2 (sl)
IL (1)	IL246987B (sl)
LT (2)	LT3348556T (sl)
ME (1)	ME03800B (sl)
MX (1)	MX2016009896A (sl)
MY (1)	MY187450A (sl)
NZ (1)	NZ722487A (sl)
PE (1)	PE20161393A1 (sl)
PH (1)	PH12016501493A1 (sl)
PL (2)	PL3348556T3 (sl)
PT (2)	PT3099684T (sl)
RS (2)	RS57533B1 (sl)
SA (1)	SA516371579B1 (sl)
SG (1)	SG11201606108RA (sl)
SI (2)	SI3348556T1 (sl)
SM (2)	SMT202000376T1 (sl)
TR (1)	TR201809440T4 (sl)
UA (1)	UA118209C2 (sl)
WO (1)	WO2015116663A1 (sl)
ZA (1)	ZA201605246B (sl)

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AU2015211119B2 (en)	2014-01-29	2019-05-30	Ucb Biopharma Sprl	Heteroaryl amides as inhibitors of protein aggregation
ES2885049T3 (es) *	2015-07-29	2021-12-13	UCB Biopharma SRL	Derivados de bis-heteroarilo como moduladores de la agregación de proteínas
CN107625767A (zh) *	2016-11-25	2018-01-26	刘淑兰	一种治疗慢性盆腔炎的药物
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US11091474B2 (en) *	2017-01-26	2021-08-17	UCB Biopharma SRL	Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation
AU2018212436A1 (en) *	2017-01-26	2019-07-25	UCB Biopharma SRL	Bis-heteroaryl derivatives as modulators of protein aggregation
MX2019008256A (es) *	2017-01-26	2019-09-09	Ucb Biopharma Sprl	Derivados de bis-heteroarilo biciclicos como moduladores de agregacion de proteinas.
AU2018265584B2 (en) *	2017-05-12	2023-09-28	Ludwig-Maximilians-Universität München	Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma
WO2019028456A1 (en)	2017-08-04	2019-02-07	Axial Biotherapeutics, Inc.	INHIBITORS OF MICROBIAL INDUCED AMYLOID FORMATION
AU2018360514A1 (en) *	2017-10-31	2020-05-14	Loma Linda University	Methods for treating traumatic brain injury
US11707452B2 (en)	2018-08-20	2023-07-25	Arvinas Operations, Inc.	Modulators of alpha-synuclein proteolysis and associated methods of use
CN118488951A (zh) *	2021-12-27	2024-08-13	上海京新生物医药有限公司	作为蛋白质聚集抑制剂的稠合双环杂芳基酰胺化合物
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WO2024184179A1 (en)	2023-03-06	2024-09-12	UCB Biopharma SRL	Minzasolmin for use in the treatment of parkinson's disease
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AU2015211119B2 (en)	2014-01-29	2019-05-30	Ucb Biopharma Sprl	Heteroaryl amides as inhibitors of protein aggregation
ES2885049T3 (es)	2015-07-29	2021-12-13	UCB Biopharma SRL	Derivados de bis-heteroarilo como moduladores de la agregación de proteínas
MX2019008256A (es)	2017-01-26	2019-09-09	Ucb Biopharma Sprl	Derivados de bis-heteroarilo biciclicos como moduladores de agregacion de proteinas.
AU2018212436A1 (en)	2017-01-26	2019-07-25	UCB Biopharma SRL	Bis-heteroaryl derivatives as modulators of protein aggregation

2015
- 2015-01-28 AU AU2015211119A patent/AU2015211119B2/en active Active
- 2015-01-28 MY MYPI2016001401A patent/MY187450A/en unknown
- 2015-01-28 SM SM20200376T patent/SMT202000376T1/it unknown
- 2015-01-28 BR BR112016017344-9A patent/BR112016017344B1/pt active IP Right Grant
- 2015-01-28 HU HUE18156929A patent/HUE050964T2/hu unknown
- 2015-01-28 PE PE2016001285A patent/PE20161393A1/es unknown
- 2015-01-28 SM SM20180318T patent/SMT201800318T1/it unknown
- 2015-01-28 CR CR20160394A patent/CR20160394A/es unknown
- 2015-01-28 RS RS20180644A patent/RS57533B1/sr unknown
- 2015-01-28 TR TR2018/09440T patent/TR201809440T4/tr unknown
- 2015-01-28 EA EA201691529A patent/EA032374B1/ru unknown
- 2015-01-28 CA CA2937967A patent/CA2937967C/en active Active
- 2015-01-28 NZ NZ722487A patent/NZ722487A/en unknown
- 2015-01-28 BR BR122018001892-5A patent/BR122018001892B1/pt active IP Right Grant
- 2015-01-28 DK DK15705417.2T patent/DK3099684T3/en active
- 2015-01-28 KR KR1020167023810A patent/KR102383038B1/ko active Active
- 2015-01-28 SI SI201531297T patent/SI3348556T1/sl unknown
- 2015-01-28 HR HRP20180813TT patent/HRP20180813T1/hr unknown
- 2015-01-28 ES ES18156929T patent/ES2808978T3/es active Active
- 2015-01-28 PL PL18156929T patent/PL3348556T3/pl unknown
- 2015-01-28 PL PL15705417T patent/PL3099684T3/pl unknown
- 2015-01-28 EP EP15705417.2A patent/EP3099684B8/en active Active
- 2015-01-28 RS RS20200827A patent/RS60547B1/sr unknown
- 2015-01-28 EP EP18156929.4A patent/EP3348556B1/en active Active
- 2015-01-28 SI SI201530252T patent/SI3099684T1/sl unknown
- 2015-01-28 UA UAA201609003A patent/UA118209C2/uk unknown
- 2015-01-28 CN CN201911278647.XA patent/CN111039939B/zh active Active
- 2015-01-28 HK HK17105014.2A patent/HK1231470A1/zh unknown
- 2015-01-28 CN CN201580017216.1A patent/CN106132960B/zh active Active
- 2015-01-28 LT LTEP18156929.4T patent/LT3348556T/lt unknown
- 2015-01-28 JP JP2016549488A patent/JP6619741B2/ja active Active
- 2015-01-28 ES ES15705417.2T patent/ES2675301T3/es active Active
- 2015-01-28 AP AP2016009347A patent/AP2016009347A0/en unknown
- 2015-01-28 PT PT15705417T patent/PT3099684T/pt unknown
- 2015-01-28 LT LTEP15705417.2T patent/LT3099684T/lt unknown
- 2015-01-28 PT PT181569294T patent/PT3348556T/pt unknown
- 2015-01-28 MX MX2016009896A patent/MX2016009896A/es active IP Right Grant
- 2015-01-28 HU HUE15705417A patent/HUE040274T2/hu unknown
- 2015-01-28 DK DK18156929.4T patent/DK3348556T3/da active
- 2015-01-28 ME MEP-2020-148A patent/ME03800B/me unknown
- 2015-01-28 WO PCT/US2015/013263 patent/WO2015116663A1/en not_active Ceased
- 2015-01-28 SG SG11201606108RA patent/SG11201606108RA/en unknown
- 2015-12-29 US US14/983,243 patent/US9738635B2/en active Active
2016
- 2016-07-27 IL IL246987A patent/IL246987B/en unknown
- 2016-07-28 SA SA516371579A patent/SA516371579B1/ar unknown
- 2016-07-28 CL CL2016001918A patent/CL2016001918A1/es unknown
- 2016-07-28 PH PH12016501493A patent/PH12016501493A1/en unknown
- 2016-07-28 ZA ZA2016/05246A patent/ZA201605246B/en unknown
- 2016-08-29 EC ECIEPI201670327A patent/ECSP16070327A/es unknown
2017
- 2017-08-01 US US15/666,503 patent/US10358443B2/en active Active
2018
- 2018-06-15 CY CY20181100630T patent/CY1120348T1/el unknown
2019
- 2019-06-04 JP JP2019104159A patent/JP6783900B2/ja active Active
- 2019-06-11 US US16/438,348 patent/US11078196B2/en active Active
2020
- 2020-07-14 HR HRP20201107TT patent/HRP20201107T8/hr unknown
- 2020-07-24 CY CY20201100682T patent/CY1123374T1/el unknown

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Publication number	Publication date
US20190308965A1 (en)	2019-10-10
MY187450A (en)	2021-09-22
CN111039939B (zh)	2023-09-19
IL246987A0 (en)	2016-09-29
EP3099684B1 (en)	2018-04-04
IL246987B (en)	2021-12-01
AU2015211119A8 (en)	2016-12-15
HRP20201107T1 (hr)	2020-10-30
SMT201800318T1 (it)	2018-07-17
HUE050964T2 (hu)	2021-01-28
CY1123374T1 (el)	2021-12-31
ME03800B (me)	2021-04-20
US10358443B2 (en)	2019-07-23
US9738635B2 (en)	2017-08-22
CN111039939A (zh)	2020-04-21
RS57533B1 (sr)	2018-10-31
WO2015116663A8 (en)	2016-09-15
KR102383038B1 (ko)	2022-04-05
US20180093979A1 (en)	2018-04-05
AU2015211119A1 (en)	2016-08-11
ZA201605246B (en)	2022-05-25
CY1120348T1 (el)	2019-07-10
US20160207912A1 (en)	2016-07-21
PL3348556T3 (pl)	2020-11-02
PH12016501493B1 (en)	2017-02-06
BR122018001892B1 (pt)	2023-05-02
JP6619741B2 (ja)	2019-12-11
PE20161393A1 (es)	2017-01-08
TR201809440T4 (tr)	2018-07-23
EP3099684A1 (en)	2016-12-07
LT3099684T (lt)	2018-06-25
NZ722487A (en)	2022-04-29
UA118209C2 (uk)	2018-12-10
WO2015116663A1 (en)	2015-08-06
ES2808978T3 (es)	2021-03-02
CA2937967A1 (en)	2015-08-06
AP2016009347A0 (en)	2016-07-31
DK3099684T3 (en)	2018-07-16
PH12016501493A1 (en)	2017-02-06
BR112016017344A2 (pt)	2017-10-03
EP3348556A1 (en)	2018-07-18
MX2016009896A (es)	2017-01-11
JP6783900B2 (ja)	2020-11-11
SA516371579B1 (ar)	2019-07-16
HRP20180813T1 (hr)	2018-07-27
KR20160113287A (ko)	2016-09-28
HRP20201107T8 (hr)	2020-12-11
JP2017505779A (ja)	2017-02-23
EA032374B1 (ru)	2019-05-31
EA201691529A1 (ru)	2017-01-30
EP3099684B8 (en)	2018-07-04
ECSP16070327A (es)	2018-05-31
SG11201606108RA (en)	2016-08-30
PT3348556T (pt)	2020-07-27
AU2015211119B2 (en)	2019-05-30
RS60547B1 (sr)	2020-08-31
LT3348556T (lt)	2020-08-10
JP2019163321A (ja)	2019-09-26
CR20160394A (es)	2016-11-01
CN106132960A (zh)	2016-11-16
CN106132960B (zh)	2019-12-17
ES2675301T3 (es)	2018-07-10
US11078196B2 (en)	2021-08-03
PT3099684T (pt)	2018-10-22
DK3348556T3 (da)	2020-08-03
SMT202000376T1 (it)	2020-09-10
CL2016001918A1 (es)	2017-01-13
EP3348556B1 (en)	2020-04-29
BR112016017344B1 (pt)	2023-05-16
PL3099684T3 (pl)	2018-09-28
HK1231470A1 (zh)	2017-12-22
HUE040274T2 (hu)	2019-03-28
SI3099684T1 (sl)	2018-08-31
CA2937967C (en)	2022-07-26
ES2808978T8 (es)	2021-03-22

Publication	Publication Date	Title
HRP20201107T8 (hr)	2020-12-11	Heteroaril amidi kao inhibitori proteinske agregacije
IL263586B (en)	2021-06-30	Inhibitors of the menin-mll interaction
UA125061C2 (uk)	2022-01-05	Сполуки гетероарилу як інгібітори ткб і їх застосування
SI3105226T1 (sl)	2019-11-29	Ciklopropilamini kot zaviralci LSD1
DK3119772T3 (da)	2019-08-26	Heteroaryl syk-hæmmere
LT3436461T (lt)	2024-03-12	Pirolotriazino junginiai kaip tam inhibitoriai
PL3167096T3 (pl)	2022-02-21	Dwuetapowy sposób nanoszenia
SI3342771T1 (sl)	2021-04-30	Heterociklični amidi kot kinazni inhibitorji
LT3237432T (lt)	2023-12-11	Baltymo gamyba
LT3512833T (lt)	2020-10-12	Heteroarilo karboksamido junginiai kaip ripk2 inhibitoriai
DK3143018T3 (da)	2021-05-31	Carboxamidderivater
HRP20181441T1 (hr)	2018-11-02	Inhibitori sintaze aldosterona
LT3212237T (lt)	2022-02-25	Metotreksato vaistinė forma
PL3319925T3 (pl)	2020-04-30	Granulacja produktów mocznikowych
DK3235799T3 (da)	2022-03-28	Oximforbindelse og herbicid
PL3350308T3 (pl)	2021-08-23	Zastosowanie włókna liocelowego
TH1601000084A (th)	2017-06-29	วิธีและองค์ประกอบของสูตรผสมแกรนูล
GB201415425D0 (en)	2014-10-15	Small molecule inhibitors of classiv bromodomain proteins
UA32644S (uk)	2016-07-25	Розгортка упаковки
TH1501004620A (th)	2017-10-19	เฮทเทอโรไซคลิก เอไมด์ ในรูปสารยับยั้งไคเนส
GB201505911D0 (en)	2015-05-20	Small molecule inhibitors of class IV bromodomain proteins
UA30463S (uk)	2015-09-25	Розгортка упаковки
TH1501005346A (th)	2018-11-01	องค์ประกอบทางเภสัชกรรมของเอส-คีตามีน ไฮโดรคลอไรด์
UA28347S (uk)	2014-11-10	Розгортка упаковки для будівельних сумішей
UA31636S (uk)	2016-03-10	Розгортка упаковки