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SI3233111T1 - Farmacevtski sestavek, ki vsebuje plazminogen, in nameni njegove uporabe - Google Patents

Farmacevtski sestavek, ki vsebuje plazminogen, in nameni njegove uporabe

Info

Publication number
SI3233111T1
SI3233111T1 SI201532035T SI201532035T SI3233111T1 SI 3233111 T1 SI3233111 T1 SI 3233111T1 SI 201532035 T SI201532035 T SI 201532035T SI 201532035 T SI201532035 T SI 201532035T SI 3233111 T1 SI3233111 T1 SI 3233111T1
Authority
SI
Slovenia
Prior art keywords
plasminogen
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
SI201532035T
Other languages
English (en)
Inventor
Martin Robitaille
Davida Blackman
Stacy Plum
William Garzon-Rodriguez
Betty Yu
Original Assignee
Kedrion Biopharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kedrion Biopharma Inc. filed Critical Kedrion Biopharma Inc.
Publication of SI3233111T1 publication Critical patent/SI3233111T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6435Plasmin (3.4.21.7), i.e. fibrinolysin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
SI201532035T 2014-12-19 2015-12-18 Farmacevtski sestavek, ki vsebuje plazminogen, in nameni njegove uporabe SI3233111T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094556P 2014-12-19 2014-12-19
EP15868755.8A EP3233111B1 (en) 2014-12-19 2015-12-18 Pharmaceutical composition comprising plasminogen and uses thereof
PCT/CA2015/000606 WO2016095013A1 (en) 2014-12-19 2015-12-18 Pharmaceutical composition comprising plasminogen and uses thereof

Publications (1)

Publication Number Publication Date
SI3233111T1 true SI3233111T1 (sl) 2024-11-29

Family

ID=56125498

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201532035T SI3233111T1 (sl) 2014-12-19 2015-12-18 Farmacevtski sestavek, ki vsebuje plazminogen, in nameni njegove uporabe

Country Status (31)

Country Link
US (3) US10441639B2 (sl)
EP (1) EP3233111B1 (sl)
JP (2) JP6805162B2 (sl)
KR (1) KR102692851B1 (sl)
CN (1) CN107249622B (sl)
AR (1) AR103215A1 (sl)
AU (1) AU2015367185B2 (sl)
CA (1) CA2971359C (sl)
CL (1) CL2017001605A1 (sl)
CO (1) CO2017007137A2 (sl)
DK (1) DK3233111T3 (sl)
ES (1) ES2988173T3 (sl)
FI (1) FI3233111T3 (sl)
HR (1) HRP20241308T1 (sl)
HU (1) HUE068351T2 (sl)
IL (1) IL252967B (sl)
LT (1) LT3233111T (sl)
MX (1) MX384519B (sl)
MY (1) MY202111A (sl)
PH (1) PH12017501118B1 (sl)
PL (1) PL3233111T3 (sl)
PT (1) PT3233111T (sl)
RS (1) RS66137B1 (sl)
RU (1) RU2711989C2 (sl)
SG (1) SG11201704839RA (sl)
SI (1) SI3233111T1 (sl)
SM (1) SMT202400390T1 (sl)
TW (1) TWI705822B (sl)
UA (1) UA123496C2 (sl)
UY (1) UY36467A (sl)
WO (1) WO2016095013A1 (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI801331B (zh) * 2015-11-03 2023-05-11 美商波麥堤克生物治療股份有限公司 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法
TW201722464A (zh) * 2015-11-10 2017-07-01 波麥堤克生化科學有限公司 用於傷口癒合之纖維蛋白溶酶原給藥方案
CN108463240A (zh) 2015-12-18 2018-08-28 泰伦基国际有限公司 一种预防或治疗糖尿病性视网膜病变的方法
ES2985007T3 (es) 2015-12-18 2024-10-31 Talengen Int Ltd Plasminógeno para su uso en el tratamiento de la nefropatía diabética
ES2961967T3 (es) 2015-12-18 2024-03-14 Talengen Int Ltd Plasminógeno para su uso en el tratamiento de la angiocardiopatía diabética
US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
JP7213553B2 (ja) 2016-12-15 2023-01-27 タレンゲン インターナショナル リミテッド 肺の繊維化を予防及び治療するための方法
WO2018107692A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗脂肪代谢紊乱及其相关病症的方法
ES2981141T3 (es) 2016-12-15 2024-10-07 Talengen Int Ltd Plasminógeno para su uso en el tratamiento de la diabetes
EP3643321B1 (en) 2017-06-19 2025-04-30 Talengen International Limited Plasminogen for use in treating parkinson's and alzheimer's disease
EP4341393A1 (en) 2021-06-08 2024-03-27 PreviPharma Consulting GmbH Process for isolating plasminogen from a blood plasma fraction
CN114191385B (zh) * 2021-12-22 2023-06-30 天士力生物医药股份有限公司 一种重组人尿激酶原注射液及其制备方法
CN119331857B (zh) * 2024-12-19 2025-05-16 南通大学 一种新型重组蛋白Plasminogen-CTM及应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
DE3119157A1 (de) * 1981-05-14 1982-12-09 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung von und danach hergestelltes plasminogen
JPH0672105B2 (ja) 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
JPS62153224A (ja) * 1985-12-27 1987-07-08 Green Cross Corp:The プラスミノゲン製剤
US5290764A (en) * 1992-01-14 1994-03-01 The Dupont Merck Pharmaceutical Company Stabilization of active plasminogen activator inhibitor-1
JPH06211691A (ja) * 1993-01-11 1994-08-02 Green Cross Corp:The プラスミノゲン乾燥製剤
JP2005272403A (ja) * 2004-03-25 2005-10-06 Nihon Pharmaceutical Co Ltd プラスミノーゲン含有溶液の処理方法
US20060257391A1 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
US20070134231A1 (en) * 2005-12-13 2007-06-14 Jani Dharmendra M Method for prolonging activity of autodegradable enzymes and compositions thereof
US20100144622A1 (en) * 2006-09-29 2010-06-10 Xinli Lin Methods for production of recombinant plasminogen and plasmin polypeptides
RU2564131C2 (ru) * 2009-07-10 2015-09-27 ТромбоДженикс НВ Варианты плазминогена и плазмина
WO2011131720A1 (en) * 2010-04-20 2011-10-27 Octapharma Ag New stabilizing agent for pharmaceutical proteins
CN103282042B (zh) * 2010-09-17 2014-12-10 巴克斯特国际公司 通过具有组氨酸的水性制剂在弱酸性至中性pH稳定的免疫球蛋白
KR20140064841A (ko) * 2011-08-12 2014-05-28 쓰롬보제닉스 엔.브이. 플라스미노겐 변이체 및 플라스민 변이체

Also Published As

Publication number Publication date
SMT202400390T1 (it) 2024-11-15
US10898553B2 (en) 2021-01-26
RU2017125931A3 (sl) 2019-07-24
LT3233111T (lt) 2024-10-10
US20170360902A1 (en) 2017-12-21
US20200023043A1 (en) 2020-01-23
CN107249622B (zh) 2021-08-03
AU2015367185A1 (en) 2017-08-10
CA2971359C (en) 2024-04-02
US11633462B2 (en) 2023-04-25
WO2016095013A8 (en) 2017-07-06
KR102692851B1 (ko) 2024-08-06
AU2015367185B2 (en) 2021-05-27
MY202111A (en) 2024-04-04
AR103215A1 (es) 2017-04-26
CN107249622A (zh) 2017-10-13
RU2017125931A (ru) 2019-01-21
CO2017007137A2 (es) 2017-09-29
MX384519B (es) 2025-03-14
CA2971359A1 (en) 2016-06-23
JP2018505209A (ja) 2018-02-22
PL3233111T3 (pl) 2024-11-18
CL2017001605A1 (es) 2018-02-02
EP3233111A4 (en) 2018-06-27
US20210106657A1 (en) 2021-04-15
IL252967A0 (en) 2017-08-31
MX2017008189A (es) 2018-03-23
TW201625294A (zh) 2016-07-16
PH12017501118A1 (en) 2017-11-27
FI3233111T3 (fi) 2024-10-09
HUE068351T2 (hu) 2024-12-28
IL252967B (en) 2020-01-30
KR20170096178A (ko) 2017-08-23
US10441639B2 (en) 2019-10-15
HRP20241308T1 (hr) 2024-12-20
WO2016095013A1 (en) 2016-06-23
UY36467A (es) 2016-07-29
ES2988173T3 (es) 2024-11-19
DK3233111T3 (da) 2024-10-07
PH12017501118B1 (en) 2021-11-05
UA123496C2 (uk) 2021-04-14
RU2711989C2 (ru) 2020-01-23
EP3233111A1 (en) 2017-10-25
JP7150804B2 (ja) 2022-10-11
PT3233111T (pt) 2024-10-10
NZ733837A (en) 2024-05-31
SG11201704839RA (en) 2017-07-28
BR112017012972A2 (pt) 2018-02-27
RS66137B1 (sr) 2024-11-29
TWI705822B (zh) 2020-10-01
JP2021059549A (ja) 2021-04-15
JP6805162B2 (ja) 2020-12-23
EP3233111B1 (en) 2024-08-07

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