SI2649068T1 - Derivati oksazolil-metiletra kot agonisti alx-receptorja - Google Patents
Derivati oksazolil-metiletra kot agonisti alx-receptorjaInfo
- Publication number
- SI2649068T1 SI2649068T1 SI201130348T SI201130348T SI2649068T1 SI 2649068 T1 SI2649068 T1 SI 2649068T1 SI 201130348 T SI201130348 T SI 201130348T SI 201130348 T SI201130348 T SI 201130348T SI 2649068 T1 SI2649068 T1 SI 2649068T1
- Authority
- SI
- Slovenia
- Prior art keywords
- oxazolyl
- receptor agonists
- alx receptor
- methylether derivatives
- methylether
- Prior art date
Links
- ZLOJSLIXCHGODY-UHFFFAOYSA-N 2-(1,3-oxazol-2-ylmethoxymethyl)-1,3-oxazole Chemical class N=1C=COC=1COCC1=NC=CO1 ZLOJSLIXCHGODY-UHFFFAOYSA-N 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2010055616 | 2010-12-07 | ||
| PCT/IB2011/055487 WO2012077049A1 (en) | 2010-12-07 | 2011-12-06 | Oxazolyl-methylether derivatives as alx receptor agonists |
| EP11804810.7A EP2649068B1 (en) | 2010-12-07 | 2011-12-06 | Oxazolyl-methylether derivatives as alx receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2649068T1 true SI2649068T1 (sl) | 2015-01-30 |
Family
ID=45444667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201130348T SI2649068T1 (sl) | 2010-12-07 | 2011-12-06 | Derivati oksazolil-metiletra kot agonisti alx-receptorja |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8846733B2 (sl) |
| EP (1) | EP2649068B1 (sl) |
| JP (1) | JP5923107B2 (sl) |
| KR (1) | KR101864463B1 (sl) |
| CN (1) | CN103261194B (sl) |
| AR (1) | AR084173A1 (sl) |
| AU (1) | AU2011340146B2 (sl) |
| CA (1) | CA2816376C (sl) |
| CY (1) | CY1116004T1 (sl) |
| DK (1) | DK2649068T3 (sl) |
| ES (1) | ES2526132T3 (sl) |
| HR (1) | HRP20150049T1 (sl) |
| MX (1) | MX2013006418A (sl) |
| PL (1) | PL2649068T3 (sl) |
| PT (1) | PT2649068E (sl) |
| RU (1) | RU2588567C2 (sl) |
| SI (1) | SI2649068T1 (sl) |
| TW (1) | TWI523853B (sl) |
| WO (1) | WO2012077049A1 (sl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9187435B2 (en) | 2010-11-17 | 2015-11-17 | Actelion Pharmaceuticals Ltd. | Bridged Spiro[2.4]heptane ester derivatives |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| TW201348219A (zh) | 2012-05-16 | 2013-12-01 | Actelion Pharmaceuticals Ltd | 作爲ａｌｘ受體激動劑之經１－（對－甲苯基）環丙基取代橋聯螺［２．４］庚烷衍生物 |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| ES2639798T3 (es) | 2013-07-18 | 2017-10-30 | Idorsia Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano con puente sustituidos con piperazina como agonistas del receptor ALX |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| ES2752733T3 (es) | 2013-11-28 | 2020-04-06 | Kyorin Seiyaku Kk | Derivados de urea deuterados o marcados isotópicamente o sales farmacológicamente aceptables de los mismos útiles como agonistas de FPRL-1 |
| JP6746613B2 (ja) | 2015-05-27 | 2020-08-26 | 杏林製薬株式会社 | ウレア誘導体、またはその薬理学的に許容される塩 |
| WO2016189877A1 (en) | 2015-05-27 | 2016-12-01 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| CA3055093A1 (en) * | 2017-03-09 | 2018-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
| CN111868052B (zh) | 2018-03-05 | 2024-03-08 | 百时美施贵宝公司 | 苯基吡咯烷酮甲酰肽2受体激动剂 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62234018A (ja) | 1986-04-02 | 1987-10-14 | Rooto Seiyaku Kk | 糖尿病併発症治療剤 |
| KR20030030029A (ko) | 2000-09-22 | 2003-04-16 | 니혼노야쿠가부시키가이샤 | Ｎ-(4-피라졸릴)아미드 유도체 및 농원예용 약제 그리고그 사용방법 |
| US20050164305A1 (en) | 2002-04-03 | 2005-07-28 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| WO2005047899A2 (en) | 2003-11-07 | 2005-05-26 | Acadia Pharmaceuticals Inc. | Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation |
| AU2005247473A1 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| JP2009514858A (ja) | 2005-11-03 | 2009-04-09 | メルク エンド カムパニー インコーポレーテッド | アリール−ピラゾリルモチーフを有するヒストンデアセチラーゼ阻害剤 |
| NZ583350A (en) | 2007-08-21 | 2012-03-30 | Senomyx Inc | Heteroaryl-hydantoin derivatives as bitter taste inhibitors |
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| DK2225231T3 (da) * | 2007-12-18 | 2011-10-17 | Actelion Pharmaceuticals Ltd | Aminotriazolderivater som alx-agonister |
| JP5510945B2 (ja) | 2009-05-18 | 2014-06-04 | アクテリオン ファーマシューティカルズ リミテッド | Ａｌｘ受容体及び／又はｆｐｒｌ２アゴニストとしての架橋スピロ［２．４］ヘプタン誘導体 |
| CN101909306A (zh) * | 2009-06-08 | 2010-12-08 | 中兴通讯股份有限公司 | 中继站管理方法及基站 |
| JP5095035B2 (ja) * | 2009-06-09 | 2012-12-12 | アクテリオン ファーマシューティカルズ リミテッド | フッ素化アミノトリアゾール誘導体 |
| ES2440790T3 (es) | 2009-06-12 | 2014-01-30 | Actelion Pharmaceuticals Ltd. | Derivados de oxazol y tiazol como agonistas del receptor del ALX |
| JP2012254939A (ja) * | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
-
2011
- 2011-12-06 SI SI201130348T patent/SI2649068T1/sl unknown
- 2011-12-06 MX MX2013006418A patent/MX2013006418A/es active IP Right Grant
- 2011-12-06 WO PCT/IB2011/055487 patent/WO2012077049A1/en not_active Ceased
- 2011-12-06 PT PT118048107T patent/PT2649068E/pt unknown
- 2011-12-06 DK DK11804810.7T patent/DK2649068T3/en active
- 2011-12-06 AU AU2011340146A patent/AU2011340146B2/en not_active Ceased
- 2011-12-06 PL PL11804810T patent/PL2649068T3/pl unknown
- 2011-12-06 HR HRP20150049AT patent/HRP20150049T1/hr unknown
- 2011-12-06 EP EP11804810.7A patent/EP2649068B1/en not_active Not-in-force
- 2011-12-06 US US13/992,143 patent/US8846733B2/en not_active Expired - Fee Related
- 2011-12-06 KR KR1020137017686A patent/KR101864463B1/ko not_active Expired - Fee Related
- 2011-12-06 RU RU2013130879/04A patent/RU2588567C2/ru not_active IP Right Cessation
- 2011-12-06 CN CN201180058458.7A patent/CN103261194B/zh not_active Expired - Fee Related
- 2011-12-06 ES ES11804810.7T patent/ES2526132T3/es active Active
- 2011-12-06 CA CA2816376A patent/CA2816376C/en not_active Expired - Fee Related
- 2011-12-06 TW TW100144916A patent/TWI523853B/zh not_active IP Right Cessation
- 2011-12-06 JP JP2013542652A patent/JP5923107B2/ja not_active Expired - Fee Related
- 2011-12-06 AR ARP110104559A patent/AR084173A1/es unknown
-
2015
- 2015-01-23 CY CY20151100075T patent/CY1116004T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5923107B2 (ja) | 2016-05-24 |
| ES2526132T3 (es) | 2015-01-07 |
| AR084173A1 (es) | 2013-04-24 |
| HRP20150049T1 (hr) | 2015-02-27 |
| KR101864463B1 (ko) | 2018-06-04 |
| KR20130133240A (ko) | 2013-12-06 |
| US20130261159A1 (en) | 2013-10-03 |
| PL2649068T3 (pl) | 2015-03-31 |
| AU2011340146B2 (en) | 2016-05-19 |
| AU2011340146A1 (en) | 2013-07-25 |
| JP2013544878A (ja) | 2013-12-19 |
| WO2012077049A1 (en) | 2012-06-14 |
| CY1116004T1 (el) | 2017-01-25 |
| CA2816376C (en) | 2018-11-20 |
| DK2649068T3 (en) | 2014-12-08 |
| EP2649068A1 (en) | 2013-10-16 |
| TW201305151A (zh) | 2013-02-01 |
| PT2649068E (pt) | 2014-12-23 |
| CN103261194A (zh) | 2013-08-21 |
| EP2649068B1 (en) | 2014-10-29 |
| RU2588567C2 (ru) | 2016-07-10 |
| CA2816376A1 (en) | 2012-06-14 |
| US8846733B2 (en) | 2014-09-30 |
| CN103261194B (zh) | 2016-02-24 |
| TWI523853B (zh) | 2016-03-01 |
| RU2013130879A (ru) | 2015-01-20 |
| MX2013006418A (es) | 2013-07-15 |
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