SI20330A - Kisle soli N-/N-(3,3-dimetilbutil)-L-alfa-aspartil/-L-fenilalanin 1-metil estra - Google Patents

Kisle soli N-/N-(3,3-dimetilbutil)-L-alfa-aspartil/-L-fenilalanin 1-metil estra Download PDF

Info

Publication number: SI20330A
Authority: SI; Slovenia
Prior art keywords: phenylalanine; aspartyl; dimethylbutyl; methyl ester; sol
Prior art date: 1997-09-11

Application number

SI9820062A

Other languages

English (en)

Slovenian (sl)

Inventor

Indra Prakash

Kurt Wachholder

Original Assignee

The Nutrasweet Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-11

Filing date

1998-09-11

Publication date

2001-02-28

1998-09-11 Application filed by The Nutrasweet Company filed Critical The Nutrasweet Company

2001-02-28 Publication of SI20330A publication Critical patent/SI20330A/sl

Links

150000003839 salts Chemical class 0.000 title claims abstract description 24
235000010357 aspartame Nutrition 0.000 title description 19
229960005190 phenylalanine Drugs 0.000 title description 16
239000002253 acid Substances 0.000 title description 12
FGOJCPKOOGIRPA-UHFFFAOYSA-N 1-o-tert-butyl 4-o-ethyl 5-oxoazepane-1,4-dicarboxylate Chemical compound CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CCC1=O FGOJCPKOOGIRPA-UHFFFAOYSA-N 0.000 title description 11
-1 maleiate Chemical compound 0.000 claims abstract description 23
239000007788 liquid Substances 0.000 claims abstract description 11
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 8
235000013615 non-nutritive sweetener Nutrition 0.000 claims abstract description 8
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims abstract description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 6
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims abstract description 6
229940050410 gluconate Drugs 0.000 claims abstract description 6
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 6
229940049920 malate Drugs 0.000 claims abstract description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
HLIAVLHNDJUHFG-UHFFFAOYSA-N neotame Chemical class CC(C)(C)CCNC(CC(O)=O)C(=O)NC(C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-UHFFFAOYSA-N 0.000 claims description 17
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical class OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 11
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
239000002904 solvent Substances 0.000 claims description 8
239000000203 mixture Substances 0.000 claims description 6
229940022663 acetate Drugs 0.000 claims description 5
229940050390 benzoate Drugs 0.000 claims description 5
229940095064 tartrate Drugs 0.000 claims description 5
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
235000003599 food sweetener Nutrition 0.000 abstract description 16
239000003765 sweetening agent Substances 0.000 abstract description 16
108010016626 Dipeptides Proteins 0.000 abstract description 6
HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical class CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 abstract description 6
108010070257 neotame Proteins 0.000 abstract description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
239000000243 solution Substances 0.000 description 9
108010011485 Aspartame Proteins 0.000 description 7
239000000605 aspartame Substances 0.000 description 7
229960003438 aspartame Drugs 0.000 description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
239000010802 sludge Substances 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
150000001875 compounds Chemical class 0.000 description 5
239000007787 solid Substances 0.000 description 5
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
239000007858 starting material Substances 0.000 description 4
230000000007 visual effect Effects 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
235000013305 food Nutrition 0.000 description 3
238000000034 method Methods 0.000 description 3
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
235000013361 beverage Nutrition 0.000 description 2
150000001860 citric acid derivatives Chemical class 0.000 description 2
150000004702 methyl esters Chemical class 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
235000019605 sweet taste sensations Nutrition 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
206010011224 Cough Diseases 0.000 description 1
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
239000004384 Neotame Substances 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
239000002262 Schiff base Substances 0.000 description 1
150000004753 Schiff bases Chemical class 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
229940024606 amino acid Drugs 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
235000012839 cake mixes Nutrition 0.000 description 1
150000001721 carbon Chemical class 0.000 description 1
235000014171 carbonated beverage Nutrition 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
150000001728 carbonyl compounds Chemical class 0.000 description 1
235000013339 cereals Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000428 dust Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
235000015203 fruit juice Nutrition 0.000 description 1
235000015270 fruit-flavoured drink Nutrition 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000000174 gluconic acid Substances 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
235000019412 neotame Nutrition 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000013618 particulate matter Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000006340 racemization Effects 0.000 description 1
235000014438 salad dressings Nutrition 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
235000015961 tonic Nutrition 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
229960000716 tonics Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
- A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Nutrition Science (AREA)
Seasonings (AREA)
Peptides Or Proteins (AREA)

SI9820062A 1997-09-11 1998-09-11 Kisle soli N-/N-(3,3-dimetilbutil)-L-alfa-aspartil/-L-fenilalanin 1-metil estra SI20330A (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5850597P	1997-09-11	1997-09-11
PCT/US1998/018902 WO1999012956A1 (en)	1997-09-11	1998-09-11	ACID SALTS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER

Publications (1)

Publication Number	Publication Date
SI20330A true SI20330A (sl)	2001-02-28

Family

ID=22017224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9820062A SI20330A (sl)	1997-09-11	1998-09-11	Kisle soli N-/N-(3,3-dimetilbutil)-L-alfa-aspartil/-L-fenilalanin 1-metil estra

Country Status (18)

Country	Link
US (1)	US6180156B1 (lt)
EP (1)	EP1012168A1 (lt)
CN (1)	CN1278827A (lt)
AU (1)	AU753013B2 (lt)
BG (1)	BG104323A (lt)
BR (1)	BR9812635A (lt)
CA (1)	CA2303436A1 (lt)
EE (1)	EE200000119A (lt)
HU (1)	HUP0003573A3 (lt)
ID (1)	ID27534A (lt)
IL (1)	IL134914A0 (lt)
LT (1)	LT4759B (lt)
NO (1)	NO20001270L (lt)
PL (1)	PL339207A1 (lt)
SI (1)	SI20330A (lt)
SK (1)	SK3272000A3 (lt)
TR (1)	TR200000730T2 (lt)
WO (1)	WO1999012956A1 (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6692778B2 (en) *	1998-06-05	2004-02-17	Wm. Wrigley Jr. Company	Method of controlling release of N-substituted derivatives of aspartame in chewing gum
WO2000056176A1 (en) *	1999-03-25	2000-09-28	The Nutrasweet Company	EDIBLE GELS SWEETENED WITH N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER
US6365216B1 (en)	1999-03-26	2002-04-02	The Nutrasweet Company	Particles of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6368651B1 (en) *	1999-05-13	2002-04-09	The Nutrasweet Company	Use of additives to modify the taste characteristics of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester
WO2000069282A1 (en) *	1999-05-13	2000-11-23	The Nutrasweet Company	Modification of the taste and physicochemical properties of neotame using hydrophobic acid additives
US7326430B2 (en) *	2000-07-18	2008-02-05	The Nutrasweet Company	Method of preparing liquid compositions for delivery of N-[N- (3,3-dimethylbutyl-L-α-aspartyl]-L-phenylalanine 1-methyl ester in food and beverage systems
US20080008790A1 (en) *	2006-06-30	2008-01-10	Michael Jensen	Seasoned food, seasoning, and method for seasoning a food product
US20080038411A1 (en) *	2006-06-30	2008-02-14	Michael Jensen	Seasoning and method for enhancing and potentiating food flavor
US7923047B2 (en) *	2006-06-30	2011-04-12	Conagra Foods Rdm, Inc.	Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20110097449A1 (en) *	2006-06-30	2011-04-28	Conagra Foods Rdm, Inc.	Seasoning and method for seasoning a food product while reducing dietary sodium intake
WO2008039533A2 (en) *	2006-09-27	2008-04-03	Conagra Foods, Inc.	Seasoning and method for enhancing and potentiating food flavor utilizing microencapsulation
CN109180914B (zh) *	2018-04-05	2021-02-02	河南金丹乳酸科技股份有限公司	利用l-乳酸经寡聚、熔融缩聚和固相缩聚生产聚l-乳酸的方法
CN112321676B (zh) *	2020-12-12	2022-06-14	山东诚汇双达药业有限公司	一种纽甜的成盐方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029701A (en)	1972-03-30	1977-06-14	General Foods Corporation	Sweetening with hydrohalide salts of dipeptide sweeteners
GB1431057A (en) *	1972-03-30	1976-04-07	Gen Foods Corp	Sweetining compositions
US4031258A (en)	1972-03-30	1977-06-21	General Foods Corporation	Inorganic salts of dipeptide sweeteners
CA1028197A (en)	1973-04-02	1978-03-21	Jeffrey H. Berg	Concentrated liquid low calorie sweetener
US4448716A (en)	1982-03-04	1984-05-15	G. D. Searle & Co.	Dipeptide sweetener-metal complexes
FR2697844B1 (fr)	1992-11-12	1995-01-27	Claude Nofre	Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr)	1994-05-09	1996-07-26	Claude Nofre	Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
AU3075195A (en)	1994-06-28	1996-01-25	Twinklestar Investments N.V.	A communication system for supplying information on objects on display by means of hand-held devices
US5728862A (en)	1997-01-29	1998-03-17	The Nutrasweet Company	Method for preparing and purifying an N-alkylated aspartame derivative
JPH10259194A (ja) *	1997-03-18	1998-09-29	Ajinomoto Co Inc	新規ジペプチド誘導体及び甘味剤

1998
- 1998-09-04 US US09/146,964 patent/US6180156B1/en not_active Expired - Fee Related
- 1998-09-11 AU AU93844/98A patent/AU753013B2/en not_active Ceased
- 1998-09-11 WO PCT/US1998/018902 patent/WO1999012956A1/en not_active Ceased
- 1998-09-11 CN CN98811056A patent/CN1278827A/zh active Pending
- 1998-09-11 BR BR9812635-0A patent/BR9812635A/pt not_active Application Discontinuation
- 1998-09-11 EE EEP200000119A patent/EE200000119A/xx unknown
- 1998-09-11 SI SI9820062A patent/SI20330A/sl unknown
- 1998-09-11 EP EP98946938A patent/EP1012168A1/en not_active Ceased
- 1998-09-11 HU HU0003573A patent/HUP0003573A3/hu unknown
- 1998-09-11 ID IDW20000471D patent/ID27534A/id unknown
- 1998-09-11 PL PL98339207A patent/PL339207A1/xx unknown
- 1998-09-11 SK SK327-2000A patent/SK3272000A3/sk unknown
- 1998-09-11 CA CA002303436A patent/CA2303436A1/en not_active Abandoned
- 1998-09-11 TR TR2000/00730T patent/TR200000730T2/xx unknown
- 1998-09-11 IL IL13491498A patent/IL134914A0/xx unknown
2000
- 2000-03-10 NO NO20001270A patent/NO20001270L/no not_active Application Discontinuation
- 2000-04-06 LT LT2000026A patent/LT4759B/lt not_active IP Right Cessation
- 2000-04-10 BG BG104323A patent/BG104323A/xx unknown

Also Published As

Publication number	Publication date
EE200000119A (et)	2000-12-15
CN1278827A (zh)	2001-01-03
AU9384498A (en)	1999-03-29
NO20001270D0 (no)	2000-03-10
BG104323A (en)	2001-02-28
PL339207A1 (en)	2000-12-04
HUP0003573A2 (hu)	2001-05-28
SK3272000A3 (en)	2000-10-09
NO20001270L (no)	2000-05-10
LT4759B (lt)	2001-02-26
BR9812635A (pt)	2000-08-22
US6180156B1 (en)	2001-01-30
LT2000026A (lt)	2000-09-25
EP1012168A1 (en)	2000-06-28
WO1999012956A1 (en)	1999-03-18
IL134914A0 (en)	2001-05-20
ID27534A (id)	2001-04-12
TR200000730T2 (tr)	2001-06-21
HUP0003573A3 (en)	2001-08-28
AU753013B2 (en)	2002-10-03
CA2303436A1 (en)	1999-03-18

Publication	Publication Date	Title
SI20331A (sl)	2001-02-28	Bazične soli N-/N-(3,3-dimetilbutil)-L-alfa-aspartil/-L-fenilalanin 1-metil estra
SI20330A (sl)	2001-02-28	Kisle soli N-/N-(3,3-dimetilbutil)-L-alfa-aspartil/-L-fenilalanin 1-metil estra
US4448716A (en)	1984-05-15	Dipeptide sweetener-metal complexes
SI20328A (sl)	2001-02-28	Sladilne soli N-/N-(3,3-dimetilbutil)-L-alfa-aspartil/-L-fenilalanin 1-metil estra
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