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SG97986A1 - Process for selective derivatization of taxanes - Google Patents

Process for selective derivatization of taxanes

Info

Publication number
SG97986A1
SG97986A1 SG200006873A SG200006873A SG97986A1 SG 97986 A1 SG97986 A1 SG 97986A1 SG 200006873 A SG200006873 A SG 200006873A SG 200006873 A SG200006873 A SG 200006873A SG 97986 A1 SG97986 A1 SG 97986A1
Authority
SG
Singapore
Prior art keywords
sup
taxanes
hydroxytaxane
acyloxy
selective derivatization
Prior art date
Application number
SG200006873A
Inventor
A Holton Robert
Zhang Zhuming
A Clark Paul
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27368950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG97986(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of SG97986A1 publication Critical patent/SG97986A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Soil Working Implements (AREA)
  • Fats And Perfumes (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process is described for converting the C(7) hydroxy group of a 10-acyloxy-7-hydroxytaxane to an acetal or ketal, the process comprising treating the 10-acyloxy-7-hydroxytaxane with a ketalizing agent in the presence of an acid catalyst to form a C(7) ketalized taxane of the formula or wherein either X<sup>31</sup> or X<sup>32</sup> represents the 10-acyloxy-7-hydroxytaxane moiety and the other of X<sup>31</sup> and X<sup>32</sup> as well as X<sup>33</sup> and X<sup>34</sup> are independently hydrocarbyl, substituted hydrocarbyl or heteroaryl moieties. Taxanes having a ketalized C(7) hydroxy group are also described.
SG200006873A 1997-08-18 1998-08-17 Process for selective derivatization of taxanes SG97986A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5600097P 1997-08-18 1997-08-18
US8126598P 1998-04-09 1998-04-09
US09/063,477 US7288665B1 (en) 1997-08-18 1998-04-20 Process for selective derivatization of taxanes

Publications (1)

Publication Number Publication Date
SG97986A1 true SG97986A1 (en) 2003-08-20

Family

ID=27368950

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200006873A SG97986A1 (en) 1997-08-18 1998-08-17 Process for selective derivatization of taxanes

Country Status (25)

Country Link
US (5) US7288665B1 (en)
EP (6) EP1170292B1 (en)
JP (1) JP2001504864A (en)
KR (1) KR100596989B1 (en)
CN (3) CN1205196C (en)
AT (3) ATE326455T1 (en)
AU (1) AU744987B2 (en)
BR (1) BR9806145A (en)
CA (2) CA2268662A1 (en)
CY (1) CY1105399T1 (en)
CZ (1) CZ296580B6 (en)
DE (3) DE69834584T2 (en)
DK (3) DK1170292T3 (en)
ES (3) ES2259646T3 (en)
HU (1) HUP0300425A3 (en)
ID (1) ID21654A (en)
IL (3) IL129386A0 (en)
NO (4) NO325139B1 (en)
NZ (1) NZ335156A (en)
PL (3) PL193674B1 (en)
PT (3) PT1170293E (en)
RU (1) RU2225402C2 (en)
SG (1) SG97986A1 (en)
WO (1) WO1999009021A1 (en)
ZA (1) ZA987394B (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
IT1308636B1 (en) * 1999-03-02 2002-01-09 Indena Spa PROCEDURE FOR THE PREPARATION OF TASSANI FROM 10-DESACETILBACCATINAIII.
HK1047937A1 (en) 2000-02-02 2003-03-14 佛罗里达州立大学研究基金有限公司 C7 carbamoyloxy substituted taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CN1362958A (en) 2000-02-02 2002-08-07 佛罗里达州立大学研究基金有限公司 C7 carbonate substituted taxanes as antitumor agents
PL350028A1 (en) 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
CA2368534A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
AR030188A1 (en) 2000-02-02 2003-08-13 Univ Florida State Res Found TAXANO COMPOUNDS REPLACED WITH ESTERS IN C7; PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND PROCESS TO TREAT A MAMMER SUBJECT THAT SUFFERS FROM A CONDITION THAT RESPONDS TO TAXANS
IL145639A (en) 2000-02-02 2007-02-11 Univ Florida State Res Found C10 heterosubstituted acetate taxanes as antitumor agents
PL350331A1 (en) 2000-02-02 2002-12-02 Univ Florida State Res Found C10 carbamoyloxy substituted taxanes as antitumor agents
US6362217B2 (en) * 2000-03-17 2002-03-26 Bristol-Myers Squibb Company Taxane anticancer agents
IT1320107B1 (en) * 2000-11-28 2003-11-18 Indena Spa PROCEDURE FOR THE PREPARATION OF TAXANIC DERIVATIVES.
IT1319682B1 (en) * 2000-12-06 2003-10-23 Indena Spa PACLITAXEL SUMMARY PROCEDURE.
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
DK2286795T3 (en) 2002-06-26 2017-02-06 Syncore Biotechnology Co Ltd PROCEDURE FOR PREPARING A Cationic LIPOSOMAL PREPARATION INCLUDING A LIPOPHIL COMPOUND
CN101039957A (en) 2003-05-16 2007-09-19 因特缪恩公司 Synthetic chemokine receptor ligands and methods of use thereof
WO2005040758A2 (en) 2003-10-24 2005-05-06 Intermune, Inc. Use of pirfenidone in therapeutic regimens
CN1303077C (en) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 Preparation process for synthesized taxane
PE20050693A1 (en) 2004-02-13 2005-09-27 Univ Florida State Res Found TAXANS REPLACED WITH CYCLOPENTIL ESTERS IN C10
WO2005087222A1 (en) 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
CN1942459A (en) * 2004-05-14 2007-04-04 免疫基因公司 Facile method for synthesizing baccatin III compounds
WO2006089209A2 (en) 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby
AU2006258012B2 (en) * 2005-06-10 2011-04-07 Florida State University Research Foundation, Inc. Processes for the preparation of docetaxel
BRPI0611954A2 (en) * 2005-06-10 2009-04-28 Univ Florida State Res Found PROCEDURES FOR THE PRODUCTION OF POLYCYCIC Fused-ring compounds
US8168216B2 (en) 2006-03-22 2012-05-01 Medigene Ag Treatment of triple receptor negative breast cancer
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
PL210984B1 (en) * 2006-10-31 2012-03-30 Inst Farmaceutyczny Docetaxel production method
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
JP4833126B2 (en) * 2007-03-26 2011-12-07 Ｎｔｎ株式会社 Lubricant deterioration detection device and bearing with detection device
CN101274923B (en) * 2007-03-27 2011-02-02 中国科学院大连化学物理研究所 Preparation for paclitaxel, baccatin III and derivates thereof
CN101274924B (en) * 2007-03-27 2010-11-10 中国科学院大连化学物理研究所 Preparation for paclitaxel and derivatives thereof
WO2009040829A1 (en) * 2007-09-27 2009-04-02 Benzochem Lifescience (P) Limited A novel process for the preparation of docetaxel
JP2011517455A (en) 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド C (10) ethyl ester and C (10) cyclopropyl ester substituted taxanes
EP2296645B1 (en) 2008-05-22 2014-11-19 Galera Therapeutics, LLC Combination antitumor therapy
US20110172293A1 (en) 2008-07-08 2011-07-14 Fish Jason E Methods and Compositions for Modulating Angiogenesis
CN101863861A (en) * 2009-04-16 2010-10-20 山东靶点药物研究有限公司 Simple and efficient method for preparing paclitaxel analogue Larotaxel
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
EP2697211A4 (en) 2011-04-01 2014-08-13 Shilpa Medicare Ltd Process for preparing docetaxel and its hydrate
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN103159704B (en) * 2011-12-12 2015-06-10 上海佰霖国际贸易有限公司 Cabazitaxel intermediates and cabazitaxel intermediate preparation method
IN2015DN00552A (en) 2012-07-19 2015-06-26 Redwood Bioscience Inc
AU2013341711A1 (en) 2012-11-12 2015-05-21 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
KR102332790B1 (en) 2013-02-15 2021-12-01 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Chimeric Antigen Receptor and Methods of Use Thereof
WO2014160185A2 (en) 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
CN103145654A (en) * 2013-04-12 2013-06-12 江苏斯威森生物医药工程研究中心有限公司 Docetaxel semi-synthesis method
WO2014191989A1 (en) * 2013-05-26 2014-12-04 Idd Therapeutics Ltd. Conjugate of a taxane and biotin and uses thereof
AU2014354643B2 (en) 2013-11-27 2020-03-05 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
CA2940269C (en) 2014-02-19 2022-08-16 Aviv Therapeutics, Inc. Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer
KR20220025946A (en) 2014-03-21 2022-03-03 애브비 인코포레이티드 Anti-egfr antibodies and antibody drug conjugates
US10654875B2 (en) 2015-11-12 2020-05-19 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
TWI760319B (en) 2015-12-30 2022-04-11 杏國新藥股份有限公司 Treatment of breast cancer
EP3231421A1 (en) 2016-04-11 2017-10-18 Greenaltech, S.L. Uses of a carotenoid in the treatment or prevention of stress induced conditions
EP3448885A4 (en) 2016-04-26 2020-01-08 R.P. Scherer Technologies, LLC ANTIBODY CONJUGATES AND METHODS OF MAKING AND USING SAME
KR102783452B1 (en) 2016-06-01 2025-03-19 세르비에 아이피 유케이 리미티드 Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
CN109562169A (en) 2016-06-08 2019-04-02 艾伯维公司 Anti-CD98 Antibody and Antibody Drug Conjugate
EP3835322A3 (en) 2016-06-08 2021-10-06 AbbVie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
CN109562168A (en) 2016-06-08 2019-04-02 艾伯维公司 Anti-CD98 Antibody and Antibody Drug Conjugate
EP3469000A1 (en) 2016-06-08 2019-04-17 AbbVie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
WO2017214322A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
TWI852903B (en) 2017-01-05 2024-08-21 杏國新藥股份有限公司 Treatment of pancreatic cancer
AU2018211081B2 (en) 2017-01-18 2025-01-02 Bioatla, Inc. Chimeric antigen receptors against Axl or Ror2 and methods of use thereof
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
CN118652192A (en) 2017-05-24 2024-09-17 德克萨斯州大学系统董事会 Linkers for antibody drug conjugates
CN111902147A (en) 2018-01-31 2020-11-06 加莱拉实验室有限责任公司 Combination cancer therapy of pentaazamacrocycle complexes and platinum-based anticancer agents
CA3096202A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating egfrviii expressing glioblastomas
EP3773633A4 (en) 2018-04-06 2022-01-26 The Regents of The University of California GLIOBLASTOMA TREATMENT METHODS
KR20210009315A (en) 2018-04-11 2021-01-26 오하이오 스테이트 이노베이션 파운데이션 Method and composition using sustained-release microparticles for delivery of eye drops
US11897928B2 (en) 2018-07-18 2024-02-13 Manzanita Pharmaceuticals, Inc. Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof
KR20220004653A (en) 2019-04-02 2022-01-11 켄조케티 바이오테크놀러지 인코포레이티드 Effluent pump-cancer antigen multispecific antibodies and compositions, reagents, kits and methods related thereto
BR112022013870A2 (en) 2020-01-29 2022-09-13 Kenjockety Biotechnology Inc ANTI-MDR1 ANTIBODIES AND USES THEREOF
US20230212305A1 (en) 2020-06-04 2023-07-06 Kenjockety Biotechnology, Inc. Anti-abcg2 antibodies and uses thereof
WO2021247423A1 (en) 2020-06-04 2021-12-09 Kenjockety Biotechnology, Inc. Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
JP7747741B2 (en) 2020-09-02 2025-10-01 ウィリアム ロバート アラスーン リビング トラスト デイテッド オーガスト 29, 2016 Anti-ABCC1 antibodies and uses thereof
US20240010747A1 (en) 2020-11-13 2024-01-11 Kenjockety Biotechnology, Inc. Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
JP2023551203A (en) 2020-11-20 2023-12-07 アール．ピー．シェーラー テクノロジーズ、エルエルシー Glycosidic double cleavage linkers for antibody-drug conjugates
AR124681A1 (en) 2021-01-20 2023-04-26 Abbvie Inc ANTI-EGFR ANTIBODY-DRUG CONJUGATES
WO2023114658A1 (en) 2021-12-13 2023-06-22 Kenjockety Biotechnology, Inc. Anti-abcb1 antibodies
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US5616739A (en) * 1992-10-05 1997-04-01 Rhone-Poulenc Rorer, S.A. Method of preparing taxane derivatives
EP0400971B1 (en) * 1989-05-31 1998-07-29 Florida State University Method for preparation of taxol
EP0629701B1 (en) * 1993-06-15 2000-01-19 Bristol-Myers Squibb Company Enzymatic hydrolysis methods for the preparation of C-10 and C-13 hydroxyl-bearing taxanes, enzymatic esterification method for the preparation of C-10 acyloxy-bearing taxanes, and use thereof in the preparation of C-13 acyloxy-bearing taxanes

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US569666A (en) * 1896-10-20 Brake-beam
FR2601676B1 (en) 1986-07-17 1988-09-23 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF TAXOL AND DESACETYL-10 TAXOL
FR2629818B1 (en) * 1988-04-06 1990-11-16 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF TAXOL
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
JPH01309997A (en) * 1988-06-09 1989-12-14 Kanto Kasei Kogyo Kk Method for obtaining copper-nickel-chromium bright electroplating having excellent corrosion resistance and plating film obtained thereby
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2678930B1 (en) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF DERIVATIVES OF BACCATIN III AND DESACETYL-10 BACCATIN III.
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
CA2254273C (en) * 1991-09-23 2003-03-25 Florida State University Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
FR2687145B1 (en) 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa NEW ANHYDRIDES OF ACIDS, THEIR PREPARATION AND THEIR PACKAGE AND
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5416225A (en) 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
US5254703A (en) 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
JPH07505887A (en) 1992-04-17 1995-06-29 アボツト・ラボラトリーズ Taxol derivative
US5440056A (en) 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
US5269442A (en) * 1992-05-22 1993-12-14 The Cornelius Company Nozzle for a beverage dispensing valve
US5470866A (en) 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5478854A (en) 1992-10-01 1995-12-26 Bristol-Myers Squibb Company Deoxy taxols
FR2696460B1 (en) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Process for the preparation of taxane derivatives.
US5412116A (en) 1992-11-06 1995-05-02 Hauser Chemical Research, Inc. Oxidation of glycoside substituted taxanes to taxol or taxol precursors and new taxane compounds formed as intermediates
FR2698363B1 (en) 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa New taxane derivatives, their preparation and the compositions containing them.
US5380751A (en) 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (en) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa New taxoids, their preparation and the pharmaceutical compositions containing them.
MX9307777A (en) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METHANE-TAXOLES, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
FR2702212B1 (en) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa New taxoids, their preparation and the pharmaceutical compositions containing them.
US5547981A (en) 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5336684A (en) 1993-04-26 1994-08-09 Hauser Chemical Research, Inc. Oxidation products of cephalomannine
FR2718137B1 (en) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Process for the preparation of trialcoylsilyl-7 baccatine III.
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
AU4133096A (en) * 1994-10-28 1996-05-23 Research Foundation Of The State University Of New York, The Taxoid derivatives, their preparation and their use as antitumor agents
US5489589A (en) 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
JPH08253465A (en) * 1995-03-17 1996-10-01 Dai Ichi Seiyaku Co Ltd Tetracyclic compound
MA23823A1 (en) * 1995-03-27 1996-10-01 Aventis Pharma Sa NEW TAXOIDS, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
FR2743074B1 (en) * 1995-12-27 1998-03-27 Seripharm METHOD FOR THE SELECTIVE PROTECTION OF BACCATIN DERIVATIVES AND ITS USE IN THE SYNTHESIS OF TAXANES
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
EP0914116B1 (en) * 1996-05-22 2000-10-11 Protarga Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
US5773461A (en) 1996-06-06 1998-06-30 Bristol-Myers Squibb Company 7-deoxy-6-substituted paclitaxels
FR2750989B1 (en) 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa PROCESS FOR MONOACYLATION OF HYDROXY TAXANES
US5750736A (en) 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
DE69725700T2 (en) 1997-05-02 2004-07-22 Pharmachemie B.V. Process for the preparation of baccatin III and its derivatives starting from 10-deacetylbaccatin III.
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5914411A (en) 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400971B1 (en) * 1989-05-31 1998-07-29 Florida State University Method for preparation of taxol
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5616739A (en) * 1992-10-05 1997-04-01 Rhone-Poulenc Rorer, S.A. Method of preparing taxane derivatives
EP0629701B1 (en) * 1993-06-15 2000-01-19 Bristol-Myers Squibb Company Enzymatic hydrolysis methods for the preparation of C-10 and C-13 hydroxyl-bearing taxanes, enzymatic esterification method for the preparation of C-10 acyloxy-bearing taxanes, and use thereof in the preparation of C-13 acyloxy-bearing taxanes
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US5637732A (en) * 1993-07-20 1997-06-10 Florida State University Tricyclic and tetracyclic taxanes

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