SG167561A1 - - Google Patents

Info

Publication number: SG167561A1
Authority: SG; Singapore

Application number

SG201009559A

Other languages

English (en)

Inventor

Wei-Guo Su

Yongxin Ren

Xiaoquiang Yan

Weihan Zhang

Haibin Yang

Yumin Cui

Original Assignee

Hutchison Medipharma Entpr Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-30

Filing date

2009-06-30

Publication date

2011-01-28

2009-06-30 Application filed by Hutchison Medipharma Entpr Ltd filed Critical Hutchison Medipharma Entpr Ltd

2011-01-28 Publication of SG167561A1 publication Critical patent/SG167561A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG201009559A 2008-06-30 2009-06-30 SG167561A1 (sl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12/164,610 US8426430B2 (en)	2008-06-30	2008-06-30	Quinazoline derivatives

Publications (1)

Publication Number	Publication Date
SG167561A1 true SG167561A1 (sl)	2011-01-28

Family

ID=41466556

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG10201604677RA SG10201604677RA (en)	2008-06-30	2009-06-30	Quinazoline Derivatives
SG201009559A SG167561A1 (sl)	2008-06-30	2009-06-30

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SG10201604677RA SG10201604677RA (en)	2008-06-30	2009-06-30	Quinazoline Derivatives

Country Status (22)

Country	Link
US (2)	US8426430B2 (sl)
EP (1)	EP2318378B1 (sl)
JP (1)	JP5602729B2 (sl)
KR (1)	KR101664503B1 (sl)
AU (1)	AU2009267136B2 (sl)
BR (1)	BRPI0908635B8 (sl)
CA (1)	CA2726040C (sl)
CY (1)	CY1114842T1 (sl)
DK (1)	DK2318378T3 (sl)
ES (1)	ES2442946T3 (sl)
HR (1)	HRP20140066T8 (sl)
MX (1)	MX2010012692A (sl)
MY (1)	MY150493A (sl)
NZ (1)	NZ589191A (sl)
PH (1)	PH12010502934A1 (sl)
PL (1)	PL2318378T3 (sl)
PT (1)	PT2318378E (sl)
RU (1)	RU2505534C2 (sl)
SG (2)	SG10201604677RA (sl)
SI (1)	SI2318378T1 (sl)
TW (1)	TWI407962B (sl)
WO (1)	WO2010002845A2 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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US9166071B2 (en)	2009-10-27	2015-10-20	Silicor Materials Inc.	Polarization resistant solar cell design using an oxygen-rich interface layer
CN102311438A (zh) *	2010-06-30	2012-01-11	和记黄埔医药（上海）有限公司	喹唑啉化合物
WO2012000182A1 (en) *	2010-06-30	2012-01-05	Hutchison Medipharma Limited	Quinazoline compounds
CN102906086B (zh) *	2010-06-30	2014-02-12	和记黄埔医药（上海）有限公司	喹唑啉化合物
TWI466888B (zh) *	2011-05-25	2015-01-01	Hutchison Medipharma Ltd	喹唑啉化合物
TWI577671B (zh) *	2011-11-14	2017-04-11	Sunshine Lake Pharma Co Ltd	Aminoquinazoline derivatives and salts thereof and methods of use thereof
CN102659692B (zh)	2012-05-04	2014-04-09	郑州泰基鸿诺药物科技有限公司	双联厄洛替尼及其制备方法
CN102702115A (zh) *	2012-05-24	2012-10-03	盛世泰科生物医药技术(苏州)有限公司	一种4-氯-7-氟-6-硝基喹唑啉的合成方法
CN102775315A (zh) *	2012-07-31	2012-11-14	上海应用技术学院	一种间氨基苯乙炔的制备方法
CN103275018B (zh) *	2013-04-26	2016-03-02	浙江工业大学	4-[3-氯-4-取代苯胺基]-6-取代甲酰氨基喹唑啉类化合物及制备和应用
CN108863951A (zh) *	2017-05-16	2018-11-23	和记黄埔医药（上海）有限公司	化合物的盐及其晶型
WO2020007219A1 (zh) *	2018-07-02	2020-01-09	南京明德新药研发有限公司	一种egfr抑制剂的晶型及其制备方法
CN110903253B (zh) *	2019-12-13	2020-12-25	西安交通大学医学院第一附属医院	一种喹唑啉酮类化合物及其制备方法和应用
US20240382475A1 (en) *	2021-08-30	2024-11-21	Zhejiang Hisun Pharmaceutical Co., Ltd.	Quinazoline Derivative, Or Preparation Method Therefor And Use Thereof
MX2024010283A (es) *	2022-02-28	2024-08-28	Sironax Ltd	Moduladores rip1, preparaciones y usos de los mismos.
CN118834200A (zh) *	2024-06-27	2024-10-25	辽宁大学	含酰胺结构的4-苯胺基喹唑啉类化合物及其应用

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US5430148A (en) *	1992-03-31	1995-07-04	Agouron Pharmaceuticals, Inc.	Antiproliferative quinazolines
JP2994165B2 (ja) *	1992-06-26	1999-12-27	ゼネカ・リミテッド	キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
GB9510757D0 (en) *	1994-09-19	1995-07-19	Wellcome Found	Therapeuticaly active compounds
GB9508565D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quiazoline derivative
DE69710712T3 (de) *	1996-04-12	2010-12-23	Warner-Lambert Co. Llc	Umkehrbare inhibitoren von tyrosin kinasen
HRP970371A2 (en) *	1996-07-13	1998-08-31	Kathryn Jane Smith	Heterocyclic compounds
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JP4044839B2 (ja)	2000-06-22	2008-02-06	ファイザー・プロダクツ・インク	異常細胞増殖を治療するための置換２環式誘導体
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DE10204462A1 (de)	2002-02-05	2003-08-07	Boehringer Ingelheim Pharma	Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
GB0206215D0 (en)	2002-03-15	2002-05-01	Novartis Ag	Organic compounds
NZ537752A (en)	2002-07-29	2006-12-22	Rigel Pharmaceuticals Inc	Use of 2,4-pyrimidinediamine compounds in the preparation of medicaments for treating autoimmune diseases
JO2785B1 (en)	2003-05-27	2014-03-15	شركة جانسين فارماسوتيكا ان. في	Quinazoline derivatives
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GB0321710D0 (en) *	2003-09-16	2003-10-15	Novartis Ag	Organic compounds
JP4503022B2 (ja)	2003-12-23	2010-07-14	ファイザー・インク	新規キノリン誘導体
KR100735639B1 (ko)	2004-12-29	2007-07-04	한미약품 주식회사	암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
WO2006071079A1 (en)	2004-12-29	2006-07-06	Hanmi Pharm. Co., Ltd.	Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof
NZ564222A (en)	2005-06-14	2011-10-28	Taigen Biotechnology Co Ltd	Pyrimidine compounds
US20090182140A1 (en) *	2005-12-02	2009-07-16	Mitsubishi Tanabe Pharma Corporation	Alicyclic Heterocyclic Compound
NZ576065A (en)	2006-09-18	2011-12-22	Boehringer Ingelheim Int	Method for treating cancer harboring egfr mutations

2008
- 2008-06-30 US US12/164,610 patent/US8426430B2/en not_active Expired - Fee Related
- 2008-07-04 TW TW097125257A patent/TWI407962B/zh not_active IP Right Cessation
2009
- 2009-06-30 BR BRPI0908635A patent/BRPI0908635B8/pt not_active IP Right Cessation
- 2009-06-30 CA CA2726040A patent/CA2726040C/en not_active Expired - Fee Related
- 2009-06-30 ES ES09774296.9T patent/ES2442946T3/es active Active
- 2009-06-30 RU RU2011103207/04A patent/RU2505534C2/ru active
- 2009-06-30 KR KR1020107025451A patent/KR101664503B1/ko not_active Expired - Fee Related
- 2009-06-30 WO PCT/US2009/049182 patent/WO2010002845A2/en not_active Ceased
- 2009-06-30 PL PL09774296T patent/PL2318378T3/pl unknown
- 2009-06-30 MX MX2010012692A patent/MX2010012692A/es active IP Right Grant
- 2009-06-30 HR HRP20140066AT patent/HRP20140066T8/hr unknown
- 2009-06-30 AU AU2009267136A patent/AU2009267136B2/en not_active Ceased
- 2009-06-30 NZ NZ589191A patent/NZ589191A/xx not_active IP Right Cessation
- 2009-06-30 SI SI200930832T patent/SI2318378T1/sl unknown
- 2009-06-30 MY MYPI20105323 patent/MY150493A/en unknown
- 2009-06-30 DK DK09774296.9T patent/DK2318378T3/da active
- 2009-06-30 PT PT97742969T patent/PT2318378E/pt unknown
- 2009-06-30 SG SG10201604677RA patent/SG10201604677RA/en unknown
- 2009-06-30 EP EP09774296.9A patent/EP2318378B1/en active Active
- 2009-06-30 JP JP2011516797A patent/JP5602729B2/ja not_active Expired - Fee Related
- 2009-06-30 PH PH12010502934A patent/PH12010502934A1/en unknown
- 2009-06-30 SG SG201009559A patent/SG167561A1/en unknown
2013
- 2013-03-18 US US13/846,140 patent/US20130217661A1/en not_active Abandoned
- 2013-11-26 CY CY20131101057T patent/CY1114842T1/el unknown

Also Published As

Publication number	Publication date
MY150493A (en)	2014-01-30
DK2318378T3 (da)	2013-11-18
HRP20140066T8 (en)	2014-03-28
RU2011103207A (ru)	2012-08-10
HRP20140066T1 (hr)	2014-02-28
US20100009958A1 (en)	2010-01-14
SI2318378T1 (sl)	2014-03-31
SG10201604677RA (en)	2016-07-28
AU2009267136B2 (en)	2013-10-10
JP2011526913A (ja)	2011-10-20
WO2010002845A3 (en)	2010-04-01
WO2010002845A2 (en)	2010-01-07
BRPI0908635A2 (pt)	2015-10-13
TW201002329A (en)	2010-01-16
EP2318378B1 (en)	2013-10-23
ES2442946T3 (es)	2014-02-14
PH12010502934A1 (en)	2010-01-07
BRPI0908635B8 (pt)	2021-05-25
US20130217661A1 (en)	2013-08-22
EP2318378A2 (en)	2011-05-11
PL2318378T3 (pl)	2014-05-30
CY1114842T1 (el)	2016-12-14
CA2726040A1 (en)	2010-01-07
KR101664503B1 (ko)	2016-10-12
RU2505534C2 (ru)	2014-01-27
PT2318378E (pt)	2014-01-03
JP5602729B2 (ja)	2014-10-08
NZ589191A (en)	2013-03-28
BRPI0908635A8 (pt)	2018-12-18
TWI407962B (zh)	2013-09-11
US8426430B2 (en)	2013-04-23
BRPI0908635B1 (pt)	2020-09-01
CA2726040C (en)	2014-08-12
KR20110025741A (ko)	2011-03-11
AU2009267136A1 (en)	2010-01-07
MX2010012692A (es)	2010-12-20
EP2318378A4 (en)	2012-05-09

Publication	Publication Date	Title
BR112016019572A2 (sl)	2017-08-15
BRPI0909040A2 (sl)	2017-09-19
BRPI0908549B8 (sl)	2021-06-08
BRPI0920750A2 (sl)	2016-02-02
BRPI0907698A2 (sl)	2017-08-22
BRPI0922455A2 (sl)	2021-12-28
BRPI0923734A2 (sl)	2017-07-11
BRPI0922669A2 (sl)	2017-07-11
BRPI0908285A2 (sl)	2017-08-29
BRPI0910485A2 (sl)	2017-08-29
BRPI0908120A2 (sl)	2017-08-22
BRPI0904541A8 (sl)	2010-09-21
BRPI0920914A2 (sl)	2017-07-11
BRPI0922550A2 (sl)	2016-02-02
SG167561A1 (sl)	2011-01-28
BRPI0909508A2 (sl)	2017-08-22
CH2352018H2 (sl)	2019-09-13
AR073287B1 (sl)	2015-09-23
BRPI0923127A (sl)	2010-07-01
BRPI0923137A2 (sl)	2010-06-10
BRMU8803485U8 (sl)	2010-09-14
CL47313B1 (sl)	2008-03-11
CN300892639S (zh)	2009-03-18	视听柜(r-2809)
CN300882908S (zh)	2009-02-11	容器盖(长方形密封保鲜)
CN300892359S (zh)	2009-03-18	布(92)