SG136969A1 - Influenza therapeutic - Google Patents
Influenza therapeuticInfo
- Publication number
- SG136969A1 SG136969A1 SG200717681-1A SG2007176811A SG136969A1 SG 136969 A1 SG136969 A1 SG 136969A1 SG 2007176811 A SG2007176811 A SG 2007176811A SG 136969 A1 SG136969 A1 SG 136969A1
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- rnai
- influenza
- inhibiting
- influenza virus
- Prior art date
Links
- 206010022000 influenza Diseases 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 4
- 230000009368 gene silencing by RNA Effects 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 241000712461 unidentified influenza virus Species 0.000 abstract 3
- 108091027967 Small hairpin RNA Proteins 0.000 abstract 2
- 108020004459 Small interfering RNA Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000010076 replication Effects 0.000 abstract 2
- 229940124447 delivery agent Drugs 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000001524 infective effect Effects 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 230000007918 pathogenicity Effects 0.000 abstract 1
- 210000004927 skin cell Anatomy 0.000 abstract 1
- 239000004055 small Interfering RNA Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides methods and compositions for inhibiting influenza infection and/or replication based on the phenomenon of RNA interference (RNAi) as well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and/or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41445702P | 2002-09-28 | 2002-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG136969A1 true SG136969A1 (en) | 2007-11-29 |
Family
ID=38077111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200717681-1A SG136969A1 (en) | 2002-09-28 | 2003-09-29 | Influenza therapeutic |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1968959B (en) |
| SG (1) | SG136969A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103966213A (en) * | 2013-02-06 | 2014-08-06 | 霍晋 | Design of siRNA sequences possessing interference effect on influenza A virus M gene and identification on interference effect |
| CN103966212A (en) * | 2013-02-06 | 2014-08-06 | 霍晋 | Design of siRNA sequences possessing interference effect on influenza A virus NP gene and application |
| CN103966214A (en) * | 2013-02-06 | 2014-08-06 | 霍晋 | Design of siRNA sequences possessing interference effect on influenza A virus NP gene and application |
| CN105002179B (en) * | 2015-07-14 | 2018-07-06 | 中国农业科学院哈尔滨兽医研究所 | It can inhibit shRNA transgenosis recombinant plasmid and its application of swine influenza virus |
| CN106947763B (en) * | 2017-03-20 | 2019-11-12 | 中国医学科学院医药生物技术研究所 | Inhalable siRNA against influenza virus infection and its application |
| CN112375758B (en) * | 2020-11-17 | 2022-12-13 | 中国人民解放军空军军医大学 | Anti-hantavirus antisense nucleic acid sequence and application thereof |
-
2003
- 2003-09-29 CN CN038254204A patent/CN1968959B/en not_active Expired - Fee Related
- 2003-09-29 SG SG200717681-1A patent/SG136969A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1968959A (en) | 2007-05-23 |
| CN1968959B (en) | 2011-12-28 |
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