SG11201900518XA - Biomarker detection system - Google Patents
Biomarker detection systemInfo
- Publication number
- SG11201900518XA SG11201900518XA SG11201900518XA SG11201900518XA SG11201900518XA SG 11201900518X A SG11201900518X A SG 11201900518XA SG 11201900518X A SG11201900518X A SG 11201900518XA SG 11201900518X A SG11201900518X A SG 11201900518XA SG 11201900518X A SG11201900518X A SG 11201900518XA
- Authority
- SG
- Singapore
- Prior art keywords
- singapore
- international
- lspr
- assembly
- nanopillar
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title abstract 4
- 238000001514 detection method Methods 0.000 title abstract 2
- 239000002061 nanopillar Substances 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 4
- 125000006850 spacer group Chemical group 0.000 abstract 4
- 239000002096 quantum dot Substances 0.000 abstract 3
- 229920002799 BoPET Polymers 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 2
- 230000001070 adhesive effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 abstract 2
- 239000004926 polymethyl methacrylate Substances 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/585—Calcitonins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 January 2018 (25.01.2018) WIP0 I PCT omit °nolo omm olo (10) International Publication Number WO 2018/017021 A3 (51) International Patent Classification: GO1N 21/64 (2006.01) GO1N 21/552 (2014.01) (21) International Application Number: PCT/SG2017/050372 (22) International Filing Date: 21 July 2017 (21.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201606001Q 21 July 2016 (21.07.2016) SG (71) Applicants: TEMASEK POLYTECHNIC [SG/SG]; 21 Tampines Avenue 1, Singapore 529757 (SG). AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10, Connexis, Singa- pore 138632 (SG). TAN TOCK SENG HOSPITAL PTE LTD [SG/SG]; 11 Jalan Tan Tock Seng, Singapore 308433 (SG). (72) Inventors: SUN, Ling Ling; c/o Temasek Polytechnic, 21 Tampines Avenue 1, Singapore 529757 (SG). NG, Willie; c/o Temasek Polytechnic, 21 Tampines Avenue 1, Sin- gapore 529757 (SG). ZHOU, Xiaodong; c/o Institute of Materials Research and Engineering 2 Fusionopolis Way, #08-03, Innovis, Singapore 138634 (SG). WONG, Ten It; c/o Institute of Materials Research and Engineering 2 Fu- sionopolis Way, #08-03, Innovis, Singapore 138634 (SG). LEO, Yee Sin; c/o Tan Tock Seng Hospital Pte Ltd, 11 Jalan Tan Tock Seng, Singapore 308433 (SG). (74) Agent: DAVIES COLLISON CAVE ASIA PTE. LTD.; 10 Collyer Quay #07-01 Ocean Financial Centre, Singapore 049315 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (54) Title: BIOMARKER DETECTION SYSTEM Layer 1 PMMA Layer 2 Double-side adhesive Mylar ® Layer 3 Single-side adhesive Mylar ® Layer 4 PMMA O N O 00 O O Figure 5 (57) : Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar. [Continued on next page] WO 2018/017021 A3 MIDEDIMOMOIDEIRDERIO 011111101011011010111 11111111101110 II MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 21 June 2018 (21.06.2018)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201606001Q | 2016-07-21 | ||
| PCT/SG2017/050372 WO2018017021A2 (en) | 2016-07-21 | 2017-07-21 | Biomarker detection system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201900518XA true SG11201900518XA (en) | 2019-02-27 |
Family
ID=60992445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900518XA SG11201900518XA (en) | 2016-07-21 | 2017-07-21 | Biomarker detection system |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11719632B2 (en) |
| EP (1) | EP3488228B1 (en) |
| CN (1) | CN110199192B (en) |
| SG (1) | SG11201900518XA (en) |
| WO (1) | WO2018017021A2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019135494A1 (en) | 2018-01-08 | 2019-07-11 | 주식회사 에스오에스랩 | Lidar device |
| US10591598B2 (en) | 2018-01-08 | 2020-03-17 | SOS Lab co., Ltd | Lidar device |
| WO2019194814A1 (en) * | 2018-04-06 | 2019-10-10 | Hewlett-Packard Development Company, L.P. | Luminescence-enhancement systems |
| KR102155425B1 (en) * | 2018-05-14 | 2020-09-11 | 주식회사 에스오에스랩 | Lidar device |
| WO2020117282A1 (en) * | 2018-12-03 | 2020-06-11 | University Of Notre Dame Du Lac | Biosensor and method for detection of analytes |
| JP7300201B2 (en) * | 2019-12-23 | 2023-06-29 | 国立研究開発法人物質・材料研究機構 | Biomolecular test chip for fluorescence detection |
| CN112881312B (en) * | 2021-01-15 | 2022-04-05 | 中山大学 | A detection device for simultaneously monitoring solution changes and sensor solid/liquid interface changes |
| CN113447474A (en) * | 2021-04-06 | 2021-09-28 | 南京精迅分子科技有限公司 | Equipment for intelligent evaluation of infection marker |
| CN113267472B (en) * | 2021-06-28 | 2023-02-14 | 郑州轻工业大学 | SPR sensor chip and preparation method thereof |
| US12094602B1 (en) * | 2023-07-11 | 2024-09-17 | Fresh Health Inc. | Verifying a performance of an oral insert |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7738096B2 (en) * | 2004-10-21 | 2010-06-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof |
| EP2472258A3 (en) * | 2006-04-04 | 2012-11-28 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| CN101236208B (en) | 2007-02-01 | 2012-07-04 | 四川大学 | Method for identifying blood albumen by chemically modified zinc oxide nanometer rod array film |
| AU2013246359B2 (en) | 2012-04-10 | 2017-03-30 | The Trustees Of Princeton University | Ultra-sensitive sensor |
| US20160003817A1 (en) * | 2012-04-10 | 2016-01-07 | The Trustees Of Princeton University | Rapid and sensitive analyte measurement assay |
| US9995749B2 (en) | 2014-02-04 | 2018-06-12 | Agency For Science, Technology And Research | Method for detecting a target analyte |
| CN107209171A (en) | 2014-10-21 | 2017-09-26 | 普林斯顿大学理事会 | system and method for personal sample analysis |
| WO2016187588A1 (en) * | 2015-05-21 | 2016-11-24 | Lamdagen Corporation | Plasmonic nanoparticles and lspr-based assays |
-
2017
- 2017-07-21 WO PCT/SG2017/050372 patent/WO2018017021A2/en not_active Ceased
- 2017-07-21 CN CN201780045273.XA patent/CN110199192B/en active Active
- 2017-07-21 SG SG11201900518XA patent/SG11201900518XA/en unknown
- 2017-07-21 US US16/318,946 patent/US11719632B2/en active Active
- 2017-07-21 EP EP17752501.1A patent/EP3488228B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110199192B (en) | 2023-01-17 |
| CN110199192A (en) | 2019-09-03 |
| EP3488228B1 (en) | 2021-05-26 |
| EP3488228A2 (en) | 2019-05-29 |
| US11719632B2 (en) | 2023-08-08 |
| WO2018017021A2 (en) | 2018-01-25 |
| WO2018017021A3 (en) | 2018-06-21 |
| US20190302022A1 (en) | 2019-10-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201900518XA (en) | Biomarker detection system | |
| SG11201900653RA (en) | Silyl-bridged bis-biphenyl-phenoxy catalysts for olefin polymerization | |
| SG11201710238QA (en) | Autonomic incident triage prioritization by performance modifier and temporal decay parameters | |
| SG11201904942YA (en) | Blockchain-based service execution method and apparatus, and electronic device | |
| SG11202000073XA (en) | Anti-cd8 antibodies and uses thereof | |
| SG11201810175YA (en) | Relational rendering of holographic objects | |
| SG11201809284UA (en) | Mobile device connection apparatus | |
| SG11201902985WA (en) | Installation trailer for coiled flexible pipe and method of utilizing same | |
| SG11201908847TA (en) | Apparatuses, systems and methods for imaging flow cytometry | |
| SG11201809793UA (en) | Tl1a antibodies and uses thereof | |
| SG11201903738QA (en) | Offshore gnss reference station apparatus, offshore gnss positioning system, and method of generating positioning reference data offshore | |
| SG11201407417VA (en) | Encoding and reconstruction of residual data based on support information | |
| SG11201805532XA (en) | Multivalent and multispecific 41bb-binding fusion proteins | |
| SG11201908639XA (en) | Germanium-bridged bis-biphenyl-phenoxy catalysts for olefin polymerization | |
| SG11201806798XA (en) | Systems and methods for allowing a user to access blocked media | |
| SG11201900655UA (en) | Mixed catalyst systems for producing multimodal elastomers | |
| SG11201907671XA (en) | Systems and methods for cracking hydrocarbon streams such as crude oils utilizing catalysts which include zeolite mixtures | |
| SG11201901168UA (en) | Apparatuses and methods including ferroelectric memory and for operating ferroelectric memory | |
| SG11201907319QA (en) | Gamma delta t cells and a method of augmenting the tumoricidal activity of the same | |
| SG11201811822WA (en) | Sensor for a fingerboard latch assembly | |
| SG11201807466PA (en) | Negative type photosensitive composition curable at low temperature | |
| SG11201810411VA (en) | Metamaterial split ring resonator, metamaterial split ring resonator array and energy harvesting apparatus | |
| SG11201805115PA (en) | Detection and quantification of target nucleic acid sequence of a microorganism | |
| SG11201811409UA (en) | Systems and methods for determining combinative service requesters | |
| SG11201902979XA (en) | Expandable drum assembly for deploying coiled pipe and method of using same |