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SG11201810171SA - Kras g12c inhibitors - Google Patents

Kras g12c inhibitors

Info

Publication number
SG11201810171SA
SG11201810171SA SG11201810171SA SG11201810171SA SG11201810171SA SG 11201810171S A SG11201810171S A SG 11201810171SA SG 11201810171S A SG11201810171S A SG 11201810171SA SG 11201810171S A SG11201810171S A SG 11201810171SA SG 11201810171S A SG11201810171S A SG 11201810171SA
Authority
SG
Singapore
Prior art keywords
boulder
walnut
array biopharma
array
international
Prior art date
Application number
SG11201810171SA
Inventor
John Fischer
Jay Fell
James Blake
Ronald Hinklin
Macedonio Mejia
Erik Hicken
Mark Chicarelli
John Gaudino
Guy Vigers
Laurence Burgess
Matthew Marx
James Christensen
Matthew Lee
Pavel Savechenkov
Henry Zecca
Tony P Tang
Original Assignee
Mirati Therapeutics Inc
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirati Therapeutics Inc, Array Biopharma Inc filed Critical Mirati Therapeutics Inc
Publication of SG11201810171SA publication Critical patent/SG11201810171SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111101110111111111111111111111111111111111111111110111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/201161 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 231/56 (2006.01) A61K 31/445 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 295/185 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/US2017/033099 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 17 May 2017 (17.05.2017) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (25) Filing Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (26) Publication Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/338,116 18 May 2016 (18.05.2016) US kind of regional protection available): ARIPO (BW, GH, 62/444,614 10 January 2017 (10.01.2017) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicants: MIRATI THERAPEUTICS, INC. [US/US]; TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 9393 Towne Centre Dr., Suite 200, San Diego, CA 92121 EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (US). ARRAY BIOPHARMA, INC. [US/US]; 3200 Wal- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, nut St., Boulder, CO 80301 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors: FISCHER, John, P.; c/o Array Biopharma, KM, ML, MR, NE, SN, TD, TG). _ Inc., 3200 Walnut St., Boulder, CO 80301 (US). FELL, Jay, Bradford; c/o Array Biopharma, Inc., 3200 Walnut Published: = St., Boulder, CO 80301 (US). BLAKE, James, F.; c/o Ar- — with international search report (Art. 2 I (3)) ray Biopharma, Inc., 3200 Walnut St., Boulder, CO 80301 = _ (US). HINKLIN, Ronald, Jay; c/o Array Biopharma, Inc., 3200 Walnut St., Boulder, CO 80301 (US). MEJIA, = Macedonio, J.; c/o Array Biopharma, Inc, 3200 Walnut = _ St., Boulder, CO 80301 (US). HICKEN, Erik, James; c/ = o Array Biopharma, Inc, 3200 Walnut St., Boulder, CO _ 80301 (US). CHICARELLI, Mark, Joseph; c/o Array Biopharma, Inc, 3200 Walnut St., Boulder, CO 80301 (US). — = GAUDINO, John, J.; c/o Array Biopharma, Inc, 3200 Wal- nut St., Boulder, CO 80301 (US). VIGERS, Guy, P.A.; c/o Array Biopharma, Inc, 3200 Walnut St., Boulder, CO = = = 80301 (US). BURGESS, Laurence, E.; c/o Array Bio- pharma, Inc, 3200 Walnut St., Boulder, CO 80301 (US). = MARX, Matthew, Arnold; c/o Mirati Therapeutics, Inc., 9393 Towne Centre Dr., Suite 200, San Diego, CA 92121 = (US). CHRISTENSEN, James, Gail; c/o Mirati Therapeu- = tics, Inc., 9393 Towne Centre Dr., Suite 200, San Diego, CA = — 92121 (US). LEE, Matthew, Randolf; c/o Mirati Thera- = peutics, Inc., 9393 Towne Centre Dr., Suite 200, San Diego, = CA 92121 (US). SAVECHENKOV, Pavel; c/o Array Bio- pharma, Inc., 3200 Walnut St., Boulder, CO 80301 (US). ZECCA, Henry, J.; c/o Array Biopharma, Inc., 3200 Wal- nut St., Boulder, CO 80301 (US). 1-1 .. (74) Agent: POLYAKOV, Mark, V. et al.; Wood, Phillips, Katz, Clark & Mortimer, 500 West Madison Street, Suite 1-1 1130, Chicago, IL 60661 (US). 1-1 1-1 0 ei IN (54) Title: KRAS G12C INHIBITORS 1-1 0 (57) : The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to ei compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods O of use therefor.
SG11201810171SA 2016-05-18 2017-05-17 Kras g12c inhibitors SG11201810171SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662338116P 2016-05-18 2016-05-18
US201762444614P 2017-01-10 2017-01-10
PCT/US2017/033099 WO2017201161A1 (en) 2016-05-18 2017-05-17 Kras g12c inhibitors

Publications (1)

Publication Number Publication Date
SG11201810171SA true SG11201810171SA (en) 2018-12-28

Family

ID=60326411

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810171SA SG11201810171SA (en) 2016-05-18 2017-05-17 Kras g12c inhibitors

Country Status (12)

Country Link
US (3) US11267812B2 (en)
EP (1) EP3458445B1 (en)
JP (1) JP7039489B2 (en)
KR (1) KR102444509B1 (en)
CN (1) CN109843856B (en)
AU (1) AU2017266911B2 (en)
CA (1) CA3024523A1 (en)
ES (1) ES2863873T3 (en)
IL (1) IL262867B (en)
MX (1) MX382339B (en)
SG (1) SG11201810171SA (en)
WO (1) WO2017201161A1 (en)

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