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SG11201708438WA - Bispecific antibody constructs for cdh3 and cd3 - Google Patents

Bispecific antibody constructs for cdh3 and cd3

Info

Publication number
SG11201708438WA
SG11201708438WA SG11201708438WA SG11201708438WA SG11201708438WA SG 11201708438W A SG11201708438W A SG 11201708438WA SG 11201708438W A SG11201708438W A SG 11201708438WA SG 11201708438W A SG11201708438W A SG 11201708438WA SG 11201708438W A SG11201708438W A SG 11201708438WA
Authority
SG
Singapore
Prior art keywords
cdh3
bispecific antibody
antibody constructs
constructs
bispecific
Prior art date
Application number
SG11201708438WA
Inventor
Bertram Weiss
Ann-Lena Frisk
Ruprecht Zierz
Peter Kufer
Tobias Raum
Doris Rau
Jonas Anlahr
Ralf LUTTERBÜSE
Lisa Nahrwold
Christoph Dahlhoff
Claudia Blümel
Patrick Hoffmann
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of SG11201708438WA publication Critical patent/SG11201708438WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201708438WA 2015-04-17 2016-04-18 Bispecific antibody constructs for cdh3 and cd3 SG11201708438WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15164154 2015-04-17
PCT/EP2016/058482 WO2016166360A1 (en) 2015-04-17 2016-04-18 Bispecific antibody constructs for cdh3 and cd3

Publications (1)

Publication Number Publication Date
SG11201708438WA true SG11201708438WA (en) 2017-11-29

Family

ID=52997289

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201708438WA SG11201708438WA (en) 2015-04-17 2016-04-18 Bispecific antibody constructs for cdh3 and cd3
SG10201909308X SG10201909308XA (en) 2015-04-17 2016-04-18 Bispecific antibody constructs for cdh3 and cd3

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201909308X SG10201909308XA (en) 2015-04-17 2016-04-18 Bispecific antibody constructs for cdh3 and cd3

Country Status (24)

Country Link
US (3) US11028171B2 (en)
EP (2) EP4276116A3 (en)
JP (1) JP6907124B2 (en)
KR (1) KR20180023892A (en)
CN (2) CN107750255B (en)
AR (1) AR104309A1 (en)
AU (2) AU2016250023B2 (en)
CA (1) CA2982682A1 (en)
CL (1) CL2017002641A1 (en)
DK (1) DK3283524T3 (en)
EA (1) EA201792193A1 (en)
ES (1) ES2945313T3 (en)
FI (1) FI3283524T3 (en)
HU (1) HUE061730T2 (en)
IL (1) IL255076B2 (en)
LT (1) LT3283524T (en)
MA (1) MA43197A (en)
MX (1) MX2017013348A (en)
PL (1) PL3283524T3 (en)
PT (1) PT3283524T (en)
SG (2) SG11201708438WA (en)
SI (1) SI3283524T1 (en)
TW (2) TWI858372B (en)
WO (1) WO2016166360A1 (en)

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CN102164961B (en) * 2008-10-01 2014-04-16 安进研发（慕尼黑）股份有限公司 Cross-species-specific PSCAxCD3, CD19xCD3, C-NETxCD3, endosialinxCD3, EpCAMxCD3, IGF-1RxCD3 or FAOalpha xCD3 bispecific single chain antibody
TWI679212B (en) 2011-11-15 2019-12-11 美商安進股份有限公司 Binding molecules for e3 of bcma and cd3
EA039859B1 (en) * 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Bispecific antibody constructs binding egfrviii and cd3
TWI829617B (en) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Antibody constructs for flt3 and cd3
TWI744242B (en) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Antibody constructs for egfrviii and cd3
TWI796283B (en) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Antibody constructs for msln and cd3
IL260920B (en) 2016-02-03 2022-09-01 Amgen Res Munich Gmbh Psma and cd3 bispecific t cell engaging antibody constructs, compositions comprising same and uses thereof
ES2905361T3 (en) 2016-02-03 2022-04-08 Amgen Res Munich Gmbh BCMA and CD3 Bispecific T-cell-Coupling Antibody Constructs
JOP20190189A1 (en) * 2017-02-02 2019-08-01 Amgen Res Munich Gmbh Low ph pharmaceutical composition comprising t cell engaging antibody constructs
CN111010867B (en) 2017-05-30 2023-05-12 俄克拉何马大学董事会 Anti-bicortical protein-like kinase 1 antibodies and methods of use thereof
CA3122010A1 (en) * 2017-12-04 2019-06-13 Coare Holdings, Inc. Anti-dclk1 antibodies and chimeric antigen receptors, and compositions and methods of use thereof
UY38041A (en) * 2017-12-29 2019-06-28 Amgen Inc CONSTRUCTION OF BIESPECFIC ANTIBODY DIRECTED TO MUC17 AND CD3
US20200339686A1 (en) * 2018-01-16 2020-10-29 Lakepharma, Inc. Bispecific antibody that binds cd3 and another target
EP3752630A4 (en) * 2018-02-14 2022-01-05 Yale University COMPOSITIONS FOR THE MODULATION OF A TREM OR TREML PROTEIN AND METHODS OF USE
WO2020094834A1 (en) * 2018-11-09 2020-05-14 Euchloe Bio Pte. Ltd. Il2rbeta/common gamma chain antibodies
SG11202111329SA (en) * 2019-06-07 2021-12-30 Adimab Llc High affinity anti-cd3 antibodies, and methods for their generation and use
JP7738914B2 (en) * 2019-12-05 2025-09-16 アーベル リミテッド Composition of TriAx antibodies, methods of making and using same
US12060434B2 (en) * 2020-02-25 2024-08-13 Gensun Biopharma Inc. Trispecific T cell engagers
WO2022204516A1 (en) * 2021-03-26 2022-09-29 The General Hospital Corporation Humanized mab107
CN117143231B (en) * 2022-10-14 2025-01-14 赛洱生命科学(哈尔滨)有限公司 Pharmaceutical composition comprising stem cell exosomes and method for preparing the same
WO2024196664A1 (en) * 2023-03-17 2024-09-26 University Of Washington Dna vaccine targeting overexpressed antigens in colorectal cancer
WO2025077833A1 (en) * 2023-10-11 2025-04-17 Suzhou Neologics Bioscience Co., Ltd. Antibodies targeting tim-3 and pd-1 and uses thereof
WO2025122927A1 (en) * 2023-12-06 2025-06-12 Integral Molecular, Inc. Antibodies directed to claudin 18.2, including bispecific formats thereof

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