SG111980A1 - Crystalline efavirenz - Google Patents

Crystalline efavirenz

Info

Publication number: SG111980A1
Authority: SG; Singapore
Prior art keywords: crystalline efavirenz; efavirenz; crystalline
Prior art date: 1998-06-11

Application number

SG200207220A

Inventor

Lilian A Radesca

Michael B Maurin

Shelley R Rabel

James R Moore

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-11

Filing date

1999-06-10

Publication date

2005-06-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22214647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG111980(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-06-10 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2005-06-29 Publication of SG111980A1 publication Critical patent/SG111980A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SG200207220A 1998-06-11 1999-06-10 Crystalline efavirenz SG111980A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8898198P	1998-06-11	1998-06-11

Publications (1)

Publication Number	Publication Date
SG111980A1 true SG111980A1 (en)	2005-06-29

Family

ID=22214647

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SG200207221A SG111981A1 (en)	1998-06-11	1999-06-10	Crystalline efavirenz
SG200207226-2A SG134977A1 (en)	1998-06-11	1999-06-10	Crystalline efavirenz
SG200207220A SG111980A1 (en)	1998-06-11	1999-06-10	Crystalline efavirenz

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
SG200207221A SG111981A1 (en)	1998-06-11	1999-06-10	Crystalline efavirenz
SG200207226-2A SG134977A1 (en)	1998-06-11	1999-06-10	Crystalline efavirenz

Country Status (21)

Country	Link
EP (1)	EP1086087A1 (en)
JP (1)	JP2002517487A (en)
CN (1)	CN1307568A (en)
AR (3)	AR018670A1 (en)
AU (1)	AU758114C (en)
BR (1)	BR9911523A (en)
CA (1)	CA2333550A1 (en)
EE (1)	EE05547B1 (en)
HR (1)	HRP990182A2 (en)
HU (1)	HUP0103819A3 (en)
IL (1)	IL139793A (en)
MY (1)	MY126450A (en)
NO (1)	NO20006255L (en)
NZ (1)	NZ507713A (en)
PL (1)	PL198504B1 (en)
SG (3)	SG111981A1 (en)
SK (1)	SK18182000A3 (en)
TW (1)	TWI235152B (en)
UA (1)	UA74324C2 (en)
WO (1)	WO1999064405A1 (en)
ZA (1)	ZA200006173B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5965729A (en)	1997-02-05	1999-10-12	Merck & Co., Inc.	Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
WO2006018853A2 (en)	2004-08-19	2006-02-23	Hetero Drugs Limited	Novel polymorphs of efavirenz
US7205402B2 (en) *	2004-09-02	2007-04-17	Bristol-Myers Squibb Company	Synthesis of a benzoxazinone
WO2008108630A1 (en) *	2007-03-02	2008-09-12	Ultimorphix Technologies B.V.	Polymorphic forms of efavirenz
WO2009011567A1 (en) *	2007-07-16	2009-01-22	Ultimorphix Technologies B.V.	Crystalline forms of efavirenz
AU2009211072B2 (en)	2008-02-04	2014-01-23	Pfizer Limited	Polymorphic form of a [1, 2, 4] triazolo [4, 3-A] pyridine derivative for treating inflammatory diseases
WO2010073254A2 (en)	2008-12-22	2010-07-01	Hetero Research Foundation	Process for preparing efavirenz polymorph
DE102009041443A1 (en)	2009-09-16	2011-03-31	Archimica Gmbh	Salts of 6-chloro-4- (cyclopropylethynyl) -1,4-dihydro-4- (trifluoromethyl) -2H-3,1-benzoxazin-2-one and their synthesis, purification and use as precursors of efavirenz
EP2471783A1 (en)	2010-12-23	2012-07-04	Esteve Química, S.A.	Novel polymorphic form of efavirenz
CN103508973B (en) *	2012-06-25	2016-04-27	上海迪赛诺药业有限公司	Prepare the method for efavirenz I type crystallization
CN102924398B (en) *	2012-11-22	2015-11-18	安徽贝克生物制药有限公司	For removing the method for the corresponding isomer of efavirenz
US9468646B2 (en)	2013-01-23	2016-10-18	Alienor Farma	Increased dosage of efavirenz for the treatment of cancer
CN105037175B (en) *	2014-07-18	2017-02-22	盐城迪赛诺制药有限公司	Method of improving optical purity of efavirenz intermediate
CN105001101B (en) *	2015-05-28	2017-11-28	乐平市瑞盛制药有限公司	A kind of synthetic method of the trifluoroacetyl aniline hydrate hydrochloride of 4 chlorine 2
CN108947855B (en) *	2018-08-10	2021-10-22	江苏沙星化工有限公司	Synthesis method of efavirenz key intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL106507A (en) *	1992-08-07	1997-11-20	Merck & Co Inc	Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
AU1694295A (en) *	1994-01-28	1995-08-15	Merck & Co., Inc.	Benzoxazinones as inhibitors of hiv reverse transcriptase
US5633405A (en) *	1995-05-25	1997-05-27	Merck & Co., Inc.	Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
AU3736197A (en) *	1996-07-26	1998-02-20	Du Pont Pharmaceuticals Company	A practical synthesis of benzoxazinones useful as hiv reverse transcripta se inhibitors
EP0929533B1 (en) *	1996-10-02	2003-09-03	Bristol-Myers Squibb Pharma Company	4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
CZ304186B6 (en) *	1997-02-05	2013-12-11	Merck Sharp & Dohme Corp.	Crystalline form of I inhibitor based on benzoxazine and process for preparing thereof

1999
- 1999-06-08 HR HR60/088,981A patent/HRP990182A2/en not_active Application Discontinuation
- 1999-06-10 IL IL139793A patent/IL139793A/en not_active IP Right Cessation
- 1999-06-10 UA UA2000127048A patent/UA74324C2/en unknown
- 1999-06-10 NZ NZ507713A patent/NZ507713A/en not_active IP Right Cessation
- 1999-06-10 AU AU44364/99A patent/AU758114C/en not_active Expired
- 1999-06-10 HU HU0103819A patent/HUP0103819A3/en unknown
- 1999-06-10 EP EP99927468A patent/EP1086087A1/en not_active Withdrawn
- 1999-06-10 EE EEP200000743A patent/EE05547B1/en unknown
- 1999-06-10 WO PCT/US1999/013199 patent/WO1999064405A1/en not_active Ceased
- 1999-06-10 SG SG200207221A patent/SG111981A1/en unknown
- 1999-06-10 SG SG200207226-2A patent/SG134977A1/en unknown
- 1999-06-10 PL PL345221A patent/PL198504B1/en unknown
- 1999-06-10 JP JP2000553414A patent/JP2002517487A/en active Pending
- 1999-06-10 MY MYPI99002384A patent/MY126450A/en unknown
- 1999-06-10 SG SG200207220A patent/SG111980A1/en unknown
- 1999-06-10 CN CN99807219A patent/CN1307568A/en active Pending
- 1999-06-10 CA CA002333550A patent/CA2333550A1/en not_active Abandoned
- 1999-06-10 BR BR9911523-9A patent/BR9911523A/en not_active Application Discontinuation
- 1999-06-10 SK SK1818-2000A patent/SK18182000A3/en unknown
- 1999-06-11 AR ARP990102809A patent/AR018670A1/en not_active Application Discontinuation
- 1999-07-03 TW TW088109817A patent/TWI235152B/en not_active IP Right Cessation
2000
- 2000-10-31 ZA ZA200006173A patent/ZA200006173B/en unknown
- 2000-12-08 NO NO20006255A patent/NO20006255L/en not_active Application Discontinuation
2010
- 2010-07-08 AR ARP100102490A patent/AR077407A2/en not_active Application Discontinuation
- 2010-07-08 AR ARP100102491A patent/AR077469A2/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ507713A (en)	2003-08-29
AR018670A1 (en)	2001-11-28
HUP0103819A2 (en)	2002-02-28
SG111981A1 (en)	2005-06-29
PL345221A1 (en)	2001-12-03
AR077469A2 (en)	2011-08-31
IL139793A (en)	2006-10-31
UA74324C2 (en)	2005-12-15
TWI235152B (en)	2005-07-01
PL198504B1 (en)	2008-06-30
EE05547B1 (en)	2012-06-15
CN1307568A (en)	2001-08-08
EP1086087A1 (en)	2001-03-28
NO20006255D0 (en)	2000-12-08
HRP990182A2 (en)	2000-02-29
IL139793A0 (en)	2002-02-10
MY126450A (en)	2006-10-31
SG134977A1 (en)	2007-09-28
JP2002517487A (en)	2002-06-18
CA2333550A1 (en)	1999-12-16
AU758114C (en)	2003-10-30
WO1999064405A1 (en)	1999-12-16
AU4436499A (en)	1999-12-30
ZA200006173B (en)	2001-10-31
NO20006255L (en)	2001-02-12
BR9911523A (en)	2001-09-18
EE200000743A (en)	2002-10-15
AU758114B2 (en)	2003-03-13
AR077407A2 (en)	2011-08-24
HUP0103819A3 (en)	2003-05-28
SK18182000A3 (en)	2001-08-06

Publication	Publication Date	Title
EP1147498A4 (en)	2002-04-03	Timing
DE59912932D1 (en)	2006-01-19	Arylphenylsubstituierte cyclische ketoenole
DE59912303D1 (en)	2005-08-25	Arylphenylsubstituierte cyclische ketoenole
PL346544A1 (en)	2002-02-11	Crystalline forms of eto2
DE59903023D1 (en)	2002-11-14	Perorale wirkstoff-suspension
DE59914151D1 (en)	2007-02-22	Arylalkanoylpyridazine
TW532464U (en)	2003-05-11	Optimized combustor
ZA985655B (en)	1998-12-30	Crystalline macrolides
PL345221A1 (en)	2001-12-03	Crystalline efavirenz
DE60042897D1 (en)	2009-10-15	Photovervielfacherröhre
DE59904407D1 (en)	2003-04-03	Chromanderivate
DE69821502D1 (en)	2004-03-11	Boroskop
PL347397A1 (en)	2002-04-08	Substituted 3-aryl-pyrazoles
GB9816729D0 (en)	1998-09-30	Substituted cyclohexylaminopyrimidines
DE59900495D1 (en)	2002-01-17	Multimetalloxidmassen
DE59900471D1 (en)	2002-01-10	Inchbremseinrichtung
HUP0101007A3 (en)	2002-02-28	Contraceptive kit for monotherapy
HUP0102476A3 (en)	2003-08-28	Substituted cyclooctadepsipeptides
DE59905941D1 (en)	2003-07-17	Methoximinophenylessigsäureamide
DE59911094D1 (en)	2004-12-23	Tryptase-inhibitoren
PL327915A1 (en)	1999-02-15	Crystalline progestagenes
GB2337526B (en)	2002-09-04	Easy rockeries
CA86780S (en)	1999-05-28	Winterfront
DE69816879D1 (en)	2003-09-04	Spandexaufwickelmaschine
AU1538P (en)	2000-08-15	Guinevere Mandevilla sanderi