SG10201912675VA - Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile - Google Patents
Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrileInfo
- Publication number
- SG10201912675VA SG10201912675VA SG10201912675VA SG10201912675VA SG10201912675VA SG 10201912675V A SG10201912675V A SG 10201912675VA SG 10201912675V A SG10201912675V A SG 10201912675VA SG 10201912675V A SG10201912675V A SG 10201912675VA SG 10201912675V A SG10201912675V A SG 10201912675VA
- Authority
- SG
- Singapore
- Prior art keywords
- cyclopentylpropanenitrile
- pyrrolo
- pyrazol
- pyrimidin
- salts
- Prior art date
Links
- 229940122245 Janus kinase inhibitor Drugs 0.000 title 1
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical compound C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94370507P | 2007-06-13 | 2007-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201912675VA true SG10201912675VA (en) | 2020-02-27 |
Family
ID=40029273
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012043428A SG182198A1 (en) | 2007-06-13 | 2008-06-12 | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| SG10201509887UA SG10201509887UA (en) | 2007-06-13 | 2008-06-12 | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| SG10201912675VA SG10201912675VA (en) | 2007-06-13 | 2008-06-12 | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012043428A SG182198A1 (en) | 2007-06-13 | 2008-06-12 | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| SG10201509887UA SG10201509887UA (en) | 2007-06-13 | 2008-06-12 | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
Country Status (41)
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105814A1 (en) * | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| AU2006309013B2 (en) | 2005-11-01 | 2012-06-28 | Impact Biomedicines, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| US7598257B2 (en) | 2005-12-13 | 2009-10-06 | Incyte Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
| US8513270B2 (en) * | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
| PT3070090T (en) | 2007-06-13 | 2019-03-20 | Incyte Holdings Corp | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| CL2008001709A1 (en) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compounds derived from pyrrolo [2,3-b] pyrimidine, jak kinase modulators; pharmaceutical composition; and use in the treatment of diseases such as cancer, psoriasis, rheumatoid arthritis, among others. |
| ES2569528T3 (en) * | 2007-11-16 | 2016-05-11 | Incyte Holdings Corporation | 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as Janus kinase inhibitors |
| UA101493C2 (en) * | 2008-03-11 | 2013-04-10 | Инсайт Корпорейшн | Azetidine and cyclobutane derivatives as jak inhibitors |
| JOP20190231A1 (en) * | 2009-01-15 | 2017-06-16 | Incyte Corp | Processes for preparing jak inhibitors and related intermediate compounds |
| JP5746981B2 (en) * | 2009-02-27 | 2015-07-08 | アムビト ビオスシエンセス コルポラチオン | JAK kinase-regulated quinazoline derivatives and methods of use thereof |
| CA2761954C (en) | 2009-05-22 | 2018-07-31 | Incyte Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| US8716303B2 (en) | 2009-05-22 | 2014-05-06 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PT2486041E (en) * | 2009-10-09 | 2013-11-14 | Incyte Corp | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| SA111320200B1 (en) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | Bicyclic Compounds and their Uses as Dual C-SRC / JAK Inhibitors |
| EA023444B1 (en) * | 2010-02-18 | 2016-06-30 | Инсайт Холдингс Корпорейшн | Cyclobutane and methylcyclobutane derivatives, composition based thereon and methods of use thereof |
| HRP20160326T1 (en) | 2010-03-10 | 2016-05-20 | Incyte Holdings Corporation | PIPERIDIN-4-IL AZETIDINE DERIVATIVES AS INHIBITORS OF JAK1 |
| EA035981B1 (en) * | 2010-05-21 | 2020-09-09 | Инсайт Холдингс Корпорейшн | Jak inhibitor formulation for topical application |
| MX2013002384A (en) | 2010-09-01 | 2013-07-05 | Ambit Biosciences Corp | Quinazoline compounds and methods of use thereof. |
| PL2635299T3 (en) * | 2010-11-02 | 2020-03-31 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| JP5917544B2 (en) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Heterocyclic substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
| JP5917545B2 (en) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| ES2547916T3 (en) * | 2011-02-18 | 2015-10-09 | Novartis Pharma Ag | MTOR / JAK inhibitor combination therapy |
| KR20140056212A (en) * | 2011-06-14 | 2014-05-09 | 노파르티스 아게 | Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm |
| BR112013032720A2 (en) | 2011-06-20 | 2016-09-13 | Incyte Corp | "azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors, composition and use of said derivatives" |
| WO2013020372A1 (en) * | 2011-08-09 | 2013-02-14 | 中国科学院上海生命科学研究院 | Methods and reagents for preventing and curing insulin resistance and diabetes mellitus |
| CA2844507A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Jak pi3k/mtor combination therapy |
| TW201313721A (en) | 2011-08-18 | 2013-04-01 | Incyte Corp | Cyclohexyl azetidine derivatives as JAK inhibitors |
| UA111854C2 (en) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS |
| US10821111B2 (en) | 2011-11-30 | 2020-11-03 | Emory University | Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections |
| CN107898790B (en) * | 2011-11-30 | 2024-06-21 | 埃默里大学 | Antiviral JAK inhibitors for the treatment or prevention of retroviral and other viral infections |
| WO2013173506A2 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| TW201406761A (en) | 2012-05-18 | 2014-02-16 | Incyte Corp | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| EP2877162A1 (en) | 2012-07-27 | 2015-06-03 | ratiopharm GmbH | Oral dosage forms for modified release comprising ruxolitinib |
| NZ707495A (en) | 2012-11-01 | 2019-01-25 | Incyte Holdings Corp | Tricyclic fused thiophene derivatives as jak inhibitors |
| SG10202111768XA (en) | 2012-11-15 | 2021-11-29 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
| CA2900529A1 (en) | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
| HUE042466T2 (en) | 2013-03-06 | 2019-06-28 | Incyte Holdings Corp | Method and intermediates for the preparation of JAK inhibitor |
| US20140343034A1 (en) * | 2013-04-25 | 2014-11-20 | Japan Tobacco Inc. | Skin barrier function improving agent |
| KR102663357B1 (en) | 2013-05-17 | 2024-05-14 | 인사이트 홀딩스 코포레이션 | Bipyrazole derivatives as jak inhibitors |
| PH12019502074B1 (en) | 2013-08-07 | 2023-10-18 | Incyte Holdings Corp | Sustained release dosage forms for a jak1 inhibitor |
| EP3049110A2 (en) * | 2013-09-23 | 2016-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for targeting tumor microenvironment and for preventing metastasis |
| EA202191009A1 (en) | 2014-04-08 | 2021-08-31 | Инсайт Корпорейшн | TREATMENT OF B-CELL MALIGNANT NOMINATIONS USING A COMBINATION OF JAK AND PI3K INHIBITORS |
| CA2947418A1 (en) | 2014-04-30 | 2015-11-05 | Incyte Corporation | Processes of preparing a jak1 inhibitor and new forms thereto |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| CN105218548A (en) * | 2014-06-09 | 2016-01-06 | 上海海和药物研究开发有限公司 | A kind of novel heterocyclic compounds and preparation method thereof and the purposes as kinase inhibitor |
| US20170224819A1 (en) | 2014-08-11 | 2017-08-10 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor |
| PL3179992T3 (en) | 2014-08-11 | 2022-08-16 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pd-1 inhibitor and/or a pd-l1 inhibitor |
| US20170231986A1 (en) | 2014-08-11 | 2017-08-17 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a BCL-2 Inhibitor |
| EP3183253B1 (en) * | 2014-08-21 | 2018-06-27 | ratiopharm GmbH | Salt of (r)-3-(4-(7h-pyrrolo [2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3-cyclopentylpropanenitrile with benzenesulfonic acid |
| EP3183252B1 (en) * | 2014-08-21 | 2021-05-12 | ratiopharm GmbH | Oxalate salt of ruxolitinib |
| WO2016035014A1 (en) * | 2014-09-01 | 2016-03-10 | Sun Pharmaceutical Industries Limited | Processes for the preparation of ruxolitinib phosphate |
| WO2016063294A2 (en) * | 2014-10-20 | 2016-04-28 | Msn Laboratories Private Limited | Process for the preparation of (r)-3-(4-(7h-pyrrolo[2,3-d], pyrimidin-4-yl)-1 h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate and its polymorphs thereof |
| CZ2014773A3 (en) | 2014-11-10 | 2016-05-18 | Zentiva, K.S. | Salts of (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile |
| WO2016077595A1 (en) | 2014-11-12 | 2016-05-19 | The General Hospital Corporation | Methods for treating neurodegenerative diseases |
| CZ2015496A3 (en) | 2015-07-14 | 2017-01-25 | Zentiva, K.S. | The crystalline salt forms of (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-pyrazol-1-yl] of propanenitrile and their preparation |
| DK3402515T3 (en) | 2016-01-12 | 2021-11-15 | Oncotracker Inc | IMPROVED PROCEDURES FOR MONITORING THE IMMUNE STATUS OF AN INDIVIDUAL |
| CZ201629A3 (en) | 2016-01-22 | 2017-08-02 | Zentiva, K.S. | Crystalline modifications of the (3R)-3-cyclopentyl-3- [4-(7H-pyrrolo [2,3-d] pyrimidin-4yl) pyrazol-1yl] propanenitrile salts and the method of their preparation |
| CN105566332B (en) * | 2016-01-29 | 2018-01-16 | 上海宣创生物科技有限公司 | Baricitinib trifluoroacetate A crystal form and B crystal form and preparation method thereof |
| CN105601635B (en) * | 2016-02-01 | 2017-12-12 | 上海宣创生物科技有限公司 | A crystal form, H crystal form and I crystal form of baricitinib phosphate and preparation method thereof |
| US20200308240A1 (en) * | 2016-04-01 | 2020-10-01 | The General Hospital Corporation | Targeting Innate Immune Signaling in Neuroinflammation and Neurodegeneration |
| CN107759600A (en) * | 2016-06-16 | 2018-03-06 | 正大天晴药业集团股份有限公司 | Crystallization as the Pyrrolopyrimidine compounds of JAK inhibitor |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| RU2644155C1 (en) * | 2016-12-12 | 2018-02-08 | Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") | 2-(3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile heminaphthyldisulfonate as janus kinase inhibitor |
| WO2018231944A1 (en) | 2017-06-13 | 2018-12-20 | Berenson James R | Diagnostic, prognostic, and monitoring methods for solid tumor cancers |
| JP2021502400A (en) * | 2017-11-03 | 2021-01-28 | アクラリス セラピューティクス,インコーポレイテッド | Substituted pyrolopyrimidine JAK inhibitor and method for making and using it |
| WO2019090143A1 (en) | 2017-11-03 | 2019-05-09 | Aclaris Therapeutics, Inc. | Pyrazolyl pyrrolo[2,3-b]pyrimidine-5-carboxylate analogs and methods of making the same |
| AR113922A1 (en) | 2017-12-08 | 2020-07-01 | Incyte Corp | LOW DOSE COMBINATION THERAPY FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS |
| SG11202007164UA (en) | 2018-01-30 | 2020-08-28 | Incyte Corp | Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
| CN119386019A (en) | 2018-02-16 | 2025-02-07 | 因赛特公司 | JAK1 pathway inhibitors for the treatment of cytokine-related disorders |
| EP3762424A1 (en) | 2018-03-08 | 2021-01-13 | Novartis AG | Use of an anti-p-selectin antibody |
| MA52655A (en) | 2018-03-30 | 2021-02-17 | Incyte Corp | BIOMARKERS FOR INFLAMMATORY SKIN DISEASE |
| WO2019191684A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
| EP3775923A1 (en) | 2018-04-13 | 2021-02-17 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| WO2019232188A1 (en) | 2018-06-01 | 2019-12-05 | Incyte Corporation | Dosing regimen for the treatment of pi3k related disorders |
| CN117285467A (en) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | Spray-dried dispersions and formulations |
| MX2021001558A (en) | 2018-08-10 | 2021-04-28 | Aclaris Therapeutics Inc | PYRROLOPYRIMIDINE TKI INHIBITORS. |
| WO2020039401A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | Treatment comprising il-1βeta binding antibodies and combinations thereof |
| ES2955717T3 (en) | 2018-09-04 | 2023-12-05 | Theravance Biopharma R&D Ip Llc | 5- to 7-membered heterocyclic amides as JAK inhibitors |
| MA54077A (en) | 2018-10-31 | 2021-09-15 | Incyte Corp | POLYTHERAPY FOR THE TREATMENT OF BLOOD DISEASES |
| US12180207B2 (en) | 2018-12-19 | 2024-12-31 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of FGFR tyrosine kinases |
| US12351571B2 (en) | 2018-12-19 | 2025-07-08 | Array Biopharma Inc. | Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases |
| WO2020132197A1 (en) | 2018-12-20 | 2020-06-25 | Incyte Corporation | Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2 |
| SG11202109563WA (en) | 2019-03-05 | 2021-09-29 | Incyte Corp | Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| US20220202820A1 (en) | 2019-04-16 | 2022-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| MX2021013224A (en) | 2019-05-02 | 2022-01-06 | Aclaris Therapeutics Inc | Substituted pyrrolopyridines as jak inhibitors. |
| EP3982971A4 (en) | 2019-06-10 | 2023-08-16 | Incyte Corporation | TOPICAL TREATMENT OF VITILIGO BY A JAK INHIBITOR |
| PH12021553254A1 (en) | 2019-06-27 | 2022-09-19 | Crispr Therapeutics Ag | Use of chimeric antigen receptor t cells and nk cell inhibitors for treating cancer |
| AU2020341575A1 (en) | 2019-09-05 | 2022-03-24 | Incyte Corporation | Ruxolitinib formulation for reduction of itch in atopic dermatitis |
| JP2022548627A (en) | 2019-09-16 | 2022-11-21 | ノバルティス アーゲー | Use of high-affinity ligand-blocking humanized anti-T cell immunoglobulin domain and mucin domain 3 (TIM-3) IGG4 antibodies for the treatment of myelofibrosis |
| KR20220063215A (en) | 2019-09-16 | 2022-05-17 | 노파르티스 아게 | Use of an MDM2 inhibitor for the treatment of myelofibrosis |
| CA3156007A1 (en) | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| WO2021072098A1 (en) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| CA3157499A1 (en) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| JP7518900B2 (en) | 2019-10-16 | 2024-07-18 | インサイト・コーポレイション | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and lichen planus (LP) - Patent Application 20070233334 |
| IL293085A (en) | 2019-11-22 | 2022-07-01 | Incyte Corp | Combined treatment that includes an alk2 inhibitor and a jak2 inhibitor |
| WO2021206766A1 (en) | 2020-04-09 | 2021-10-14 | Children's Hospital Medical Center | Sars-cov-2 infection biomarkers and uses thereof |
| EP3892280A3 (en) | 2020-04-09 | 2022-01-12 | Children's Hospital Medical Center | Sars-cov-2 infection biomarkers and uses thereof |
| US11324750B2 (en) | 2020-04-09 | 2022-05-10 | Children's Hospital Medical Center | Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection |
| JP2023528223A (en) | 2020-05-13 | 2023-07-04 | ディスク・メディシン・インコーポレイテッド | Anti-Hemoduvelin (HJV) Antibodies for Treating Myelofibrosis |
| RS66432B1 (en) | 2020-06-02 | 2025-02-28 | Incyte Corp | PROCESS OF OBTAINING JAK1 INHIBITORS |
| EP4161528B1 (en) | 2020-06-03 | 2025-11-05 | Incyte Corporation | Combination of ruxolitinib with incb057643 for use in the treatment of myeloproliferative neoplasms |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| EP4171585A1 (en) | 2020-06-26 | 2023-05-03 | CRISPR Therapeutics AG | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| PE20231308A1 (en) | 2020-08-18 | 2023-08-24 | Incyte Corp | PROCESS AND INTERMEDIATE TO PREPARE A JAK1 INHIBITOR |
| WO2022040180A1 (en) | 2020-08-18 | 2022-02-24 | Incyte Corporation | Process and intermediates for preparing a jak inhibitor |
| WO2022061351A1 (en) | 2020-09-16 | 2022-03-24 | Incyte Corporation | Topical treatment of vitiligo |
| CN117440814A (en) | 2020-10-02 | 2024-01-23 | 因赛特公司 | Topical ruxolitinib for the treatment of lichen planus |
| US20230372334A1 (en) | 2020-10-08 | 2023-11-23 | Novartis Ag | Use of an erk inhibitor for the treatment of myelofibrosis |
| US20240000777A1 (en) | 2020-10-08 | 2024-01-04 | Novartis Ag | Use of an erk inhibitor for the treatment of myelofibrosis |
| LT4255442T (en) | 2020-12-04 | 2025-07-25 | Incyte Corporation | Jak inhibitor with a vitamin d analog for treatment of skin diseases |
| AU2021396231A1 (en) | 2020-12-08 | 2023-06-22 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of vitiligo |
| TW202237083A (en) | 2021-01-11 | 2022-10-01 | 美商英塞特公司 | Combination therapy comprising jak pathway inhibitor and rock inhibitor |
| CA3206708A1 (en) | 2021-02-25 | 2022-09-01 | Ida ARONCHIK | Use of a bet inhibitor alone or in combination with fedratinib or ruxolitinib for treating a hematological malignancy such as myelofibrosis |
| UA129643C2 (en) | 2021-05-03 | 2025-06-18 | Інсайт Корпорейшн | Jak1 pathway inhibitors for the treatment of prurigo nodularis |
| EP4359402A1 (en) | 2021-06-25 | 2024-05-01 | Theravance Biopharma R&D IP, LLC | Imidazolo indazole compounds as jak inhibitors |
| EP4370504A1 (en) | 2021-07-12 | 2024-05-22 | Incyte Corporation | Process and intermediates for preparing baricitinib |
| KR20240107151A (en) | 2021-11-17 | 2024-07-08 | 알트루바이오 인코퍼레이티드 | Methods of using anti-PSGL-1 antibodies in combination with JAK inhibitors to treat T-cell mediated inflammatory diseases or cancer |
| WO2023102559A1 (en) | 2021-12-03 | 2023-06-08 | Incyte Corporation | Topical formulations of ruxolitinib with an organic amine ph adjusting agent for treatment of skin diseases |
| WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
| US20230399331A1 (en) | 2022-06-14 | 2023-12-14 | Incyte Corporation | Solid forms of jak inhibitor and process of preparing the same |
| CA3263118A1 (en) | 2022-08-03 | 2024-02-08 | Medichem S A | STABLE ORAL PHARMACEUTICAL FORMULATION CONTAINING RUXOLITINIB HELIFUMARATE |
| WO2024099396A1 (en) * | 2022-11-11 | 2024-05-16 | 浙江奥翔药业股份有限公司 | Ruxolitinib crystal and pharmaceutical composition thereof |
| WO2024187416A1 (en) * | 2023-03-15 | 2024-09-19 | Zhejiang Qizheng Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising ruxolitinib |
| WO2024187415A1 (en) | 2023-03-15 | 2024-09-19 | Zhejiang Qizheng Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising ruxolitinib |
| WO2024216287A1 (en) * | 2023-04-14 | 2024-10-17 | Emory University | Uses of jak inhibitors in the management of sepsis and comorbidities |
| WO2024243225A1 (en) | 2023-05-21 | 2024-11-28 | Incyte Corporation | Topical ruxolitinib foam |
| EP4491175A1 (en) | 2023-07-10 | 2025-01-15 | Genepharm S.A. | A solid oral composition of ruxolitinib |
| US12247034B1 (en) | 2024-04-19 | 2025-03-11 | Sun Pharmaceutical Industries, Inc. | Crystalline form of deuruxolitinib phosphate |
Family Cites Families (286)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2985589A (en) | 1957-05-22 | 1961-05-23 | Universal Oil Prod Co | Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets |
| US3832460A (en) * | 1971-03-19 | 1974-08-27 | C Kosti | Anesthetic-vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue |
| US4140755A (en) | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
| GB2030584B (en) | 1978-10-03 | 1983-03-23 | Lankro Chem Ltd | Photopolymerisable solder resist compositions |
| JPS5553537A (en) | 1978-10-13 | 1980-04-19 | Barron Robert Michael | Abrasive foam material and its preparation |
| DE3036390A1 (en) | 1980-09-26 | 1982-05-13 | Troponwerke GmbH & Co KG, 5000 Köln | Antiinflammatory intermediate 7H-pyrrolo-(2,3-D)-pyrimidine derivs. - prepd. by dealkylation of 7-phenyl:ethyl derivs. by reaction with hydrochloric, phosphoric or poly:phosphoric acid |
| DE3220113A1 (en) | 1982-05-28 | 1983-12-01 | Basf Ag, 6700 Ludwigshafen | DIFLUORMETHOXIPHENYLTHIOPHOSPHORSAEUREESTER |
| US4402832A (en) | 1982-08-12 | 1983-09-06 | Uop Inc. | High efficiency continuous separation process |
| US4548990A (en) | 1983-08-15 | 1985-10-22 | Ciba-Geigy Corporation | Crosslinked, porous polymers for controlled drug delivery |
| US4498991A (en) | 1984-06-18 | 1985-02-12 | Uop Inc. | Serial flow continuous separation process |
| NL8403224A (en) | 1984-10-24 | 1986-05-16 | Oce Andeno Bv | DIOXAPHOSPHORINANS, THEIR PREPARATION AND THE USE FOR SPLITTING OF OPTICALLY ACTIVE COMPOUNDS. |
| CA1306260C (en) | 1985-10-18 | 1992-08-11 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
| JPH0781138B2 (en) | 1986-12-02 | 1995-08-30 | 株式会社資生堂 | Antioxidant |
| DE69027440T2 (en) | 1989-10-11 | 1997-02-06 | Teijin Ltd | BIZYCLIC PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM |
| IT1258781B (en) | 1992-01-16 | 1996-02-29 | Zambon Spa | OPHTHALMIC PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYLCISTEIN AND POLYVINYL ALCOHOL |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| AU671491B2 (en) | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| US6638905B2 (en) | 1993-06-18 | 2003-10-28 | The Salk Institute For Biological Studies | Cloning and recombinant production of CFR receptor(s) |
| JPH0710876A (en) | 1993-06-24 | 1995-01-13 | Teijin Ltd | Pyrrolo(2,3-d)pyrimidine having cyclic amino group at 4-position |
| EP0727217A3 (en) | 1995-02-10 | 1997-01-15 | Suntory Ltd | Pharmaceutical composition containing god-type ellagitannin as active ingredient |
| US5856326A (en) | 1995-03-29 | 1999-01-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| IL117580A0 (en) | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
| DE69618959T2 (en) | 1995-07-05 | 2002-08-29 | E.I. Du Pont De Nemours And Co., Wilmington | PYRIMIDONE AND THEIR USE AS FUNGICIDES |
| HUP9900330A3 (en) | 1995-07-06 | 2001-08-28 | Novartis Ag | Pyrrolopyrimidines and processes for the preparation thereof |
| US5630943A (en) | 1995-11-30 | 1997-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Discontinuous countercurrent chromatographic process and apparatus |
| GB9604361D0 (en) | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| CA2250232A1 (en) | 1996-04-03 | 1997-10-09 | Allen I. Oliff | A method of treating cancer |
| AU2802297A (en) | 1996-04-18 | 1997-11-07 | Merck & Co., Inc. | A method of treating cancer |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| WO1997045412A1 (en) | 1996-05-30 | 1997-12-04 | Merck & Co., Inc. | A method of treating cancer |
| US6624138B1 (en) * | 2001-09-27 | 2003-09-23 | Gp Medical | Drug-loaded biological material chemically treated with genipin |
| CA2286239A1 (en) | 1997-04-07 | 1998-10-15 | Merck & Co., Inc. | A method of treating cancer |
| US6060038A (en) | 1997-05-15 | 2000-05-09 | Merck & Co., Inc. | Radiolabeled farnesyl-protein transferase inhibitors |
| US6063284A (en) | 1997-05-15 | 2000-05-16 | Em Industries, Inc. | Single column closed-loop recycling with periodic intra-profile injection |
| JP2001513502A (en) | 1997-08-11 | 2001-09-04 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 5,6-Heteroaryldipyrido [2,3-b: 3 ', 2'-f] azepines and their use in the prevention and treatment of HIV infection |
| US6075056A (en) | 1997-10-03 | 2000-06-13 | Penederm, Inc. | Antifungal/steroid topical compositions |
| US6025366A (en) | 1998-04-02 | 2000-02-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| TR200100189T2 (en) | 1998-06-04 | 2001-05-21 | Abbott Laboratories | Anti-inflammatory compounds against cell adhesion |
| US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| PL198640B1 (en) | 1998-06-19 | 2008-07-31 | Pfizer Prod Inc | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
| PA8474101A1 (en) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS |
| WO2000009495A1 (en) | 1998-08-11 | 2000-02-24 | Novartis Ag | Isoquinoline derivatives with angiogenesis inhibiting activity |
| JP2000119271A (en) | 1998-08-12 | 2000-04-25 | Hokuriku Seiyaku Co Ltd | 1H-imidazopyridine derivative |
| PT1109534E (en) * | 1998-09-10 | 2003-06-30 | Nycomed Danmark As | PHARMACEUTICAL COMPOUNDS FOR QUICK RELEASE PHARMACOSES |
| JP3869128B2 (en) | 1998-09-11 | 2007-01-17 | 株式会社ルネサステクノロジ | Manufacturing method of semiconductor integrated circuit device |
| US6413419B1 (en) | 1998-10-29 | 2002-07-02 | Institut Francais Du Petrole | Process and device for separation with variable-length chromatographic |
| FR2785196B1 (en) | 1998-10-29 | 2000-12-15 | Inst Francais Du Petrole | METHOD AND DEVICE FOR SEPARATION WITH VARIABLE LENGTH CHROMATOGRAPHIC AREAS |
| US6375839B1 (en) | 1998-10-29 | 2002-04-23 | Institut Francais Du Petrole | Process and device for separation with variable-length chromatographic zones |
| US6133031A (en) | 1999-08-19 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense inhibition of focal adhesion kinase expression |
| AU3248600A (en) | 1999-03-03 | 2000-09-21 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| WO2000063168A1 (en) | 1999-04-16 | 2000-10-26 | Coelacanth Chemical Corporation | Synthesis of azetidine derivatives |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| CA2387535A1 (en) | 1999-10-13 | 2001-04-19 | Banyu Pharmaceutical Co., Ltd. | Substituted imidazolidinone derivatives |
| MXPA02005675A (en) * | 1999-12-10 | 2002-09-02 | Pfizer Prod Inc | PYRROLO[2,3 d]PYRIMIDINE COMPOUNDS. |
| HUP0203895A3 (en) * | 1999-12-24 | 2004-09-28 | Aventis Pharma Ltd West Mallin | Substituted azaindoles and pharmaceutical compositions containing them and their use |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| ATE250924T1 (en) | 2000-04-07 | 2003-10-15 | Medidom Lab | EYE MEDICINAL CONTAINING CYCLOSPORINE, HYALURONIC ACID AND POLYSORBATES |
| WO2001081345A1 (en) | 2000-04-20 | 2001-11-01 | Mitsubishi Pharma Corporation | Aromatic amide compounds |
| CN1440408B (en) | 2000-04-25 | 2012-07-18 | 艾科斯有限公司 | Inhibitor of human phosphatidylinositol 3-kinase delta |
| AU2001275495B2 (en) | 2000-06-16 | 2006-08-17 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| US6335342B1 (en) * | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
| CA2413313C (en) * | 2000-06-23 | 2011-06-14 | Mitsubishi Pharma Corporation | Antitumor effect potentiators |
| SK17342002A3 (en) | 2000-06-26 | 2004-06-08 | Pfizer Products Inc. | Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents |
| DE60105023T2 (en) | 2000-06-28 | 2005-08-18 | Smithkline Beecham P.L.C., Brentford | wet grinding |
| EP1343781B1 (en) | 2000-12-05 | 2008-09-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| GB0100622D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
| US20040077654A1 (en) | 2001-01-15 | 2004-04-22 | Bouillot Anne Marie Jeanne | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
| US20040102455A1 (en) | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| US6884804B2 (en) * | 2001-05-16 | 2005-04-26 | Vertex Pharmaceuticals Incorporated | Inhibitors of Src and other protein kinases |
| US7301023B2 (en) | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| GB0115393D0 (en) | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| US6852727B2 (en) * | 2001-08-01 | 2005-02-08 | Merck & Co., Inc. | Benzimisazo[4,5-f]isoquinolinone derivatives |
| CN100391958C (en) | 2001-09-19 | 2008-06-04 | 安万特医药股份有限公司 | Compound (I) |
| US6429231B1 (en) | 2001-09-24 | 2002-08-06 | Bradley Pharmaceuticals, Inc. | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use |
| BRPI0213739B8 (en) | 2001-10-30 | 2021-05-25 | Dana Farber Cancer Inst Inc | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
| JP2003155285A (en) | 2001-11-19 | 2003-05-27 | Toray Ind Inc | Cyclic nitrogen-containing derivative |
| CN1582272A (en) | 2001-11-30 | 2005-02-16 | 帝人株式会社 | Process for preparing 5-(3-cyanophenyl)-3-formylbenzoic acid compound |
| GT200200234A (en) | 2001-12-06 | 2003-06-27 | NEW CRYSTAL COMPOUNDS | |
| US6995144B2 (en) | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| US7304061B2 (en) * | 2002-04-26 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic inhibitors of ERK2 and uses thereof |
| EP1503757B1 (en) | 2002-05-02 | 2007-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| CN1658836A (en) | 2002-05-07 | 2005-08-24 | 控制传输系统公司 | Processes for forming a drug delivery device |
| CA2486183C (en) | 2002-05-23 | 2012-01-10 | Cytopia Pty Ltd. | Protein kinase inhibitors |
| PE20040522A1 (en) | 2002-05-29 | 2004-09-28 | Novartis Ag | DIARYLUREA DERIVATIVES DEPENDENT ON PROTEIN KINASE |
| CN1630668A (en) | 2002-06-26 | 2005-06-22 | 出光兴产株式会社 | Hydrogenated copolymer, process for producing the same, and hot melt adhesive composition comprising the same |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
| JPWO2004007472A1 (en) | 2002-07-10 | 2005-11-17 | 小野薬品工業株式会社 | CCR4 antagonist and pharmaceutical use thereof |
| US7026296B2 (en) | 2002-09-20 | 2006-04-11 | Alcon, Inc. | Methods of treating dry eye disorders |
| US20040204404A1 (en) | 2002-09-30 | 2004-10-14 | Robert Zelle | Human N-type calcium channel blockers |
| JP4688498B2 (en) | 2002-11-04 | 2011-05-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | Heteroaryl-pyrimidine derivatives as JAK inhibitors |
| AR042052A1 (en) | 2002-11-15 | 2005-06-08 | Vertex Pharma | USEFUL DIAMINOTRIAZOLS AS INHIBITORS OF PROTEINQUINASES |
| MXPA05005576A (en) | 2002-11-26 | 2005-07-27 | Pfizer Prod Inc | Method of treatment of transplant rejection. |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| TWI335819B (en) | 2002-12-24 | 2011-01-11 | Alcon Inc | Use of oculosurface selective glucocorticoid in the treatment of dry eye |
| TW200418806A (en) | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
| US7444183B2 (en) * | 2003-02-03 | 2008-10-28 | Enteromedics, Inc. | Intraluminal electrode apparatus and method |
| WO2004072063A1 (en) | 2003-02-07 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl substituted pyrolls useful as inhibitors of protein kinases |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| EP1615906A1 (en) | 2003-04-03 | 2006-01-18 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| SE0301373D0 (en) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
| SE0301372D0 (en) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
| FR2857454B1 (en) | 2003-07-08 | 2006-08-11 | Aventis Pasteur | DOSAGE OF TECHIC ACIDS OF BACTERIA GRAM + |
| US20050043346A1 (en) | 2003-08-08 | 2005-02-24 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
| CA2536954C (en) | 2003-08-29 | 2012-11-27 | Exelixis, Inc. | C-kit modulators and methods of use |
| WO2005026129A1 (en) | 2003-09-15 | 2005-03-24 | Gpc Biotech Ag | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| AR045944A1 (en) | 2003-09-24 | 2005-11-16 | Novartis Ag | ISOQUINOLINE DERIVATIVES 1.4-DISPOSED |
| TWI343256B (en) | 2003-10-24 | 2011-06-11 | Santen Pharmaceutical Co Ltd | Cornea-conjunctiva disorder treating agent |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| MXPA06005882A (en) | 2003-11-25 | 2006-06-27 | Pfizer Prod Inc | Method of treatment of atherosclerosis. |
| KR20060096153A (en) | 2003-12-17 | 2006-09-07 | 화이자 프로덕츠 인코포레이티드 | Pyrrolo [2,3-d] pyrimidine compounds for the treatment of transplant rejection |
| ES2308299T3 (en) | 2003-12-19 | 2008-12-01 | Schering Corp | TIADIAZOLS AS LIGANDS OF CXC-AND CC-CHEMIOKIN RECEPTORS. |
| PT1696920E (en) | 2003-12-19 | 2015-01-14 | Plexxikon Inc | Compounds and methods for development of ret modulators |
| PL1706385T3 (en) | 2003-12-23 | 2011-03-31 | Astex Therapeutics Ltd | Pyrazole derivatives as protein kinase modulators |
| US20050239806A1 (en) | 2004-01-13 | 2005-10-27 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| CA2559285A1 (en) | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| DE602005027825D1 (en) | 2004-03-30 | 2011-06-16 | Vertex Pharma | AS AZHIBITORS OF JAK AND OTHER PROTEIN KINASES SUITABLE AZAINDOLE |
| EP1750727A2 (en) | 2004-04-23 | 2007-02-14 | Exelixis, Inc. | Kinase modulators and methods of use |
| WO2005105988A2 (en) | 2004-04-28 | 2005-11-10 | Vertex Pharmaceuticals Incorporated | Crystal structure of human jak3 kinase domain complex and binding pockets thereof |
| WO2005105814A1 (en) * | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| JP2007536310A (en) | 2004-05-03 | 2007-12-13 | ノバルティス アクチエンゲゼルシャフト | Combination comprising S1P receptor agonist and JAK3 kinase inhibitor |
| US20060074102A1 (en) | 2004-05-14 | 2006-04-06 | Kevin Cusack | Kinase inhibitors as therapeutic agents |
| PE20060426A1 (en) | 2004-06-02 | 2006-06-28 | Schering Corp | TARTARIC ACID DERIVATIVES AS INHIBITORS OF MMPs, ADAMs, TACE AND TNF-alpha |
| ES2396135T3 (en) | 2004-06-10 | 2013-02-19 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| EP1760071A4 (en) | 2004-06-23 | 2008-03-05 | Ono Pharmaceutical Co | Compound having s1p receptor binding potency and use thereof |
| WO2006004984A1 (en) | 2004-06-30 | 2006-01-12 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of protein kinases |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| FR2873691B1 (en) | 2004-07-29 | 2006-10-06 | Sanofi Synthelabo | AMINO-PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| WO2006013114A1 (en) | 2004-08-06 | 2006-02-09 | Develogen Aktiengesellschaft | Use of a timp-2 secreted protein product for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome |
| WO2006022459A1 (en) | 2004-08-23 | 2006-03-02 | Mogam Biotechnology Institute | Primer and probe for detection of sars coronavirus, kit comprising the primer and/or the probe, and detection method thereof |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| HRP20080429T3 (en) | 2004-10-13 | 2008-09-30 | F. Hoffmann - La Roche Ag | Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| UY29177A1 (en) | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | SUBSTITUTED DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA, COMPOSITIONS THAT CONTAIN METHODS FOR THEIR PREPARATION AND ITS USES |
| DK1812440T3 (en) | 2004-11-04 | 2011-01-31 | Vertex Pharma | Pyrazolo [1,5-a] pyrimidines which can be used as inhibitors of protein kinases |
| BRPI0517887A (en) | 2004-11-24 | 2008-10-21 | Novartis Ag | combinations of inhibitors of jaks |
| US7517870B2 (en) | 2004-12-03 | 2009-04-14 | Fondazione Telethon | Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization |
| WO2006065916A1 (en) | 2004-12-14 | 2006-06-22 | Alcon, Inc. | Method of treating dry eye disorders using 13(s)-hode and its analogs |
| US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
| WO2006067445A2 (en) | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Csf-1r kinase inhibitors |
| AR054416A1 (en) | 2004-12-22 | 2007-06-27 | Incyte Corp | PIRROLO [2,3-B] PIRIDIN-4-IL-AMINAS AND PIRROLO [2,3-B] PIRIMIDIN-4-IL-AMINAS AS INHIBITORS OF THE JANUS KINASES. PHARMACEUTICAL COMPOSITIONS. |
| US20090124635A1 (en) | 2005-01-20 | 2009-05-14 | Pfizer Inc. | Chemical compounds |
| RU2434871C2 (en) * | 2005-02-03 | 2011-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Pyrrolopyrimidines used as protein kinase inhibitors |
| WO2007044050A2 (en) | 2005-02-04 | 2007-04-19 | Bristol-Myers Squibb Company | 1h-imidazo[4,5-d]thieno[3,2-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
| JP2008533145A (en) | 2005-03-15 | 2008-08-21 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Compounds and compositions as protein kinase inhibitors |
| BRPI0610514A2 (en) | 2005-04-05 | 2016-11-16 | Pharmacopeia Inc | compound, pharmaceutical composition, and method of treating a disorder |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| MX2007014619A (en) * | 2005-05-20 | 2009-02-13 | Vertex Pharma | Pyrrolopyridines useful as inhibitors of protein kinase. |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| CA2611720A1 (en) | 2005-06-08 | 2006-12-14 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
| CA2608367C (en) | 2005-06-08 | 2014-08-19 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2006136823A1 (en) | 2005-06-21 | 2006-12-28 | Astex Therapeutics Limited | Heterocyclic containing amines as kinase b inhibitors |
| US7863288B2 (en) | 2005-06-22 | 2011-01-04 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP2007010876A (en) | 2005-06-29 | 2007-01-18 | Fujinon Corp | Lens drive device |
| EP2251341A1 (en) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| FR2889662B1 (en) | 2005-08-11 | 2011-01-14 | Galderma Res & Dev | OIL-IN-WATER EMULSION FOR TOPICAL APPLICATION IN DERMATOLOGY |
| US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
| US20070149506A1 (en) * | 2005-09-22 | 2007-06-28 | Arvanitis Argyrios G | Azepine inhibitors of Janus kinases |
| ES2401192T3 (en) | 2005-09-30 | 2013-04-17 | Vertex Pharmceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| WO2007044894A2 (en) | 2005-10-11 | 2007-04-19 | Chembridge Research Laboratories, Inc. | Cell-free protein expression systems and methods of use thereof |
| US7867949B2 (en) | 2005-10-14 | 2011-01-11 | Sumitomo Chemical Company, Limited | Hydrazide compound and pesticidal use of the same |
| RU2463302C2 (en) | 2005-10-28 | 2012-10-10 | Астразенека Аб | 4-(3-aminopyrazole)pyrimidine applicable as tyrosine kinase inhibitors for treating malignant growth |
| AU2006309013B2 (en) | 2005-11-01 | 2012-06-28 | Impact Biomedicines, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| WO2007062459A1 (en) | 2005-11-29 | 2007-06-07 | Cytopia Research Pty Ltd | Selective kinase inhibitors based on pyridine scaffold |
| US7598257B2 (en) | 2005-12-13 | 2009-10-06 | Incyte Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
| US20130137681A1 (en) | 2005-12-13 | 2013-05-30 | Incyte Corporation | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS |
| WO2007076423A2 (en) | 2005-12-22 | 2007-07-05 | Smithkline Beecham Corporation | INHIBITORS OF Akt ACTIVITY |
| US7282588B2 (en) | 2005-12-23 | 2007-10-16 | Smithkline Beecham | Azaindole inhibitors of aurora kinases |
| BRPI0706537A2 (en) | 2006-01-17 | 2011-03-29 | Vertex Pharma | azaindoles useful as janus kinases inhibitors |
| WO2007084667A2 (en) * | 2006-01-19 | 2007-07-26 | Osi Pharmaceutical, Inc. | Fused heterobicyclic kinase inhibitors |
| WO2007090141A2 (en) | 2006-02-01 | 2007-08-09 | Smithkline Beecham Corporation | Pyrrolo [2, 3, b] pyridine derivatives useful as raf kinase inhibitors |
| US7745477B2 (en) | 2006-02-07 | 2010-06-29 | Hoffman-La Roche Inc. | Heteroaryl and benzyl amide compounds |
| JPWO2007105637A1 (en) | 2006-03-10 | 2009-07-30 | 小野薬品工業株式会社 | Nitrogen-containing heterocyclic derivatives and drugs containing them as active ingredients |
| EP2003132B1 (en) | 2006-04-03 | 2014-03-05 | Astellas Pharma Inc. | Oxadiazole derivatives as S1P1 agonists |
| AU2007235487A1 (en) | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| EP2059515A2 (en) | 2006-04-12 | 2009-05-20 | Pfizer Limited | Pyrrolidine derivatives as modulators of chemokine ccr5 receptors |
| WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| US7691811B2 (en) | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
| JO3235B1 (en) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | Pyrrolopyrimidine compounds and their uses |
| JP2009544625A (en) | 2006-07-20 | 2009-12-17 | メーメット・カーラマン | Benzothiophene inhibitors of RHO kinase |
| WO2008013622A2 (en) | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| WO2008016123A1 (en) | 2006-08-03 | 2008-02-07 | Takeda Pharmaceutical Company Limited | GSK-3β INHIBITOR |
| WO2008022164A2 (en) | 2006-08-16 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Pyrazine compounds, their use and methods of preparation |
| KR20090060333A (en) | 2006-09-08 | 2009-06-11 | 노파르티스 아게 | N-biaryl (hetero) arylsulfonamide derivatives useful for the treatment of diseases mediated by lymphocyte interactions |
| WO2008035376A2 (en) | 2006-09-19 | 2008-03-27 | Council Of Scientific & Industrial Research | A novel bio-erodible insert for ophthalmic applications and a process for the preparation thereof |
| TW200837064A (en) | 2006-10-04 | 2008-09-16 | Pharmacopeia Inc | 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression |
| TW200831104A (en) | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| US20120225057A1 (en) | 2006-10-11 | 2012-09-06 | Deciphera Pharmaceuticals, Llc | Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases |
| MY146474A (en) | 2006-11-06 | 2012-08-15 | Supergen Inc | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| US20080119496A1 (en) | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
| NZ577127A (en) | 2006-11-22 | 2012-03-30 | Incyte Corp | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
| WO2008067119A2 (en) | 2006-11-27 | 2008-06-05 | Smithkline Beecham Corporation | Novel compounds |
| KR20090095648A (en) | 2006-12-15 | 2009-09-09 | 아보트 러보러터리즈 | Novel oxadiazole compounds |
| US7687522B2 (en) | 2006-12-20 | 2010-03-30 | Amgen Inc. | Substituted pyridines and pyrimidines and their use in treatment of cancer |
| AU2007338793B2 (en) | 2006-12-20 | 2012-05-03 | Amgen Inc. | Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer |
| JP5315252B2 (en) | 2006-12-22 | 2013-10-16 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | Gels useful for transporting ophthalmic drugs |
| US8513270B2 (en) * | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
| WO2008082840A1 (en) | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Pim kinase inhibitors as cancer chemotherapeutics |
| KR20080062876A (en) | 2006-12-29 | 2008-07-03 | 주식회사 대웅제약 | Novel Antifungal Triazole Derivatives |
| WO2008082839A2 (en) | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Pim kinase inhibitors as cancer chemotherapeutics |
| JP5330274B2 (en) | 2007-03-01 | 2013-10-30 | ノバルティス アーゲー | PIM kinase inhibitor and method of use thereof |
| HRP20130660T1 (en) | 2007-04-03 | 2013-08-31 | Array Biopharma, Inc. | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| JP5603770B2 (en) | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | CCR2 receptor antagonist and use thereof |
| GB0710528D0 (en) | 2007-06-01 | 2007-07-11 | Glaxo Group Ltd | Novel compounds |
| PT3070090T (en) | 2007-06-13 | 2019-03-20 | Incyte Holdings Corp | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| CL2008001709A1 (en) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compounds derived from pyrrolo [2,3-b] pyrimidine, jak kinase modulators; pharmaceutical composition; and use in the treatment of diseases such as cancer, psoriasis, rheumatoid arthritis, among others. |
| RU2445098C2 (en) | 2007-07-11 | 2012-03-20 | Пфайзер Инк. | Pharmaceutical composition and methods of treating dry-eye syndrome |
| EA201000113A1 (en) | 2007-08-01 | 2010-08-30 | Пфайзер Инк. | PYRAZOL COMPOUNDS |
| WO2009049028A1 (en) | 2007-10-09 | 2009-04-16 | Targegen Inc. | Pyrrolopyrimidine compounds and their use as janus kinase modulators |
| EP2217235A4 (en) | 2007-11-15 | 2011-01-12 | Musc Found For Res Dev | PROTEIN INHIBITORS PIM KINASES, COMPOSITIONS AND METHODS FOR TREATING CANCER |
| ES2569528T3 (en) * | 2007-11-16 | 2016-05-11 | Incyte Holdings Corporation | 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as Janus kinase inhibitors |
| GB0723815D0 (en) | 2007-12-05 | 2008-01-16 | Glaxo Group Ltd | Compounds |
| CA2711384C (en) | 2008-01-18 | 2016-07-26 | Institute Of Organic Chemistry And Biochemistry As Cr, V.V.I. | Cytostatic 7-deazapurine nucleosides |
| UA106037C2 (en) | 2008-02-04 | 2014-07-25 | Мерк'Юрі Терап'Ютікс, Інк. | Modulators of ampk (amp-activated protein kinase) |
| PE20091577A1 (en) | 2008-03-03 | 2009-11-05 | Novartis Ag | PIM KINASE INHIBITORS AND METHODS FOR THEIR USE |
| UA101493C2 (en) | 2008-03-11 | 2013-04-10 | Инсайт Корпорейшн | Azetidine and cyclobutane derivatives as jak inhibitors |
| CN102015686B (en) | 2008-03-21 | 2014-07-02 | 诺华股份有限公司 | Novel heterocyclic compounds and uses therof |
| EP3650017A1 (en) | 2008-06-26 | 2020-05-13 | Anterios, Inc. | Dermal delivery |
| UY31952A (en) | 2008-07-02 | 2010-01-29 | Astrazeneca Ab | 5-METHYLIDENE-1,3-THIAZOLIDINE-2,4-DIONAS REPLACED AS PIM QUINASE INHIBITORS |
| FR2933409B1 (en) | 2008-07-03 | 2010-08-27 | Centre Nat Rech Scient | NEW PYRROLO ° 2,3-a! CARBAZOLES AND THEIR USE AS INHIBITORS OF PIM KINASES |
| US8557809B2 (en) | 2008-08-19 | 2013-10-15 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
| TWI496779B (en) | 2008-08-19 | 2015-08-21 | Array Biopharma Inc | Triazolopyridine compounds as pim kinase inhibitors |
| ME01269B (en) | 2008-08-20 | 2013-06-20 | Zoetis Services Llc | Pyrrolo[2,3-d]pyrimidine compounds |
| JP5564045B2 (en) | 2008-09-02 | 2014-07-30 | ノバルティス アーゲー | Bicyclic kinase inhibitor |
| DK2344474T3 (en) | 2008-09-02 | 2015-12-14 | Novartis Ag | Picolinamidderivater as kinase inhibitors |
| JP5584215B2 (en) | 2008-09-02 | 2014-09-03 | ノバルティス アーゲー | Heterocyclic PIM kinase inhibitor |
| CL2009001884A1 (en) | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Use of 3-cyclopentyl-3- [4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl) -1h-pyrazol-1-yl) propanonitrile, janus kinase inhibitor, and use of a composition that understands it for the treatment of dry eye. |
| JOP20190231A1 (en) | 2009-01-15 | 2017-06-16 | Incyte Corp | Processes for preparing jak inhibitors and related intermediate compounds |
| EP2210890A1 (en) | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| US8716303B2 (en) | 2009-05-22 | 2014-05-06 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CA2761954C (en) | 2009-05-22 | 2018-07-31 | Incyte Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| UA110324C2 (en) | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| WO2011025685A1 (en) | 2009-08-24 | 2011-03-03 | Merck Sharp & Dohme Corp. | Jak inhibition blocks rna interference associated toxicities |
| TW201111385A (en) | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
| WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| WO2011029802A1 (en) | 2009-09-08 | 2011-03-17 | F. Hoffmann-La Roche Ag | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
| EP2305660A1 (en) | 2009-09-25 | 2011-04-06 | Almirall, S.A. | New thiadiazole derivatives |
| PT2486041E (en) | 2009-10-09 | 2013-11-14 | Incyte Corp | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| EP2491039A1 (en) | 2009-10-20 | 2012-08-29 | Cellzome Limited | Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors |
| EP2332917B1 (en) | 2009-11-11 | 2012-08-01 | Sygnis Bioscience GmbH & Co. KG | Compounds for PIM kinase inhibition and for treating malignancy |
| US9468676B2 (en) | 2009-11-24 | 2016-10-18 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| EP2506852A4 (en) | 2009-12-04 | 2013-06-19 | Univ Texas | INTERFERON PROCESSING IN COMBINATION WITH BLOCKING OF STAT3 ACTIVATION |
| RU2012132278A (en) | 2010-01-12 | 2014-02-20 | Ф. Хоффманн-Ля Рош Аг | TRICYCLIC HETEROCYCLIC COMPOUNDS CONTAINING THEIR COMPOSITIONS AND WAYS OF THEIR APPLICATION |
| SA111320200B1 (en) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | Bicyclic Compounds and their Uses as Dual C-SRC / JAK Inhibitors |
| EA023444B1 (en) | 2010-02-18 | 2016-06-30 | Инсайт Холдингс Корпорейшн | Cyclobutane and methylcyclobutane derivatives, composition based thereon and methods of use thereof |
| HRP20160326T1 (en) | 2010-03-10 | 2016-05-20 | Incyte Holdings Corporation | PIPERIDIN-4-IL AZETIDINE DERIVATIVES AS INHIBITORS OF JAK1 |
| RU2012148246A (en) | 2010-04-14 | 2014-05-20 | Эррэй Биофарма Инк. | 5, 7- SUBSTITUTED-IMIDAZO [1, 2-C] PYRIMIDINES AS JAK-KINAZ INHIBITORS |
| EP2390252A1 (en) | 2010-05-19 | 2011-11-30 | Almirall, S.A. | New pyrazole derivatives |
| EA035981B1 (en) | 2010-05-21 | 2020-09-09 | Инсайт Холдингс Корпорейшн | Jak inhibitor formulation for topical application |
| US8637529B2 (en) | 2010-06-11 | 2014-01-28 | AbbYie Inc. | Pyrazolo[3,4-d]pyrimidine compounds |
| US9351943B2 (en) | 2010-07-01 | 2016-05-31 | Matthew T. McLeay | Anti-fibroblastic fluorochemical emulsion therapies |
| WO2012045010A1 (en) | 2010-09-30 | 2012-04-05 | Portola Pharmaceuticals, Inc. | Combinations of 4-(3-(2h-1,2,3-triazo-2-yl) phenylamino)-2-((1r,2s)-2-aminocyclohexylamino) pyrimidine-5-carboxamide and fludarabine |
| CN101974161B (en) | 2010-09-30 | 2012-10-31 | 中国科学院西双版纳热带植物园 | A method for dissolving and rapidly hydrolyzing lignocellulosic biomass and its equipment and application |
| JP5917545B2 (en) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| JP5917544B2 (en) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Heterocyclic substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
| MX2013006261A (en) | 2010-12-03 | 2013-10-01 | Ym Biosciences Australia Pty | Treatment of jak2-mediated conditions. |
| ES2547916T3 (en) | 2011-02-18 | 2015-10-09 | Novartis Pharma Ag | MTOR / JAK inhibitor combination therapy |
| BR112013032720A2 (en) | 2011-06-20 | 2016-09-13 | Incyte Corp | "azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors, composition and use of said derivatives" |
| CA2844507A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Jak pi3k/mtor combination therapy |
| TW201313721A (en) | 2011-08-18 | 2013-04-01 | Incyte Corp | Cyclohexyl azetidine derivatives as JAK inhibitors |
| UA111854C2 (en) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS |
| TW201406761A (en) | 2012-05-18 | 2014-02-16 | Incyte Corp | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| US10155987B2 (en) | 2012-06-12 | 2018-12-18 | Dana-Farber Cancer Institute, Inc. | Methods of predicting resistance to JAK inhibitor therapy |
| EP2890691B1 (en) | 2012-08-31 | 2018-04-25 | Principia Biopharma Inc. | Benzimidazole derivatives as itk inhibitors |
| US9263059B2 (en) | 2012-09-28 | 2016-02-16 | International Business Machines Corporation | Deep tagging background noises |
| US20140095210A1 (en) | 2012-10-02 | 2014-04-03 | CareRev, Inc. | Computer-implemented method and system for facilitating information sharing, communication, and collaboration in a healthcare facility |
| NZ707495A (en) | 2012-11-01 | 2019-01-25 | Incyte Holdings Corp | Tricyclic fused thiophene derivatives as jak inhibitors |
| SG10202111768XA (en) | 2012-11-15 | 2021-11-29 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
| HUE042466T2 (en) | 2013-03-06 | 2019-06-28 | Incyte Holdings Corp | Method and intermediates for the preparation of JAK inhibitor |
| KR102663357B1 (en) | 2013-05-17 | 2024-05-14 | 인사이트 홀딩스 코포레이션 | Bipyrazole derivatives as jak inhibitors |
| TWI503855B (en) | 2013-07-05 | 2015-10-11 | Timotion Technology Co Ltd | Limit switch and linear actuator with the limit switch |
| PH12019502074B1 (en) | 2013-08-07 | 2023-10-18 | Incyte Holdings Corp | Sustained release dosage forms for a jak1 inhibitor |
| WO2015026818A1 (en) | 2013-08-20 | 2015-02-26 | Incyte Corporation | Survival benefit in patients with solid tumors with elevated c-reactive protein levels |
| AU2015222913B2 (en) | 2014-02-28 | 2019-12-12 | Incyte Holdings Corporation | JAK1 inhibitors for the treatment of myelodysplastic syndromes |
| EA202191009A1 (en) | 2014-04-08 | 2021-08-31 | Инсайт Корпорейшн | TREATMENT OF B-CELL MALIGNANT NOMINATIONS USING A COMBINATION OF JAK AND PI3K INHIBITORS |
| CA2947418A1 (en) | 2014-04-30 | 2015-11-05 | Incyte Corporation | Processes of preparing a jak1 inhibitor and new forms thereto |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
-
2008
- 2008-06-12 PT PT16152794T patent/PT3070090T/en unknown
- 2008-06-12 KR KR1020157002074A patent/KR20150036210A/en not_active Ceased
- 2008-06-12 DK DK13198120.1T patent/DK2740731T3/en active
- 2008-06-12 MY MYPI20095311A patent/MY154969A/en unknown
- 2008-06-12 EP EP25166280.5A patent/EP4606378A3/en active Pending
- 2008-06-12 US US12/137,892 patent/US20080312259A1/en not_active Abandoned
- 2008-06-12 CU CU20120155A patent/CU24179B1/en active IP Right Grant
- 2008-06-12 SI SI200831217T patent/SI2173752T2/en unknown
- 2008-06-12 HR HRP20140541TT patent/HRP20140541T4/en unknown
- 2008-06-12 DK DK08770794.9T patent/DK2173752T4/en active
- 2008-06-12 ES ES08770794T patent/ES2467665T5/en active Active
- 2008-06-12 CN CN2008801029033A patent/CN101932582B/en active Active
- 2008-06-12 JP JP2010512343A patent/JP5475653B2/en active Active
- 2008-06-12 EA EA201070013A patent/EA019784B1/en unknown
- 2008-06-12 SG SG2012043428A patent/SG182198A1/en unknown
- 2008-06-12 ES ES16152794T patent/ES2714092T3/en active Active
- 2008-06-12 CN CN201310367212.9A patent/CN103524509B/en active Active
- 2008-06-12 UA UAA201000232A patent/UA99467C2/en unknown
- 2008-06-12 BR BRPI0814254A patent/BRPI0814254B8/en active IP Right Grant
- 2008-06-12 SI SI200831621A patent/SI2740731T1/en unknown
- 2008-06-12 ES ES13198120.1T patent/ES2575797T3/en active Active
- 2008-06-12 SG SG10201509887UA patent/SG10201509887UA/en unknown
- 2008-06-12 EP EP13198120.1A patent/EP2740731B1/en active Active
- 2008-06-12 EP EP16152794.0A patent/EP3070090B1/en not_active Revoked
- 2008-06-12 DK DK16152794.0T patent/DK3070090T3/en active
- 2008-06-12 WO PCT/US2008/066662 patent/WO2008157208A2/en not_active Ceased
- 2008-06-12 SG SG10201912675VA patent/SG10201912675VA/en unknown
- 2008-06-12 RS RS20190251A patent/RS58449B1/en unknown
- 2008-06-12 TR TR2019/03488T patent/TR201903488T4/en unknown
- 2008-06-12 PL PL16152794T patent/PL3070090T3/en unknown
- 2008-06-12 EP EP21200662.1A patent/EP4011883B1/en active Active
- 2008-06-12 EP EP18203965.1A patent/EP3495369B1/en active Active
- 2008-06-12 HU HUE13198120A patent/HUE029236T2/en unknown
- 2008-06-12 MX MX2013005828A patent/MX342814B/en unknown
- 2008-06-12 PT PT87707949T patent/PT2173752E/en unknown
- 2008-06-12 LT LTEP16152794.0T patent/LT3070090T/en unknown
- 2008-06-12 NZ NZ581803A patent/NZ581803A/en unknown
- 2008-06-12 SI SI200832042T patent/SI3070090T1/en unknown
- 2008-06-12 RS RS20140152A patent/RS53245B2/en unknown
- 2008-06-12 PL PL08770794.9T patent/PL2173752T5/en unknown
- 2008-06-12 RS RS20160375A patent/RS54878B1/en unknown
- 2008-06-12 HU HUE16152794A patent/HUE043732T2/en unknown
- 2008-06-12 KR KR1020107000805A patent/KR101549876B1/en active Active
- 2008-06-12 ME MEP-2009-345A patent/ME00960B/en unknown
- 2008-06-12 ES ES18203965T patent/ES2903444T3/en active Active
- 2008-06-12 CA CA2689663A patent/CA2689663C/en active Active
- 2008-06-12 GE GEAP200811637A patent/GEP20125533B/en unknown
- 2008-06-12 PL PL13198120.1T patent/PL2740731T3/en unknown
- 2008-06-12 EP EP08770794.9A patent/EP2173752B2/en active Active
- 2008-06-12 MX MX2009013402A patent/MX2009013402A/en active IP Right Grant
- 2008-06-12 AU AU2008266183A patent/AU2008266183B2/en active Active
-
2009
- 2009-12-06 IL IL202524A patent/IL202524A/en active IP Right Grant
- 2009-12-09 CR CR11151A patent/CR11151A/en unknown
- 2009-12-10 DO DO2009000280A patent/DOP2009000280A/en unknown
- 2009-12-10 ZA ZA2009/08826A patent/ZA200908826B/en unknown
- 2009-12-10 TN TNP2009000514A patent/TN2009000514A1/en unknown
- 2009-12-10 GT GT200900314A patent/GT200900314A/en unknown
- 2009-12-11 CU CU2009000213A patent/CU23933B1/en active IP Right Grant
- 2009-12-11 NI NI200900216A patent/NI200900216A/en unknown
- 2009-12-14 EC EC2009009802A patent/ECSP099802A/en unknown
- 2009-12-16 CO CO09144142A patent/CO6251256A2/en active IP Right Grant
-
2010
- 2010-01-08 SM SM201000002T patent/SMP201000002B/en unknown
- 2010-01-12 MA MA32505A patent/MA31517B1/en unknown
-
2013
- 2013-12-05 US US14/097,598 patent/US20140094477A1/en not_active Abandoned
- 2013-12-05 US US14/097,588 patent/US8722693B2/en active Active
-
2014
- 2014-04-18 US US14/256,383 patent/US8822481B1/en active Active
- 2014-04-18 US US14/256,311 patent/US8829013B1/en active Active
- 2014-05-01 IL IL232410A patent/IL232410A0/en active IP Right Grant
- 2014-05-06 US US14/270,915 patent/US9376439B2/en active Active
- 2014-05-07 CY CY20141100323T patent/CY1115145T1/en unknown
-
2016
- 2016-05-25 US US15/164,518 patent/US10016429B2/en active Active
- 2016-06-13 CY CY20161100513T patent/CY1117693T1/en unknown
- 2016-06-21 HR HRP20160717TT patent/HRP20160717T1/en unknown
-
2018
- 2018-06-08 US US16/003,210 patent/US10610530B2/en active Active
-
2019
- 2019-01-16 IL IL264276A patent/IL264276B/en active IP Right Grant
- 2019-02-28 HR HRP20190385TT patent/HRP20190385T1/en unknown
- 2019-03-07 CY CY20191100273T patent/CY1121338T1/en unknown
- 2019-06-11 NO NO2019025C patent/NO2019025I1/en unknown
-
2020
- 2020-03-02 US US16/806,244 patent/US11213528B2/en active Active
-
2021
- 2021-01-26 IL IL280401A patent/IL280401B/en unknown
- 2021-10-31 IL IL287708A patent/IL287708B1/en unknown
- 2021-11-29 US US17/536,925 patent/US20220288078A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL287708A (en) | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile | |
| ZA200908820B (en) | Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile | |
| SI3184526T1 (en) | Pyrrolo(2,3-d)pyrimidine derivatives as janus kinase inhibitor | |
| HUS2000006I1 (en) | Substituted pyrazolo[1,5-]pyrimidine compounds as trk kinase inhibitors | |
| IL192298A0 (en) | Heterocyclic janus kinase 3 inhibitors | |
| IL184504A0 (en) | 4-(2,6-dichlorobenzoylamino)-1h-pyrazole-3-carboxylic acid piperidin-4-ylamid acid addition salts as kinase inhibitors | |
| EP1713793A4 (en) | Pyrimidinone compounds useful as kinase inhibitors |