[go: up one dir, main page]

SE9501472D0 - Truncated IGF-I - Google Patents

Truncated IGF-I

Info

Publication number
SE9501472D0
SE9501472D0 SE9501472A SE9501472A SE9501472D0 SE 9501472 D0 SE9501472 D0 SE 9501472D0 SE 9501472 A SE9501472 A SE 9501472A SE 9501472 A SE9501472 A SE 9501472A SE 9501472 D0 SE9501472 D0 SE 9501472D0
Authority
SE
Sweden
Prior art keywords
igf
truncated
truncated variant
expressing
variant
Prior art date
Application number
SE9501472A
Other languages
Swedish (sv)
Inventor
Rolf Eriksson
Stig Johansson
Harriet Roennholm
Anna Skottner
Karin Sonesson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to SE9501472A priority Critical patent/SE9501472D0/en
Publication of SE9501472D0 publication Critical patent/SE9501472D0/en
Priority to PCT/SE1996/000520 priority patent/WO1996033216A1/en
Priority to AU54129/96A priority patent/AU5412996A/en
Priority to IL11790796A priority patent/IL117907A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a truncated variant of IGF-I having 1-69 of the amino acids of authentic IGF-I (IGF-I(1-69)) and a method of obtaining the truncated IGF-I either by expressing of IGF-I in yeast cells, enzymatic cleavage and thereafter isolating the truncated IGF-I from the medium or by introducing a plasmid encoding for the truncated variant of IGF-I and expressing the truncated variant of IGF-I. The invention also relates to a pharmaceutical composition containing this new truncated variant of IGF-I and to the use of IGF-I(1-69) for the preparation of a medicament.
SE9501472A 1995-04-21 1995-04-21 Truncated IGF-I SE9501472D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SE9501472A SE9501472D0 (en) 1995-04-21 1995-04-21 Truncated IGF-I
PCT/SE1996/000520 WO1996033216A1 (en) 1995-04-21 1996-04-19 Truncated igf-i
AU54129/96A AU5412996A (en) 1995-04-21 1996-04-19 Truncated igf-i
IL11790796A IL117907A0 (en) 1995-04-21 1996-05-14 Truncated IGF-I

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9501472A SE9501472D0 (en) 1995-04-21 1995-04-21 Truncated IGF-I

Publications (1)

Publication Number Publication Date
SE9501472D0 true SE9501472D0 (en) 1995-04-21

Family

ID=20398031

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9501472A SE9501472D0 (en) 1995-04-21 1995-04-21 Truncated IGF-I

Country Status (4)

Country Link
AU (1) AU5412996A (en)
IL (1) IL117907A0 (en)
SE (1) SE9501472D0 (en)
WO (1) WO1996033216A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
SE9802938D0 (en) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
IL143866A0 (en) 1999-01-06 2002-04-21 Genentech Inc Insulin-like growth factor (igf) i mutant variants
JP2002535967A (en) 1999-01-06 2002-10-29 ジェネンテック・インコーポレーテッド Insulin-like growth factor (IGF) I variants
CA2376284A1 (en) * 1999-06-21 2000-12-28 Murdoch Childrens Research Institute A method for the prophylaxis and/or treatment of medical disorders
WO2001087323A2 (en) 2000-05-16 2001-11-22 Genentech, Inc. Method for treating cartilage disorders
MXPA03007042A (en) 2001-02-09 2004-05-24 Genentech Inc Crystallization of igf-1.
US7071300B2 (en) 2001-03-14 2006-07-04 Genentech, Inc. IGF antagonist peptides
WO2005049792A2 (en) 2003-09-12 2005-06-02 Tercica, Inc. Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency
US20210008172A1 (en) 2019-07-11 2021-01-14 Opko Biologics Ltd. Long-acting igf-1 or igf-1 variants and methods of producing same
GB201913196D0 (en) 2019-09-12 2019-10-30 Univ Newcastle Culture method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126324A (en) * 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
NZ255461A (en) * 1992-08-20 1996-12-20 Biotechnology & Biolog Science Specific binding molecules for insulin-like-growth-factor-1 (igf-1), antigens capable of generating them and their use in enhancing igf-1 activity
SE9402332D0 (en) * 1994-07-01 1994-07-01 Pharmacia Ab IGF-1

Also Published As

Publication number Publication date
AU5412996A (en) 1996-11-07
WO1996033216A1 (en) 1996-10-24
IL117907A0 (en) 1996-08-04

Similar Documents

Publication Publication Date Title
DK0770139T3 (en) A fungus in which the areA gene has been modified, as well as an areA gene from aspergillus oryzae
AU7381098A (en) Polypeptides having prolyl pipeptidyl aminopeptidase activity and nucleic acids encoding same
SE9501472D0 (en) Truncated IGF-I
AU7327596A (en) Preparation of phosphorothioate oligomers
AU4200897A (en) Novel host cells and methods of producing proteins
BG103977A (en) Low molecular rotamase enzymic activity inhibitors
AU4981101A (en) Subtilisin variants
IL157644A0 (en) Method for the purification of a protein preparation with erythropoietin activity
WO1993009235A3 (en) Ubiquitin-specific proteases
EP0859833A4 (en) RECOMBINANT HEPATITIS C VIRUS REPLICASE
ES8504458A1 (en) Preparation of DNA sequences and DNA recombinant molecules coding for the cholera toxine units A and B, the products obtained and compositions containing the unit(s) obtained.
DE69720026T2 (en) METHOD FOR PRODUCING D-AMINO ACIDS BY DIRECT FERMENTATION
AU4940096A (en) Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production
ATE85345T1 (en) NEW CADIODILATIN FRAGMENT, PROCESS FOR ITS PRODUCTION AND ITS APPLICATION.
AU2529095A (en) Vaccine against mycobacterial infections
AU5658196A (en) Method for pharmaceutical delivery
WO2001027154A3 (en) Membrane translocating peptide drug delivery system
BR0014519A (en) Signal sequences for the preparation of leu-herudin through e. coli in the culture medium
WO1995015391A3 (en) Aspergillus expression system
AU6839994A (en) Dna encoding prostaglandin receptor ep1
PL348669A1 (en) Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
EP2281892A3 (en) Methods for producing polypeptides in respiratory-deficient Trichoderma cells
AUPM772494A0 (en) Improvements in production of proteins in host cells
AU6378994A (en) Plant promoter, microorganisms and plant cells containing a unit for the expression of a protein of interest comprising said promoter
IL129139A0 (en) Vertebrate smoothened proteins