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SE9003706L - METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS - Google Patents

METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS

Info

Publication number
SE9003706L
SE9003706L SE9003706A SE9003706A SE9003706L SE 9003706 L SE9003706 L SE 9003706L SE 9003706 A SE9003706 A SE 9003706A SE 9003706 A SE9003706 A SE 9003706A SE 9003706 L SE9003706 L SE 9003706L
Authority
SE
Sweden
Prior art keywords
liposomes
proteoliposomes
gel
lipids
methods
Prior art date
Application number
SE9003706A
Other languages
Swedish (sv)
Other versions
SE9003706D0 (en
Inventor
Eva Greijer
Maria Wallsten
Per Lundahl
Qing Yang
Original Assignee
Eva Greijer
Maria Wallsten
Lundahl
Qing Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eva Greijer, Maria Wallsten, Lundahl, Qing Yang filed Critical Eva Greijer
Priority to SE9003706A priority Critical patent/SE9003706L/en
Publication of SE9003706D0 publication Critical patent/SE9003706D0/en
Priority to EP19910920486 priority patent/EP0559698A1/en
Priority to JP4500582A priority patent/JPH06505913A/en
Priority to PCT/SE1991/000788 priority patent/WO1992009267A1/en
Priority to AU89268/91A priority patent/AU8926891A/en
Publication of SE9003706L publication Critical patent/SE9003706L/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291—Gel sorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28047—Gels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

This invention relates to methods of immobilizing liposomes or proteoliposomes in cross-linked or non-cross-linked materials with a three-dimensional network, like gel beads or gel particles, or beads or particles of similar materials. The liposomes are trapped within the matrix or pores of the gel or material by formation of sufficiently large liposomes from a liposome suspension or an emulsion of lipids. The methods comprise preparing a suspension of liposomes and/or proteoliposomes, or an emulsion of lipids, or lipids and protein(s), and water in organic solvent; mixing the material with the suspension or the emulsion; increasing the average size of the liposomes and/or proteoliposomes which have entered the material, or effect uptake and association of emulsified lipids [and protein(s)] in the material by evaporating the organic solvent, whereby liposomes and/or proteoliposomes are formed; and removing non-immobilized liposomes and/or proteoliposomes. The used gel beads show an immobilization capacity corresponding to at least 20 mu mol of phospholipids per ml packed gel, or a total internal liposome volume of at least 50 mu mol per ml gel. The invention comprises gel beads or similar materials with immobilized liposomes, proteoliposomes and/or liposomes with included or inserted drugs, substances or macromolecules, and their use for chromatographic, medical, veterinary, biotechnological, synthetic, analytical and/or cosmetic purposes.
SE9003706A 1990-11-21 1990-11-21 METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS SE9003706L (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SE9003706A SE9003706L (en) 1990-11-21 1990-11-21 METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS
EP19910920486 EP0559698A1 (en) 1990-11-21 1991-11-20 Methods of immobilizing liposomes in gel beads and similar materials, gel beads and similar materials with immobilized liposomes prepared by such methods and uses thereof
JP4500582A JPH06505913A (en) 1990-11-21 1991-11-20 Methods of immobilizing liposomes in gel beads and similar materials, immobilized liposomes prepared by such methods, and uses thereof
PCT/SE1991/000788 WO1992009267A1 (en) 1990-11-21 1991-11-20 Methods of immobilizing liposomes in gel beads and similar materials, gel beads and similar materials with immobilized liposomes prepared by such methods and uses thereof
AU89268/91A AU8926891A (en) 1990-11-21 1991-11-20 Methods of immobilizing liposomes in gel beads and similar materials, gel beads and similar materials with immobilized liposomes prepared by such methods and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003706A SE9003706L (en) 1990-11-21 1990-11-21 METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS

Publications (2)

Publication Number Publication Date
SE9003706D0 SE9003706D0 (en) 1990-11-21
SE9003706L true SE9003706L (en) 1992-05-22

Family

ID=20380966

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003706A SE9003706L (en) 1990-11-21 1990-11-21 METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS

Country Status (5)

Country Link
EP (1) EP0559698A1 (en)
JP (1) JPH06505913A (en)
AU (1) AU8926891A (en)
SE (1) SE9003706L (en)
WO (1) WO1992009267A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1489167A4 (en) * 2002-03-01 2006-06-07 Nat Inst Of Advanced Ind Scien IMMOBILIZED CELLS AND LIPOSOMES AND METHOD OF IMMOBILIZATION THEREOF
DE102005037844A1 (en) * 2005-08-04 2007-04-05 Intendis Gmbh Anhydrous multi-phase gel system
AU2012261730B2 (en) * 2005-08-04 2014-05-08 Intendis Gmbh Anhydrous multiphase gel system
JP6522387B2 (en) * 2015-03-27 2019-05-29 株式会社キレートジャパン Hydrogel-containing cosmetic

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
JPS60231609A (en) * 1984-04-28 1985-11-18 Terumo Corp Liposome pharmaceutical
US4921757A (en) * 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
GB8522963D0 (en) * 1985-09-17 1985-10-23 Biocompatibles Ltd Microcapsules

Also Published As

Publication number Publication date
JPH06505913A (en) 1994-07-07
WO1992009267A1 (en) 1992-06-11
EP0559698A1 (en) 1993-09-15
SE9003706D0 (en) 1990-11-21
AU8926891A (en) 1992-06-25

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