SE8603099L - Distamycinderivat och forfarande for deras framstellning - Google Patents

Distamycinderivat och forfarande for deras framstellning

Info

Publication number: SE8603099L
Authority: SE; Sweden
Prior art keywords: image; alkyl; group; halogen; procedures
Prior art date: 1985-07-16

Application number

SE8603099A

Other languages

English (en)

Other versions

SE8603099D0 (sv

SE468594B (sv

Inventor

F Arcamone

N Mongelli

F Animati

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-16

Filing date

1986-07-11

Publication date

1987-01-17

1986-07-11 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1986-07-11 Publication of SE8603099D0 publication Critical patent/SE8603099D0/sv

1987-01-17 Publication of SE8603099L publication Critical patent/SE8603099L/sv

1993-02-15 Publication of SE468594B publication Critical patent/SE468594B/sv

Links

UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
229910052736 halogen Inorganic materials 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
125000004069 aziridinyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
-1 methyloxiranyl Chemical group 0.000 abstract 1
125000000466 oxiranyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

SE8603099A 1985-07-16 1986-07-11 Distamycinderivat, foerfarande foer deras framstaellning och en farmaceutisk komposition SE468594B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB858517923A GB8517923D0 (en)	1985-07-16	1985-07-16	Distamycin derivatives

Publications (3)

Publication Number	Publication Date
SE8603099D0 SE8603099D0 (sv)	1986-07-11
SE8603099L true SE8603099L (sv)	1987-01-17
SE468594B SE468594B (sv)	1993-02-15

Family

ID=10582358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8603099A SE468594B (sv)	1985-07-16	1986-07-11	Distamycinderivat, foerfarande foer deras framstaellning och en farmaceutisk komposition

Country Status (29)

Country	Link
US (1)	US4738980A (sv)
JP (1)	JPH0780842B2 (sv)
KR (1)	KR940003495B1 (sv)
CN (2)	CN85103908A (sv)
AT (1)	AT386822B (sv)
AU (1)	AU584723B2 (sv)
BE (1)	BE905109A (sv)
CA (1)	CA1247627A (sv)
CH (1)	CH671958A5 (sv)
CZ (1)	CZ277823B6 (sv)
DE (1)	DE3623853C2 (sv)
DK (1)	DK335886A (sv)
ES (1)	ES2000346A6 (sv)
FI (1)	FI82929C (sv)
FR (1)	FR2585019B1 (sv)
GB (2)	GB8517923D0 (sv)
GR (1)	GR861840B (sv)
HU (1)	HU198087B (sv)
IE (1)	IE59275B1 (sv)
IL (1)	IL79401A (sv)
IT (1)	IT1213103B (sv)
NL (1)	NL8601838A (sv)
NO (1)	NO169014C (sv)
NZ (1)	NZ216828A (sv)
PH (1)	PH23459A (sv)
PT (1)	PT82985B (sv)
SE (1)	SE468594B (sv)
SU (2)	SU1535378A3 (sv)
ZA (1)	ZA865262B (sv)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE468642B (sv) *	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
US5310752A (en) *	1986-05-20	1994-05-10	Farmitalia Carlo Erba Spa	Site specific alkylating agents
US5049579A (en) *	1986-05-20	1991-09-17	Farmitalia Carlo Erba, S.R.L.	Site specific alkylating agents
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
AU1224392A (en) *	1991-02-06	1992-09-07	Synphar Laboratories, Inc.	Oligopeptide antiretroviral agents
IT1262921B (it) *	1992-01-10	1996-07-22	Federico Arcamone	Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
DE4205948C2 (de) *	1992-02-24	1996-10-31	Mannesmann Ag	Farbbandkassette für ein endloses Farbband
US5273991A (en) *	1992-07-29	1993-12-28	Research Corporation Technologies, Inc.	Imidazole-containing compositions and methods of use thereof analogs of distamycin
US5637621A (en) *	1994-11-14	1997-06-10	Nzym, Inc.	Methods and compositions for treating Botrytis infections
AU4107796A (en) *	1994-11-14	1996-06-06	Nzym, Inc.	Methods and compositions for treating phytopathogenic fungi infections
US5629348A (en) *	1994-11-14	1997-05-13	Nzym, Inc.	Methods and compositions for treating septoria infections
DE19805431A1 (de) *	1998-02-11	1999-08-12	Merck Patent Gmbh	Heteroaromatische Oligoamide als Affinitätsliganden
US7078536B2 (en) *	2001-03-14	2006-07-18	Genesoft Pharmaceuticals, Inc.	Charged compounds comprising a nucleic acid binding moiety and uses therefor
US6555693B2 (en)	2000-03-16	2003-04-29	Genesoft, Inc.	Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
ITTO20010633A1 (it) *	2001-07-02	2003-01-02	Univ Ferrara	Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
US7498349B2 (en)	2002-08-02	2009-03-03	Genesoft Pharmaceuticals, Inc.	Biaryl compounds having anti-infective activity
US7265129B2 (en) *	2002-10-25	2007-09-04	Genesoft Pharmaceuticals, Inc.	Anti-infective biaryl compounds
US7129214B2 (en)	2002-12-10	2006-10-31	Oscient Pharmaceuticals Corporation	Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
US20070269420A1 (en) *	2003-11-24	2007-11-22	Chunduru Srinivas K	Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases
JP6682504B2 (ja) *	2015-03-30	2020-04-15	ＭｅｉｊｉＳｅｉｋａファルマ株式会社	エピルビシンの製造方法およびその新規な製造中間体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA557568A (en) *		1958-05-20	J. Weiss Martin	Substituted aminopyrrolecarboxylic acids and esters
CA547128A (en) *		1957-10-08	W. Waller Coy	Substituted pyrrolecarboxamidopyrroles
FR86210E (sv) *	1963-04-04	1966-03-23
FR90359E (sv) *	1963-07-26	1968-02-14
DE1795539A1 (de) *	1963-07-26	1972-01-13	Farmaceutici Italia	Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
BE666612A (sv) *	1963-07-26	1965-11-03
US3420844A (en) *	1963-07-26	1969-01-07	Farmaceutici Italia	Pyrrole-2-carboxamido-propionamidines
NL130086C (sv) *	1964-07-14	1970-06-15
SE468642B (sv) *	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents

1985
- 1985-06-08 CN CN198585103908A patent/CN85103908A/zh active Pending
- 1985-07-16 GB GB858517923A patent/GB8517923D0/en active Pending
- 1985-10-03 US US06/783,508 patent/US4738980A/en not_active Expired - Fee Related
1986
- 1986-07-11 SE SE8603099A patent/SE468594B/sv not_active IP Right Cessation
- 1986-07-11 AT AT0188786A patent/AT386822B/de not_active IP Right Cessation
- 1986-07-14 AU AU60203/86A patent/AU584723B2/en not_active Ceased
- 1986-07-14 IL IL79401A patent/IL79401A/xx not_active IP Right Cessation
- 1986-07-14 NL NL8601838A patent/NL8601838A/xx not_active Application Discontinuation
- 1986-07-14 HU HU862903A patent/HU198087B/hu not_active IP Right Cessation
- 1986-07-14 ES ES8600291A patent/ES2000346A6/es not_active Expired
- 1986-07-14 IE IE187486A patent/IE59275B1/en not_active IP Right Cessation
- 1986-07-14 NZ NZ216828A patent/NZ216828A/xx unknown
- 1986-07-15 IT IT8621124A patent/IT1213103B/it active
- 1986-07-15 DK DK335886A patent/DK335886A/da not_active Application Discontinuation
- 1986-07-15 CH CH2821/86A patent/CH671958A5/de not_active IP Right Cessation
- 1986-07-15 PT PT82985A patent/PT82985B/pt not_active IP Right Cessation
- 1986-07-15 GR GR861840A patent/GR861840B/el unknown
- 1986-07-15 JP JP61164878A patent/JPH0780842B2/ja not_active Expired - Lifetime
- 1986-07-15 SU SU864027842A patent/SU1535378A3/ru active
- 1986-07-15 PH PH34013A patent/PH23459A/en unknown
- 1986-07-15 ZA ZA865262A patent/ZA865262B/xx unknown
- 1986-07-15 DE DE3623853A patent/DE3623853C2/de not_active Expired - Fee Related
- 1986-07-15 NO NO862861A patent/NO169014C/no unknown
- 1986-07-15 KR KR1019860005716A patent/KR940003495B1/ko not_active Expired - Fee Related
- 1986-07-15 CA CA000513756A patent/CA1247627A/en not_active Expired
- 1986-07-15 FR FR868610295A patent/FR2585019B1/fr not_active Expired
- 1986-07-15 BE BE0/216923A patent/BE905109A/fr not_active IP Right Cessation
- 1986-07-16 CZ CS865411A patent/CZ277823B6/cs unknown
- 1986-07-16 GB GB8617293A patent/GB2178037B/en not_active Expired
- 1986-07-16 FI FI862960A patent/FI82929C/sv not_active IP Right Cessation
- 1986-07-16 CN CN86104774A patent/CN1026984C/zh not_active Expired - Fee Related
1987
- 1987-11-11 SU SU874203631A patent/SU1538893A3/ru active

Also Published As

Publication number	Publication date
ZA865262B (en)	1987-03-25
SE8603099D0 (sv)	1986-07-11
NO169014B (no)	1992-01-20
PH23459A (en)	1989-08-07
CN1026984C (zh)	1994-12-14
HU198087B (en)	1989-07-28
ES2000346A6 (es)	1988-02-16
US4738980A (en)	1988-04-19
DE3623853A1 (de)	1987-01-29
CH671958A5 (sv)	1989-10-13
PT82985B (pt)	1989-01-30
IL79401A0 (en)	1986-10-31
CN86104774A (zh)	1987-02-11
DK335886D0 (da)	1986-07-15
ATA188786A (de)	1988-03-15
GB2178037A (en)	1987-02-04
KR870001228A (ko)	1987-03-12
DK335886A (da)	1987-01-17
IT8621124A0 (it)	1986-07-15
IL79401A (en)	1991-05-12
GB2178037B (en)	1989-07-26
JPH0780842B2 (ja)	1995-08-30
KR940003495B1 (ko)	1994-04-23
FI82929C (sv)	1991-05-10
FR2585019B1 (fr)	1989-07-13
SU1535378A3 (ru)	1990-01-07
CN85103908A (zh)	1986-11-05
PT82985A (pt)	1986-08-01
GB8517923D0 (en)	1985-08-21
JPS6230755A (ja)	1987-02-09
IE861874L (en)	1987-01-16
CZ277823B6 (en)	1993-06-16
IE59275B1 (en)	1994-02-09
GB8617293D0 (en)	1986-08-20
SE468594B (sv)	1993-02-15
AU6020386A (en)	1987-01-22
NZ216828A (en)	1989-11-28
GR861840B (en)	1986-11-18
AT386822B (de)	1988-10-25
NO862861L (no)	1987-01-19
AU584723B2 (en)	1989-06-01
HUT41814A (en)	1987-05-28
SU1538893A3 (ru)	1990-01-23
CS541186A3 (en)	1992-09-16
NL8601838A (nl)	1987-02-16
FI82929B (fi)	1991-01-31
BE905109A (fr)	1987-01-15
NO169014C (no)	1992-04-29
DE3623853C2 (de)	1995-12-21
FI862960A0 (fi)	1986-07-16
IT1213103B (it)	1989-12-07
NO862861D0 (no)	1986-07-15
CA1247627A (en)	1988-12-28
FR2585019A1 (fr)	1987-01-23
FI862960L (fi)	1987-01-17

Publication	Publication Date	Title
SE8603099L (sv)	1987-01-17	Distamycinderivat och forfarande for deras framstellning
ATE24001T1 (de)	1986-12-15	Substituierte 1-hydroxyethyl-triazolyl-derivate.
ATE6507T1 (de)	1984-03-15	Piperidinderivate, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
FI915970A0 (fi)	1991-12-18	Laekemedel, som aer nyttiga vid vaord av cancer och som har antihistaminegenskaper.
ES8503667A1 (es)	1985-03-16	Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina.
SE8603098L (sv)	1987-01-17	Poly-4-aminopyrrol-2-karboxamidoderivat och forfarande for deras framstellning
PT81794B (pt)	1988-05-27	Processo de preparacao de novos derivados da pristinamicina iib e das suas composicoes farmaceuticas
NO890440L (no)	1990-01-15	Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
ES555006A0 (es)	1987-03-01	Procedimiento para preparar compuestos de 5-alaquil-1-fenil-2-piperazinoalquilpirazolin-3-ona.
ES508343A0 (es)	1982-11-01	"procedimiento para la preparacion de nuevas pirimido (5,4-d) pirimidinas trisustituidas".
SE7902302L (sv)	1979-09-16	Nya n-fenylalaninderivat, deras framstellning och deras anvendning som lekemedel
DK0379414T3 (da)	1994-02-14	Derivater af 1,8-benzonaphthyridin og fremstilling deraf
ES8201525A1 (es)	1981-12-16	Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina
DE69005318D1 (de)	1994-02-03	1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen.
ES8206550A1 (es)	1982-08-16	Un procedimiento para la preparacion de derivados de 2-desoxi-3-5-di-o-alquilcarbonil-5-fluorurina.
SE8701524L (sv)	1988-10-11	Nya sulfonamider och deras framstaellningsfoerfarande
SE8100122L (sv)	1981-07-15	Nya 2-aminometyl-6-halo-fenoler, framstellning derav och farmaceutiska kompositioner innehallande dessa
DK128892A (da)	1992-10-22	Benzyletherderivater

Legal Events

Date	Code	Title	Description
1995-01-31	NAL	Patent in force	Ref document number: 8603099-6 Format of ref document f/p: F
1999-03-29	NUG	Patent has lapsed	Ref document number: 8603099-6 Format of ref document f/p: F

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

Ref document number: 8603099-6

Format of ref document f/p: F

1999-03-29

NUG

Patent has lapsed