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SE8404768L - 9- (AMINOALKYL) -8-HYDROXIADENINES AND SETS FOR THEIR PREPARATION - Google Patents

9- (AMINOALKYL) -8-HYDROXIADENINES AND SETS FOR THEIR PREPARATION

Info

Publication number
SE8404768L
SE8404768L SE8404768A SE8404768A SE8404768L SE 8404768 L SE8404768 L SE 8404768L SE 8404768 A SE8404768 A SE 8404768A SE 8404768 A SE8404768 A SE 8404768A SE 8404768 L SE8404768 L SE 8404768L
Authority
SE
Sweden
Prior art keywords
preparation
aminoalkyl
compounds
hydrogen
hydroxiadenines
Prior art date
Application number
SE8404768A
Other languages
Swedish (sv)
Other versions
SE8404768D0 (en
Inventor
A Holy
I Votruba
I Rosenberg
A Merta
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CS703483A external-priority patent/CS248907B1/en
Priority claimed from CS703583A external-priority patent/CS248908B1/en
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Publication of SE8404768D0 publication Critical patent/SE8404768D0/en
Publication of SE8404768L publication Critical patent/SE8404768L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention relates to new compounds of general formula <IMG> (I) where R1 and R3 is hydrogen, alkyl, or the hydroxyalkyl group, R2 hydrogen or the hydroxy group, X is H or CO(CH2)6R4, n is 0 or 1, and R4 is the residue of a suitable support e.g. a macromolecular dextran gel. The present invention also provides a method of preparation of these compounds, i.e. of 9-(aminoalkyl)-8-hydroxy-adenines or derivatives thereof. The above compounds may serve as ligands for the preparation of modified polymerous dextran gels for affinity chromatography of S-adenosyl-L-homocysteine hydrolase.
SE8404768A 1983-09-27 1984-09-24 9- (AMINOALKYL) -8-HYDROXIADENINES AND SETS FOR THEIR PREPARATION SE8404768L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS703483A CS248907B1 (en) 1983-09-27 1983-09-27 97Aminoalkyl / 8-hydroxyadenines and processes for their preparation
CS703583A CS248908B1 (en) 1983-09-27 1983-09-27 Dextran Gel Affinity Carriers and Method for their Preparation

Publications (2)

Publication Number Publication Date
SE8404768D0 SE8404768D0 (en) 1984-09-24
SE8404768L true SE8404768L (en) 1985-03-28

Family

ID=25746420

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8404768A SE8404768L (en) 1983-09-27 1984-09-24 9- (AMINOALKYL) -8-HYDROXIADENINES AND SETS FOR THEIR PREPARATION

Country Status (3)

Country Link
CA (1) CA1220148A (en)
DE (1) DE3435491A1 (en)
SE (1) SE8404768L (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4667543B2 (en) * 1996-07-03 2011-04-13 大日本住友製薬株式会社 New purine derivatives
US7196093B2 (en) 2003-04-09 2007-03-27 General Atomics Reversible inhibitors of SAH hydrolase and uses thereof
US7517887B2 (en) * 2003-04-09 2009-04-14 General Atomics Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
US7868011B2 (en) 2003-04-09 2011-01-11 General Atomics Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
TWI392678B (en) 2004-03-26 2013-04-11 Dainippon Sumitomo Pharma Co 9-substituted-8-oxoadenine compound
JP2009542645A (en) 2006-07-05 2009-12-03 アストラゼネカ・アクチエボラーグ 8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
JP5480637B2 (en) 2007-03-19 2014-04-23 アストラゼネカ・アクチエボラーグ 9-Substituted-8-oxo-adenine compounds as TOLL-like receptor (TLR7) modulators
ATE530549T1 (en) 2007-03-19 2011-11-15 Astrazeneca Ab 9-SUBSTITUTED 8-OXOADENINE COMPOUNDS AS MODULATORS OF THE TOLL-LIKE RECEPTOR (TLR7)
US8044056B2 (en) 2007-03-20 2011-10-25 Dainippon Sumitomo Pharma Co., Ltd. Adenine compound
DK2155743T3 (en) 2007-05-08 2012-11-05 Astrazeneca Ab Imidazoquinolines with immunomodulatory properties
UY31531A1 (en) 2007-12-17 2009-08-03 SALTS DERIVED FROM 8-OXOADENINE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THERAPY AS TOLL TYPE RECEIVER MODULATORS (TLR)
WO2009091032A1 (en) 2008-01-17 2009-07-23 Dainippon Sumitomo Pharma Co., Ltd. Method for producing adenine compound
CN103370317B (en) 2010-12-16 2015-10-07 阿斯利康(瑞典)有限公司 Imidazo[4,5-c]quinolin-1-yl derivatives useful in therapy
JP5978226B2 (en) 2010-12-17 2016-08-24 大日本住友製薬株式会社 Purine derivatives

Also Published As

Publication number Publication date
DE3435491A1 (en) 1985-04-04
CA1220148A (en) 1987-04-07
SE8404768D0 (en) 1984-09-24

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Legal Events

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Effective date: 19881025