SE8204238L - Forfarande for framstellning av nya derivat av vinkristin och leurosidin - Google Patents
Forfarande for framstellning av nya derivat av vinkristin och leurosidinInfo
- Publication number
- SE8204238L SE8204238L SE8204238A SE8204238A SE8204238L SE 8204238 L SE8204238 L SE 8204238L SE 8204238 A SE8204238 A SE 8204238A SE 8204238 A SE8204238 A SE 8204238A SE 8204238 L SE8204238 L SE 8204238L
- Authority
- SE
- Sweden
- Prior art keywords
- denotes
- group
- leurosidine
- christine
- vine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 3
- JXLYSJRDGCGARV-PJXZDTQASA-N Leurosidine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-PJXZDTQASA-N 0.000 title 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 title 1
- JXLYSJRDGCGARV-KSNABSRWSA-N ac1l29ym Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-KSNABSRWSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 3
- UKTNDLHXQNQKBH-UHFFFAOYSA-N 2,3-dihydro-1h-indole;1h-indole Chemical compound C1=CC=C2NCCC2=C1.C1=CC=C2NC=CC2=C1 UKTNDLHXQNQKBH-UHFFFAOYSA-N 0.000 claims 1
- KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (1)
1. Patentkrav Ftrfarande for framstAllning av ett 4-desacetylderiva av diner indol-dihydroindol med den allmanna formeln: 5' R3 7:.21/Nit R4 I24C \\II°fl. ,72' I, 13 \3-6 vrC-0-CH3 0 234. R och R bar de oven anglvna betydelserna, hydrolyseras under aura eller basiska betingelser i en reaktionsblandning, varefter den bildade produkten utvinnes sAsom fri bas eller sAsom ett farmaceutiskt godtagbart salt darav. dgr R2 betecknar CH3 eller CHO, och dal"' en av symbolerna R3 och R4 betecknar H och den andra betecknar C2H, samt farmaceutiskt godtagbara salter ddrav,kAnnetecknat av att ett 4-acetoxiderivat av dimes- indol-dihydroindol med den allmanna formeln: 7'4 4 ir 2' 13c AJ\N/8' (V) 16,117, H3 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76059577A | 1977-01-19 | 1977-01-19 | |
| US05/853,979 US4143041A (en) | 1977-01-19 | 1977-11-25 | 4'-Deoxyvincristine and related compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8204238L true SE8204238L (sv) | 1982-07-08 |
| SE8204238D0 SE8204238D0 (sv) | 1982-07-08 |
| SE444684B SE444684B (sv) | 1986-04-28 |
Family
ID=27116837
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7800555A SE425852B (sv) | 1977-01-19 | 1978-01-17 | Analogiforfarande for framstellning av derivat av vinkristin och leurosidin |
| SE8204238A SE444684B (sv) | 1977-01-19 | 1982-07-08 | Forfarande for framstellning av 4-desacetylderivat av vinkristin och leurosidin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7800555A SE425852B (sv) | 1977-01-19 | 1978-01-17 | Analogiforfarande for framstellning av derivat av vinkristin och leurosidin |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5390299A (sv) |
| AR (1) | AR217459A1 (sv) |
| AT (1) | AT363620B (sv) |
| BG (2) | BG33158A3 (sv) |
| CA (2) | CA1088526A (sv) |
| CH (1) | CH635106A5 (sv) |
| CS (2) | CS194832B2 (sv) |
| DD (1) | DD134527A5 (sv) |
| DE (1) | DE2801748A1 (sv) |
| DK (1) | DK144420C (sv) |
| FR (1) | FR2378032A1 (sv) |
| GB (1) | GB1593231A (sv) |
| GR (1) | GR68940B (sv) |
| IE (1) | IE46308B1 (sv) |
| IL (1) | IL53813A (sv) |
| IT (1) | IT1174356B (sv) |
| MX (1) | MX5112E (sv) |
| NL (1) | NL7800667A (sv) |
| NZ (1) | NZ186232A (sv) |
| PL (1) | PL109695B1 (sv) |
| PT (1) | PT67535B (sv) |
| RO (2) | RO73126A (sv) |
| SE (2) | SE425852B (sv) |
| YU (1) | YU7278A (sv) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0649314U (ja) * | 1992-12-11 | 1994-07-05 | ヒノマル株式会社 | 食品包装容器 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2296418B1 (sv) * | 1974-12-30 | 1978-07-21 | Anvar | |
| IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
-
1978
- 1978-01-16 CS CS78292A patent/CS194832B2/cs unknown
- 1978-01-16 GB GB1692/78A patent/GB1593231A/en not_active Expired
- 1978-01-16 DE DE19782801748 patent/DE2801748A1/de not_active Withdrawn
- 1978-01-16 YU YU00072/78A patent/YU7278A/xx unknown
- 1978-01-16 BG BG038402A patent/BG33158A3/xx unknown
- 1978-01-16 GR GR55178A patent/GR68940B/el unknown
- 1978-01-16 BG BG040832A patent/BG33293A3/xx unknown
- 1978-01-16 IL IL53813A patent/IL53813A/xx unknown
- 1978-01-16 CS CS785375A patent/CS194850B2/cs unknown
- 1978-01-16 NZ NZ186232A patent/NZ186232A/xx unknown
- 1978-01-16 PT PT67535A patent/PT67535B/pt unknown
- 1978-01-17 AR AR270733A patent/AR217459A1/es active
- 1978-01-17 SE SE7800555A patent/SE425852B/sv not_active IP Right Cessation
- 1978-01-17 CA CA295,086A patent/CA1088526A/en not_active Expired
- 1978-01-17 DK DK22478A patent/DK144420C/da not_active IP Right Cessation
- 1978-01-17 FR FR7801262A patent/FR2378032A1/fr active Granted
- 1978-01-17 CA CA295,114A patent/CA1088527A/en not_active Expired
- 1978-01-18 CH CH53578A patent/CH635106A5/de not_active IP Right Cessation
- 1978-01-18 IE IE106/78A patent/IE46308B1/en unknown
- 1978-01-18 AT AT0035478A patent/AT363620B/de not_active IP Right Cessation
- 1978-01-18 IT IT19388/78A patent/IT1174356B/it active
- 1978-01-18 MX MX786780U patent/MX5112E/es unknown
- 1978-01-19 RO RO7892948A patent/RO73126A/ro unknown
- 1978-01-19 NL NL7800667A patent/NL7800667A/xx not_active Application Discontinuation
- 1978-01-19 DD DD78203301A patent/DD134527A5/xx unknown
- 1978-01-19 PL PL1978204091A patent/PL109695B1/pl unknown
- 1978-01-19 JP JP479378A patent/JPS5390299A/ja active Granted
- 1978-01-19 RO RO7899202A patent/RO78290A/ro unknown
-
1982
- 1982-07-08 SE SE8204238A patent/SE444684B/sv not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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