SE8103963L - 10-alkynyl-steroider - Google Patents

10-alkynyl-steroider

Info

Publication number: SE8103963L
Authority: SE; Sweden
Prior art keywords: alkyl; aromatase inhibitors; image; steroids; alkynyl
Prior art date: 1980-06-27

Application number

SE8103963A

Other languages

Unknown language ( )

English (en)

Other versions

SE452325B (sv

Inventor

Brian W Metcalf

J O Neal Johnston

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-27

Filing date

1981-06-24

Publication date

1981-12-28

1981-06-24 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1981-12-28 Publication of SE8103963L publication Critical patent/SE8103963L/sv

1987-11-23 Publication of SE452325B publication Critical patent/SE452325B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE8103963A 1980-06-27 1981-06-24 10-alkynyl-steroider samt forfarande for framstellning av dessa SE452325B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16345180A	1980-06-27	1980-06-27

Publications (2)

Publication Number	Publication Date
SE8103963L true SE8103963L (sv)	1981-12-28
SE452325B SE452325B (sv)	1987-11-23

Family

ID=22590066

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8103963A SE452325B (sv)	1980-06-27	1981-06-24	10-alkynyl-steroider samt forfarande for framstellning av dessa

Country Status (23)

Country	Link
US (1)	US4322416A (sv)
JP (1)	JPS5738797A (sv)
AT (1)	AT385510B (sv)
AU (1)	AU542273B2 (sv)
BE (1)	BE889401A (sv)
CA (1)	CA1173431A (sv)
CH (1)	CH646984A5 (sv)
DE (1)	DE3124780A1 (sv)
DK (2)	DK161151C (sv)
ES (1)	ES503345A0 (sv)
FR (1)	FR2485543A1 (sv)
GB (2)	GB2078749B (sv)
HK (1)	HK72686A (sv)
IE (1)	IE51351B1 (sv)
IL (1)	IL63143A (sv)
IT (1)	IT1171339B (sv)
MY (1)	MY8700055A (sv)
NL (1)	NL8103101A (sv)
NO (1)	NO156693C (sv)
NZ (1)	NZ197494A (sv)
PH (1)	PH16787A (sv)
SE (1)	SE452325B (sv)
ZA (1)	ZA814220B (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0100566B1 (en) *	1982-07-14	1986-02-19	Akzo N.V.	Novel 19-thio-androstane derivatives
EP0114033B1 (de) *	1982-12-21	1988-10-12	Ciba-Geigy Ag	Substituierte Azabicycloalkane, ihre Verwendung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verfahren zur Herstellung dieser Verbindungen
DE3323321A1 (de) *	1983-06-24	1985-01-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels
DE3338212C2 (de) *	1983-10-18	1995-05-18	Schering Ag	1-Methyl-androsta-1,4,6-trien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
US4634694A (en) *	1984-01-14	1987-01-06	Akzo N.V.	Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives
US4546098A (en) *	1984-04-13	1985-10-08	The Rockefeller University	Estrogen synthesis inhibitors
FR2569408B1 (fr) *	1984-08-24	1986-10-03	Roussel Uclaf	Nouveaux steroides substitues en position 10 par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
GB8531747D0 (en) *	1985-12-24	1986-02-05	Erba Farmitalia	10beta-alkynylestrene derivatives
FR2594830B1 (fr) *	1986-02-24	1988-06-03	Roussel Uclaf	Nouveaux 13 epi ou d-homo steroides substitues en position 10b par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
FR2594829B1 (fr) *	1986-02-24	1988-06-03	Roussel Uclaf	Nouveaux steroides 9 (11) satures substitues en position 10 par un radical comportant une triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
US4874891A (en) *	1986-05-01	1989-10-17	Washington University	Open "D" ring hormone analogs
US4910191A (en) *	1988-06-28	1990-03-20	Merrell Dow Pharmaceuticals Inc.	19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
US4882322A (en) *	1988-10-27	1989-11-21	Merrell Dow Pharmaceuticals Inc.	3β,17β-hydroxy-substituted steroids and related steroidal compounds
FR2640976B1 (sv) *	1988-12-22	1994-10-28	Roussel Uclaf
US5162337A (en) *	1990-10-05	1992-11-10	Merck & Co., Inc.	Animal growth promotion
US5126488A (en) *	1990-11-30	1992-06-30	Merrell Dow Pharmaceuticals Inc.	2β,19-methyleneamino bridged steroids as aromatase inhibitors
US5166201A (en) *	1990-11-30	1992-11-24	Merrell Dow Pharmaceuticals Inc.	2β,19-ethylene bridged steroids as aromatase inhibitors
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
FR2677027B1 (fr) *	1991-05-27	1993-09-10	Roussel Uclaf	Nouveaux produits sterouides substitues en position 6, et comportant, en position 10, un radical thioethyle, leur procede de preparation leurs intermediaires, leur application comme medicaments.
DE4435368A1 (de) *	1994-09-22	1996-03-28	Schering Ag	Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
US5866558A (en) *	1997-05-08	1999-02-02	Regents Of The University Of Minnesota	6-alkynyl steroids
EP1854465A1 (en) *	2006-05-12	2007-11-14	Alexander Tobias Teichmann	Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers
CA2794565C (en)	2010-04-08	2018-08-21	Emory University	Substituted androst-4-ene diones
EP3666276A1 (en)	2018-12-14	2020-06-17	dcic Biopharmaceutical Limited	Medication against estrogen-receptor beta (erbeta) positive breast tumor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3127427A (en) *	1962-07-17	1964-03-31	Hoffmann La Roche	10-alkenyl-steroids and process therefor
US3218316A (en) *	1963-08-26	1965-11-16	Syntex Corp	10beta-ethynyl-19-norandrostane derivatives

1981
- 1981-04-27 US US06/258,214 patent/US4322416A/en not_active Expired - Lifetime
- 1981-06-20 IL IL63143A patent/IL63143A/xx not_active IP Right Cessation
- 1981-06-22 DK DK274681A patent/DK161151C/da not_active IP Right Cessation
- 1981-06-22 CH CH411981A patent/CH646984A5/de not_active IP Right Cessation
- 1981-06-22 PH PH25798A patent/PH16787A/en unknown
- 1981-06-22 CA CA000380295A patent/CA1173431A/en not_active Expired
- 1981-06-22 ZA ZA814220A patent/ZA814220B/xx unknown
- 1981-06-22 NZ NZ197494A patent/NZ197494A/en unknown
- 1981-06-24 SE SE8103963A patent/SE452325B/sv not_active IP Right Cessation
- 1981-06-24 DE DE19813124780 patent/DE3124780A1/de active Granted
- 1981-06-25 ES ES503345A patent/ES503345A0/es active Granted
- 1981-06-26 BE BE0/205229A patent/BE889401A/fr not_active IP Right Cessation
- 1981-06-26 NO NO812197A patent/NO156693C/no not_active IP Right Cessation
- 1981-06-26 IT IT8148780A patent/IT1171339B/it active
- 1981-06-26 FR FR8112642A patent/FR2485543A1/fr active Granted
- 1981-06-26 GB GB8119813A patent/GB2078749B/en not_active Expired
- 1981-06-26 IE IE1434/81A patent/IE51351B1/en not_active IP Right Cessation
- 1981-06-26 NL NL8103101A patent/NL8103101A/nl not_active IP Right Cessation
- 1981-06-26 JP JP9849481A patent/JPS5738797A/ja active Granted
- 1981-06-26 AT AT0285781A patent/AT385510B/de not_active IP Right Cessation
- 1981-06-30 AU AU72370/81A patent/AU542273B2/en not_active Ceased
1983
- 1983-06-20 GB GB08316702A patent/GB2135314B/en not_active Expired
1986
- 1986-09-25 HK HK726/86A patent/HK72686A/xx not_active IP Right Cessation
1987
- 1987-12-30 MY MY55/87A patent/MY8700055A/xx unknown
1990
- 1990-03-22 DK DK075190A patent/DK162447C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO812197L (no)	1981-12-28
HK72686A (en)	1986-10-03
DE3124780C2 (sv)	1992-04-23
DK162447B (da)	1991-10-28
GB8316702D0 (en)	1983-07-20
US4322416A (en)	1982-03-30
FR2485543B1 (sv)	1983-12-23
BE889401A (fr)	1981-12-28
IT8148780A0 (it)	1981-06-26
DK161151B (da)	1991-06-03
JPS5738797A (en)	1982-03-03
IT8148780A1 (it)	1982-12-26
ES8302025A1 (es)	1983-01-01
CA1173431A (en)	1984-08-28
DE3124780A1 (de)	1982-06-03
IE811434L (en)	1981-12-27
NO156693C (no)	1987-11-04
ZA814220B (en)	1982-07-28
GB2078749A (en)	1982-01-13
NL8103101A (nl)	1982-01-18
DK161151C (da)	1991-11-18
AT385510B (de)	1988-04-11
AU542273B2 (en)	1985-02-14
NL192455B (sv)	1997-04-01
IL63143A0 (en)	1981-09-13
AU7237081A (en)	1982-01-07
NO156693B (no)	1987-07-27
MY8700055A (en)	1987-12-31
ATA285781A (de)	1987-09-15
ES503345A0 (es)	1983-01-01
IE51351B1 (en)	1986-12-10
CH646984A5 (de)	1984-12-28
NZ197494A (en)	1984-11-09
DK274681A (da)	1981-12-28
FR2485543A1 (fr)	1981-12-31
DK162447C (da)	1992-03-23
JPH021159B2 (sv)	1990-01-10
IT1171339B (it)	1987-06-10
NL192455C (sv)	1997-08-04
DK75190D0 (da)	1990-03-22
GB2078749B (en)	1983-11-16
SE452325B (sv)	1987-11-23
PH16787A (en)	1984-02-22
GB2135314B (en)	1985-04-17
IL63143A (en)	1984-10-31
GB2135314A (en)	1984-08-30
DK75190A (da)	1990-03-22

Publication	Publication Date	Title
SE8103963L (sv)	1981-12-28	10-alkynyl-steroider
NO905546D0 (no)	1990-12-21	11-beta-substituerte progesteronanaloger.
SE7908727L (sv)	1980-06-12	Fosfinylalkanoylproliner
FI823923A0 (fi)	1982-11-16	Antifibrinolytiskt aktiva foereningar
ES527954A1 (es)	1985-11-01	Un procedimiento para preparar isoxazoles
AU567338B2 (en)	1987-11-19	Aziridino substituted nitro-imidazoles
SE8103988L (sv)	1981-12-28	10-(1,2-propadienyl)steroider och kompositioner innehallande desamma, med terapeutisk anvendning
DK429089D0 (da)	1989-08-30	Alkylbenzylaminer
SE7910072L (sv)	1980-06-08	Pyrrolo- eller pyrido(2,1-c)(1,4)tiaziner eller -tiazepiner
GB1531946A (en)	1978-11-15	Cyclopentane derivatives useful as perfuming agents
DE3162656D1 (en)	1984-04-19	Cyclohexane-1,3-dione derivatives
ES479444A1 (es)	1979-11-16	Un procedimiento para preparar derivados de pirrolidincarbo-xaldehido y piperidicarboxaldehido.
ES2066756T3 (es)	1995-03-16	Nuevos derivados de tironina.
ATE18044T1 (de)	1986-03-15	Substituierte thiazolidinylester von mineralsaeuren.
YU7389A (en)	1990-12-31	Process for obtaining reagents for hydroxyalkylizing, this way obtained new reagents and their use
ATE26268T1 (de)	1987-04-15	2-alkoxyaminosulfonylbenzolsulfonyl-harnstoffderivate.
IE791781L (en)	1980-03-21	4, 5-methano-bufadienolide rhamnosides
SE8103598L (sv)	1981-12-10	Antiinflammatoriska medel for yttre anvendning
DE3461079D1 (en)	1986-12-04	Unsaturated compounds, their preparation and use
ES2016931B3 (es)	1990-12-16	Procedimiento de preparación de nuevas amidas alifáticas y cicloalifáticas de piridilalquilaminas o de sus derivados N-óxidos.
FI820201L (fi)	1982-07-25	Foerfarande foer framstaellning av nya n-substituerade polyglycidyl-urazolfoereningar
FR2363629A1 (fr)	1978-03-31	Activateurs pour percomposes
ZA868089B (en)	1987-06-24	Bisthiolphosphate,their manufacture,their use for combatting pests,and agents therefor
ATE36536T1 (de)	1988-09-15	Phosphoroimidate.
ES8407044A1 (es)	1984-09-01	"un procedimiento para preparar nuevos compuestos de urea"

Legal Events

Date	Code	Title	Description
1995-01-31	NAL	Patent in force	Ref document number: 8103963-8 Format of ref document f/p: F
2001-02-19	NUG	Patent has lapsed	Ref document number: 8103963-8 Format of ref document f/p: F

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

Ref document number: 8103963-8

Format of ref document f/p: F

2001-02-19

NUG

Patent has lapsed