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SE8100339L - BETA-LACTAMAS INHIBITOR - Google Patents

BETA-LACTAMAS INHIBITOR

Info

Publication number
SE8100339L
SE8100339L SE8100339A SE8100339A SE8100339L SE 8100339 L SE8100339 L SE 8100339L SE 8100339 A SE8100339 A SE 8100339A SE 8100339 A SE8100339 A SE 8100339A SE 8100339 L SE8100339 L SE 8100339L
Authority
SE
Sweden
Prior art keywords
lactamas
beta
inhibitor
esters
sulfone
Prior art date
Application number
SE8100339A
Other languages
Swedish (sv)
Other versions
SE455702B (en
Inventor
W J Gottstein
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/214,833 external-priority patent/US4340539A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8100339L publication Critical patent/SE8100339L/en
Publication of SE455702B publication Critical patent/SE455702B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

2???-Chloromethyl-2???- methylpenam-3???-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of ???-lactamases. The invention also includes a number of intermediate 6???-bromo analogues of esters of the aforementioned acid and of the sulfoxide and sulfone thereof.
SE8100339A 1980-01-21 1981-01-21 2 BETA-CHLOROMETHYL-2ALFA-METHYLPENAM-3ALFA-CARBOXYLIC ACID SULPHONES ITS SALTS AND PHYSIOLOGY HYDRAULIC ESTABLES WITH BETALACTAMASHIN INHIBITIVE EFFECTS, PREPARATION FOR PREPARING THEREOF SE455702B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11389480A 1980-01-21 1980-01-21
US21483180A 1980-12-11 1980-12-11
US06/214,833 US4340539A (en) 1980-01-21 1980-12-11 Derivatives of 6-bromo penicillanic acid

Publications (2)

Publication Number Publication Date
SE8100339L true SE8100339L (en) 1981-09-01
SE455702B SE455702B (en) 1988-08-01

Family

ID=27381401

Family Applications (5)

Application Number Title Priority Date Filing Date
SE8100339A SE455702B (en) 1980-01-21 1981-01-21 2 BETA-CHLOROMETHYL-2ALFA-METHYLPENAM-3ALFA-CARBOXYLIC ACID SULPHONES ITS SALTS AND PHYSIOLOGY HYDRAULIC ESTABLES WITH BETALACTAMASHIN INHIBITIVE EFFECTS, PREPARATION FOR PREPARING THEREOF
SE8502285A SE8502285L (en) 1980-01-21 1985-05-08 ANTIBACTERIAL COMPOSITION
SE8502286A SE466203B (en) 1980-01-21 1985-05-08 ESTRARS FOR PREPARING A BETA-LACTAMAS INHIBITOR
SE9000190A SE9000190L (en) 1980-01-21 1990-01-19 ESTER FOR PREPARATION OF A BETA LACTAMA INHIBITOR
SE9000189A SE9000189L (en) 1980-01-21 1990-01-19 ESTRARS FOR PREPARING A BETA LACTAMA INHIBITOR

Family Applications After (4)

Application Number Title Priority Date Filing Date
SE8502285A SE8502285L (en) 1980-01-21 1985-05-08 ANTIBACTERIAL COMPOSITION
SE8502286A SE466203B (en) 1980-01-21 1985-05-08 ESTRARS FOR PREPARING A BETA-LACTAMAS INHIBITOR
SE9000190A SE9000190L (en) 1980-01-21 1990-01-19 ESTER FOR PREPARATION OF A BETA LACTAMA INHIBITOR
SE9000189A SE9000189L (en) 1980-01-21 1990-01-19 ESTRARS FOR PREPARING A BETA LACTAMA INHIBITOR

Country Status (12)

Country Link
KR (1) KR850001066B1 (en)
CA (1) CA1175807A (en)
CH (2) CH651571A5 (en)
DE (1) DE3101527A1 (en)
DK (3) DK162717C (en)
GB (1) GB2070592B (en)
HU (2) HU188606B (en)
IL (1) IL61880A (en)
NL (1) NL8100209A (en)
NO (5) NO160298C (en)
OA (1) OA06748A (en)
SE (5) SE455702B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
EP0134302B1 (en) * 1983-09-15 1987-06-16 Bristol-Myers Company Pharmaceutical compositions for treating resistant bacteria including anaerobes
GB2157286B (en) * 1984-04-12 1987-12-31 Leo Pharm Prod Ltd B-lactam antibiotic potentiators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN149747B (en) * 1977-06-07 1982-04-03 Pfizer
DE2912511C2 (en) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmaceutical composition containing penicillanic acid
IE49880B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
KR850001465A (en) 1985-03-18
OA06748A (en) 1982-06-30
DK162769B (en) 1991-12-09
SE455702B (en) 1988-08-01
DK285790D0 (en) 1990-11-30
HU184380B (en) 1984-08-28
SE8502286D0 (en) 1985-05-08
SE9000189D0 (en) 1990-01-19
SE8502285D0 (en) 1985-05-08
NO861945L (en) 1981-07-22
HU188606B (en) 1986-04-28
DK162717C (en) 1992-04-21
DK285890D0 (en) 1990-11-30
KR850001066B1 (en) 1985-07-25
SE9000190D0 (en) 1990-01-19
NO161677C (en) 1989-09-13
GB2070592B (en) 1983-05-11
CA1175807A (en) 1984-10-09
NO160298B (en) 1988-12-27
NO164300C (en) 1990-09-19
NO164299C (en) 1990-09-19
DK285890A (en) 1990-11-30
NO861946L (en) 1981-07-22
DK164938B (en) 1992-09-14
NO810166L (en) 1981-07-22
DE3101527A1 (en) 1982-02-18
SE9000190L (en) 1991-07-20
DK162717B (en) 1991-12-02
GB2070592A (en) 1981-09-09
NO853450L (en) 1981-07-22
IL61880A (en) 1984-11-30
DK21881A (en) 1981-07-22
SE466203B (en) 1992-01-13
CH649087A5 (en) 1985-04-30
NO164298B (en) 1990-06-11
DK285790A (en) 1990-11-30
NO161677B (en) 1989-06-05
NO861944L (en) 1981-07-22
NO164299B (en) 1990-06-11
DK162769C (en) 1992-04-27
DK164938C (en) 1993-02-01
SE9000189L (en) 1991-07-20
NO164298C (en) 1990-09-19
CH651571A5 (en) 1985-09-30
NO164300B (en) 1990-06-11
SE8502286L (en) 1985-05-08
SE8502285L (en) 1985-05-08
NL8100209A (en) 1981-08-17
NO160298C (en) 1989-04-05

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