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SE8008935L - PROCEDURE FOR THE PREPARATION OF 4-SUBSTITUTED IMIDAZOLE COMPOUNDS - Google Patents

PROCEDURE FOR THE PREPARATION OF 4-SUBSTITUTED IMIDAZOLE COMPOUNDS

Info

Publication number
SE8008935L
SE8008935L SE8008935A SE8008935A SE8008935L SE 8008935 L SE8008935 L SE 8008935L SE 8008935 A SE8008935 A SE 8008935A SE 8008935 A SE8008935 A SE 8008935A SE 8008935 L SE8008935 L SE 8008935L
Authority
SE
Sweden
Prior art keywords
compound
imidazole compounds
procedure
preparation
substituted imidazole
Prior art date
Application number
SE8008935A
Other languages
Swedish (sv)
Other versions
SE452887B (en
Inventor
J J Lewis
R L Webb
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/771,044 external-priority patent/US4119781A/en
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of SE8008935L publication Critical patent/SE8008935L/en
Publication of SE452887B publication Critical patent/SE452887B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The imidazole compounds of the general formula II represent valuable intermediates for preparing pharmacologically active compounds. They are obtained by reacting a compound of the formula I in an organic solvent under basic conditions with a compound of formula R<2>-H. The symbols used in the general formulae I and II are defined in Claim 1.

Claims (3)

PATENMKRPV .4. F6rening enligt krav 1, kiinnetebknad an alt ndmnda fdrening dr j5-metylimidazoly1)-4-metyl7trifenylfosfoniMmklomid.. 5. Fdrening enlist krav 1, k4nnetecknad an all ndmnda f6rening in /T5-memylimid300ly1)-4-metyl7trifenylfosfoniumbromid. van: . . 1113 4r vdte alien ldgre alkyl; R- in v4te,- 14gre alkyl, trifluoretyl bensyl, aminoe 11er cur R4 Ur fen g -3! , bensyl eller kloensyl; ' cur1 rbPATENMKRPV .4. A compound according to claim 1, wherein said compound (5-methylimidazolyl-4-methyl7-triphenylphosphonium chloride) has a compound. of:. . 1113 4r vdte alien lower alkyl; R- in v4te, - 14gre alkyl, trifluoroethyl benzyl, aminoe 11er cur R4 Ur fen g -3! , benzyl or clenzyl; 'cur1 rb R- in ldgre alkyl eller' fenyl; och X in halogen.R- is lower alkyl or phenyl; and X in halogen. 2. Forening pnligt krav I, k4nnetemknad av att R1'Mr metyl.A compound according to claim 1, characterized in that R1 'is methyl. 3. Forening enligt krav 2; kUnnetecknad aV alt R5 dr fenyl..A compound according to claim 2; kUnnetecknad avV R5 dr phenyl ..
SE8008935A 1977-02-22 1980-12-18 PHOSPHONIUM METHYLIMIDAZOLE SUBSTANCE USED AS INTERMEDIATE IN THE PREPARATION OF CERTAIN PHARMACOLOGICALLY ACTIVE GUANIDINE AND TIOCHARBAMIDE COMPOUNDS SE452887B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/771,044 US4119781A (en) 1975-10-29 1977-02-22 Process for preparing 4-substituted imidazole compounds

Publications (2)

Publication Number Publication Date
SE8008935L true SE8008935L (en) 1980-12-18
SE452887B SE452887B (en) 1987-12-21

Family

ID=25090518

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7704870A SE442199B (en) 1977-02-22 1977-04-27 PROCEDURE FOR PREPARING 4-SUBSTITUTED IMIDAZOLD DERIVATIVES
SE8008935A SE452887B (en) 1977-02-22 1980-12-18 PHOSPHONIUM METHYLIMIDAZOLE SUBSTANCE USED AS INTERMEDIATE IN THE PREPARATION OF CERTAIN PHARMACOLOGICALLY ACTIVE GUANIDINE AND TIOCHARBAMIDE COMPOUNDS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7704870A SE442199B (en) 1977-02-22 1977-04-27 PROCEDURE FOR PREPARING 4-SUBSTITUTED IMIDAZOLD DERIVATIVES

Country Status (22)

Country Link
AR (1) AR217073A1 (en)
AT (1) AT355015B (en)
BE (1) BE853954R (en)
CA (1) CA1084052A (en)
CH (2) CH631167A5 (en)
DE (1) DE2718715A1 (en)
DK (1) DK168277A (en)
ES (1) ES458153A1 (en)
FI (1) FI73208C (en)
FR (1) FR2381031A2 (en)
GB (1) GB1582865A (en)
HU (1) HU174840B (en)
IE (1) IE45035B1 (en)
IL (1) IL51898A (en)
IN (1) IN148285B (en)
IT (1) IT1078449B (en)
LU (1) LU77200A1 (en)
MX (1) MX4663E (en)
NL (1) NL7704617A (en)
NO (1) NO152903C (en)
PT (1) PT66446B (en)
SE (2) SE442199B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4158013A (en) 1977-06-03 1979-06-12 Bristol-Myers Company N-Cyano-N'-alkynyl-N"-2-mercaptoethylguanidines
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
SE452887B (en) 1987-12-21
DK168277A (en) 1978-08-23
FI73208C (en) 1987-09-10
ES458153A1 (en) 1978-04-01
NO152903C (en) 1985-12-11
FR2381031B2 (en) 1982-09-17
FI771291A7 (en) 1978-08-23
HU174840B (en) 1980-03-28
DE2718715A1 (en) 1978-08-31
MX4663E (en) 1982-07-21
IE45035B1 (en) 1982-06-02
IL51898A (en) 1980-07-31
IN148285B (en) 1981-01-03
NO152903B (en) 1985-09-02
CA1084052A (en) 1980-08-19
ATA289577A (en) 1979-07-15
NO771453L (en) 1978-08-23
AT355015B (en) 1980-02-11
NL7704617A (en) 1978-08-24
FR2381031A2 (en) 1978-09-15
SE7704870L (en) 1978-08-23
BE853954R (en) 1977-10-26
IL51898A0 (en) 1977-06-30
CH631168A5 (en) 1982-07-30
IT1078449B (en) 1985-05-08
GB1582865A (en) 1981-01-14
PT66446B (en) 1978-09-22
SE442199B (en) 1985-12-09
PT66446A (en) 1977-05-01
AR217073A1 (en) 1980-02-29
IE45035L (en) 1978-08-22
LU77200A1 (en) 1977-08-17
FI73208B (en) 1987-05-29
CH631167A5 (en) 1982-07-30

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