SE8007141L - PROCEDURE FOR PREPARING PENICILLANIC ACID DERIVATIVES - Google Patents
PROCEDURE FOR PREPARING PENICILLANIC ACID DERIVATIVESInfo
- Publication number
- SE8007141L SE8007141L SE8007141A SE8007141A SE8007141L SE 8007141 L SE8007141 L SE 8007141L SE 8007141 A SE8007141 A SE 8007141A SE 8007141 A SE8007141 A SE 8007141A SE 8007141 L SE8007141 L SE 8007141L
- Authority
- SE
- Sweden
- Prior art keywords
- carboxy group
- acid derivatives
- penicillanic acid
- procedure
- antibiotics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the formula I <IMAGE> in which R1 stands for hydrogen, alkyl, alkoxy, halogen, or trifluoromethyl, and R2 stands for a carboxy group or for a protected carboxy group, in particular an esterified carboxy group; or, if appropriate, a salt thereof, are obtained by oxidising the corresponding penicillanic acid derivatives or their sulfoxides with hydrogen peroxide in the presence of a tungsten or molybdenum catalyst. This process eliminates secondary degradative oxidative side reactions and simplifies the isolation and purification of the product, thus providing high yields and thereby being particularly suited for large scale production. The compounds of formula I, depending upon the meanings of R1 and R2, are of value as beta -lactamase inhibitors and/or antibiotics, and/or as intermediates in the production of antibiotics and/or beta -lactamase inhibitors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7935284 | 1979-10-11 | ||
| GB7942062 | 1979-12-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8007141L true SE8007141L (en) | 1981-04-12 |
| SE449613B SE449613B (en) | 1987-05-11 |
Family
ID=26273161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8007141A SE449613B (en) | 1979-10-11 | 1980-10-10 | PROCEDURE FOR PREPARING 1,1-DIOXOPENICILLANIC ACID DERIVATIVES |
Country Status (11)
| Country | Link |
|---|---|
| CA (1) | CA1142174A (en) |
| CH (1) | CH646174A5 (en) |
| DE (1) | DE3037896A1 (en) |
| DK (1) | DK154085C (en) |
| FR (1) | FR2467210A1 (en) |
| GB (1) | GB2059960B (en) |
| IE (1) | IE50650B1 (en) |
| IT (1) | IT1132938B (en) |
| LU (1) | LU82842A1 (en) |
| NL (1) | NL8005626A (en) |
| SE (1) | SE449613B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331599A (en) * | 1981-02-02 | 1982-05-25 | Pfizer Inc. | Sparingly water-soluble salts of penicillanic acid 1,1-dioxide |
| US4381263A (en) * | 1981-03-23 | 1983-04-26 | Pfizer Inc. | Process for the preparation of penicillanic acid esters |
| IN159362B (en) * | 1981-03-23 | 1987-05-09 | Pfizer | |
| US4502988A (en) * | 1983-08-08 | 1985-03-05 | Eli Lilly And Company | Oxidation process |
| GB2206579B (en) * | 1987-07-10 | 1991-05-29 | Erba Farmitalia | 6a and 6b-(substituted methyl)-penicillanic acid derivatives |
| CN102977120B (en) * | 2012-12-14 | 2015-05-27 | 江西富祥药业股份有限公司 | Method for preparing and crystallizing sulbactam pivoxyl |
-
1980
- 1980-09-22 IE IE1963/80A patent/IE50650B1/en unknown
- 1980-09-23 GB GB8030709A patent/GB2059960B/en not_active Expired
- 1980-10-07 DE DE19803037896 patent/DE3037896A1/en not_active Withdrawn
- 1980-10-08 DK DK424080A patent/DK154085C/en active
- 1980-10-09 CA CA000362093A patent/CA1142174A/en not_active Expired
- 1980-10-09 IT IT25223/80A patent/IT1132938B/en active
- 1980-10-10 FR FR8021730A patent/FR2467210A1/en active Granted
- 1980-10-10 LU LU82842A patent/LU82842A1/en unknown
- 1980-10-10 NL NL8005626A patent/NL8005626A/en not_active Application Discontinuation
- 1980-10-10 CH CH760280A patent/CH646174A5/en not_active IP Right Cessation
- 1980-10-10 SE SE8007141A patent/SE449613B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT8025223A0 (en) | 1980-10-09 |
| DK154085C (en) | 1989-02-27 |
| IT1132938B (en) | 1986-07-09 |
| DE3037896A1 (en) | 1981-04-23 |
| IE801963L (en) | 1981-04-11 |
| GB2059960B (en) | 1983-10-19 |
| LU82842A1 (en) | 1981-06-04 |
| NL8005626A (en) | 1981-04-14 |
| DK424080A (en) | 1981-04-12 |
| FR2467210B1 (en) | 1983-08-19 |
| IE50650B1 (en) | 1986-06-11 |
| DK154085B (en) | 1988-10-10 |
| CA1142174A (en) | 1983-03-01 |
| SE449613B (en) | 1987-05-11 |
| CH646174A5 (en) | 1984-11-15 |
| GB2059960A (en) | 1981-04-29 |
| FR2467210A1 (en) | 1981-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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