SE8001008L - ANTIATEROGENA 6-HALOGEN FUROCROMONES - Google Patents
ANTIATEROGENA 6-HALOGEN FUROCROMONESInfo
- Publication number
- SE8001008L SE8001008L SE8001008A SE8001008A SE8001008L SE 8001008 L SE8001008 L SE 8001008L SE 8001008 A SE8001008 A SE 8001008A SE 8001008 A SE8001008 A SE 8001008A SE 8001008 L SE8001008 L SE 8001008L
- Authority
- SE
- Sweden
- Prior art keywords
- methyl
- alkyl
- hydrogen
- alkylthio
- alkoxy
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 2
- -1 phenylthiomethyl Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 abstract 1
- 101000585507 Solanum tuberosum Cytochrome b-c1 complex subunit 7 Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A furochromone of the formula <IMAGE> wherein A is -CH=CR13-, -CX=CR14, -C[CH2S(O)nR10]=-C(CH3)-, -CH2-CHR14- or -CHR17-, in which n is zero, one or 2; R10 is C1-5 alkyl; R13 is isopropyl, C4-8 alkyl, (C1-7 alkoxy)methyl, (C1-7 alkylthio)methyl, trifluoromethyl, optionally substituted phenoxymethyl or phenylthiomethyl in which any substituents are selected from chlorine, fluorine, trifluoromethyl, C1-3 alkyl and C1-3 alkoxy, C3-10 cycloalkyl, (C1-5 alkylthio)methyl, (C1-5 alkylsulfinyl)methyl, (C1-5 alkylsulfonyl)methyl or -CH2NR8R9 in which either R8 and R9 are the same or different and are each hydrogen, C1-12 alkyl or C6-12 aryl or NR8R9 is an optionally substituted saturated or unsaturated C2-7 heterocyclic ring with up to 2 additional heteroatoms selected from oxygen, nitrogen and sulfur, and from 4 to 8 atoms in the ring, any substituents being selected from C1-4 alkyl, (C1-7 alkoxy)methyl, (C1-7 alkylthio)methyl, C1-4 hydroxyalkyl and phenyl; R14 is hydrogen, C1-8 alkyl, (C1-7 alkoxy)methyl, (C1-7 alkylthio)methyl, trifluoromethyl, optionally substituted phenoxymethyl or phenylthiomethyl as defined above or C3-10 cycloalkyl; R17 is hydrogen or C1-8 alkyl; and X is chlorine, bromine or iodine; one of R3 and R4 is methoxy and the other is hydrogen or methoxy, provided that R13 is not -CH2NR8R9 when R4 is hydrogen; and one of R20 and R21 is hydrogen and the other is hydroxy when A is -CH2-CHR14- or R20 and R21 together are oxo when A is not -CH2-CHR14-; or a pharmacologically acceptable salt thereof when R13 is -CH2NR8R9.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1181679A | 1979-02-13 | 1979-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8001008L true SE8001008L (en) | 1980-08-14 |
Family
ID=21752090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8001008A SE8001008L (en) | 1979-02-13 | 1980-02-08 | ANTIATEROGENA 6-HALOGEN FUROCROMONES |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS55111487A (en) |
| AU (1) | AU529561B2 (en) |
| BE (1) | BE881707A (en) |
| CH (1) | CH645376A5 (en) |
| DE (1) | DE3004756A1 (en) |
| FR (1) | FR2449091A1 (en) |
| GB (1) | GB2043059B (en) |
| IT (1) | IT1165553B (en) |
| NL (1) | NL8000861A (en) |
| SE (1) | SE8001008L (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5855419A (en) * | 1981-09-28 | 1983-04-01 | Tsumura Juntendo Inc | Hypotensor |
| DE68919475T2 (en) * | 1988-08-16 | 1995-05-11 | Upjohn Co | BIVALENT LIGANDS, EFFECTIVE TO BLOCK THE ACAT ENZYME. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1197454B (en) * | 1958-09-11 | 1965-07-29 | Thiemann Chem Pharm Fab | Process for the preparation of a readily water-soluble kellin derivative |
-
1980
- 1980-01-23 AU AU54865/80A patent/AU529561B2/en not_active Ceased
- 1980-02-01 GB GB8003416A patent/GB2043059B/en not_active Expired
- 1980-02-04 IT IT47792/80A patent/IT1165553B/en active
- 1980-02-08 SE SE8001008A patent/SE8001008L/en not_active Application Discontinuation
- 1980-02-08 DE DE19803004756 patent/DE3004756A1/en not_active Withdrawn
- 1980-02-12 NL NL8000861A patent/NL8000861A/en not_active Application Discontinuation
- 1980-02-12 FR FR8003032A patent/FR2449091A1/en active Granted
- 1980-02-13 JP JP1649380A patent/JPS55111487A/en active Pending
- 1980-02-13 BE BE0/199389A patent/BE881707A/en not_active IP Right Cessation
- 1980-02-13 CH CH118180A patent/CH645376A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL8000861A (en) | 1980-08-15 |
| JPS55111487A (en) | 1980-08-28 |
| FR2449091B1 (en) | 1983-07-29 |
| BE881707A (en) | 1980-08-13 |
| DE3004756A1 (en) | 1980-08-21 |
| AU5486580A (en) | 1980-08-21 |
| AU529561B2 (en) | 1983-06-09 |
| FR2449091A1 (en) | 1980-09-12 |
| GB2043059A (en) | 1980-10-01 |
| IT1165553B (en) | 1987-04-22 |
| CH645376A5 (en) | 1984-09-28 |
| IT8047792A0 (en) | 1980-02-04 |
| GB2043059B (en) | 1983-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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