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SE8000962L - NEW ASSOCIATIONS AND PROCEDURES FOR THEIR PREPARATION - Google Patents

NEW ASSOCIATIONS AND PROCEDURES FOR THEIR PREPARATION

Info

Publication number
SE8000962L
SE8000962L SE8000962A SE8000962A SE8000962L SE 8000962 L SE8000962 L SE 8000962L SE 8000962 A SE8000962 A SE 8000962A SE 8000962 A SE8000962 A SE 8000962A SE 8000962 L SE8000962 L SE 8000962L
Authority
SE
Sweden
Prior art keywords
cycloalkyl
hydrogen
procedures
preparation
methyl
Prior art date
Application number
SE8000962A
Other languages
Swedish (sv)
Other versions
SE450381B (en
Inventor
A Scherm
K Hummel
D Peteri
Original Assignee
Merz & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz & Co filed Critical Merz & Co
Publication of SE8000962L publication Critical patent/SE8000962L/en
Publication of SE450381B publication Critical patent/SE450381B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds of the formula <IMAGE> wherein R is 3-pyridinyl or 2-(4- chlorophenoxy)-2-methyl-propyl; R<1> is hydrogen, C5-14 cycloalkyl, (C5-14 cycloalkyl)methyl, (C5-14 cycloalkyl)carbonyl, (C5-14 cycloalkyl)acetyl, 1-adamantyl, 1- adamantylmethyl, 1-adamantylcarbonyl, 1-adamantylacetyl, cumyl, p-chlorobenzoyl, piperidino or 2- pyrimidinyl; and R<2> is hydrogen, -(CH2)4-, halogen, C1-6 alkyl, cycloalkyl, methoxy, ethoxy, trifluoromethyl or nitro; provided that R<2> is C1-6 cycloalkyl or -(CH2)4- when R<1> is hydrogen; or a pharmaceutically acceptable acid addition salts thereof may be used in the treatment of hyperlipidemias.
SE8000962A 1979-02-08 1980-02-06 ESTIMATES OF NICOTIC ACID AND 2- (P-CHLORPHENOXY) -ISOSMORIC ACID FOR USE AS A LIPID SENSITIVE AGENT SE450381B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2904757 1979-02-08

Publications (2)

Publication Number Publication Date
SE8000962L true SE8000962L (en) 1980-08-09
SE450381B SE450381B (en) 1987-06-22

Family

ID=6062456

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8000962A SE450381B (en) 1979-02-08 1980-02-06 ESTIMATES OF NICOTIC ACID AND 2- (P-CHLORPHENOXY) -ISOSMORIC ACID FOR USE AS A LIPID SENSITIVE AGENT

Country Status (22)

Country Link
JP (1) JPS55129245A (en)
AR (1) AR228251A1 (en)
AT (1) AT374797B (en)
AU (1) AU532208B2 (en)
BE (1) BE881626A (en)
CA (1) CA1135689A (en)
CH (1) CH644092A5 (en)
DK (1) DK152360C (en)
ES (1) ES488345A0 (en)
FR (1) FR2448532A1 (en)
GB (1) GB2041937B (en)
GR (1) GR73905B (en)
HU (1) HU182099B (en)
IE (1) IE49385B1 (en)
IL (1) IL59337A (en)
IT (1) IT1141197B (en)
MX (1) MX6377E (en)
NL (1) NL8000826A (en)
PL (1) PL123379B1 (en)
SE (1) SE450381B (en)
SG (1) SG51185G (en)
YU (1) YU33880A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3891219T1 (en) * 1988-01-22 1990-02-01 Kh Nii Endokrinologii I Chimii P-CHLORPHENOXYSOBUTTERIC ACID AND DEZYLES AND MEDICINAL PRODUCTS BASED ON THE TREATMENT OF HYPERLIPIDAEMIA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3175M (en) * 1963-06-25 1965-03-08 Analyses Et De Rech S Biolog M New chemical compounds with peripheral vasodilating action.
DE2352012A1 (en) * 1972-11-01 1974-05-09 Ciba Geigy Ag NEW ALIPHATICALLY SUBSTITUTED ARYLCHALCOGENO-HYDROCARBON DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
ES438246A1 (en) * 1975-06-04 1977-01-16 Alter Sa A PROCEDURE FOR THE PREPARATION OF GLYCOL 2- (P-CHLOROPHENOCY) -2-METHYLPROPINATE NICOTINATE.
JPS57102866A (en) * 1980-12-19 1982-06-26 Kyorin Pharmaceut Co Ltd Nicotinic acid derivative and its preparation

Also Published As

Publication number Publication date
DK152360B (en) 1988-02-22
AU532208B2 (en) 1983-09-22
NL8000826A (en) 1980-08-12
ES8101552A1 (en) 1980-12-16
IE800236L (en) 1980-08-08
JPS6126993B2 (en) 1986-06-23
GB2041937B (en) 1983-04-13
HU182099B (en) 1983-12-28
BE881626A (en) 1980-08-08
AR228251A1 (en) 1983-02-15
JPS55129245A (en) 1980-10-06
IL59337A (en) 1984-10-31
GR73905B (en) 1984-05-21
PL123379B1 (en) 1982-10-30
IE49385B1 (en) 1985-10-02
ATA70380A (en) 1983-10-15
AU5535580A (en) 1980-08-14
CA1135689A (en) 1982-11-16
AT374797B (en) 1984-05-25
CH644092A5 (en) 1984-07-13
YU33880A (en) 1983-06-30
PL221888A1 (en) 1980-10-20
DK53680A (en) 1980-08-09
MX6377E (en) 1985-05-23
FR2448532B1 (en) 1984-12-14
GB2041937A (en) 1980-09-17
IT1141197B (en) 1986-10-01
FR2448532A1 (en) 1980-09-05
ES488345A0 (en) 1980-12-16
IT8019782A0 (en) 1980-02-08
DK152360C (en) 1988-08-01
SE450381B (en) 1987-06-22
SG51185G (en) 1986-01-24

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