SE7910390L - ANTIBACTERIAL AGENTS - Google Patents
ANTIBACTERIAL AGENTSInfo
- Publication number
- SE7910390L SE7910390L SE7910390A SE7910390A SE7910390L SE 7910390 L SE7910390 L SE 7910390L SE 7910390 A SE7910390 A SE 7910390A SE 7910390 A SE7910390 A SE 7910390A SE 7910390 L SE7910390 L SE 7910390L
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- easily removable
- antibacterial agents
- group
- removable ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
This invention relates to phosphorane compounds of the formula <IMG> wherein Y is hydrogen, ethyl or hydroxyethyl, Q is phenyl or (lower) alkyl, R" is an easily removable ester group and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3- position is protected by an easily removable ester protecting group. The compounds of the present invention are of use as intermediates in the preparation of penem compounds having potent antibacterial activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96866378A | 1978-12-18 | 1978-12-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7910390L true SE7910390L (en) | 1981-06-18 |
| SE454779B SE454779B (en) | 1988-05-30 |
Family
ID=25514601
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7910391A SE448995B (en) | 1978-12-18 | 1979-12-17 | 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES AND PROCEDURES FOR PREPARING THEREOF |
| SE7910390A SE454779B (en) | 1978-12-18 | 1979-12-17 | 2,6-DISUBSTITUTED PENEM SOCIETIES, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION THEREOF WITH ANTIBACTERIAL EFFECT |
| SE8405719A SE461395B (en) | 1978-12-18 | 1984-11-14 | 4- (2'-AZIDOETOXIACETYLTIO) -1- (2 '-TRIFENYLFOSFORANYLIDEN-2 "-acetate) -2-azetidinones |
| SE8405813A SE464027B (en) | 1978-12-18 | 1984-11-19 | INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES |
| SE8405812A SE8405812D0 (en) | 1978-12-18 | 1984-11-19 | INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM COMPOUNDS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7910391A SE448995B (en) | 1978-12-18 | 1979-12-17 | 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES AND PROCEDURES FOR PREPARING THEREOF |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8405719A SE461395B (en) | 1978-12-18 | 1984-11-14 | 4- (2'-AZIDOETOXIACETYLTIO) -1- (2 '-TRIFENYLFOSFORANYLIDEN-2 "-acetate) -2-azetidinones |
| SE8405813A SE464027B (en) | 1978-12-18 | 1984-11-19 | INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES |
| SE8405812A SE8405812D0 (en) | 1978-12-18 | 1984-11-19 | INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM COMPOUNDS |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS60222486A (en) |
| AU (4) | AU541717B2 (en) |
| CA (2) | CA1286661C (en) |
| CH (2) | CH643265A5 (en) |
| DK (5) | DK533879A (en) |
| ES (1) | ES487034A0 (en) |
| FI (2) | FI67853C (en) |
| GR (2) | GR81420B (en) |
| IE (3) | IE50597B1 (en) |
| IL (2) | IL58576A (en) |
| SE (5) | SE448995B (en) |
| YU (4) | YU43628B (en) |
| ZA (2) | ZA796812B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8509180D0 (en) * | 1985-04-10 | 1985-05-15 | Erba Farmitalia | Penem derivatives |
| US4826832A (en) * | 1986-05-06 | 1989-05-02 | Ciba-Geigy Corporation | Penen compounds |
| AU718806B2 (en) * | 1995-02-17 | 2000-04-20 | Daiichi Asubio Pharma Co., Ltd. | Penem derivatives and antimicrobial agent containing the same |
| ATE283707T1 (en) | 1998-01-13 | 2004-12-15 | Daiichi Suntory Pharma Co Ltd | ANTIBACTERIAL COMPOSITION FOR TOPICAL APPLICATION CONTAINING FAROPENEM |
| JP2005239696A (en) | 2004-01-30 | 2005-09-08 | Daiichi Suntory Pharma Co Ltd | Pharmaceutical hard capsules containing inorganic substances |
| CN112746066B (en) * | 2021-01-25 | 2023-10-31 | 洛阳华荣生物技术有限公司 | L-lysine decarboxylase mutant and application thereof |
-
1979
- 1979-10-29 IL IL58576A patent/IL58576A/en unknown
- 1979-11-07 GR GR60450A patent/GR81420B/el unknown
- 1979-11-12 YU YU2760/79A patent/YU43628B/en unknown
- 1979-11-26 IL IL58804A patent/IL58804A/en unknown
- 1979-11-29 GR GR60633A patent/GR74491B/el unknown
- 1979-12-10 JP JP79159315D patent/JPS60222486A/en active Pending
- 1979-12-11 AU AU53710/79A patent/AU541717B2/en not_active Ceased
- 1979-12-13 FI FI793905A patent/FI67853C/en not_active IP Right Cessation
- 1979-12-13 FI FI793903A patent/FI69845C/en not_active IP Right Cessation
- 1979-12-13 AU AU53787/79A patent/AU539983B2/en not_active Ceased
- 1979-12-14 ZA ZA00796812A patent/ZA796812B/en unknown
- 1979-12-14 DK DK533879A patent/DK533879A/en not_active Application Discontinuation
- 1979-12-14 ZA ZA00796813A patent/ZA796813B/en unknown
- 1979-12-14 DK DK533779A patent/DK161520C/en not_active IP Right Cessation
- 1979-12-17 CA CA000342069A patent/CA1286661C/en not_active Expired - Fee Related
- 1979-12-17 SE SE7910391A patent/SE448995B/en not_active IP Right Cessation
- 1979-12-17 SE SE7910390A patent/SE454779B/en not_active IP Right Cessation
- 1979-12-17 YU YU3076/79A patent/YU43464B/en unknown
- 1979-12-18 IE IE1853/85A patent/IE50597B1/en unknown
- 1979-12-18 IE IE2246/85A patent/IE49877B1/en unknown
- 1979-12-18 ES ES487034A patent/ES487034A0/en active Granted
- 1979-12-18 CH CH1121979A patent/CH643265A5/en not_active IP Right Cessation
- 1979-12-18 CH CH1121879A patent/CH643846A5/en not_active IP Right Cessation
- 1979-12-18 IE IE2462/79A patent/IE49876B1/en unknown
-
1982
- 1982-09-27 YU YU2157/82A patent/YU42125B/en unknown
- 1982-09-27 YU YU2153/82A patent/YU43280B/en unknown
-
1983
- 1983-03-08 CA CA000423146A patent/CA1268183A/en not_active Expired - Fee Related
-
1984
- 1984-08-24 AU AU32408/84A patent/AU557545B2/en not_active Ceased
- 1984-09-10 AU AU32884/84A patent/AU563015B2/en not_active Ceased
- 1984-11-14 SE SE8405719A patent/SE461395B/en not_active IP Right Cessation
- 1984-11-19 SE SE8405813A patent/SE464027B/en not_active IP Right Cessation
- 1984-11-19 SE SE8405812A patent/SE8405812D0/en not_active Application Discontinuation
-
1990
- 1990-10-01 DK DK237690A patent/DK237690A/en not_active Application Discontinuation
- 1990-10-01 DK DK236590A patent/DK161970C/en not_active IP Right Cessation
-
1991
- 1991-07-15 DK DK135291A patent/DK135291A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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