SE7807038L - SUBSTITUTED 1-THIENYL AND FURYL-2,3,4,5 TETRAHYDRO-1H-3 BENZAZEPINE COMPOUNDS - Google Patents
SUBSTITUTED 1-THIENYL AND FURYL-2,3,4,5 TETRAHYDRO-1H-3 BENZAZEPINE COMPOUNDSInfo
- Publication number
- SE7807038L SE7807038L SE7807038A SE7807038A SE7807038L SE 7807038 L SE7807038 L SE 7807038L SE 7807038 A SE7807038 A SE 7807038A SE 7807038 A SE7807038 A SE 7807038A SE 7807038 L SE7807038 L SE 7807038L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- carbon atoms
- hydrogen
- compounds
- relates
- Prior art date
Links
- -1 1-THIENYL Chemical class 0.000 title abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- NTQITNFCVDCQEC-UHFFFAOYSA-N 5-(furan-2-yl)-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1NCCC2=CC=CC=C2C1C1=CC=CO1 NTQITNFCVDCQEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000008038 benzoazepines Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to substituted 1-thienyl- and 1- furyl-2,3,4,5-tetrahydro-1H-3-benzazepines with two hydroxyl substituents in the benzene ring of the benzazepine nucleus, these compounds having a dopaminergic activity. The invention also relates to a process for the preparation of these compounds, which have the formula <IMAGE> (where R is a hydrogen atom, a benzyl or phenylethyl group, a lower alkanoyl group with 1-5 carbon atoms, a lower alkyl group with 1-5 carbon atoms, a hydroxyalkyl group or a lower alkenyl group with 3-5 carbon atoms; R1 is a hydrogen or halogen atom or a trifluoromethyl, methylthio, trifluoromethylthio, methyl or methoxy group; R2 and R3 are hydrogen atoms, lower alkyl groups with 1-5 carbon atoms, lower alkanoyl groups with 2-5 carbon atoms, or jointly methylene or ethylene groups; R4 is a hydrogen or halogen atom, a cyanomethyl, methyl or carbomethoxy group; and X stands for -O- or -S-). The invention also relates to pharmacologically acceptable non-toxic salts of these compounds, together with pharmaceutical compositions containing them.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7807038A SE430418B (en) | 1978-06-20 | 1978-06-20 | Substituted 1-thienyl- and 1-furyl-2,3,4,5-tetrahydro-1H- 3-benzazepines and a process for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7807038A SE430418B (en) | 1978-06-20 | 1978-06-20 | Substituted 1-thienyl- and 1-furyl-2,3,4,5-tetrahydro-1H- 3-benzazepines and a process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7807038L true SE7807038L (en) | 1979-12-21 |
| SE430418B SE430418B (en) | 1983-11-14 |
Family
ID=20335252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7807038A SE430418B (en) | 1978-06-20 | 1978-06-20 | Substituted 1-thienyl- and 1-furyl-2,3,4,5-tetrahydro-1H- 3-benzazepines and a process for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| SE (1) | SE430418B (en) |
-
1978
- 1978-06-20 SE SE7807038A patent/SE430418B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE430418B (en) | 1983-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8103744A1 (en) | A METHOD FOR THE PREPARATION OF PHTHALIMIDINE DERIVATIVES | |
| PT79845B (en) | Process for preparing imidazodiazepine derivatives and of pharmaceutical compositions containing the same | |
| EP0233793A3 (en) | Decahydroquinoline derivatives, process for their preparation, intermediates for their preparation, their use as medicaments and compositions containing them | |
| ES548204A0 (en) | A METHOD FOR PREPARING A DERIVATIVE OF 1-PIPERAZIN-3-FENI- LINDANO | |
| DE3274860D1 (en) | Triazoloquinazolones and their salts, process and intermediates for preparing them, their use as medicines and compositions containing them | |
| IL66694A0 (en) | Dibenzazepine derivatives,their preparation and pharmaceutical compositions containing them | |
| HUT44482A (en) | Process for production of n-/-2-oxo-/n-/2methil-phenil/-n-benzil-amino/-ethil/-n-/2/-dimethil-amino/-ethil/-carbamates or ureids and medical preparatives containing such compounds | |
| SE7807038L (en) | SUBSTITUTED 1-THIENYL AND FURYL-2,3,4,5 TETRAHYDRO-1H-3 BENZAZEPINE COMPOUNDS | |
| DE3165179D1 (en) | Indolobenzoxazine derivatives, their salts, process for their preparation, their use as medicaments and compositions containing them | |
| DE3468104D1 (en) | New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use | |
| DE3365933D1 (en) | Substituted thienobenzodiazepinones, process for their preparation and medicines containing these compounds | |
| DE3163567D1 (en) | Cycloheptindole derivatives and their acid-addition salts, their preparation, their use as medicaments and compositions containing them | |
| ZA829526B (en) | (1,2)-fused 1,4-benzodiazepine compounds, process for their preparation and compounds containing them | |
| DE3068245D1 (en) | Substituted 2-phenylamino-2-imidazolines, acid addition salts thereof, medicaments containing them and process for preparing them | |
| FR2432505A1 (en) | NOVEL 5-IODO-3-NITRO-4-HYDROXYBENZONITRILE SALTS, THEIR PREPARATION AND COMPOSITIONS CONTAINING THE SAME | |
| ES500108A0 (en) | PROCEDURE FOR PREPARING NEW BENZOTIOPYRAN (2,3-C) PI-RIDINAS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7807038-0 Effective date: 19900522 Format of ref document f/p: F |