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SE7408321L - - Google Patents

Info

Publication number
SE7408321L
SE7408321L SE7408321A SE7408321A SE7408321L SE 7408321 L SE7408321 L SE 7408321L SE 7408321 A SE7408321 A SE 7408321A SE 7408321 A SE7408321 A SE 7408321A SE 7408321 L SE7408321 L SE 7408321L
Authority
SE
Sweden
Prior art keywords
carbon atoms
denotes
carbalkoxy
appropriately substituted
alkyl
Prior art date
Application number
SE7408321A
Inventor
H Loewe
J Urbanietz
R Krisch
D Duwel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of SE7408321L publication Critical patent/SE7408321L/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
    • C07D235/32Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The novel anthelmintically active 2-carbalkoxy-amino-benzimidazole-5(6)-phenyl ethers and thioethers of the formula I <IMAGE> wherein R1 denotes alkyl having 1 to 4 carbon atoms, R2 and R3 independently of one another each denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl having 1 to 4 carbon atoms or carbalkoxy having 1 to 4 carbon atoms in the alkoxy radical, R4 denotes hydrogen or chlorine and X denotes oxygen of sulphur, are prepared by reaction of appropriately substituted o-phenylenediamine derivatives with an appropriately substituted dithiomethyleneamino-formic acid ester. The compounds are valuable chemotherapeutics for the control of parasitic diseases in man and animals. They are particularly active against a large number of helminths, for example Haemonchus, Trichostrongylus, Ostertagia, Strongyloides, Cooperia, Chabertia, Oesophagostomum, Hyostrongylus, Ankylostoma, Askaris and Heterakis.
SE7408321A 1973-06-26 1974-06-25 SE7408321L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2332343A DE2332343A1 (en) 1973-06-26 1973-06-26 2-CARBALCOXY-AMINO-BENZIMIDAZOL-5 (6) PHENYL ETHER, THEIR PRODUCTION AND USE IN AGENTS AGAINST HELMETS

Publications (1)

Publication Number Publication Date
SE7408321L true SE7408321L (en) 1974-12-27

Family

ID=5885065

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7408321A SE7408321L (en) 1973-06-26 1974-06-25

Country Status (12)

Country Link
JP (1) JPS5758343B2 (en)
AT (1) AT342041B (en)
CA (1) CA1031781A (en)
CH (1) CH614706A5 (en)
DE (1) DE2332343A1 (en)
DK (1) DK341474A (en)
ES (1) ES427455A1 (en)
HU (1) HU168527B (en)
IT (1) IT1056735B (en)
NL (1) NL7408394A (en)
SE (1) SE7408321L (en)
YU (1) YU37147B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028455A1 (en) * 1979-10-12 1981-05-13 Imperial Chemical Industries Plc 5-Phenylselenobenzimidazole derivatives, their preparation and anthelmintic or fasciolicidal compositions containing them
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents

Also Published As

Publication number Publication date
NL7408394A (en) 1974-12-30
HU168527B (en) 1976-05-28
YU178074A (en) 1982-06-18
YU37147B (en) 1984-08-31
CH614706A5 (en) 1979-12-14
DE2332343A1 (en) 1975-01-16
ES427455A1 (en) 1976-07-16
IT1056735B (en) 1982-02-20
ATA525274A (en) 1977-07-15
JPS5758343B2 (en) 1982-12-09
DK341474A (en) 1975-03-17
AT342041B (en) 1978-03-10
JPS5040564A (en) 1975-04-14
CA1031781A (en) 1978-05-23

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