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SE547146C2 - Fluid-handling device, syringe adaptor and method for facilitating the flow of a mobile phase through a stationary phase - Google Patents

Fluid-handling device, syringe adaptor and method for facilitating the flow of a mobile phase through a stationary phase

Info

Publication number
SE547146C2
SE547146C2 SE2351458A SE2351458A SE547146C2 SE 547146 C2 SE547146 C2 SE 547146C2 SE 2351458 A SE2351458 A SE 2351458A SE 2351458 A SE2351458 A SE 2351458A SE 547146 C2 SE547146 C2 SE 547146C2
Authority
SE
Sweden
Prior art keywords
fluid
barrel
facilitating
flow
handling device
Prior art date
Application number
SE2351458A
Other versions
SE2351458A1 (en
Inventor
Dale Allen Dreyer
Fritiof Pontén
Original Assignee
Biotech Fluidics Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotech Fluidics Ab filed Critical Biotech Fluidics Ab
Priority to SE2351458A priority Critical patent/SE2351458A1/en
Priority to PCT/SE2024/051105 priority patent/WO2025136203A1/en
Publication of SE547146C2 publication Critical patent/SE547146C2/en
Publication of SE2351458A1 publication Critical patent/SE2351458A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6021—Adjustable pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • B01D15/122—Solid phase extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1801—Radial flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1894—Liquid-liquid chromatography, e.g. centrifugal partition chromatography or extraction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1896—Membrane chromatography or membrane adsorbers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • B01D15/222—Arrangements of modules or cassettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/522—Physical parameters pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6069—Construction of the column body with compartments or bed substructure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Device (10) comprising: an outer barrel (12) having: a proximal end (18) comprising an opening (20) for an inner barrel (14), and a distal end (22) comprising a fluid outlet (24), and an inner barrel (14) slidably mounted inside the outer barrel (12). The inner barrel (14) comprises a proximal end (28) for receiving a cartridge (30) containing a stationary phase (32). The device (10) comprises a seal (38) on the inner barrel (14) or an inner surface (16) of the outer barrel (12). The seal (38) creates an internal volume (40) between the barrels at the distal end (22) of the outer barrel (12). Sliding the inner barrel (14) towards the proximal end (18) of the outer barrel (12) increases this internal volume (40). A fluid channel (42) extends through the inner barrel (14) connecting the fluid exit duct (34) of said cartridge (30) to said internal volume (40).
SE2351458A 2023-12-19 2023-12-19 Fluid-handling device, syringe adaptor and method for facilitating the flow of a mobile phase through a stationary phase SE2351458A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SE2351458A SE2351458A1 (en) 2023-12-19 2023-12-19 Fluid-handling device, syringe adaptor and method for facilitating the flow of a mobile phase through a stationary phase
PCT/SE2024/051105 WO2025136203A1 (en) 2023-12-19 2024-12-18 Fluid-handling device, syringe adaptor and method for facilitating the flow of a mobile phase through a stationary phase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE2351458A SE2351458A1 (en) 2023-12-19 2023-12-19 Fluid-handling device, syringe adaptor and method for facilitating the flow of a mobile phase through a stationary phase

Publications (2)

Publication Number Publication Date
SE547146C2 true SE547146C2 (en) 2025-04-29
SE2351458A1 SE2351458A1 (en) 2025-04-29

Family

ID=95482316

Family Applications (1)

Application Number Title Priority Date Filing Date
SE2351458A SE2351458A1 (en) 2023-12-19 2023-12-19 Fluid-handling device, syringe adaptor and method for facilitating the flow of a mobile phase through a stationary phase

Country Status (2)

Country Link
SE (1) SE2351458A1 (en)
WO (1) WO2025136203A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510058A (en) * 1982-08-15 1985-04-09 Technion Research & Development Foundation, Ltd. Method for a new type of chromatography and device therefor
US5186839A (en) * 1988-06-03 1993-02-16 Manac Inc. Syringe type column for chromatography
US6068766A (en) * 1997-11-12 2000-05-30 Dyax Corporation Apparatus and method for making a sealable connection to a chromatography cartridge
WO2002060556A1 (en) * 2001-02-01 2002-08-08 Biotome Inc. Self-contained vacuum cartridge
US6811688B1 (en) * 1999-05-20 2004-11-02 Downstream Media Limited Chromatography columns

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510058A (en) * 1982-08-15 1985-04-09 Technion Research & Development Foundation, Ltd. Method for a new type of chromatography and device therefor
US5186839A (en) * 1988-06-03 1993-02-16 Manac Inc. Syringe type column for chromatography
US6068766A (en) * 1997-11-12 2000-05-30 Dyax Corporation Apparatus and method for making a sealable connection to a chromatography cartridge
US6811688B1 (en) * 1999-05-20 2004-11-02 Downstream Media Limited Chromatography columns
WO2002060556A1 (en) * 2001-02-01 2002-08-08 Biotome Inc. Self-contained vacuum cartridge

Also Published As

Publication number Publication date
WO2025136203A1 (en) 2025-06-26
SE2351458A1 (en) 2025-04-29

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