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SE0202114L - Polymer affinity matrix, process for its preparation and use - Google Patents

Polymer affinity matrix, process for its preparation and use

Info

Publication number
SE0202114L
SE0202114L SE0202114A SE0202114A SE0202114L SE 0202114 L SE0202114 L SE 0202114L SE 0202114 A SE0202114 A SE 0202114A SE 0202114 A SE0202114 A SE 0202114A SE 0202114 L SE0202114 L SE 0202114L
Authority
SE
Sweden
Prior art keywords
fluid
matrix
affinity matrix
polymer affinity
preparation
Prior art date
Application number
SE0202114A
Other languages
Swedish (sv)
Other versions
SE0202114D0 (en
SE526038C2 (en
Inventor
Reinhold Deppisch
Hermann Goehl
Bernd Wittner
Werner Beck
Wolfgang Rapp
Original Assignee
Gambro Lundia Ab
Wolfgang Rapp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gambro Lundia Ab, Wolfgang Rapp filed Critical Gambro Lundia Ab
Priority to SE0202114A priority Critical patent/SE526038C2/en
Publication of SE0202114D0 publication Critical patent/SE0202114D0/en
Priority to JP2004519465A priority patent/JP2006505385A/en
Priority to KR1020057000302A priority patent/KR101036995B1/en
Priority to AT03738845T priority patent/ATE389178T1/en
Priority to EP03738845A priority patent/EP1519721B1/en
Priority to AU2003245217A priority patent/AU2003245217A1/en
Priority to PCT/SE2003/001166 priority patent/WO2004004707A1/en
Priority to ES03738845T priority patent/ES2304518T3/en
Priority to US10/520,532 priority patent/US20060134595A1/en
Priority to DE60319702T priority patent/DE60319702T2/en
Priority to CN038161427A priority patent/CN1665494A/en
Publication of SE0202114L publication Critical patent/SE0202114L/en
Publication of SE526038C2 publication Critical patent/SE526038C2/en
Priority to US12/219,356 priority patent/US20090047654A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A polymer affinity matrix for the binding of one or more substances in a fluid or removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a spacer and a ligand, containing arginine as a binding unit.
SE0202114A 2002-07-08 2002-07-08 Polymer affinity matrix, process for its preparation and use thereof SE526038C2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SE0202114A SE526038C2 (en) 2002-07-08 2002-07-08 Polymer affinity matrix, process for its preparation and use thereof
CN038161427A CN1665494A (en) 2002-07-08 2003-07-04 Polymer affinity matrix and its production method and use
PCT/SE2003/001166 WO2004004707A1 (en) 2002-07-08 2003-07-04 Polymer affinity matrix, a method for the production and use thereof
KR1020057000302A KR101036995B1 (en) 2002-07-08 2003-07-04 Polymer Affinity Substrates and Methods of Making and Uses thereof
AT03738845T ATE389178T1 (en) 2002-07-08 2003-07-04 POLYMER AFFINITY MATRIX, METHOD FOR THE PRODUCTION AND USE THEREOF
EP03738845A EP1519721B1 (en) 2002-07-08 2003-07-04 Polymer affinity matrix, a method for the production and use thereof
AU2003245217A AU2003245217A1 (en) 2002-07-08 2003-07-04 Polymer affinity matrix, a method for the production and use thereof
JP2004519465A JP2006505385A (en) 2002-07-08 2003-07-04 Polymer affinity matrix, production method thereof, and use thereof
ES03738845T ES2304518T3 (en) 2002-07-08 2003-07-04 MATRIX OF POLYMERIC AFFINITY, A METHOD OF PRODUCTION AND USE OF THE SAME.
US10/520,532 US20060134595A1 (en) 2002-07-08 2003-07-04 Polymer affinity matrix, a method for the production and use thereof
DE60319702T DE60319702T2 (en) 2002-07-08 2003-07-04 POLYMEREFFINITY MATRIX, PROCESS FOR THEIR PREPARATION AND USE
US12/219,356 US20090047654A1 (en) 2002-07-08 2008-07-21 Polymer affinity matrix, a method for the production and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0202114A SE526038C2 (en) 2002-07-08 2002-07-08 Polymer affinity matrix, process for its preparation and use thereof

Publications (3)

Publication Number Publication Date
SE0202114D0 SE0202114D0 (en) 2002-07-08
SE0202114L true SE0202114L (en) 2004-01-09
SE526038C2 SE526038C2 (en) 2005-06-21

Family

ID=20288453

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0202114A SE526038C2 (en) 2002-07-08 2002-07-08 Polymer affinity matrix, process for its preparation and use thereof

Country Status (11)

Country Link
US (2) US20060134595A1 (en)
EP (1) EP1519721B1 (en)
JP (1) JP2006505385A (en)
KR (1) KR101036995B1 (en)
CN (1) CN1665494A (en)
AT (1) ATE389178T1 (en)
AU (1) AU2003245217A1 (en)
DE (1) DE60319702T2 (en)
ES (1) ES2304518T3 (en)
SE (1) SE526038C2 (en)
WO (1) WO2004004707A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
JP4378685B2 (en) * 2004-01-16 2009-12-09 ニプロ株式会社 Dialysis machine
WO2005113023A1 (en) * 2004-04-26 2005-12-01 Haik Jr George M Use of arginine and like substances and methylglyoxal and like substances in dialysis machines
DE102004029573A1 (en) * 2004-06-18 2005-12-29 Gambro Lundia Ab Apheresis material or adsorbant for removing, depleting or inactivating macrophage migration inhibitory factor, comprises macrophage migration inhibitory factor-binding molecules on a solid carrier
EP1974215B1 (en) * 2006-01-06 2017-12-27 EMD Millipore Corporation Affinity chromatography matrices and methods of making and using the same
AU2007272494B2 (en) 2006-07-14 2011-07-28 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
GB0621452D0 (en) 2006-10-27 2006-12-06 Ucl Business Plc Therapy for liver disease
WO2009009188A2 (en) * 2007-04-19 2009-01-15 3M Innovative Properties Company Uses of water-dispersible silica nanoparticles for attaching biomolecules
WO2008131063A1 (en) * 2007-04-19 2008-10-30 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
US8911833B2 (en) * 2008-04-30 2014-12-16 Xyleco, Inc. Textiles and methods and systems for producing textiles
JP2010029595A (en) * 2008-07-31 2010-02-12 Fujifilm Corp Harmful substance removal material and its method
US8454547B2 (en) 2009-02-25 2013-06-04 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
CN102276937B (en) * 2010-06-12 2013-06-05 中国石油化工股份有限公司 Antibacterial polystyrene composition and preparation method thereof
CN102621296A (en) * 2012-01-06 2012-08-01 天津医科大学 Method of coupling protein onto carboxylated polystyrene microspheres with spacer arms
JP6231263B2 (en) * 2012-07-17 2017-11-15 株式会社島津製作所 Affinity support and method of capturing a substance using the same
EP3052445B1 (en) 2013-09-30 2018-01-03 3M Innovative Properties Company Guanidine-functionalized metal silicate particles and methods of making and using such particles
WO2015129622A1 (en) * 2014-02-28 2015-09-03 昭和電工株式会社 Filler for liquid chromatography and liquid chromatography column
CN104072752B (en) * 2014-07-03 2015-09-23 湖南尔康制药股份有限公司 A kind of method of boric acid ester exchange process synthesizing polyethylene glycol-12-hydroxy stearic acid ester
CN104045824B (en) * 2014-07-03 2015-08-26 湖南尔康制药股份有限公司 A kind of method of solid supported method synthesizing polyethylene glycol-12-hydroxy stearic acid ester
CN104190387B (en) * 2014-09-11 2016-08-17 福州新北生化工业有限公司 A kind of except gel of pyrogen and its preparation method and application in liquid
CN104959120B (en) * 2015-06-19 2017-05-10 佛山市博新生物科技有限公司 Inflammatory factor adsorbing agent for blood perfusion and preparation method
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
US10786615B2 (en) * 2016-03-02 2020-09-29 Exthera Medical Corporation Method for treating drug intoxication
EP3426229A4 (en) * 2016-03-08 2019-11-06 Cytosorbents Corporation USE OF A HEMOCOMPATIBLE POROUS POLYMER PEARL SORBENT FOR THE REMOVAL OF MOLECULAR MOLECULAR MOLECULES ASSOCIATED WITH PATHOGENIC AGENTS (PAMP) AND MOLECULAR MOLECULAR MOLECULES ASSOCIATED WITH INJURIES (DAMP)
IT201600079328A1 (en) * 2016-07-28 2018-01-28 Altergon Sa Improved method for the decontamination of biological material by partition and inactivation
EP3506999A1 (en) * 2016-09-05 2019-07-10 Drei Lilien PVG GmbH & Co. KG Open-pore membrane having an inner space-spanning polymeric structural network for electrophoretic material-selective separation and methods for producing and using same
CA3058871C (en) * 2017-04-06 2022-11-22 Asahi Kasei Kabushiki Kaisha Hydrophilic colored cellulose microparticles
EP3392265A1 (en) * 2017-04-20 2018-10-24 SETLANCE S.r.l. Methods for removing bacterial toxins from a biological fluid
CN107475454B (en) * 2017-09-21 2020-05-26 中山大学 Zika virus nucleic acid detection method based on electrochemical luminescence amplification principle
CN107764803B (en) * 2017-09-21 2021-04-13 中山大学 A biomarker detection method using electrochemiluminescence imaging recognition technology
CN107488723B (en) * 2017-09-21 2020-11-27 中山大学 A method for detecting telomerase activity based on the principle of electrochemiluminescence cascade
US20190210018A1 (en) * 2017-09-25 2019-07-11 Plexium, Inc. Oligonucleotide encoded chemical libraries
GB201717555D0 (en) * 2017-10-25 2017-12-06 Nonwovens Innovation & Res Institute Ltd Blood filter
EA036052B1 (en) * 2019-04-28 2020-09-21 Товарищество С Ограниченной Ответственностью "Научный Производственно-Технический Центр "Жалын" (Тоо "Научный Производственно-Технический Центр "Жалын") Blood perfusion detoxification device
BR112021021141A2 (en) 2019-05-16 2021-12-14 Exthera Medical Corp Method to Modulate Endothelial Glycalyx Structure
CN114225919B (en) * 2021-11-26 2023-07-04 江苏贝美医疗科技有限公司 Endotoxin adsorbent and preparation method and application thereof
JP2023143402A (en) * 2022-03-25 2023-10-06 ジーエルサイエンス株式会社 Treatment method and treatment liquid for endotoxin contaminants

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4111838A (en) * 1977-09-09 1978-09-05 Eastman Kodak Company Composition for chromatography
CA1320718C (en) * 1987-06-08 1993-07-27 Richard Frederick Hammen Chromatographic material
EP0546055B1 (en) * 1990-08-31 1996-07-10 Regents Of The University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5646120A (en) * 1990-10-24 1997-07-08 Allelix Biopharmaceuticals, Inc. Peptide-based inhibitors of HIV replication
SE468881B (en) * 1991-01-09 1993-04-05 Kabi Pharmacia Ab APPLICATION OF CERTAIN PHARMACEUTICALS FOR THE PREPARATION OF MEDICINAL PRODUCTS FOR TREATMENT OF ENDOTOXIN-INDEXED EFFECTS AND THE PREPARATION OF ENDOTOXINES FROM MISCELLANEOUS SOLUTIONS
WO1998032790A1 (en) * 1997-01-27 1998-07-30 Flowgenix Corporation Porous articles with surface functionality and uses thereof
WO2000031536A2 (en) * 1998-11-23 2000-06-02 President And Fellows Of Harvard College Detecting structural or synthetic information about chemical compounds
US6774102B1 (en) * 1999-09-29 2004-08-10 Gambro Dialysatoren Gmbh & Co. Kg Extracorporeal endotoxin removal method
ES2274044T3 (en) * 2001-05-21 2007-05-16 Omrix Biopharmaceuticals S.A. DISPOSAL OF PLASMINE (PLASMINOGEN) OF PROTEIN SOLUTIONS.

Also Published As

Publication number Publication date
JP2006505385A (en) 2006-02-16
DE60319702T2 (en) 2009-03-12
ES2304518T3 (en) 2008-10-16
KR101036995B1 (en) 2011-05-25
AU2003245217A1 (en) 2004-01-23
EP1519721A1 (en) 2005-04-06
KR20050025322A (en) 2005-03-14
SE0202114D0 (en) 2002-07-08
ATE389178T1 (en) 2008-03-15
US20060134595A1 (en) 2006-06-22
CN1665494A (en) 2005-09-07
SE526038C2 (en) 2005-06-21
US20090047654A1 (en) 2009-02-19
WO2004004707A1 (en) 2004-01-15
DE60319702D1 (en) 2008-04-24
EP1519721B1 (en) 2008-03-12

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