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RU98106104A - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives

Info

Publication number
RU98106104A
RU98106104A RU98106104/04A RU98106104A RU98106104A RU 98106104 A RU98106104 A RU 98106104A RU 98106104/04 A RU98106104/04 A RU 98106104/04A RU 98106104 A RU98106104 A RU 98106104A RU 98106104 A RU98106104 A RU 98106104A
Authority
RU
Russia
Prior art keywords
group
disease
endothelin
substituent
salt
Prior art date
Application number
RU98106104/04A
Other languages
Russian (ru)
Other versions
RU2170734C2 (en
Inventor
Хирата Митсутеру
Деуси Такео
Такахаси Йосио
Тамура Масахиро
Охсима Такеси
Ода Тосиаки
Исикава Тетсуя
Соноки Хироюки
Сиратсути Масами
Original Assignee
Кова Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кова Ко., Лтд. filed Critical Кова Ко., Лтд.
Publication of RU98106104A publication Critical patent/RU98106104A/en
Application granted granted Critical
Publication of RU2170734C2 publication Critical patent/RU2170734C2/en

Links

Claims (10)

1. Производное пиримидина следующей формулы (I) или соль этого производного:
Figure 00000001

где R1 представляет гидроксильную группу, низшую алкоксигруппу, фенилоксигруппу, которая может иметь заместитель, аралкилоксигруппу, которая может иметь заместитель, или NR2R3;
Х представляет атом кислорода или N-R4;
m равно 2 или 3;
n равно 1 или 2
(где каждый из R2 и R3, которые могут быть идентичными или могут отличаться друг от друга, представляет атом водорода, гидроксильную группу, низшую алкильную группу, которая может иметь заместитель, фенильную группу, которая может иметь заместитель, аралкильную группу, которая может иметь заместитель, или гетероциклическую группу, которая может иметь заместитель; R4 представляет низшую алкильную группу, фенильную группу, формильную группу или низшую алкоксикарбонильную группу).1. A pyrimidine derivative of the following formula (I) or a salt of this derivative:
Figure 00000001

where R 1 represents a hydroxyl group, a lower alkoxy group, a phenyloxy group which may have a substituent, an aralkyloxy group which may have a substituent, or NR 2 R 3 ;
X represents an oxygen atom or NR 4 ;
m is 2 or 3;
n is 1 or 2
(where each of R 2 and R 3 , which may be identical or may differ from each other, represents a hydrogen atom, a hydroxyl group, a lower alkyl group that may have a substituent, a phenyl group that may have a substituent, an aralkyl group that may have a substituent, or a heterocyclic group which may have a substituent; R 4 represents a lower alkyl group, a phenyl group, a formyl group or a lower alkoxycarbonyl group). 2. Лекарственный препарат, содержащий в качестве активного ингредиента производное пиримидина по п.1 или соль указанного производного. 2. A medicament containing, as an active ingredient, a pyrimidine derivative according to claim 1 or a salt of said derivative. 3. Лекарственный препарат по п.2, который полезен для профилактики или лечения болезни, вызванной эндотелином. 3. The drug according to claim 2, which is useful for the prevention or treatment of a disease caused by endothelin. 4. Лекарственный препарат по п.3, где болезнью, индуцированной эндотелином, является болезнь, протекающая с расстройством кровообращения. 4. The drug according to claim 3, where the disease induced by endothelin is a disease that occurs with circulatory disorders. 5. Фармацевтическая композиция, содержащая производное пиримидина по п.1 или соль указанного производного, и фармацевтически приемлемый носитель. 5. A pharmaceutical composition comprising a pyrimidine derivative according to claim 1 or a salt of said derivative, and a pharmaceutically acceptable carrier. 6. Применение в качестве лекарственного средства соединения по п.1 или соли указанного соединения. 6. The use as a medicine of a compound according to claim 1 or a salt of said compound. 7. Применение по п.6, где указанное лекарственное средство служит в качестве средства для профилактики или лечения болезни, индуцированной эндотелином. 7. The use according to claim 6, where the specified drug serves as a means for the prevention or treatment of disease induced by endothelin. 8. Применение по п.7, где болезнью, индуцированной эндотелином, является болезнь, протекающая с расстройством кровообращения. 8. The use according to claim 7, where the disease induced by endothelin is a disease that occurs with circulatory disorders. 9. Способ профилактики и лечения болезни, индуцированной эндотелином, отличающийся тем, что вводят эффективное количество соединения по п.1 или соли указанного соединения. 9. A method for the prevention and treatment of endothelin-induced disease, characterized in that an effective amount of a compound according to claim 1 or a salt of said compound is administered. 10. Способ профилактики и лечения по п.9, где болезнью, индуцированной эндотелином, является болезнь, протекающая с расстройством кровообращения. 10. The method of prevention and treatment according to claim 9, where the disease induced by endothelin is a disease that occurs with circulatory disorders.
RU98106104/04A 1995-09-06 1996-09-04 Derivatives of pyrimidine, pharmaceutical composition and method of prophylaxis and treatment of disease RU2170734C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7/228907 1995-09-06
JP22890795 1995-09-06

Publications (2)

Publication Number Publication Date
RU98106104A true RU98106104A (en) 2000-03-27
RU2170734C2 RU2170734C2 (en) 2001-07-20

Family

ID=16883731

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98106104/04A RU2170734C2 (en) 1995-09-06 1996-09-04 Derivatives of pyrimidine, pharmaceutical composition and method of prophylaxis and treatment of disease

Country Status (14)

Country Link
US (1) US5883092A (en)
EP (1) EP0852226B1 (en)
KR (1) KR100453097B1 (en)
CN (1) CN1105711C (en)
AT (1) ATE254607T1 (en)
AU (1) AU703892B2 (en)
CA (1) CA2230516C (en)
DE (1) DE69630799T2 (en)
ES (1) ES2210384T3 (en)
HU (1) HUP9903526A3 (en)
NO (1) NO310235B1 (en)
PT (1) PT852226E (en)
RU (1) RU2170734C2 (en)
WO (1) WO1997009318A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020177A1 (en) 1994-12-28 1996-07-04 Kowa Co., Ltd. Pyrimidine derivatives
CA2326427A1 (en) * 1998-03-31 1999-10-07 Koichiro Yamada Preventives/remedies for urinary disorder
CA2315614C (en) * 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
PT1254121E (en) * 2000-01-25 2006-06-30 Hoffmann La Roche PREPARATION OF SULFONAMIDES
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
CA2784937A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
WO2011078143A1 (en) * 2009-12-22 2011-06-30 塩野義製薬株式会社 Pyrimidine derivatives and pharmaceutical composition containing same
CN105246877A (en) 2013-05-31 2016-01-13 兴和株式会社 New forms of pyrimidine compounds with dibenzylamine structure

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU751007A1 (en) * 1979-02-05 1990-11-07 Институт биохимии АН ЛитССР 2-[n-[4-(3,3-dimethyltriazeno)-benzenesulfonyl]amido]-4,6-dimethypyrimidine displaying anti-inflammatory activity
HU177184B (en) * 1979-05-11 1981-08-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 2,3- and 3,4-disubstituted-hexahydro-pyrimido-square bracket-1,2-a-square bracket closed-asepines
FI64367C (en) * 1980-02-26 1986-08-05 Orion Yhtymae Oy OIL FRAMSTAELLNING AV ALFA FORM AV PRAZOSINHYDROCHLORIDE
US4490374A (en) * 1982-09-30 1984-12-25 Ortho Pharmaceutical Corporation 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
SU1433958A1 (en) * 1985-07-26 1988-10-30 Институт Органического Синтеза Ан Латвсср 2-oxo-4-(0-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine displaying coronary-dilating effect
SU1533693A1 (en) * 1987-05-14 1990-01-07 1-Й Московский Медицинский Институт Им.И.М.Сеченова Method of treating myocardial infarction patients
TW270116B (en) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (en) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity
DE4128116C1 (en) * 1991-08-24 1993-02-25 Schmidt Reuter Ingenieurgesellschaft Mbh & Partner Kg, 5000 Koeln, De
TW287160B (en) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
WO1996020177A1 (en) * 1994-12-28 1996-07-04 Kowa Co., Ltd. Pyrimidine derivatives

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