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RU93054165A - IMIDAZOPYRIDINE DERIVATIVES, METHOD FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT - Google Patents

IMIDAZOPYRIDINE DERIVATIVES, METHOD FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT

Info

Publication number
RU93054165A
RU93054165A RU93054165/04A RU93054165A RU93054165A RU 93054165 A RU93054165 A RU 93054165A RU 93054165/04 A RU93054165/04 A RU 93054165/04A RU 93054165 A RU93054165 A RU 93054165A RU 93054165 A RU93054165 A RU 93054165A
Authority
RU
Russia
Prior art keywords
treatment
producing
pharmaceutical composition
imidazopyridine derivatives
ring
Prior art date
Application number
RU93054165/04A
Other languages
Russian (ru)
Other versions
RU2114845C1 (en
Inventor
Алкер Дэвид
Джон Басс Альберт
Купер Кельвин
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919102997A external-priority patent/GB9102997D0/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of RU93054165A publication Critical patent/RU93054165A/en
Application granted granted Critical
Publication of RU2114845C1 publication Critical patent/RU2114845C1/en

Links

Claims (1)

Соединение формулы (I), в которой Х - СН или N; Z - СН=СН или S; A - СН2СН2, СН= СН, СН/ОН/СН2 или СОСН2; В - направленная связь или -СН2-, -СН/СН3/2-, или когда Z представляет СН=СН, В может образовывать циклопентановое кольцо, слитое с прикрепленным бензольным кольцом, Y завершает сконденсированное бензо- или тиенильное кольцо, которое необязательно замещено гало- или С-С4 алкилом; n равно 0,1 или 2, а m равно 0 или 1, являющиеся антагонистами как ТАФ, так и гистамина Н1, обладают свойствами, которые позволяют использовать их в лечении аллергических воспалительных заболеваний, таких как аллергический ренит.A compound of formula (I) in which X is CH or N; Z is CH = CH or S; A is CH 2 CH 2 , CH = CH, CH / OH / CH 2 or COCH 2 ; B - directional bond or -CH 2 -, -CH / CH 3/2 - or when Z is CH = CH, B may form a cyclopentane ring fused to the attached benzene ring, Y completes a fused benzo or thienyl ring which optionally substituted by halo or C -C 4 alkyl; n is 0.1 or 2, and m is 0 or 1, which are antagonists of both TAF and histamine H 1 , have properties that allow them to be used in the treatment of allergic inflammatory diseases, such as allergic renitis.
RU93054165A 1991-02-13 1992-01-24 Imidazopyridine derivatives or their pharmaceutically acceptable salts, method of their synthesis and pharmaceutical composition showing antagonistic activity with respect to histamine h1 RU2114845C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919102997A GB9102997D0 (en) 1991-02-13 1991-02-13 Therapeutic agents
GB9102997.5 1991-02-13

Publications (2)

Publication Number Publication Date
RU93054165A true RU93054165A (en) 1996-09-10
RU2114845C1 RU2114845C1 (en) 1998-07-10

Family

ID=10689943

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93054165A RU2114845C1 (en) 1991-02-13 1992-01-24 Imidazopyridine derivatives or their pharmaceutically acceptable salts, method of their synthesis and pharmaceutical composition showing antagonistic activity with respect to histamine h1

Country Status (29)

Country Link
US (1) US5358953A (en)
EP (1) EP0572425B1 (en)
JP (1) JP2506541B2 (en)
KR (1) KR970005302B1 (en)
CN (1) CN1040326C (en)
AT (1) ATE109482T1 (en)
AU (1) AU650322B2 (en)
BR (1) BR9205615A (en)
CA (1) CA2099381C (en)
CZ (1) CZ280504B6 (en)
DE (1) DE69200304T2 (en)
DK (1) DK0572425T3 (en)
EG (1) EG20085A (en)
ES (1) ES2059212T3 (en)
FI (1) FI933531A7 (en)
GB (1) GB9102997D0 (en)
HU (2) HUT65947A (en)
IE (1) IE65125B1 (en)
IL (1) IL100887A (en)
MX (1) MX9200589A (en)
MY (1) MY108437A (en)
NO (1) NO300592B1 (en)
NZ (1) NZ241597A (en)
PL (1) PL169304B1 (en)
RU (1) RU2114845C1 (en)
TW (1) TW227000B (en)
WO (1) WO1992014734A1 (en)
YU (1) YU48238B (en)
ZA (1) ZA921005B (en)

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ES2042421B1 (en) * 1992-05-22 1994-08-01 Uriach & Cia Sa J PROCEDURE FOR OBTAINING 8-CHLORINE-11- * 1 - * (5-METHYL-3-PIRIDIL) METHYL * -4-PIPERIDILIDEN * -6,11-DIHYDRO-5H-BENZO * 5,6 * CYCLOHEPTA * 1 , 2-B * PIRIDINE.
US5753671A (en) * 1994-08-10 1998-05-19 British Biotech Pharmaceuticals Limited Imidazopyridine derivatives as dual histamine (H1) and platelet activating factor (PAF) antagonists
ES2087038B1 (en) * 1994-11-07 1997-03-16 Uriach & Cia Sa J NEW PIPERIDINES WITH ANTAGONIST ACTIVITY OF THE PAF.
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
MX9707187A (en) * 1995-08-05 1997-11-29 British Biotech Pharm Imidazopyridine derivatives.
SE9801526D0 (en) * 1998-04-29 1998-04-29 Astra Ab New compounds
AU2001279313B2 (en) 2000-08-04 2007-03-01 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
ES2572454T3 (en) 2003-05-15 2016-05-31 Ampio Pharmaceuticals Inc Treatment of diseases mediated by T lymphocytes
US7687515B2 (en) * 2006-01-17 2010-03-30 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
CA2713293A1 (en) 2008-01-30 2009-08-06 Nippon Zoki Pharmaceutical Co., Ltd. Piperidine derivative
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc METHODS AND THERAPEUTIC COMPOUNDS
CN103619839B (en) * 2011-06-28 2016-06-01 福建省闽东力捷迅药业有限公司 Anti-allergic benzocycloheptathiophene derivatives
EA028343B1 (en) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Treatment of degenerative joint disease
AU2012323320B2 (en) 2011-10-10 2017-05-11 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP2771007B1 (en) * 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
MX2015010937A (en) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same.
WO2016028790A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN113880801A (en) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 A kind of tricyclic compound, its preparation method and its medical use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (en) * 1963-04-24
EP0404797B1 (en) * 1988-03-15 1995-02-01 G.D. Searle & Co. 1H/3H-[4-(N,N-CYCLOALKYL AND/OR BRANCHED-ALKYLCARBOXAMIDO) -BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
CA1341370C (en) * 1988-04-28 2002-06-18 John J. Powinski Fused polycyclic compounds, methods of manufacture, and their use as paf antagonists, antihistamines and/or antiinflammatory agents
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
US5114919A (en) * 1990-02-26 1992-05-19 Merck & Co., Inc. Adjuncts in cancer chemotherapy
ATE112567T1 (en) * 1990-05-09 1994-10-15 Pfizer IMIDAZO(4,5-C>PYRIDINE AS PAF ANTAGONIST.

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