RU2847925C1 - Double syringe and piston adapter - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine and can be used to separate blood samples in order to obtain plasma with a high platelet content for use in PRP or plasma therapy, as well as for the separation of other biological media (SVF). A double syringe for obtaining blood plasma contains a cylindrical syringe body of a larger diameter with a Luer-Lock screw connector located in its lower part and protrusions-stops in its upper part, inside which is placed a cylindrical syringe body of smaller diameter with a Luer-Lock screw connector at the bottom and protrusions-stops at the top. A piston with a rod attached to it is placed in the cylindrical syringe body of smaller diameter. A piston adapter is attached to one end of the Luer-Lock screw connector of the smaller diameter cylindrical syringe body. The piston adapter is made in the form of a cylinder with an outer diameter corresponding to the inner diameter of the larger diameter cylindrical syringe body and having a through central hole for collecting plasma from the larger diameter syringe. The adapter piston is a cylinder having a through central hole for collecting plasma from the larger diameter syringe of the above-described double syringe, a groove at the front for installing a sealing ring, and a neck at the rear, at the end of which there is a flange with symmetrically arranged lugs. In the rear part of the through central hole, there is a conical recess, the taper and depth of which correspond to the taper and depth of the conical tip of the smaller diameter syringe of the above-described double syringe, and the diameter of the rim corresponds to the diameter of the thread of the Luer-Lock screw connector of the smaller diameter syringe of the above-described double syringe.

EFFECT: simplification of the product design, reduction in the number of operations and time costs, increase in functionality and standardisation of medical syringes, reduction in cost.

2 cl, 5 dwg

Description

The invention relates to medicine and can be used for separating a blood sample to obtain plasma with a high platelet content and use in PRP or plasma therapy, as well as for separating other biological media (SVF).

PRP or plasma therapy is a method of restoration and rejuvenation of the body based on the introduction of the patient's own blood plasma, enriched with platelets and growth factors.

The method has been widely used in various fields: traumatology, gynecology, dentistry, ophthalmology, cosmetology, trichology.

The main feature of plasma therapy is that the “medicine”, prepared from the patient’s own blood, does not cause allergic reactions, is completely compatible with the body and is safe.

A medical product known as Glo PRP [http://online.zakon.kz/Document/?doc_id=31528882#pos=20;-366, accessed on 20.09.2016] is a syringe that includes a cylindrical body with a conical tip, a rod, a piston and a seal placed in the cylindrical body.

To separate the blood into its components, an anticoagulant is drawn into the syringe and blood is drawn using a venous catheterization kit. The syringe is connected to a special container tube. The plunger is removed from the syringe. The syringe is placed in a centrifuge and centrifuged. During centrifugation, the bulk of the red blood cell mass settles at the bottom of the syringe. To empty the red blood cell mass into the container tube, the plunger is inserted into the syringe and turned clockwise. The container tube containing the red blood cell mass and the plunger are then disconnected from the syringe, while the syringe is connected to the cap. Centrifugation is repeated, after which the syringe is released from the cap, connected to the plunger, and the syringe connector. The plunger is then lowered to fill the syringe for plasma injection.

This product allows for the separation of blood components and the production of blood plasma for injection, but it requires a large number of operations to connect and disconnect the syringe with the rod and piston, which entails an increase in the duration of the process of obtaining blood plasma for injection and can also lead to its loss.

The "Tube-Syringe for Obtaining Blood Plasma with a High Platelet Content" (RU174784) is known. The tube-syringe for obtaining blood plasma with a high platelet content comprises a cylindrical body with a conical tip located in the lower part of the cylindrical body and stop projections located in the upper part of the cylindrical body, as well as a piston located inside the cylindrical body, made in the form of a prefabricated rubber cuff.

Also known as "Medical Device for Obtaining Platelet-Rich Blood Plasma" (RU176780). The medical device for obtaining platelet-rich blood plasma comprises a cylindrical body with a conical tip, a piston formed by two rubber seals, a rod with a 1.25 mm thread running along its entire length, and a removable plug with an internal thread running 1.25 mm.

A common drawback of these devices is that after centrifugation, the plasma is withdrawn from the cylindrical body using an injection syringe. The conical tip must first be removed from the cap and connected to a special adapter. This increases the number of operations, the amount of medical equipment waste, and the risk of contamination due to human error.

To eliminate the disadvantages inherent in medical devices of the "Syringe-test tube" type, two-chamber syringes are used.

It is highly desirable to have a cost-effective, simple, self-contained dual-chamber syringe that isolates the components of a drug or blood. Furthermore, such a device eliminates the need for additional syringes, containers of medication, and diluents required for mixing individual components of a drug.

A two-chamber syringe EP3804788 is known, comprising: a syringe barrel having a front end, a rear end and at least one bypass projection located along the longitudinal extension of the syringe barrel; a finger gripping element connected to the rear end of the syringe barrel, wherein the finger gripping element comprises at least one projection extending radially inward from its inner surface; a plunger rod operatively connected to the finger gripping element; a guide track is formed on the plunger rod and comprises a portion of a helical track and a portion of a longitudinal track; and upon relative displacement of the plunger rod and the finger gripping element, at least one projection is guided along the guide track.

An improved dual-chamber syringe apparatus, WO9917820, is known. It represents an improved design of a dual-chamber syringe apparatus that can be used with commercially available syringe barrels, which are typically smooth syringes with a uniform cylindrical bore with an open end into which a plunger rod with a piston is inserted. In one embodiment, the piston rod is installed inside the barrel and carries a reservoir of diluent. The piston rod has a lower end with a piston or valve element.

The valve element allows the liquid diluent to flow through the valve element to the dry drug product when the piston rod moves from its retracted position to its extended position. The plunger rod and cylinder may have a correspondingly uniform cylindrical shape.

The valve element may be a flexible element, such as a flexible disk. At least one flow orifice extends through the circular end wall of the syringe, and the valve element closes the flow orifice when the piston rod moves from the retracted to the extended position.

The plunger rod is provided with a flow channel through which the diluent flows from the reservoir into the cylinder channel when the plunger rod moves from the retracted position to the extended position.

Many of the patents discussed above are highly complex designs consisting of numerous interconnected and telescopic parts, some of which require springs to operate. Another significant drawback is the limited applicability of the proposed syringes.

The ACT SOLOPHARM double syringe [https://actsolo.com/#!/tab/351341930-4] is known, which includes an outer cylinder with a tip for screwing on a needle, an inner cylinder that acts as a syringe and a plunger with a piston.

Venous blood is collected using a venous catheterization kit; the syringe can be used with an anticoagulant. After the blood is collected, the protective cap is installed, and the syringe is placed in a centrifuge and spun. During centrifugation, the bulk of the red blood cells settles at the bottom of the syringe. To collect the collected plasma from the outer cylinder into the inner cylinder of the syringe, press the stop on the outer cylinder while slowly pulling up on the plunger of the inner syringe barrel. Unscrew the inner syringe counterclockwise and attach the needle.

The disadvantage of the well-known double syringe is the complexity of the design, limited application, and high cost of manufacture.

The technical result consists in simplifying the design of the product, reducing the number of operations and time costs, increasing the functionality and unification of medical syringes, and reducing the cost.

The technical result achieved is that a double syringe for obtaining blood plasma, comprising a cylindrical syringe body of a larger diameter with a Luer-Lock screw connector located in its lower part and stop projections in its upper part, inside which a cylindrical syringe body of a smaller diameter is placed with a Luer-Lock screw connector in the lower part and stop projections in the upper part, wherein a piston with a rod attached to it is placed in the cylindrical syringe body of a smaller diameter, is characterized in that a piston-adapter is fixed at one end to the Luer-Lock screw connector of the cylindrical syringe body of a smaller diameter, made in the form of a cylinder with an outer diameter corresponding to the inner diameter of the cylindrical syringe body of a larger diameter, and having a through central hole for collecting plasma from a syringe of a larger diameter.

The adapter piston is a cylinder having a through central hole for collecting plasma from a syringe of a larger diameter of a double syringe, in the front part - a groove for installing a sealing ring, and in the rear part - a neck, on the end of which there is a flange with symmetrically located chamfers, while in the rear part of the through central hole there is a conical recess, the taper and depth of which corresponds to the taper and depth of the conical tip of the syringe of a smaller diameter of the double syringe, and the diameter of the flange corresponds to the diameter of the thread of the screw connector of the Luer-Lock type of syringe of a smaller diameter of the double syringe.

Fig. 1 shows the double syringe before use.

Fig. 2 shows a double syringe in the process of collecting blood to obtain blood plasma.

Fig. 3 shows a double syringe that functions as a syringe-test tube.

Fig. 4 shows the process of collecting blood plasma after centrifugation.

Fig. 5 shows the adapter piston.

The following units and parts are shown in the provided graphic materials:

1. Cylindrical syringe body with a larger diameter;

2. Large diameter Luer-Lock type syringe screw connector;

3. Larger diameter syringe stop protrusions;

4. Cylindrical syringe body of smaller diameter;

5. Smaller diameter Luer-Lock type syringe screw connector;

6. The syringe stop projections have a smaller diameter;

7. Piston adapter;

8. Smaller diameter syringe plunger;

9. Smaller diameter syringe plunger;

10. Needle;

11. Blood collected;

12. Front protective cap;

13. Rear protective cap;

14. Erythrocyte mass;

15. Blood plasma;

16. Cylinder;

17. Groove;

18. Neck;

19. Bead;

20. Lyska;

21. Central hole;

22. Conical recess.

Implementation of the invention.

The dual syringe and plunger adapter is designed to separate blood samples to obtain platelet-rich plasma for use in PRP or plasma therapy, as well as for separating other biological fluids (SVF).

It comprises a cylindrical syringe body 1 of a larger diameter with a Luer-Lock screw connector 2 located at its bottom and stop projections at its top, a piston adapter 7 secured at one end to the Luer-Lock screw connector of a cylindrical syringe body of a smaller diameter, the bottom of which has a Luer-Lock screw connector and the top of which has stop projections. A piston with a rod attached to it is housed within the cylindrical body of the smaller diameter syringe.

The adapter piston is shaped like a cylinder, with its diameter corresponding to the inner diameter of the larger-diameter cylindrical body of the syringe. To ensure tighter contact and prevent fluid spillage, an O-ring is installed in a groove at the front of the adapter piston. The rear of the adapter piston has a neck with a flange with symmetrically spaced flats. The flange diameter matches the thread diameter of a Luer-Lock screw connector, allowing the adapter piston to be screwed onto any syringe equipped with this connector. The adapter piston has a through-hole central opening for plasma extraction from a larger-diameter syringe. To ensure tighter contact and prevent leakage, a conical recess is provided at the rear, the taper and depth of which match the taper and depth of the conical tip of the smaller-diameter syringe.

Example (Fig. 1-5)

A double syringe includes a cylindrical body 1 of a syringe of a larger diameter with a screw connector 2 of the Luer-Lock type located in its lower part and stop projections 3 in its upper part. In the cylindrical body 1 of the syringe of a larger diameter, a cylindrical body 4 of a syringe of a smaller volume is placed, in the lower part of which there is a screw connector 5 of the Luer-Lock type, and in the upper part - stop projections 6. In the cylindrical body 4 of the syringe of a smaller diameter, a piston 8 is placed with a rod 9 attached to it. The role of the piston in the syringe of a larger diameter is performed by a piston-adapter 7, fixed at one end to the screw connector 5 of the Luer-Lock type of the cylindrical body 4 of the syringe of a smaller diameter.

The adapter piston 7 is designed as a cylinder 16, the cylinder's diameter corresponding to the inner diameter of the larger-diameter cylindrical body 1 of the syringe. The front of the adapter piston 7 has a groove 17 for a sealing ring, and the rear of the adapter piston 7 has a neck 18, on the end of which is a flange 19 with symmetrically located chamfers 20, the flange diameter corresponding to the thread diameter of the Luer-Lock screw connector. The piston has a through central bore 21 with a conical recess 22 at the rear.

The device works as follows.

The plunger-adapter 7 with flange 19 is screwed onto screw connector 5 of the Luer-Lock type of cylindrical body 4 of the smaller diameter syringe. The plunger-adapter 7 is inserted into cylindrical body 1 of the larger diameter syringe. The front protective cap 12 is removed and needle 10 is screwed onto the tip with screw connector 2 of the Luer-Lock type of cylindrical body 1 of the larger diameter syringe. The required volume of venous blood is withdrawn by lifting the plunger-adapter 7 by moving cylindrical body 4 of the smaller volume syringe by stop projections 6 (Fig. 2).

After drawing venous blood into the larger-diameter syringe, screw on the front protective cap 12. This positions the piston-adapter 7 in its uppermost position. Unscrew the cylindrical body 4 of the smaller-diameter syringe from the piston-adapter 7, and screw on the rear protective cap 13. The larger-diameter syringe thus functions as a test tube syringe (Fig. 3).

The syringe tube is placed in a centrifuge to obtain platelet-rich blood plasma and centrifuged. Centrifugation separates the blood, settling the red blood cell mass 14 in the lower portion of the cylindrical body 1, while the blood plasma 15, intended for injection, settles between the red blood cell mass 14 and the piston adapter 7.

After centrifugation is complete, the resulting plasma is collected from the cylindrical body 1 of the larger diameter syringe using an injection syringe, after first screwing the cylindrical body 4 of the smaller volume syringe onto the adapter piston 7. The extraction of plasma is facilitated by the vacuum formed when the piston 8 of the smaller diameter syringe is raised, as well as the piston pressure created by the adapter piston 7 when it moves downwards (Fig. 4).

Thus, using standard syringes with a piston adapter allows them to be used as syringe-tubes, as well as for various medical procedures in various fields: traumatology, gynecology, dentistry, ophthalmology, cosmetology, and trichology. Moreover, with different piston adapter sizes, a matching pair can be selected from two syringes of different diameters.

Claims (2)

1. A double syringe for obtaining blood plasma, comprising a cylindrical body of a syringe of a larger diameter with a Luer-Lock screw connector located in its lower part and stop projections in the upper part, inside which a cylindrical body of a syringe of a smaller diameter is placed with a Luer-Lock screw connector in the lower part and stop projections in the upper part, wherein a piston with a rod attached to it is placed in the cylindrical body of the syringe of the smaller diameter, characterized in that a piston-adapter is fixed at one end to the Luer-Lock screw connector of the cylindrical body of the syringe of the smaller diameter, made in the form of a cylinder with an outer diameter corresponding to the inner diameter of the cylindrical body of the syringe of the larger diameter, and having a through central hole for collecting plasma from the syringe of the larger diameter. 2. A piston adapter, characterized in that it is a cylinder having a through central opening for collecting plasma from a syringe of a larger diameter of a double syringe according to claim 1, in the front part - a groove for installing a sealing ring, and in the rear part - a neck, on the end of which there is a flange with symmetrically located chamfers, while in the rear part of the through central opening there is a conical recess, the taper and depth of which corresponds to the taper and depth of the conical tip of the syringe of a smaller diameter of the double syringe according to claim 1, and the diameter of the flange corresponds to the diameter of the thread of the screw connector of the Luer-Lock type of the syringe of a smaller diameter of the double syringe according to claim 1.