RU2519766C1 - Method of treating gastritis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: 1 glass of an aqueous infusion of swallowwort herb or garden sage herb is orally administered daily on an empty stomach in the morning 1-2 hours before meals for 10 days. That is followed by administering an aqueous infusion of camomile blossom daily on an empty stomach for 10 days also. For the further 10 days, an aqueous infusion of plantain leaves is administered daily on an empty stomach; the infusions of chamomile blossom and plantain leaves are taken in a dose of 1/2 glass 3-5 times a day 30 minutes before meals. Administering the aqueous infusions is combined with orally daily administering an infusion of Saint-John's-wort for 30 days orally in a dose of 50 drops per 1/2 glass of water 3 times a day 30 minutes before meals. After that, the liquid biocomplex Normoflorin is orally administered 3 times a day daily for 4 weeks 30 minutes before meals in age doses. Normoflorin L is used for the first and second administration, and Normoflorin B - for the third one.

EFFECT: effective treatment ensured by Helicobacter pylori growth inhibition, antiseptic, anti-inflammatory herb action improving gastric mucosa trophism in a combination with the positive effect on the nervous system.

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Description

The invention relates to medicine, in particular to gastroenterology, and can be used to treat chronic gastritis in adults and children.

A known method of treating chronic gastritis and peptic ulcer of the duodenum, characterized in that the patient is orally administered a solution of bactisporin 3 doses 3 times a day before meals for the first 3 days, then 2 doses 2 times for 7 days. The method allows to act on Helicobacter pylori and stimulate the regeneration of the gastric and duodenal mucosa, prevents the development of dysbiosis [patent RU 2187318, 2002].

A known method of treating periodontitis, combined with peptic ulcer of the stomach and duodenum, including applications on periodontal tissues and ingestion of 40% alcohol tincture of the medicinal collection, consisting of calendula flowers, pharmacy chamomile flowers, bird mountain grass, taken in equal mass parts, with dissolved in it with ecdysterone to obtain 0.01% of its solution [patent RU 2205653, 2003].

A known method of treating chronic H. pylori-associated gastritis by monotherapy with the probiotic "Laminolact" in a dose of 3 tablets 3 times a day for 1 month. The method provides the elimination of Helicobacter pylori against the background of activation of a local immune response in the gastric mucosa by affecting the microflora and the immune system of the colon [patent RU 2246957, 2005].

A known method of treating erosive and ulcerative lesions of the gastric mucosa, characterized in that prescribed esomeprazole, a dose of 20 mg 1 time per day before meals. Additionally, a mixture of a lyophilized culture of Lactobacterium plantarum 8P-A3 at a dose of 4 × 10 ⁹ in 1 ml of suspension and almagel in a ratio of 1: 1 is prescribed. The mixture is prepared before use, a dose of 25 ml 3 times a day 30-40 minutes after a meal, the course of treatment is 21 days [patent RU 2449787, 05/10/2012].

The prototype of the invention is a method of treating Helicobacter pylori associated chronic peptic ulcer of the stomach and duodenum, which consists in conducting drug therapy, which includes oral administration of bismuth subcitrate, omeprazole, amoxicillin and furazolidone, an immunomodulator of microbial origin and lactobacterium complex. As an immunomodulator of microbial origin, ribomunil is administered in a dose of 750 mg. In the first month once a day in the morning on an empty stomach in the first 4 days of each week. In the next 2 months - the first 4 days of each month. A complex of bifidobacteria and lactobacilli (LB complex) of 5 ml, within 25 days from the first day of taking antibacterial drugs. Reception 30 minutes before a meal. The content of microbial bodies in 1 ml of the complex 10 ¹⁰ -10 ¹² [patent RU 2416408, 2011]. The disadvantages of this method are the large drug load and functional overload of the liver and kidneys associated with drug withdrawal, as well as toxic effects on the gastrointestinal tract, central nervous system, musculoskeletal, genitourinary, hematopoietic systems, etc., the use of antibiotics causes the resistance of microorganisms to them, the inability of the latter penetrate through the protective layer of gastric mucus, which leads to the elimination of normal microflora and the preservation of pathogenic (H. Pylori colonizes under a layer of mucus), which causes dysbiosis , Immunodeficiency and reducing colonization resistance, preservation of pain and dyspeptic phenomena ( "posleeradikatsionny syndrome"), the reversal of the gastric mucosa are at issue, used drugs can not be used for children, but this treatment is the prototype of pregnancy may be a teratogen.

The technical result when using the invention is the prevention of side effects of drugs, the therapeutic effect of herbal infusions on the body as a whole system, on the gastric mucosa and the improvement of the functional state of the stomach, regulation of the central nervous system, gastrointestinal tract and urinary system, natural stimulation of biological processes of immunity, reduction of regeneration time mucous membrane with minimal risk of metaplasia and carcinogenesis, the possibility of use in pediatrics and patients with the disease E kidney and liver.

The specified technical result is achieved by the fact that in the method of treating gastritis, which includes exposure to pathogenic microflora and colonization of the mucous membrane of the gastrointestinal tract with lactobacilli and bifidobacteria, according to the invention, water is orally administered daily on an empty stomach every day on an empty stomach 1-2 hours before meals. infusion of large celandine herb or medicinal sage herb in a dose of 1 glass for 10 days, then for 10 days daily on an empty stomach, an aqueous infusion of chamomile flowers, for the next 10 days daily empty stomach water infusion of plantain leaves, and infusions of chamomile flowers and plantain leaves are administered in a dose of 1/2 cup 3-5 times a day 30 minutes before meals, at the same time as water infusions for 30 days, St. John's wort tincture is administered in a dose of 50 drops 1/2 cup water 3 times a day 30 minutes before meals, after which, to inhibit the growth of Helicobacter pylori and increase the colonization potential of the mucous membrane of the gastrointestinal tract daily, for 4 weeks 30 minutes before meals 3 times a day, the solution is orally But rmoflorin in age dosages, while Normoflorin L is used in the first and second doses of the drug, and Normoflorin B. in the third.

The proposed method for the treatment of gastritis is as follows. Against the background of maintaining a healthy lifestyle (observing the regime of the day, including avoiding stressful situations); rational and wholesome (balanced, benign) nutrition; the maximum limit if it is possible to stop, drink alcohol, smoke tobacco, take synthetic medications that cause changes in the gastric mucosa, sanitation of the oral cavity, to restore the functions of the gastrointestinal tract, urinary system and affect pathogenic microflora daily on an empty stomach in the morning, 1-2 hours before meals , at a time, in a dose of one glass (one teaspoon of dry grass without top in a glass of boiling water), an aqueous infusion of celandine herb or medicinal sage herb is orally administered (one teaspoon of dry grass per st boiling water) for 10 days, then also for 10 days daily on an empty stomach water infusion of chamomile flowers, for the next 10 days (optionally the next 40 days) daily fasting water infusion of plantain leaves, with infusions of chamomile flowers and plantain leaves a dose of 1/2 cup (one tablespoon of dry grass per cup of boiling water) 3-5 times a day 30 minutes before meals, at the same time to regulate the central nervous system with water infusions for 30 days, St. John's wort tincture (50 g of chopped dry grass) is orally administered daily hypericum on melt in 0.5 liters of 40% or 50% alcohol for 4 weeks) at a dose of 50 drops per 1/2 cup of water 3 times a day 30 minutes before meals, after which to inhibit the growth of Helicobacter pylori and increase the colonization potential of the gastrointestinal mucosa daily for 4 weeks, Normoflorin liquid biocomplex is orally administered 3 times a day in age dosages, with Normoflorin L used in the first and second doses of the drug, and Normoflorin B in the third dose: taken orally 30 minutes before meals, shake immediately before use, dilute 1: 3 any food liquid not higher than 37 ° C.

In the proposed method of treatment there is no toxic and immunosuppressive effect of pharmaceuticals obtained synthetically, medicinal herbs and lacto- and bifidobacteria of completely natural origin are used. Does not require preparation in pharmacy conditions.

The causes of chronic gastritis are manifold and often combined, most often inflammation of the gastric mucosa is a consequence of a violation of the functions of a number of organs and systems. For the full treatment of gastritis, it is important to restore the functioning of the nervous system, urinary system, gastrointestinal tract at the systemic, histological and cellular levels.

Herbal preparations are easier to absorb and tolerated by the body (a person is genetically predisposed for a period of centuries of herbal treatment), have a wide therapeutic range and many therapeutic effects, can accumulate in the body, which means that they have a therapeutic effect for a long time, and probiotics, in addition to restoring the natural microbial balance, have bacteriostatic and immunomodulating effects.

The therapeutic effect is achieved due to:

1. Regulation of the nervous system (Hypericum perforatum).

2. Restoring the function of all the organs of the gastrointestinal tract (the full functioning of the glands, which means digestion, the ingestion of nutrients, the movement of the food lump into the intestines, etc.) and the urinary system (in order to improve cellular metabolism, remove toxins) - all herbs used;

3. Elimination of symptoms of chronic inflammation of the gastric mucosa, intestines with infusions of herbs:

1) disinfectant, antiseptic, vasoconstrictor action (large celandine);

2) an anesthetic that reduces inflammation (chamomile);

3) promotes the regeneration, improvement of trophism and mucus formation of the epithelium of the gastric mucosa (large plantain);

4) the impact on pathogenic microflora and the restoration of the colonization potential of the gastrointestinal mucosa (stomach, oral cavity, intestines) with normal microflora (lactobacillus and bifidobacteria).

Thus, the active components of St. John's wort herb have a beneficial effect on the nervous system, celandine herbs contribute to the removal of pathogenic microflora, including Helicobacter pylori. If it is impossible or unwilling to use large celandine, you can replace it with medicinal sage grass, which also has bactericidal properties. Chamomile infusion provides an analgesic effect and reduces inflammation, plantain infusion contributes to the epithelization and normalization of the activity of the epithelium of the gastric mucosa. On the restored gastrointestinal mucosa, favorable conditions are created for colonization with normal microflora.

It is known that often gastritis, or their exacerbations, are psychogenic (somatoform) disorders, and peptic ulcer is a psychosomatic disease (included in the "Chicago Seven"). Hans Selye in his work on stress noted that erosion is a consequence of the action of stress on the body. Thus, it is important to restore the central nervous system (antidepressant and soothing, restore the balance of the sympathetic and parasympathetic nervous systems), then the nervous regulation of the gastrointestinal tract (motility of all organs - peristalsis and elimination of spastic phenomena), regulation of the functions of the digestive glands (secretion of all secrets in the stomach, liver , pancreas, intestines), improvement of blood circulation and microcirculation, neurological trophism, transmission of impulses, reflexes, therefore, we use alcohol tincture of St. John's wort perforated nnoy and infusions of selected herbs.

Hypericum perforatum has a calming, anti-inflammatory, antitumor, improves blood circulation, antiseptic, fungicidal, analgesic, astringent, wound healing, anthelmintic, antispasmodic, choleretic, diuretic effect. The most important pharmacological effect of St. John's wort is the effect on the level of serotonin and melatonin in the central nervous system, the regulation of noradrenergic mediator systems, which determines the antidepressant properties of the plant. Hypericin, an essential substance of hypericum (soluble in alcohol), has a positive effect on the nervous system (Gelarium), without side effects, unlike antidepressants (pharmaceuticals). The same substance has antimicrobial (including against Staphylococcus aureus), antiviral effect, improves the glycogen-forming function of the liver, helps reduce blood sugar, has anti-inflammatory and general strengthening effect. Restores capillaries due to vitamin P, and ascorbic acid. Vitamins and provitamins (A, E, PP) restore the metabolic processes of the cell, affect the structure and function of the epithelium.

The use of large celandine in medicine is based on its antispasmodic, hypotensive, antibacterial, fungicidal, antiviral, choleretic, anthelminthic, diuretic, cytostatic, cytotoxic (actions to inhibit the growth of malignant tumors) actions, to reduce the reactivity of the autonomic nervous system. A positive property of celandine is that it contributes to an increase in the content of hemoglobin, red blood cells. Helicobacter pylori is able to absorb alimentary iron to maintain its growth, which leads to iron deficiency anemia. The dose of celandine grass used is not toxic for oral use.

Chamomile flowers are known for antispasmodic, anti-inflammatory, analgesic, sedative, emollient, diuretic, choleretic, astringent, hemostatic, mild laxative properties. Chamazulen and azulene enhance regenerative processes, weaken allergic reactions, have a local anesthetic effect, inhibiting lipid peroxidation, and have an antioxidant effect.

The active substances of large plantain inhibit the growth of pathogenic microflora, have a sedative, antispasmodic, hypotensive, antiallergic, antitumor effect. Hemostatic properties are manifested due to factor T, which improves blood coagulation.

Flavanoids contained in herbs eliminate dyspeptic symptoms in the gastrointestinal tract, have an antispasmodic effect on the smooth muscles of the bile ducts, intestines, blood vessels and ureters, anti-inflammatory, wound healing effect. Alkaloids have an exciting effect, enhance the tone of smooth muscles, stimulate intestinal motility, bile secretion, the release of pancreatic juice (which is important for timely emptying of the stomach), as well as the secretion of saliva, reduce the proteolytic activity of pepsin, also have a pronounced, morphine-like, anesthetic pressure, normal heartbeat.

The antacid properties of infusions are due to two components: increased secretion of mucus and enveloping, tanning properties. The sedative properties of chamomile contribute to a decrease in the secretion of gastric juice under stress and a change in its chemical composition to a less aggressive one.

The wound healing effect characteristic of herbal infusions is achieved by tanning erosive zones, restoring the functions of the epithelium (also the work of ciliated cilia), vasostimulating granulations and preventing petechial bleeding on the macerated surface.

The active substances of herbs have a diuretic and urinary disinfectant effect, which is important for removing toxins accumulated as a result of a violation of the gastrointestinal tract and improving metabolic processes in the body.

The antioxidant activity of herbal infusions, Normoflorins and the pronounced antihypoxic effect of plantain are important in case of poor blood supply to the gastric mucosa (tissue hypoxia), and in peptic ulcer disease not associated with Helicobacter pylori (“old sores”).

The advantage is also the total effect of vasoconstrictive, anti-inflammatory, antitoxic, vascular wall strengthening effects of infusions and effects on the chemical composition of mucus of lacto- and bifidobacteria, which reduce the concentration of inflammatory mediators. Infusions of medicinal plants have a stimulating effect on the biological activity of lactobacilli, increasing specific, antagonistic, adhesive, lactobacillus activity, antibiotic resistance and resistance to biological fluids of the gastrointestinal tract of the macroorganism. The metabolism products of flavonoids by lactobacilli have high antibacterial and fungistatic activity. In addition, lactobacilli and bifidobacteria are able to act on various parts of the immune system, regulating non-specific and specific cellular and humoral immunity, which ensures the effectiveness of treatment in the focus of inflammation and macroorganism. Due to the release of antibiotic-like substances - bacteriocins, lactic acid, a protective biofilm is created on the gastrointestinal mucosa, protecting against viruses, bacteria, fungi, protozoa, the presence of the colonization potential is preserved. Lactobacilli can even colonize the stomach, which is of great importance for their antagonistic effect against H. pylori. In the genome of L. acidophilus (Normoflorin L), resistance to an acidic habitat is encoded. Adapted to the extreme conditions of L. acidophilus, it can help inhibit the growth and elimination of H. pylori in the stomach. Bacteria Normoflorins L and B are in a biologically active state, begin to work from the first minutes of getting on the mucosa, stimulate the phagocytic activity of neutrophils, macrophages, synthesis of immunoglobulin A and participate in the formation of interferons, are able to suppress the production of Ig E, that is, they are a natural immunomodulator and reduce sensitization organism (as a result of sensitization of H. pylori, an abnormally high level of Ig E is formed) Domestic product, antagonistically active in relation to the conditionally pathogenic, pathogenic flora of our region.

Treatment can be carried out on an outpatient basis - it allows you to relieve inflammation, achieve rapid mucosal regeneration and long-term remission of the disease. Also, the treatment of gastritis with this method prevents the development of complications of the disease, being a prevention of erosive gastritis, gastric ulcer, intestinal metaplasia and dysplasia, polyps, gastric bleeding, stomach cancer, anemia, vitamin deficiency, intestinal dysbiosis.

This method treated 18 patients. In all cases, the specified technical result was achieved.

The invention is illustrated by the following example.

EZF, born in 1972, after stress complained of: a feeling of heaviness and discomfort in the epigastric region, belching, bloating, rumbling, unstable stool, lack of appetite. Intolerance to antibacterial drugs (“urticaria”). FGS results: erosive gastritis, duodenal ulcer.

Scheduled compliance with the regime of the day, including avoidance of stressful situations; rational and nutritious nutrition; treatment was prescribed: to restore the functions of the gastrointestinal tract, urinary system and affect the pathogenic microflora daily on an empty stomach in the morning, 1-2 hours before meals, once, in a dose of one glass (one teaspoon of dry grass without top in a glass of boiling water), orally administer an aqueous infusion of grass large celandine for 10 days, then also for 10 days daily on an empty stomach water infusion of chamomile flowers, for the next 10 days daily on an empty stomach water infusion of plantain leaves, and infusions of chamomile flowers and plantain leaves in a dose of 1/2 cup (one tablespoon of dry grass per glass of boiling water) 3-5 times a day 30 minutes before meals, at the same time to regulate the performance of St. John's wort tincture (50 g crushed daily) to regulate the nervous system with water infusions for 30 days St. John's wort dry grass is infused in 0.5 liters of 40% or 50% alcohol for 4 weeks) at a dose of 50 drops per 1/2 cup of water 3 times a day 30 minutes before meals, after which to inhibit the growth of Helicobacter pylori and increase the colonization potential of the mucosa gastrointestinal tract daily for 4 weeks orally 3 times a day ki liquid Normoflorin biocomplex in age dosages, while in the first and second doses of the drug Normoflorin L is used, and in the third Normoflorin B: taken orally 30 minutes before meals.

Within 2 weeks, irritability, a feeling of discomfort and heaviness in the epigastric region, and bloating decreased. By the end of treatment, all symptoms stopped, no relapses were observed during the year. At the control endoscopy after 3 months: healing of erosion of the stomach and peptic ulcer on the mucous membrane of the duodenal bulb.

Claims (1)

A method of treating gastritis, including exposure to pathogenic microflora and colonization of the gastrointestinal mucosa by lactobacilli and bifidobacteria, characterized in that to infect pathogenic microflora daily on an empty stomach daily, 1-2 hours before a meal, an aqueous infusion of celandine grass or large sage herbs is orally administered a dose of 1 glass for 10 days, then for 10 days daily on an empty stomach water infusion of chamomile flowers, for the next 10 days daily on an empty stomach water infusion of plantain leaves, and infusions of rum flowers psyllium leaves and leaves are administered in a dose of 1/2 cup 3-5 times a day 30 minutes before meals, at the same time as water infusions for 30 days, St. John's wort tincture is administered orally at a dose of 50 drops per 1/2 cup of water 3 times a day 30 minutes before meals, after which, to inhibit the growth of Helicobacter pylori and increase the colonization potential of the mucous membrane of the gastrointestinal tract daily for 4 weeks 30 minutes before meals, 3 times a day, Normoflorin solution is orally administered at age dosages, while the first and the second dose of the drug and polzujut Normoflorin A, and the third Normoflorin B.