RU2423998C1 - Disinfectant "mixamin" - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfectants used in medicine, veterinary science, food industry, household, and intended for disinfecting of various objects. The disinfectant "Mixamin" contains mixed quaternary ammonium salts (QAS) - alkyldimethylbenzylammonium chloride (7.5 %) and didecyldimethylammonium chloride (2.5 %), dodecyldipropylenetriamine (3.0 %), and also tetrasodium salt of ethylene diamine of tetraacetic acid (5.0 %), propylene glycol (7.5 %) and water (to 100 %).

EFFECT: invention provides intensified antimicrobial activity, reduced toxicity, prolonged shelf life of the disinfectant up to 5 years, and of its working solutions up to 28 days.

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Description

The invention relates to disinfectants used in medicine, veterinary medicine, food industry, public utilities, catering, laboratories of any profile and is intended for disinfection of various objects.

The closest in technical essence to the present invention is a disinfectant selected as a prototype, containing a mixture of quaternary ammonium salts, dodecyldipropylene triamine and water (http://www.infodez.ru/production/laina-med consisting of alkyl dimethylbenzylammonium chloride and didecyldimethylammonium chloride) -instr-080606.doc. 2008).

The disadvantages of the prototype is the low antimicrobial activity of the agent with a decrease in the concentration of working solutions, increased toxicity and insufficient shelf life of the agent and its working solutions, as well as the lack of antimicrobial activity against viruses, SARS, bird flu H5N1, swine influenza, human influenza, the causative agent of tularemia and anaerobic bacteria.

The technical result achieved by the invention consists in enhancing antimicrobial activity by improving the physicochemical properties of the agent by reducing the concentration of working solutions by two or more times, reducing toxicity, increasing the shelf life of the disinfectant to 5 years, and its working solutions to 28 days, as well as in providing antimicrobial activity against SARS viruses, H5N1 bird flu, swine flu, human flu, tularemia and anaerobic ba terium with mandatory preservation of antimicrobial activity against pathogens of nosocomial infections, tuberculosis, especially dangerous infections (OOIs) - plague, cholera, tularemia, anthrax, including spores, enteric and parenteral hepatitis viruses (including hepatitis A, B and C), HIV, poliomyelitis, adenoviruses, herpes, etc., fungi of the genus Candida, Trichophyton and Aspergillus.

The technical result is achieved by the fact that a disinfectant containing a mixture of quaternary ammonium salts, dodecyldipropylenetriamine and water consisting of alkyldimethylbenzylammonium chloride and didecyldimethylammonium chloride additionally contains a tetrasodium salt of ethylenediamine tetraacetic acid, and the following are used in the amount of water: share,%: alkyldimethylbenzylammonium chloride 7.5, didecyldimethylammonium chloride 2.5, dod tsildipropilentriamin 3.0 tetrasodium salt of ethylenediamine tetraacetic acid 5.0 Propylene Glycol 7.5 and water to 100.

It is the choice of components at the above values that can enhance antimicrobial activity while reducing the concentration of working solutions by two or more times, reduce the toxicity of the disinfectant, increase the shelf life of the disinfectant up to 5 years, and its working solutions up to 28 days, and also provide antimicrobial activity in against atypical pneumonia viruses (SARS), bird flu H5N1, swine flu, human flu, tularemia and anaerobic bacteria, which is confirmed by the state register walkie-talkie No. 77.99.1.2.U. 2829.4.10, test report No. 650-363-10 of 05.31.10, Certificate of Conformity No. РОСС RU. AY12. V20925 and a letter from LLC SPC Rodemos.

Disinfectant “Mixamin” is a clear liquid from colorless to yellow with a weak specific odor, consisting of active ingredients (AI) alkyl dimethylbenzylammonium chloride 7.5%, didecyldimethylammonium chloride 2.5%, forming a mixture of quaternary ammonium compounds (HOUR), the active substance dodecyldipropylenetriamine 3.0%, from synergists - tetrasodium salt of ethylenediamine tetraacetic acid 5.0% and propylene glycol 7.5%, which increase the activity of the above active substances, and from water up to 100%.

This disinfectant retains its properties after freezing and subsequent thawing. Solutions do not spoil the processed surfaces, do not discolor fabrics, do not cause corrosion of metals.

This combination of components allows you to provide antimicrobial activity against gram-negative and gram-positive bacteria (including pathogens of nosocomial infections, tuberculosis, anaerobic, especially dangerous infections (OOI) - plague, cholera, tularemia, anthrax, including spores), viruses (including viruses of enteric and parenteral hepatitis (including hepatitis A, B and C), HIV, poliomyelitis, adenoviruses, SARS viruses, H5N1 avian influenza, HINI swine flu, human flu, herpes, etc.), fungi of the genus Kandy a, Trichophyton Aspergillus and possesses detergent properties.

The use of HOUR and amines (dodecyldipropylenetriamine) as a DV complex in combination with synergists makes it possible to use the agent in relation to anthrax spores (heated solutions of “Mixamin” to 50 ° С). In addition, during the study of the disinfectant activity of the Miksamin agent on test surfaces and test objects contaminated with bacteria and spores of vaccine and avirulent strains of especially dangerous infections, anaerobic bacteria and molds, it was found that the working solutions of the agent have pronounced bactericidal properties in relation to causative agents of especially dangerous infections, anaerobic infections, fungicidal properties in relation to molds and sporocidal activity.

Disinfectant working solutions are prepared in containers from any material without damage by adding Mixamin to room temperature drinking water in accordance with the calculations shown in table 1.

Table 1 shows the preparation of disinfectant working solutions.

Table 1 The concentration of the working solution,% The amount of funds and water (ml) required for the preparation of working solution in volume: on the drug by Far East 1 liter 10 l HOUR Triamine means water means water 0.05 0.005 0.0015 0.5 999.5 5 9995 0.1 0.01 0.003 one 999 10 9990 0.2 0.02 0.006 2 998 twenty 9980 0.25 0,025 0.0075 2.5 997.5 25 9975 0.3 0,03 0.009 3 997 thirty 9970 0.5 0.05 0.015 5 995 fifty 9950 1,0 0.1 0,03 10 990 one hundred 9900 1,5 0.15 0,045 fifteen 985 150 9850 2.0 0.2 0.06 twenty 980 200 9800 2.5 0.25 0,075 25 975 250 9750 3.0 0.3 0.09 thirty 970 300 9700 4.0 0.4 0.12 40 960 400 9600 5,0 0.5 0.15 fifty 950 500 9500 7.0 0.7 0.21 70 930 700 9300

Disinfection of objects is carried out by means of wiping, irrigation, immersion, soaking.

Table 2 shows the modes of disinfection of various objects with “Mixamin” solutions for viral infections (including enteric and parenteral hepatitis viruses (including hepatitis A, B and C), HIV, poliomyelitis, adenoviruses, “SARS” viruses (SARS), bird flu H5N1, swine flu, human flu, herpes, etc.) etiology.

table 2 Disinfection objects The concentration of the working solution,% (for the drug) Disinfection time, min The method of disinfection Indoor surfaces, hard furniture, furnishings, exterior surfaces of appliances, apparatus, ambulance 0.3 60 Rubbing or irrigation 0.5 thirty Sanitary equipment 0.3 60 Rubbing or irrigation 0.5 thirty Dishes without food residues (including disposable) 0.3 thirty Immersion 0.5 fifteen Dishes with leftover food (including disposable) 0.3 60 Immersion 0.5 thirty Glassware; items for washing dishes 0.3 60 Immersion 0.5 thirty Uncontaminated linen 0.3 90 Soak 0.5 60 Lingerie contaminated with biological substrates 0.3 120 Soak 0.5 90 1,0 60 Harvesting material, inventory 0.3 120 Soak 0.5 90 1,0 60 Toys, sports equipment 0.3 60 Dipping, rubbing 0.5 thirty Patient care items made of metals, rubbers, plastics, glass 0.5 60 Wipe, dive 1,0 thirty

Table 3 shows the modes of disinfection of various objects with solutions of “Mixamin” for especially dangerous infections of bacterial etiology (plague, cholera, tularemia).

Table 3 Disinfection object The concentration of the solution for the drug,% Disinfection time, min The method of disinfection Indoor surfaces, hard furniture, surfaces of devices, apparatus 0.05
0.1 60
thirty Rubbing or irrigation Sanitary equipment 0.05
0.1 60
thirty Irrigation The dishes are clean (no food residue) 0.05 60 Immersion Dishes with leftover food 0.2 120 Immersion Laboratory glassware 0.2 60 Immersion Excreted laundry 0.2 120 Soak Care items, toys 0.1 60 Immersion Medical devices made of corrosion-resistant metals, glass, plastics, rubber 0.1 60 Dipping or soaking Medical waste 0.2 120 Soak Cleaning equipment 0.2 120 Soak

Table 4 shows the modes of disinfection of various objects with solutions of “Mixamin” during contamination with anaerobic bacteria.

Table 4 Disinfection object The concentration of the solution for the drug,% Disinfection time, min The method of disinfection Indoor surfaces, hard furniture, surfaces of devices, appliances 2.0
5,0 120
60 Rubbing, irrigation The dishes are clean 2.0 120 Immersion Dishes with leftover food 5,0 120 Immersion Laboratory glassware 5,0 120 Immersion Excreted laundry 5,0 120 Soak Medical products from corrosion-resistant metals, glass, rubber, plastics 2.0 120 Immersion Patient care items, toys 2.0 120 Immersion Sanitary equipment, rubber mats 2.0
5,0 120
60 Irrigation Medical waste 5,0 120 Soak Harvesting materials 5,0 120 Soak

According to the parameters of acute toxicity, this disinfectant, when introduced into the stomach, belongs to the 3rd class of moderately hazardous substances, when applied to the skin - to the 4th class of low-hazard substances according to the classification GOST 12.1.007-76, and when introduced into the peritoneum - to the 4th class of low toxic substances. In case of inhalation exposure in the form of vapors according to the degree of volatility (C ₂₀ ), the agent is also low-hazard. The product is irritating in contact with the skin and conjunctival eye; does not have sensitizing activity. Working solutions in a concentration of less than 1.5% with a single exposure do not have a local irritant effect on contact with the skin and do not cause eye irritation in concentrations below 0.5%.

The disinfectant is intended for disinfection and washing of surfaces in rooms, hard furniture, surfaces of apparatuses, devices, sanitary equipment, tableware, laboratory, pharmacy (including single use), linen, toys, patient care items, cleaning equipment, rubber mats, shoes made of plastics, rubber and other synthetic materials for infections of bacterial (including tuberculosis), viral and fungal (candidiasis, dermatophytosis) etiology during preventive , current and final disinfection in medical and prophylactic (including neonatology departments, obstetric care, wards of newborns, intensive care and resuscitation departments, traumatology, burn departments, departments of bone marrow transplantation, hematology, etc.) and child care facilities, obstetric hospitals, physiotherapy departments, pharmacies, clinical, microbiological, diagnostic, bacteriological, virological and other laboratories, treatment rooms, points and stations erelivaniya and blood sampling on sanitary transport, infectious foci; for disinfection of medical waste of groups B and C from textile (cotton swabs, used dressings, disposable underwear and bedding, staff clothing, masks, etc.) and other materials (utensils, including laboratory single-use items, single-use medical devices ); for disinfection, including combined with pre-sterilization cleaning of medical devices (including surgical and dental instruments, including rotating, rigid and flexible endoscopes and instruments for them) for infections of bacterial (including tuberculosis), viral and fungal (candidiasis and dermatophytosis) etiology; for pre-sterilization cleaning of medical devices from various materials (including surgical and dental instruments) manually; for preliminary, pre-sterilization or final cleaning of endoscopes manually; preliminary and pre-sterilization cleaning of instruments for endoscopes manually; for carrying out general cleanups in hospitals, child care facilities (including neonatology departments); for disinfection of incubators for premature babies; for disinfection of vehicles, including salons of ambulance; for disinfecting surfaces in rooms, hard furniture, sanitary equipment, surfaces of devices and apparatus, medical devices, linen, dishes, patient care items, toys, cleaning equipment, medical waste in the foci of especially dangerous infections; for disinfecting surfaces in rooms, hard furniture, the outer surfaces of devices and apparatuses during preventive disinfection at the pharmaceutical and biotechnological industries for the production of non-sterile medicines in rooms of cleanliness classes C and D; for disinfection of objects affected by molds of the genus Aspergillus.

Claims (1)

A disinfectant containing alkyldimethylbenzylammonium chloride and didecyldimethylammonium chloride, a mixture of quaternary ammonium salts, dodecyldipropylenetriamine and water, characterized in that it additionally contains tetrasodium salt of ethylenediamine tetraacetic acid, with the following components being used, while the amount of water is not reduced. . %:
Alkyldimethylbenzylammonium chloride 7.5 Didecyldimethylammonium chloride 2,5 Dodecyldipropylene triamine 3.0 Ethylenediamine tetraacetic acid tetrasodium salt 5,0 Propylene glycol 7.5 Water Up to 100