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RU2495031C2 - Производные 5-(4-метансульфонилфенил)тиазола для лечения острых и хронических воспалительных заболеваний - Google Patents

Производные 5-(4-метансульфонилфенил)тиазола для лечения острых и хронических воспалительных заболеваний Download PDF

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RU2495031C2
RU2495031C2 RU2011101439/04A RU2011101439A RU2495031C2 RU 2495031 C2 RU2495031 C2 RU 2495031C2 RU 2011101439/04 A RU2011101439/04 A RU 2011101439/04A RU 2011101439 A RU2011101439 A RU 2011101439A RU 2495031 C2 RU2495031 C2 RU 2495031C2
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tnf
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РОЙО Виктор РУБИО
ЛА ЭРА МАРТИНЕС Антонио ДЕ
ДЕ МОН СОТО Мельчор АЛЬВАРЕС
МУНЬОС Ана МУНЬОС
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Фаэс Фарма, С.А.
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Priority claimed from EP08380177A external-priority patent/EP2135864A1/en
Priority claimed from US12/139,661 external-priority patent/US7781594B2/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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RU2011101439/04A 2008-06-16 2009-06-15 Производные 5-(4-метансульфонилфенил)тиазола для лечения острых и хронических воспалительных заболеваний RU2495031C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08380177.9 2008-06-16
EP08380177A EP2135864A1 (en) 2008-06-16 2008-06-16 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases
US12/139,661 2008-06-16
US12/139,661 US7781594B2 (en) 2008-06-16 2008-06-16 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases
PCT/EP2009/057324 WO2009153226A1 (en) 2008-06-16 2009-06-15 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases

Publications (2)

Publication Number Publication Date
RU2011101439A RU2011101439A (ru) 2012-07-27
RU2495031C2 true RU2495031C2 (ru) 2013-10-10

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RU2011101439/04A RU2495031C2 (ru) 2008-06-16 2009-06-15 Производные 5-(4-метансульфонилфенил)тиазола для лечения острых и хронических воспалительных заболеваний

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EP (1) EP2313382A1 (es)
JP (1) JP2011524352A (es)
KR (1) KR20110022679A (es)
CN (1) CN102083806A (es)
AR (1) AR072113A1 (es)
AU (1) AU2009259451B2 (es)
BR (1) BRPI0915325A2 (es)
CA (1) CA2728139A1 (es)
CO (1) CO6331429A2 (es)
IL (1) IL209801A0 (es)
MA (1) MA32473B1 (es)
MX (1) MX2010013978A (es)
NZ (1) NZ589894A (es)
RU (1) RU2495031C2 (es)
SA (1) SA109300384B1 (es)
TW (1) TWI403506B (es)
UY (1) UY31896A (es)
WO (1) WO2009153226A1 (es)
ZA (1) ZA201008877B (es)

Families Citing this family (5)

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FR2961695B1 (fr) * 2010-06-29 2012-07-06 Galderma Res & Dev Utilisation de composes dans le traitement ou la prevention de troubles cutanes
RU2502513C2 (ru) * 2012-01-11 2013-12-27 Государственное бюджетное учреждение здравоохранения Свердловской области "Свердловский областной клинический психоневрологический госпиталь для ветеранов войн" (ГБУЗ СО "СОКП Госпиталь для ветеранов войн") Способ лечения больных с полиорганной патологией озонотерапией
BR112020009477A2 (pt) * 2017-11-23 2020-11-03 Immunic Ag compostos e regime de dosagem para uso na prevenção ou tratamento de doenças inflamatórias e/ou autoimunes
KR102076936B1 (ko) * 2019-08-12 2020-02-13 연세대학교 산학협력단 티아졸 또는 이의 염을 유효성분으로 포함하는 알러지성 질환 또는 아토피 피부염 예방 또는 치료용 조성물
IT202000008125A1 (it) * 2020-04-16 2021-10-16 Minerva Srl Acidi carbossilici 3-aza-biciclo[3.2.1]ottani e loro derivati per l’uso nel trattamento di infiammazioni

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124342A (en) * 1989-02-08 1992-06-23 Abbott Laboratories 4-hydroxythiazoles as 5-lipoxygenase inhibitors
WO2001027094A1 (en) * 1999-10-12 2001-04-19 Japan Tobacco Inc. Hypertriglyceridemia remedies and antiobestics
US20050026902A1 (en) * 2003-01-31 2005-02-03 Timothy Maziasz Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents
EA007933B1 (ru) * 2001-08-13 2007-02-27 Янссен Фармацевтика Н.В. 2,4,5-тризамещенные производные тиазолила и их противовоспалительная активность

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Publication number Priority date Publication date Assignee Title
JPH10504542A (ja) * 1994-07-27 1998-05-06 ジー.ディー.サール アンド カンパニー 炎症処置用の置換チアゾール化合物
DE69635048T2 (de) * 1995-06-12 2006-02-16 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124342A (en) * 1989-02-08 1992-06-23 Abbott Laboratories 4-hydroxythiazoles as 5-lipoxygenase inhibitors
WO2001027094A1 (en) * 1999-10-12 2001-04-19 Japan Tobacco Inc. Hypertriglyceridemia remedies and antiobestics
EA007933B1 (ru) * 2001-08-13 2007-02-27 Янссен Фармацевтика Н.В. 2,4,5-тризамещенные производные тиазолила и их противовоспалительная активность
US20050026902A1 (en) * 2003-01-31 2005-02-03 Timothy Maziasz Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents

Non-Patent Citations (4)

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Title
FRANCIS A.J. KERDESKY et al.: "4-Hydroxythiazole inhibitors of 5-lipoxygenase", J. Med. Chem., 1991, vol.34, no.7, p.2158-2165. *
JACQUES YVES GAUTHIER et al.: "Synthesis and biological evaluation of 2,3-diarylthiophenes as selective COX-2 inhibitors. Part II: Replacing the heterocycle", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, vol.6, no.1, p.87-92. *
MARYVONNE FERREY et al.: "A new synthesis of 4-hydroxythiazoles", SYNTHESIS, 1976, no.4, p.261-262. *
MARYVONNE FERREY et al.: "A new synthesis of 4-hydroxythiazoles", SYNTHESIS, 1976, no.4, p.261-262. JACQUES YVES GAUTHIER et al.: "Synthesis and biological evaluation of 2,3-diarylthiophenes as selective COX-2 inhibitors. Part II: Replacing the heterocycle", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, vol.6, no.1, p.87-92. FRANCIS A.J. KERDESKY et al.: "4-Hydroxythiazole inhibitors of 5-lipoxygenase", J. Med. Chem., 1991, vol.34, no.7, p.2158-2165. *

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Publication number Publication date
MX2010013978A (es) 2011-03-29
NZ589894A (en) 2011-08-26
RU2011101439A (ru) 2012-07-27
EP2313382A1 (en) 2011-04-27
CN102083806A (zh) 2011-06-01
TWI403506B (zh) 2013-08-01
SA109300384B1 (ar) 2013-04-20
CO6331429A2 (es) 2011-10-20
KR20110022679A (ko) 2011-03-07
AR072113A1 (es) 2010-08-04
AU2009259451A1 (en) 2009-12-23
BRPI0915325A2 (pt) 2015-10-27
ZA201008877B (en) 2012-02-29
UY31896A (es) 2010-01-29
AU2009259451B2 (en) 2013-03-14
CA2728139A1 (en) 2009-12-23
WO2009153226A1 (en) 2009-12-23
IL209801A0 (en) 2011-02-28
JP2011524352A (ja) 2011-09-01
MA32473B1 (fr) 2011-07-03
TW201010988A (en) 2010-03-16

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