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RU2356547C2 - Способы лечения рака с использованием ингибиторов hdac - Google Patents

Способы лечения рака с использованием ингибиторов hdac Download PDF

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RU2356547C2
RU2356547C2 RU2006109467/14A RU2006109467A RU2356547C2 RU 2356547 C2 RU2356547 C2 RU 2356547C2 RU 2006109467/14 A RU2006109467/14 A RU 2006109467/14A RU 2006109467 A RU2006109467 A RU 2006109467A RU 2356547 C2 RU2356547 C2 RU 2356547C2
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saha
pharmaceutically acceptable
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Николас Дж. БАКОПУЛОС (US)
Николас Дж. Бакопулос
Джуди Х. ЧИАО (US)
Джуди Х. Чиао
Томас А. МИЛЛЕР (US)
Томас А. Миллер
Кэролин М. ПЭРАДАЙЗ (US)
Кэролин М. ПЭРАДАЙЗ
Виктория М. РИЧОН (US)
Виктория М. Ричон
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Мерк ЭйчДиЭйСи Рисерч ЛЛС
Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids

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Abstract

Группа изобретений относится к медицине, а именно к онкологии, и может быть использована для лечения мезотелиомы или фолликулярной лимфомы. Для этого получают фармацевтическую композицию для перорального введения, содержащую эффективное количество субероиланилид-гидроксаминовой кислоты (SAHA). Предлагается также использовать эти композиции в наборе. Группа изобретений обеспечивает эффективное лечение указанных видов опухолей за счет угнетения пролиферации опухолевых клеток. 4 н. и 10 з.п. ф-лы, 5 табл., 17 ил.

Description

Текст описания приведен в факсимильном виде.
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Claims (14)

1. Применение субероиланилид-гидроксаминовой кислоты (SAHA), представленной структурой
Figure 00000127

или ее фармацевтически приемлемой соли или гидрата, и фармацевтически приемлемого носителя или разбавителя для получения перорального лекарственного средства для введения субъекту для лечения мезотелиомы.
2. Применение по п.1, где указанное лекарственное средство вводят дважды в день в дозе 300 мг периодически.
3. Применение по п.2, где указанное лекарственное средство вводят от трех до пяти дней в неделю.
4. Применение по п.3, где указанное лекарственное средство вводят три дня в неделю.
5. Применение по п.1, где указанное лекарственное средство вводят один раз в день в дозе 400 мг.
6. Применение по п.5, где указанное лекарственное средство вводят в течение 14 дней после перерыва 7 дней без введения.
7. Применение по п.1, где указанное лекарственное средство вводят один раз в день в дозе 300 мг.
8. Применение по п.7, где указанное лекарственное средство вводят в течение 14 дней после перерыва 7 дней без введения.
9. Применение по любому из пп.1-8, где SAHA представляет собой активный ингредиент указанной композиции.
10. Фармацевтическая композиция для перорального введения, содержащая субероиланилид-гидроксаминовую кислоту (SAHA), представленную структурой
Figure 00000127

или ее фармацевтически приемлемую соль или гидрат, для применения при лечении мезотелиомы.
11. Фармацевтическая композиция по п.10, которую вводят 3 дня в неделю 300 мг дважды в день.
12. Набор, включающий в себя, по меньшей мере, одну фармацевтически эффективную единичную дозу SAHA или ее фармацевтически приемлемой соли или гидрата, где фармацевтически эффективная единичная доза составляет примерно 300 мг, и инструкции по лечению мезотелиомы путем перорального введения три дня в неделю 300 мг дважды в день.
13. Применение субероиланилид-гидроксаминовой кислоты (SAHA), представленной структурой
Figure 00000127

или ее фармацевтически приемлемой соли или гидрата, и фармацевтически приемлемого носителя или разбавителя для получения перорального лекарственного средства для введения субъекту для лечения фолликулярной лимфомы.
14. Применение по п.13, где SAHA вводится в дозе 200 мг дважды в день.
RU2006109467/14A 2003-08-26 2004-08-26 Способы лечения рака с использованием ингибиторов hdac RU2356547C2 (ru)

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US10/650,025 2003-08-26
US10/650,025 US7148257B2 (en) 2002-03-04 2003-08-26 Methods of treating mesothelioma with suberoylanilide hydroxamic acid
US10/665,079 2003-09-16
US10/665,079 US20040127523A1 (en) 2002-03-04 2003-09-16 Methods of treating cancer with HDAC inhibitors

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