RU2119283C1 - Agent for contact action and keratophage killing - Google Patents

Abstract

FIELD: insecticides. SUBSTANCE: invention relates to chemical agents of contact action for killing domestic insects - keratophages (moth and skin beetles). Agent has: deltamethrin (IR-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid (S)-3-phenoxy--α--cyanobenzyl ester), microamounts of ortho-xylene, calcium alkyl-(C₁₀-C₁₈)-benzenesulfonate, butylhydroxytoluene and citral and alkylphenol ethoxylated with 9-12 moles ethylene oxide. Distilled water is used as a solvent. The indicated components are taken at the definite ratio. EFFECT: increased duration of insecticide effect, decreased toxicity for man and other warm-blooded animals. 1 tbl, 1 ex

Description

 The invention relates to contact chemical agents for controlling domestic insects and can be used to destroy keratophages: moths and carpet beetles.

 To destroy keratophages, chemical means of both fumigation and contact action are used. The latter should be considered more preferable, since they can be used to protect wool products, both in open and closed storage.

 Contact means for the destruction of keratophages are known, which are solutions in organic solvents of organophosphorus insecticides, for example dichlorfos (see Copyright Certificate N 1544335, prior. 12.06.88, publ. In Bull. N 7, 02/23/90) or foxime (see The collection of abstracts of the conference "Modern directions of medical disinsection and disinfestation", held October 17-18, 1981, All-Union Scientific-Research Institute of Disinfection and Sterilization. - M .: 1981, p. 92-94 "Means of combating synanthropic keratophages") . In recent years, more effective and less hazardous for warm-blooded animals contact agents for destroying keratophages, which are solutions in organic solvents of synthetic pyrethroids, such as permethrin, have become known (see Copyright Certificate No. 1701226, prior. September 29, 89, published in Bull. N 48, 12.30.91).

 The most effective and at the same time the safest for humans and other warm-blooded animals should be considered a means of contact action for the destruction of keratophages, which is a solution of a relatively new synthetic pyrethroid-deltamethrin (IR-cis-3- (2,2-dibromovinyl) -2, 2-dimethylpropanecarboxylic acid (S) -3-phenoxy-α-cyanobenzyl ether) in organic solvents, in particular in diacetone alcohol or nephras (deltamethrin is practically insoluble in water).

 This product, taken as a prototype, has the commercial name "Defen" and contains 0.002% deltamethrin (see List N 0017-94 of domestic and foreign disinfectants approved for use on the territory of the Russian Federation. Section "Disinfectants". Page 3 , p. 7. Published by the Ministry of Health of the Russian Federation in 1994, Moscow).

The described prototype tool, however, has significant disadvantages. Firstly, this product, both when stored in a polymer container and after application to the substrate, does not have a sufficiently high stability, which reduces the duration of its insecticidal effect. In particular, after applying the agent to the woolen fabric (25 cm ³ per 1 m ^{2 of} surface), 100% death of the moth caterpillars and skin larvae is ensured for 6 and 4 months, respectively, after which the insecticidal activity of the agent decreases sharply. In addition, when storing the product in a polymer container, its acute insecticidal activity begins to drop noticeably after 10 months.

 Secondly, due to the fact that about 99% of the mass of the product is in organic solvents, the use of the drug in residential premises cannot be considered completely safe for humans and other warm-blooded animals. The combination of diacetone alcohol or nefras with deltamethrin leads to the fact that when it enters the stomach, it qualifies as moderately dangerous.

The aim of this invention is to increase the duration of the insecticidal action of an agent containing 0.002% deltamethrin, as well as reducing its toxicity to warm-blooded animals. This is achieved by the fact that the deltamethrin-based agent contains micro amounts of O-xylene, alkyl (C ₁₀ -C ₁₈ ) calcium benzenesulfonate and butyl hydroxytoluene, as well as additional ingredients previously used in antimole agents, in particular, citral and polyglycol ether of alkyl phenol, ethoxylated 9-12 moles of ethylene oxide in which the alkyl group is represented by a propylene trimer. The above combination of ingredients allows you to dissolve the "insoluble" deltamethrin in distilled water, which is replaced by relatively toxic organic solvents. The proposed tool is characterized by the following ratio of ingredients wt.%:
Deltamethrin (IR-cis-3- (2,2-dibromovinyl) -2,2-dimethylpropanecarboxylic acid (S) -3-phenoxy-α-cyanobenzyl ether - 0.0018-0.0022
O-xylene - 0.0620-0.0670
Alkyl (C ₁₀ -C ₁₈ ) calcium benzenesulfonate - 0.0048-0.0052
Butylhydroxytoluene - 0.0028-0.0032
Citral - 0.4900-0.5100
Alkylphenol ethoxylated with 9-12 moles of ethylene oxide in which the alkyl group is represented by a propylene trimer
Distilled water - Up to 100,0000
Example. For entomological tests and toxicological studies in semi-industrial conditions, 100 kg of the proposed product was prepared. The preparation was carried out in a steel enameled reactor equipped with a propeller stirrer (60 min ^-1 ). 99.125 kg of distilled water was poured into the reactor at room temperature. Then, with the stirrer operating and at room temperature, 300 g of ethylene oxide 9–12 moles of alkyl phenol ethoxylated (in which the alkyl group is represented by a propylene trimer), 500 g of citral, 5 g of alkyl (C ₁₀ -C ₁₈ ) calcium benzenesulfonate, and 3 g of butyl hydroxytoluene were successively added to the reactor. 65 g of O-xylene and 2 g of deltamethrin. The ingredients were mixed until a clear solution was obtained, which was then passed through a glass fiber filter and poured into vials.

Entomological tests of the proposed agent were carried out in laboratory conditions on cultures of the moth Tineola bisseelliella Hum and skin eater Attadenus smirnovi. In the experiments, 3-4-week-old moth caterpillars and 11-12-week insect breeding skin larvae were used. Samples of purely woolen fabric (art. 1134) 40x40 mm in size were used as a substrate. Tissue samples were treated with the proposed tool and tool - prototype, filled in polymer bottles equipped with valves - sprayers. The liquid flow rate was 25 cm ³ per 1 m of surface. After processing, tissue samples were dried at a temperature of 20 ^o C for 24 hours. For each of the dried tissue samples, 30 moth caterpillars or 30 skin-bearer larvae were planted. The experiments were conducted in triplicate. Tissue samples with insects placed on them were laid in glass cups with a diameter of 40 and a height of 50 mm. The cups were covered with cotton cloth on top, after which they were placed in a thermostat, where they were kept at 20 ^o C. The insect death (acute insecticidal activity) was recorded one day after insect infusion. To assess the duration of residual insecticidal action, the samples of the treated tissue were stored in the light at room temperature, taking them for testing 4, 6, and 8 months after treatment. Evaluation of insecticidal activity was performed in the same way as in the acute experiment. In addition, the insecticidal effect was evaluated after storage of the proposed funds and funds - prototype in polymer bottles. From the vials, tissue samples were sprayed after 6; eight; 10 and 12 months after preparation. Processing of tissue samples and assessment of acute insecticidal activity was performed as described above. The results of the described tests are shown in the table.

 As follows from this table, the proposed tool can significantly increase the duration of the insecticidal action in comparison with the means of the prototype. In particular, for moth caterpillars - up to 8 months, instead of 6, and for skin-bearer larvae - up to 8 months, instead of 4. At the same time, it was shown that during storage of the proposed product, its acute insecticidal activity lasts 12 months, instead of 8 - for the prototype product.

Toxicological studies of the proposed funds are given by standard methods. In particular, in an acute experiment on white rats and white mice, toxicity was determined when administered orally. In both cases, the death of the animals did not occur even with the introduction of 10,000 mg per kg of body weight (DL ₅₀ for the prototype is 3000 mg / kg of white mice and 2600 mg / kg in white rats).

 When inhaled seeding animals with the proposed tool, no deviations from the norm (in comparison with the group of control animals) were not found in experimental animals. When seeding with a prototype agent (both diacetone alcohol and nephras), obvious symptoms of drug poisoning were noted.

Claims (1)

A contact action for the destruction of keratophages based on synthetic pyrethroid - deltamethrin (1R-cis-3- (2,2-dibromovinyl) -2,2-dimethylcyclopropanecarboxylic acid (S) -3-phenoxy-α-cyanobenzyl ether in a solvent, characterized in that it contains trace amounts of O-xylene, alkyl (C ₁₀ - C ₁₈ ) calcium benzenesulfonate and butyl hydroxytoluene, citral and ethylene oxide 9-12 moles of ethylene oxide alkyl phenol, in which the alkyl group is represented by a propylene trimer and contains distilled water as a solvent, ratio of ingredients, wt.%:
Deltamethrin (1R-cis-3- (2,2-dibromovinyl) -2, 2-dimethylcyclopropanecarboxylic acid (S) -3-phenoxy-α-cyanobenzyl ether - 0.0018 - 0.0022
O-Xylene - 0.0620 - 0.0670
Alkyl (C ₁₀ - C ₁₈ ) calcium benzenesulfonate - 0.0048 - 0.0052
Butylhydroxytoluene - 0.0028 - 0.0032
Citral - 0.4900 - 0.5100
Alkylphenol ethoxylated with 9 to 12 moles of ethylene oxide, in which the alkyl group is represented by a propylene trimer - 0.2800 - 0.3200
Distilled water - Up to 100,0000yu

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