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RU2019126220A - Однодоменные антитела, направленные против внутриклеточных антигенов - Google Patents

Однодоменные антитела, направленные против внутриклеточных антигенов Download PDF

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RU2019126220A
RU2019126220A RU2019126220A RU2019126220A RU2019126220A RU 2019126220 A RU2019126220 A RU 2019126220A RU 2019126220 A RU2019126220 A RU 2019126220A RU 2019126220 A RU2019126220 A RU 2019126220A RU 2019126220 A RU2019126220 A RU 2019126220A
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sdab
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alox12
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RU2019126220A
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RU2019126220A3 (ru
RU2742248C2 (ru
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Сунанда СИНГХ
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Сингх Биотекнолоджи, Ллк
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Claims (15)

1. Однодоменное антитело (sdAb) к арахидонат-12-липоксигеназе (ALOX12).
2. Однодоменное антитело (sdAb) к арахидонат-12-липоксигеназе (ALOX12), содержащее аминокислотную последовательность, представленную в SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 51 или SEQ ID NO: 52.
3. Способ лечения заболевания, предотвращения развития заболевания или предотвращения рецидива заболевания у субъекта с применением sdAb к ALOX12 по пп. 1 или 2, который включает введение эффективного количества sdAb к ALOX12 субъекту, нуждающемуся в этом.
4. Способ по п. 3, отличающийся тем, что субъектом является млекопитающее.
5. Способ по п. 4, отличающийся тем, что млекопитающим является человек.
6. Способ по п. 3, отличающийся тем, что sdAb к ALOX12 вводят в комбинации с одним или более соединениями.
7. Способ по п. 3, отличающийся тем, что введение эффективного количества sdAb к ALOX12 субъекту, нуждающемуся в этом, включает внутривенное введение, внутримышечное введение, пероральный прием, ректальное введение, энтеральное введение, парентеральное введение, внутриглазное введение, подкожное введение, трансдермальное введение, введение в виде глазных капель, введение в виде назального спрея, введение путем ингаляции или распыления, местное введение и введение в качестве имплантируемого лекарственного средства.
8. Выделенный полипептид, содержащий аминокислотную последовательность, представленную в SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 51 или SEQ ID NO: 52.
9. Антитело, направленное к полипептиду по п. 8.
10. Способ измерения уровней sdAb к ALOX12 в образце от субъекта, включающий этапы, на которых:
a) создают мышиное моноклональное антитело, направленное против одного или более доменов полипептида, содержащего аминокислотную последовательность, представленную в SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 51 или SEQ ID NO: 52;
b) получают образец от субъекта;
c) проводят количественный иммунологический анализ с мышиным моноклональным антителом и образцом для определения количества sdAb у субъекта; и
d) определяют количество sdAb у субъекта.
11. Способ по п. 10, отличающийся тем, что количественный иммунологический анализ включает иммуноферментный анализ (ИФА), анализ специфического мечения аналита и повторного захвата (SALRA), жидкостную хроматографию, масс-спектрометрию, сортировку клеток на проточном цитометре, или их комбинацию.
RU2019126220A 2015-11-02 2016-11-02 Однодоменные антитела, направленные против внутриклеточных антигенов RU2742248C2 (ru)

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CN113557246B (zh) * 2019-07-24 2023-09-01 韩国基础科学支援研究院 靶向αvβ3整联蛋白的单域抗体
CN111234019B (zh) * 2020-01-16 2022-06-24 佛山汉腾生物科技有限公司 抗ctla-4纳米抗体、药物组合物及其应用
CN111184864B (zh) * 2020-01-20 2022-01-14 武汉大学 Alox12特异性抑制剂在制备治疗非酒精性脂肪肝病和/或ⅱ型糖尿病的药物中的应用
CN113214392B (zh) * 2020-12-30 2022-07-01 中国人民解放军海军军医大学 抗水母毒素纳米抗体ky031、制备方法及用途
CN115414482A (zh) * 2022-07-13 2022-12-02 同济大学 Stat3信号通路抑制剂的应用

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