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RU2018133283A - Сложные эфиры для лечения офтальмологических воспалительных заболеваний - Google Patents

Сложные эфиры для лечения офтальмологических воспалительных заболеваний Download PDF

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RU2018133283A
RU2018133283A RU2018133283A RU2018133283A RU2018133283A RU 2018133283 A RU2018133283 A RU 2018133283A RU 2018133283 A RU2018133283 A RU 2018133283A RU 2018133283 A RU2018133283 A RU 2018133283A RU 2018133283 A RU2018133283 A RU 2018133283A
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resolvin
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inflammatory lipoid
composition
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RU2018133283A
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RU2018133283A3 (ru
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Аннабелль ГАЛЛУА
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Джонсон Энд Джонсон Вижн Кэа, Инк.
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Claims (22)

1. Офтальмологический продукт, представляющий собой герметично упакованный водный раствор, в котором размещена для хранения контактная линза, включающая композицию, содержащую сложный эфир противовоспалительного липоидного медиатора, который представляет собой продукт реакции противовоспалительного липоидного медиатора и полиола, имеющего длину цепи от 4 до 10 атомов углерода, где сложный эфир выбирают из группы, состоящей из
этерифицированного противовоспалительного липоидного медиатора, выбранного из:
a) простагландина, выбранного из группы, состоящей из простагландина E1 (PGE1), простагландина Е3 (PGE3) и их комбинации; или
b) ресольвина, выбранного из группы, состоящей из ресольвина E1 (RvE1), ресольвина E2 (RvE2), ресольвина D1 (RvD1), ресольвина D2 (RvD2), ресольвина D3 (RvD3), ресольвина D4 (RvD4) и их комбинации; или
c) липоксина, выбранного из группы, состоящей из липоксина A4 (LXA), липоксина B4 (LXB4) и их комбинации; или
d) содержит протектин D1 (PD1); или
e) содержит 13-цис-ретиноевую кислоту; или
f) содержит анандамид;
и где композиция содержит 10% по весу или менее кислотной формы противовоспалительного липоидного медиатора, и где, кроме того, водный раствор выбран из физиологического раствора, буферного раствора и воды.
2. Продукт по п.1, где сложный эфир присутствует в композиции в терапевтически эффективном количестве.
3. Продукт по п.1, где композиция не содержит жирных кислот.
4. Продукт по п.1, где композиция содержит 5% по весу или менее кислотной формы противовоспалительного липоидного медиатора.
5. Продукт по п.4, где композиция содержит 1% по весу или менее кислотной формы противовоспалительного липоидного медиатора.
6. Продукт по п.5, где сложный эфир присутствует в композиции в количестве от 0,025% до 0,5% по весу в расчете на общую массу композиции.
7. Продукт по п.1, где противовоспалительный липоидный медиатор является простагландином, выбранным из группы, состоящей из простагландина E1 (PGE1), простагландина Е3 (PGE3) или метаболически стабильного аналога и их комбинации.
8. Продукт по п.1, где противовоспалительный липоидный медиатор является ресольвином, выбранным из группы, состоящей из ресольвина E1 (RvE1), ресольвина E2 (RvE2), ресольвина D1 (RvD1), ресольвина D2 (RvD2), ресольвина D3 (RvD3), ресольвина D4 (RvD4) или метаболически стабильного аналога и их комбинации.
9. Продукт по п.1, где противовоспалительный липоидный медиатор содержит протектин D1 (PD1) или метаболически стабильный аналог.
10. Продукт по п.1, где противовоспалительный липоидный медиатор содержит 13-цис-ретиноевую кислоту.
11. Продукт по п.5, в которой противовоспалительный липоидный медиатор содержит анандамид.
12. Продукт по п.1, где водный раствор содержит одно или несколько веществ, выбранных из: поверхностно-активного вещества, эмульгатора, смачивающего агента, хеланта и антиоксиданта.
13. Продукт по п.1, где водный раствор содержит один или более ингредиентов, выбранных из группы, состоящей из полисорбата 80™, Тилоксапола™, метил глюцета-20, витамина Е, диэтилентриаминпентауксусной кислоты, борной кислоты, бората натрия и хлорида натрия.
14. Продукт по п.1, где полиол выбран из группы, состоящей из полиэтиленгликоля, поливинилового спирта, инозитола, сорбитола, ксилитола, эритритола, а также их комбинации.
RU2018133283A 2011-06-30 2018-09-20 Сложные эфиры для лечения офтальмологических воспалительных заболеваний RU2018133283A (ru)

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Application Number Priority Date Filing Date Title
US201161503158P 2011-06-30 2011-06-30
US61/503,158 2011-06-30
US13/495,052 US8865685B2 (en) 2011-06-30 2012-06-13 Esters for treatment of ocular inflammatory conditions
US13/495,052 2012-06-13

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RU2014102996A RU2640506C9 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2017110540A RU2673230C1 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2017142720A RU2707961C2 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2014102958A RU2627438C2 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2017125922A RU2747953C2 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2018133283A RU2018133283A (ru) 2011-06-30 2018-09-20 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2018136873A RU2018136873A (ru) 2011-06-30 2018-10-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2019137026A RU2019137026A (ru) 2011-06-30 2019-11-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний

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RU2017110540A RU2673230C1 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2017142720A RU2707961C2 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
RU2014102958A RU2627438C2 (ru) 2011-06-30 2012-06-19 Сложные эфиры для лечения офтальмологических воспалительных заболеваний
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US (7) US10383839B2 (ru)
EP (3) EP3556346B1 (ru)
JP (4) JP6352177B2 (ru)
KR (4) KR102203310B1 (ru)
CN (5) CN107260716A (ru)
AR (2) AR086825A1 (ru)
AU (10) AU2012275759A1 (ru)
BR (2) BR112013033941A2 (ru)
CA (2) CA2840152C (ru)
ES (1) ES2743174T3 (ru)
PL (1) PL3556346T3 (ru)
RU (8) RU2640506C9 (ru)
TW (4) TWI633883B (ru)
WO (2) WO2013003113A1 (ru)

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US10383839B2 (en) 2011-06-30 2019-08-20 Johnson & Johnson Vision Care, Inc. Esters for treatment of ocular inflammatory conditions
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