RU2018114868A - Композиция гиперицина для фотодинамической диагностики - Google Patents
Композиция гиперицина для фотодинамической диагностики Download PDFInfo
- Publication number
- RU2018114868A RU2018114868A RU2018114868A RU2018114868A RU2018114868A RU 2018114868 A RU2018114868 A RU 2018114868A RU 2018114868 A RU2018114868 A RU 2018114868A RU 2018114868 A RU2018114868 A RU 2018114868A RU 2018114868 A RU2018114868 A RU 2018114868A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- hypericin
- pvp
- composition according
- salt
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 10
- 229940005608 hypericin Drugs 0.000 title claims 4
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 title claims 4
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 title claims 4
- YDOIFHVUBCIUHF-UHFFFAOYSA-N 9,11,13,16,18,20-hexahydroxy-5,24-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(26),2,4(25),5,8,10,12,14(28),15(27),16,18,20,23-tridecaene-7,22-dione Chemical compound OC1=CC(O)=C2C(O)=C3C(=O)C=C(C)C4=C5C(C)=CC(=O)C6=C(O)C7=C(O)C=C(O)C8=C7C(=C56)C(=C34)C2=C18 YDOIFHVUBCIUHF-UHFFFAOYSA-N 0.000 title 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 8
- BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000008139 complexing agent Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- -1 alkali metal salt Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000008366 buffered solution Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000010668 complexation reaction Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000012052 hydrophilic carrier Substances 0.000 claims 1
- 239000012051 hydrophobic carrier Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000003504 photosensitizing agent Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/121—Ketones acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0071—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form solution, solute
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (10)
1. Композиция для фотодинамической диагностики, содержащая на полимерном комплексообразователе связанный или комплексованный гиперицин, отличающаяся тем, что гиперицин присутствует в виде соли.
2. Композиция по п.1, отличающаяся тем, что комплексообразователь представляет собой полиэтиленгликоль или поли-N-виниламид.
3. Композиция по п.2, отличающаяся тем, что поли-N-виниламид представляет собой поливинилпирролидон (PVP) с различной степенью полимеризации и сшивания.
4. Композиция по п.3, отличающаяся тем, что поливинилпирролидон представляет собой PVP k17, PVP k25 или PVP k30.
5. Композиция по одному из пп. 1-4, отличающаяся тем, что соль гиперицина представляет собой соль щелочного металла, в частности, калиевую соль или, предпочтительно, натриевую соль.
6. Способ получения композиции по одному из пп. 1-5, отличающийся тем, что соль гиперицина связывается с полиэтиленгликолем или поли-N-виниламидом или образует комплекс с ним, предпочтительно с поливинилпирролидоном (PVP).
7. Способ по п.6, отличающийся тем, что комплексообразование проводится в водном, при необходимости забуференном, растворе.
8. Способ по п. 6 или 7, отличающийся тем, что композиция приготавливается для внутривенного, внутриполостного, ингаляционного, орального, внутрибрюшинного и местного введения, в гидрофильных или гидрофобных носителях, предпочтительно в форме раствора, крема, геля, аэрозоля, эмульсий или в форме пластыря.
9. Способ по п. 7 или 8, отличающийся тем, что водный раствор заливается во флаконы для инъекций и подвергается лиофилизации.
10. Применение композиции по одному из пп. 1-5, или полученной по одному из пп. 6-9 композиции, для приготовления фотосенсибилизатора, применимого при фотофизической или фотодинамической диагностике и для раннего выявления рака.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA629/2015 | 2015-09-28 | ||
| AT6292015 | 2015-09-28 | ||
| PCT/AT2016/000034 WO2017054018A1 (de) | 2015-09-28 | 2016-04-07 | Formulierung von hypericin zur photodynamischen diagnose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018114868A true RU2018114868A (ru) | 2019-10-28 |
| RU2018114868A3 RU2018114868A3 (ru) | 2019-10-28 |
Family
ID=55854523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018114868A RU2018114868A (ru) | 2015-09-28 | 2016-04-07 | Композиция гиперицина для фотодинамической диагностики |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9629932B2 (ru) |
| EP (1) | EP3237019B1 (ru) |
| JP (1) | JP6800232B2 (ru) |
| KR (1) | KR20180080210A (ru) |
| CN (1) | CN108289967A (ru) |
| AU (1) | AU2016330390B2 (ru) |
| CA (1) | CA3000419C (ru) |
| DK (1) | DK3237019T3 (ru) |
| ES (1) | ES2762902T3 (ru) |
| MX (1) | MX2018003802A (ru) |
| PL (1) | PL3237019T3 (ru) |
| RU (1) | RU2018114868A (ru) |
| WO (1) | WO2017054018A1 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108715693B (zh) * | 2018-06-29 | 2020-08-25 | 南方科技大学 | 一种光化学除去氧气来保护光敏剂的三重激发态的介质以及方法和应用 |
| EP3593815A1 (de) | 2018-07-13 | 2020-01-15 | Planta Naturstoffe Vertriebsges.m.b.h. | Hypericin-pvp komplex mit hohem hypericinanteil |
| CN114504551B (zh) * | 2020-11-16 | 2024-01-02 | 北京厚燊维康科技有限责任公司 | 可用于光动力治疗或诊断的制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19756677A1 (de) | 1997-12-19 | 1999-06-24 | Krewel Meuselbach Gmbh | Arzneipflanzentrockenextrakte |
| DE19814014A1 (de) | 1997-12-19 | 1999-09-30 | Krewel Meuselbach Gmbh | Arzneipflanzentrockenextrakte |
| EP1040825A1 (en) * | 1999-03-11 | 2000-10-04 | K.U. Leuven Research & Development | Means for diagnosing bladder carcinoma |
| AT408835B8 (de) | 2000-05-23 | 2002-07-25 | Andreas Dipl Ing Dr Kubin | Präparation von hypericin gebunden an polyvinylpyrrolidon (pvp) verschiedenen polymerisations- und vernetzungsgrades |
| CN102525937B (zh) * | 2012-01-21 | 2013-07-17 | 中国农业科学院兰州畜牧与兽药研究所 | 一种金丝桃素白蛋白纳米粒的制备方法 |
| DE102014204138A1 (de) | 2014-03-06 | 2015-09-24 | Briu Gmbh | Pharmazeutische Formulierung, Verfahren zur Herstellung der pharmazeutischen Formulierung und Infusionslösung sowie deren Verwendung als Medizinprodukt und/oder als Medikament |
| US10143751B2 (en) * | 2015-09-28 | 2018-12-04 | Sanochemia Pharmazeutika Ag | Photodynamic therapy, formulation usable for this purpose, and method for the production and use thereof |
-
2015
- 2015-10-08 US US14/878,573 patent/US9629932B2/en active Active
-
2016
- 2016-04-07 CA CA3000419A patent/CA3000419C/en active Active
- 2016-04-07 MX MX2018003802A patent/MX2018003802A/es unknown
- 2016-04-07 CN CN201680060829.8A patent/CN108289967A/zh active Pending
- 2016-04-07 KR KR1020187012194A patent/KR20180080210A/ko not_active Ceased
- 2016-04-07 JP JP2018535201A patent/JP6800232B2/ja active Active
- 2016-04-07 RU RU2018114868A patent/RU2018114868A/ru not_active Application Discontinuation
- 2016-04-07 PL PL16718844T patent/PL3237019T3/pl unknown
- 2016-04-07 ES ES16718844T patent/ES2762902T3/es active Active
- 2016-04-07 WO PCT/AT2016/000034 patent/WO2017054018A1/de not_active Ceased
- 2016-04-07 AU AU2016330390A patent/AU2016330390B2/en not_active Ceased
- 2016-04-07 DK DK16718844.0T patent/DK3237019T3/da active
- 2016-04-07 EP EP16718844.0A patent/EP3237019B1/de active Active
-
2017
- 2017-03-27 US US15/469,602 patent/US9775900B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL3237019T3 (pl) | 2020-04-30 |
| CN108289967A (zh) | 2018-07-17 |
| ES2762902T3 (es) | 2020-05-26 |
| AU2016330390B2 (en) | 2019-05-02 |
| EP3237019B1 (de) | 2019-10-09 |
| EP3237019A1 (de) | 2017-11-01 |
| US9629932B2 (en) | 2017-04-25 |
| CA3000419A1 (en) | 2017-04-06 |
| AU2016330390A1 (en) | 2018-05-10 |
| BR112018006066A2 (pt) | 2018-10-09 |
| US20170087256A1 (en) | 2017-03-30 |
| JP6800232B2 (ja) | 2020-12-16 |
| MX2018003802A (es) | 2019-06-24 |
| US9775900B2 (en) | 2017-10-03 |
| CA3000419C (en) | 2021-03-16 |
| DK3237019T3 (da) | 2020-01-13 |
| JP2018534349A (ja) | 2018-11-22 |
| KR20180080210A (ko) | 2018-07-11 |
| US20170196976A1 (en) | 2017-07-13 |
| RU2018114868A3 (ru) | 2019-10-28 |
| WO2017054018A1 (de) | 2017-04-06 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200210 |