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RU2018113750A3 - - Google Patents

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Publication number
RU2018113750A3
RU2018113750A3 RU2018113750A RU2018113750A RU2018113750A3 RU 2018113750 A3 RU2018113750 A3 RU 2018113750A3 RU 2018113750 A RU2018113750 A RU 2018113750A RU 2018113750 A RU2018113750 A RU 2018113750A RU 2018113750 A3 RU2018113750 A3 RU 2018113750A3
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RU
Russia
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RU2018113750A
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RU2730622C2 (ru
RU2018113750A (ru
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/313Phosphorodithioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3517Marker; Tag
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00Reactions demanding special reaction conditions
    • C12Q2527/107Temperature of melting, i.e. Tm
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10Detection mode being characterised by the assay principle
    • C12Q2565/102Multiple non-interacting labels
    • C12Q2565/1025Multiple non-interacting labels labels being on the same oligonucleotide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10Detection mode being characterised by the assay principle
    • C12Q2565/107Alteration in the property of hybridised versus free label oligonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Road Signs Or Road Markings (AREA)
  • Glass Compositions (AREA)
  • Pens And Brushes (AREA)
RU2018113750A 2015-09-22 2016-09-22 Улучшенное выявление коротких гомополимерных повторов RU2730622C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15186341.2 2015-09-22
EP15186341 2015-09-22
PCT/EP2016/072605 WO2017050934A1 (en) 2015-09-22 2016-09-22 Improved detection of short homopolymeric repeats

Publications (3)

Publication Number Publication Date
RU2018113750A RU2018113750A (ru) 2019-10-23
RU2018113750A3 true RU2018113750A3 (ru) 2020-03-11
RU2730622C2 RU2730622C2 (ru) 2020-08-24

Family

ID=54196858

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018113750A RU2730622C2 (ru) 2015-09-22 2016-09-22 Улучшенное выявление коротких гомополимерных повторов

Country Status (9)

Country Link
US (2) US11028431B2 (ru)
EP (2) EP3353320B1 (ru)
JP (1) JP6906504B2 (ru)
KR (1) KR102648647B1 (ru)
CN (1) CN108350506A (ru)
CA (1) CA2999403A1 (ru)
ES (1) ES2950346T3 (ru)
RU (1) RU2730622C2 (ru)
WO (1) WO2017050934A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3652336B1 (en) * 2017-07-12 2024-04-17 Institut Curie Method for detecting a mutation in a microsatellite sequence
CN114717313A (zh) 2018-01-23 2022-07-08 拜奥卡蒂斯生物股份有限公司 检测癌症中微卫星不稳定性的生物标志物组和方法
CN111868256A (zh) 2018-01-23 2020-10-30 比奥卡尔齐斯股份有限公司 用于分析解离解链曲线数据的方法
WO2019156983A1 (en) * 2018-02-06 2019-08-15 Ultima Genomics, Inc. Methods for nucleic acid detection
WO2020002621A2 (en) * 2018-06-29 2020-01-02 F. Hoffmann-La Roche Ag Detection of microsatellite instability
JP7681520B2 (ja) * 2019-05-13 2025-05-22 ペンタベース エーピーエス 変異体核酸を検出するための融解温度法、キットおよびレポータオリゴ

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
JPH08238100A (ja) * 1995-03-03 1996-09-17 Eiken Chem Co Ltd 所定の配列を有する核酸を特異的に検出する方法、並びに該方法に使用されるプローブ及びキット
DE60113945T2 (de) * 2000-11-15 2006-06-29 Roche Diagnostics Gmbh Verfahren zur Analyse von Wiederkehrenden PCR-Podukten, das auf der Analyse von DNS-Schmelzkurven basiert
US6818420B2 (en) * 2002-02-27 2004-11-16 Biosource International, Inc. Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same
KR20110101254A (ko) * 2002-06-12 2011-09-15 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 A형 간염 바이러스 핵산의 포획, 검출 및 정량을 위한 올리고뉴클레오티드의 동정방법
US20050053942A1 (en) * 2002-06-24 2005-03-10 Sakari Kauppinen Methods and systems for detection and isolation of a nucleotide sequence
ATE534465T1 (de) 2005-06-23 2011-12-15 Biocartis Sa Kartusche, system und verfahren für automatisierte medizinische diagnosen
JP5049274B2 (ja) 2005-06-30 2012-10-17 ビオカルティ ソシエテ アノニム 自動化医療診断のためのカートリッジ
US7977108B2 (en) * 2005-07-25 2011-07-12 Roche Molecular Systems, Inc. Method for detecting a mutation in a repetitive nucleic acid sequence
US8778637B2 (en) * 2006-03-28 2014-07-15 Canon U.S. Life Sciences, Inc. Method and apparatus for applying continuous flow and uniform temperature to generate thermal melting curves in a microfluidic device
BRPI1010208A2 (pt) 2009-04-14 2019-09-24 Biocartis Sa tratamento de uma amostra com energia acústica focalizada
US20120135874A1 (en) * 2009-05-08 2012-05-31 The Johns Hopkins University Single molecule spectroscopy for analysis of cell-free nucleic acid biomarkers
WO2010135916A1 (zh) * 2009-05-26 2010-12-02 厦门大学 一种单管检测多个单核苷酸变异或单核苷酸多态性的方法
US9114399B2 (en) * 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
JP5917248B2 (ja) * 2011-05-09 2016-05-11 アークレイ株式会社 HGF遺伝子のpolyArepeat数変異多型検出用プローブおよびその用途
WO2013128281A1 (en) * 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
KR20150005597A (ko) * 2012-04-10 2015-01-14 브이아이비 브이지더블유 암에서 미소부수체 불안정성을 검출하고 dna 염기 삭제 수선 경로의 저해에 의한 종합적 치사율을 결정하기 위한 표지
EP2943590A4 (en) * 2013-01-13 2017-02-15 Unitaq Bio Methods and compositions for pcr using blocked and universal primers

Also Published As

Publication number Publication date
EP3353320A1 (en) 2018-08-01
RU2730622C2 (ru) 2020-08-24
EP4299763A2 (en) 2024-01-03
JP6906504B2 (ja) 2021-07-21
CA2999403A1 (en) 2017-03-30
US20210246499A1 (en) 2021-08-12
WO2017050934A1 (en) 2017-03-30
KR102648647B1 (ko) 2024-03-18
KR20180053743A (ko) 2018-05-23
US20180371537A1 (en) 2018-12-27
RU2018113750A (ru) 2019-10-23
US11028431B2 (en) 2021-06-08
EP3353320B1 (en) 2023-06-07
CN108350506A (zh) 2018-07-31
EP3353320C0 (en) 2023-06-07
JP2018528780A (ja) 2018-10-04
ES2950346T3 (es) 2023-10-09

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