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RU2018105003A - Композиции, содержащие аморфный эмодепсид - Google Patents

Композиции, содержащие аморфный эмодепсид Download PDF

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Publication number
RU2018105003A
RU2018105003A RU2018105003A RU2018105003A RU2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A
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RU
Russia
Prior art keywords
spp
emodepside
nematode
amorphic
compositions containing
Prior art date
Application number
RU2018105003A
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English (en)
Other versions
RU2761529C2 (ru
RU2018105003A3 (ru
Inventor
Венката-Рангарао КАНИКАНТИ
Петра ЛАНГЕ
Ханс-Юрген ХАМАНН
Петер КЛЯЙНЕБУДДЕ
Original Assignee
Байер Фарма Акциенгезельшафт
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47358491&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2018105003(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Фарма Акциенгезельшафт filed Critical Байер Фарма Акциенгезельшафт
Publication of RU2018105003A publication Critical patent/RU2018105003A/ru
Publication of RU2018105003A3 publication Critical patent/RU2018105003A3/ru
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Publication of RU2761529C2 publication Critical patent/RU2761529C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Claims (4)

1. Способ лечения или профилактики от эндопаразита, включающий введение нуждающемуся в этом человеку или животному эффективного количества фармацевтической композиции, содержащей эмодепсид в поливинилпирролидоновой матрице, причем по меньшей мере 50% эмодепсида находятся в аморфном состоянии.
2. Способ по п. 1, причем эндопаразит представляет собой гельминт, выбранный из нематоды.
3. Способ по п. 2, причем эндопаразит представляет собой нематоду, выбранную из отряда Trichinellida, Tylenchida, Rhabditina, Spirurida.
4. Способ no п. 3, причем нематода выбрана из Trichuris spp., Trichinella spp., Strongyloides spp., Ancylostoma spp., Enterobius spp., Ascaris spp., Toxascaris spp., Dracunculus spp., Loa spp., Brugia spp., Wuchereria spp., Onchocerca spp.
RU2018105003A 2011-12-21 2012-12-18 Композиции, содержащие аморфный эмодепсид RU2761529C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11194878 2011-12-21
EP11194878.2 2011-12-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2014129620A Division RU2651761C2 (ru) 2011-12-21 2012-12-18 Композиции, содержащие аморфный эмодепсид

Publications (3)

Publication Number Publication Date
RU2018105003A true RU2018105003A (ru) 2019-02-22
RU2018105003A3 RU2018105003A3 (ru) 2021-06-11
RU2761529C2 RU2761529C2 (ru) 2021-12-09

Family

ID=47358491

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2018105003A RU2761529C2 (ru) 2011-12-21 2012-12-18 Композиции, содержащие аморфный эмодепсид
RU2014129620A RU2651761C2 (ru) 2011-12-21 2012-12-18 Композиции, содержащие аморфный эмодепсид

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2014129620A RU2651761C2 (ru) 2011-12-21 2012-12-18 Композиции, содержащие аморфный эмодепсид

Country Status (24)

Country Link
US (3) US9539331B2 (ru)
EP (1) EP2793861B1 (ru)
JP (1) JP6185930B2 (ru)
KR (2) KR101979049B1 (ru)
CN (2) CN108187028A (ru)
AU (2) AU2012357848C1 (ru)
BR (1) BR112014014973A2 (ru)
CA (1) CA2859787C (ru)
CL (1) CL2014001637A1 (ru)
CO (1) CO6990713A2 (ru)
CR (1) CR20140293A (ru)
DO (1) DOP2014000140A (ru)
EC (1) ECSP14005917A (ru)
ES (1) ES2734352T3 (ru)
HK (1) HK1255536A1 (ru)
IL (1) IL233183B (ru)
MX (2) MX368209B (ru)
MY (2) MY175307A (ru)
NI (1) NI201400065A (ru)
PH (2) PH12014501438B1 (ru)
RU (2) RU2761529C2 (ru)
UA (1) UA115232C2 (ru)
WO (1) WO2013092558A1 (ru)
ZA (1) ZA201404529B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9539331B2 (en) 2011-12-21 2017-01-10 Bayer Intellectual Property Gmbh Preparations containing amorphous emodepside
WO2016187534A1 (en) 2015-05-20 2016-11-24 Merial, Inc. Anthelmintic depsipeptide compounds
EP3388065B1 (en) * 2015-12-08 2024-01-24 CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd. Decoquinate solid dispersion, method for preparing same and use thereof
SG11201805368YA (en) 2015-12-28 2018-07-30 Merial Inc Anthelmintic depsipeptide compounds
WO2018093920A1 (en) 2016-11-16 2018-05-24 Merial, Inc. Anthelmintic depsipeptide compounds
CN114195732A (zh) * 2022-01-04 2022-03-18 丽珠集团福州福兴医药有限公司 一种艾默德斯的单晶型iii及其制备方法
CN115444927B (zh) * 2022-09-19 2023-06-02 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) 艾默德斯在制备治疗三阴性乳腺癌的药物中的应用
WO2025233804A1 (en) * 2024-05-07 2025-11-13 Animol Discovery, Inc. Method of treating heartworm with emodepside

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU669883B2 (en) 1992-03-17 1996-06-27 Astellas Pharma Inc. Depsipeptide derivative, production thereof and use thereof
DE19918325A1 (de) * 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
DE10000792A1 (de) * 2000-01-11 2001-07-19 Bernhard C Lippold Formulierungen von Wirkstoffen in Form einer festen Dispersion
DE10031044A1 (de) 2000-06-26 2002-01-03 Bayer Ag Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere
DE10358525A1 (de) * 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
DE102004055316A1 (de) * 2004-11-16 2006-05-18 Bayer Healthcare Ag Verhinderung vertikaler Endoparasiten-Infektionen
DE102005011779A1 (de) * 2005-03-11 2006-09-14 Bayer Healthcare Ag Endoparasitizide Mittel
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
RU2315614C1 (ru) * 2006-04-19 2008-01-27 Бийтемир Ахмедович Султанбеков Средство "грепол" и способ применения его при паразитарных заболеваниях
DK2118055T3 (da) * 2007-02-09 2013-11-04 Zoetis Uk Ltd Antiparasitmidler
DE102008022520A1 (de) * 2008-05-07 2009-11-12 Bayer Animal Health Gmbh Feste Arzneimittelformulierung mit verzögerter Freisetzung
EP2355802A1 (de) * 2008-11-14 2011-08-17 Ratiopharm GmbH Intermediate und orale darreichungsformen enthaltend lenalidomid
DE102009012423A1 (de) 2009-03-10 2010-09-16 Bayer Animal Health Gmbh Zubereitung auf Ölbasis
US9539331B2 (en) 2011-12-21 2017-01-10 Bayer Intellectual Property Gmbh Preparations containing amorphous emodepside

Also Published As

Publication number Publication date
RU2761529C2 (ru) 2021-12-09
AU2018202376B2 (en) 2019-06-20
JP2015502377A (ja) 2015-01-22
WO2013092558A1 (de) 2013-06-27
PH12014501438A1 (en) 2014-10-08
ES2734352T3 (es) 2019-12-05
EP2793861B1 (de) 2019-05-01
CA2859787C (en) 2020-09-08
MX368209B (es) 2019-09-24
CN104023710A (zh) 2014-09-03
AU2012357848A1 (en) 2014-07-10
AU2012357848B2 (en) 2018-01-04
IL233183A0 (en) 2014-07-31
US20140371139A1 (en) 2014-12-18
ECSP14005917A (es) 2015-12-31
AU2012357848C1 (en) 2018-07-19
KR20140107296A (ko) 2014-09-04
RU2014129620A (ru) 2016-02-10
CN108187028A (zh) 2018-06-22
KR101978620B1 (ko) 2019-08-28
AU2018202376A1 (en) 2018-04-26
US20170182118A1 (en) 2017-06-29
PH12018500368A1 (en) 2018-07-23
RU2018105003A3 (ru) 2021-06-11
RU2651761C2 (ru) 2018-04-23
MX2014007224A (es) 2014-09-22
MX356094B (es) 2018-05-14
EP2793861A1 (de) 2014-10-29
CO6990713A2 (es) 2014-07-10
UA115232C2 (uk) 2017-10-10
KR101979049B1 (ko) 2019-05-15
US10251932B2 (en) 2019-04-09
BR112014014973A8 (pt) 2017-06-13
US9539331B2 (en) 2017-01-10
NZ625817A (en) 2016-08-26
NI201400065A (es) 2015-12-10
CA2859787A1 (en) 2013-06-27
JP6185930B2 (ja) 2017-08-23
CL2014001637A1 (es) 2014-11-21
MY203648A (en) 2024-07-11
KR20180084141A (ko) 2018-07-24
DOP2014000140A (es) 2014-07-31
PH12014501438B1 (en) 2017-09-15
US20180153957A1 (en) 2018-06-07
CR20140293A (es) 2014-07-14
HK1255536A1 (zh) 2019-08-23
ZA201404529B (en) 2017-06-28
BR112014014973A2 (pt) 2017-06-13
IL233183B (en) 2020-01-30
MY175307A (en) 2020-06-18

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