RU2018146249A - Модуляция активности гепарин-связывающего эпидермального фактора роста для заживления барабанной перепонки - Google Patents
Модуляция активности гепарин-связывающего эпидермального фактора роста для заживления барабанной перепонки Download PDFInfo
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- RU2018146249A RU2018146249A RU2018146249A RU2018146249A RU2018146249A RU 2018146249 A RU2018146249 A RU 2018146249A RU 2018146249 A RU2018146249 A RU 2018146249A RU 2018146249 A RU2018146249 A RU 2018146249A RU 2018146249 A RU2018146249 A RU 2018146249A
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- composition
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- eardrum
- perforation
- healing
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- 230000000694 effects Effects 0.000 title claims 4
- 238000000034 method Methods 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 7
- 210000003454 tympanic membrane Anatomy 0.000 claims 4
- 230000003111 delayed effect Effects 0.000 claims 3
- 102000018710 Heparin-binding EGF-like Growth Factor Human genes 0.000 claims 2
- 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- OFCWIPGKPUJTDP-CFVMTHIKSA-N (2s,3r)-n-hydroxy-2-methyl-n'-[(1s)-2-(methylamino)-2-oxo-1-phenylethyl]-3-(2-methylpropyl)butanediamide Chemical compound ONC(=O)[C@@H](C)[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NC)C1=CC=CC=C1 OFCWIPGKPUJTDP-CFVMTHIKSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 241000021559 Dicerandra Species 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 235000010654 Melissa officinalis Nutrition 0.000 claims 1
- 206010045210 Tympanic Membrane Perforation Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000865 liniment Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
- A61F11/20—Ear surgery
- A61F11/202—Surgical middle-ear ventilation or drainage, e.g. permanent; Implants therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0076—Sprayable compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/18—Internal ear or nose parts, e.g. ear-drums
- A61F2002/183—Ear parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Acoustics & Sound (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Composite Materials (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Claims (13)
1. Способ ингибирования заживления перфорации барабанной перепонки у индивидуума, причем указанный способ предусматривает контактирование места перфорации барабанной перепонки с составом, содержащим эффективную дозу агента, ингибирующего активность HB-EGF.
2. Способ по п. 1, предусматривающий этап создания перфорации в барабанной перепонке перед этапом контактирования.
3. Способ по п. 1, отличающийся тем, что индивидуум представляет собой человека.
4. Способ по п. 1, отличающийся тем, что состав представлен в виде водного раствора, геля, лосьона, бальзама, пасты или другой несущей среды.
5. Способ по п. 1, отличающийся тем, что композицию вводят в виде жидкости, которая впоследствии отвердевает, чтобы оставаться прилегающей к барабанной перепонке.
6. Способ по п. 1, отличающийся тем, что состав представляет собой гель с замедленным высвобождением.
7. Способ по п. 1, отличающийся тем, что гель с замедленным высвобождением является биоразлагаемым.
8. Способ по п. 7, отличающийся тем, что гель с замедленным высвобождением содержит сшитый сополимер хитозана и полилактида.
9. Способ по п. 8, отличающийся тем, что гель с замедленным высвобождением дополнительно содержит фибриноген.
10. Способ по п. 17, отличающийся тем, что состав помещают через перфорацию барабанной перепонки.
11. Способ по п. 10, отличающийся тем, что состав является биоразлагаемым и растворяется со временем.
12. Способ по п. 1, отличающийся тем, что агентом, который ингибирует активность HB-EGF, является OSU8-1/KB-R7785.
13. Состав для применения в способе по любому из пп. 1-12.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361823749P | 2013-05-15 | 2013-05-15 | |
| US61/823,749 | 2013-05-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015148636A Division RU2676483C2 (ru) | 2013-05-15 | 2014-04-09 | Модуляция активности гепаринсвязывающего эпидермального фактора роста для заживления барабанной перепонки |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018146249A true RU2018146249A (ru) | 2019-01-18 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018146249A RU2018146249A (ru) | 2013-05-15 | 2014-04-09 | Модуляция активности гепарин-связывающего эпидермального фактора роста для заживления барабанной перепонки |
| RU2015148636A RU2676483C2 (ru) | 2013-05-15 | 2014-04-09 | Модуляция активности гепаринсвязывающего эпидермального фактора роста для заживления барабанной перепонки |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2015148636A RU2676483C2 (ru) | 2013-05-15 | 2014-04-09 | Модуляция активности гепаринсвязывающего эпидермального фактора роста для заживления барабанной перепонки |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20160074476A1 (ru) |
| EP (2) | EP2996709B1 (ru) |
| JP (1) | JP6316943B2 (ru) |
| KR (1) | KR102318748B1 (ru) |
| CN (2) | CN105555296A (ru) |
| AU (2) | AU2014265901B2 (ru) |
| BR (2) | BR122020011229B1 (ru) |
| CA (1) | CA2912411C (ru) |
| CY (1) | CY1123464T1 (ru) |
| DK (1) | DK2996709T3 (ru) |
| ES (1) | ES2805002T3 (ru) |
| HR (1) | HRP20200971T1 (ru) |
| HU (1) | HUE049294T2 (ru) |
| IL (2) | IL242454B (ru) |
| LT (1) | LT2996709T (ru) |
| MX (2) | MX2015015774A (ru) |
| PH (2) | PH12015502577B1 (ru) |
| PL (1) | PL2996709T3 (ru) |
| PT (1) | PT2996709T (ru) |
| RS (1) | RS60412B1 (ru) |
| RU (2) | RU2018146249A (ru) |
| SG (1) | SG11201509347UA (ru) |
| SI (1) | SI2996709T1 (ru) |
| UA (1) | UA120037C2 (ru) |
| WO (1) | WO2014186075A2 (ru) |
| ZA (1) | ZA201508289B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102634748B1 (ko) | 2018-06-15 | 2024-02-13 | 삼성전자주식회사 | 포토 마스크용 펠리클 및 이의 제조 방법 |
| AU2020319755A1 (en) * | 2019-07-31 | 2022-03-10 | Astellas Pharma Inc. | Pharmaceutical composition for otic administration |
| KR102084146B1 (ko) * | 2019-09-03 | 2020-03-04 | (주)제이앤킴 | 이관 기능부전 치료를 위한 이관 내 삽입 스텐트 |
| WO2021163610A1 (en) * | 2020-02-13 | 2021-08-19 | Spiral Therapeutics Inc. | Treatment of otic diseases and conditions |
| EP4218822A4 (en) * | 2020-09-25 | 2024-10-16 | Astellas Pharma Inc. | Pharmaceutical composition for otic administration |
| US11984398B2 (en) | 2021-03-08 | 2024-05-14 | Changxin Memory Technologies, Inc. | Semiconductor structure and manufacturing method thereof |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| AU3124793A (en) | 1991-10-29 | 1993-06-07 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
| US6514533B1 (en) * | 1992-06-11 | 2003-02-04 | Alkermas Controlled Therapeutics, Inc. | Device for the sustained release of aggregation-stabilized, biologically active agent |
| US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| WO1997041899A1 (en) | 1996-05-03 | 1997-11-13 | Innogenetics N.V. | New medicaments containing gelatin cross-linked with oxidized polysaccharides |
| US5971953A (en) | 1998-01-09 | 1999-10-26 | Bachynsky; Nicholas | Dual chamber syringe apparatus |
| WO1999017820A1 (en) | 1997-10-03 | 1999-04-15 | Texas Pharmaceuticals, Inc. | Improved dual chamber syringe apparatus |
| US6191109B1 (en) * | 1997-10-31 | 2001-02-20 | Children's Hospital, Inc. | Methods of treating intestinal ischemia using heparin-binding epidermal growth factor |
| JP2002512200A (ja) * | 1998-04-17 | 2002-04-23 | アンジオジェニックス， インコーポレイテッド | 治療的な脈管形成因子およびその使用方法 |
| US20030040701A1 (en) | 1999-12-28 | 2003-02-27 | Dalmose Asger Lau | Dual chamber syringe with a dual function piston |
| WO2001070269A1 (en) | 2000-03-24 | 2001-09-27 | Akzo Nobel N.V. | Keratinocyte growth inhibitors and hydroxamic acid derivatives |
| US7067492B2 (en) | 2001-09-06 | 2006-06-27 | Omnio Ab | Method of promoting healing of a tympanic membrane perforation |
| US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| US20090148486A1 (en) * | 2005-04-28 | 2009-06-11 | Helen Lu | Compositions and methods for treating pulp inflammations caused by infection or trauma |
| US20070038298A1 (en) * | 2005-06-30 | 2007-02-15 | Sulner Joseph W | Repair of tympanic membrane using placenta derived collagen biofabric |
| WO2007037514A1 (ja) | 2005-09-28 | 2007-04-05 | Kagoshima University | ヘパリン結合性上皮増殖因子様増殖因子の新規医薬用途 |
| WO2008134635A1 (en) | 2007-04-30 | 2008-11-06 | Nationwide Children's Hospital | Heparin binding epidermal growth factor (hb-egf) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation |
| US20090192079A1 (en) * | 2007-10-09 | 2009-07-30 | Genzyme Corporation | Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen |
| US20110142819A1 (en) * | 2008-01-22 | 2011-06-16 | Omnio Healer Ab | Method of improving would healing |
| US8822410B2 (en) * | 2008-05-19 | 2014-09-02 | Children's Medical Center Corporation | Tympanic membrane permeating ear drops and uses thereof |
| KR101604150B1 (ko) * | 2008-06-26 | 2016-03-16 | 노벨파마 컴퍼니 리미티드 | 고막 또는 외이도 재생제 |
| CA2771436A1 (en) * | 2009-08-17 | 2011-02-24 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient |
| CN103037892A (zh) * | 2010-02-22 | 2013-04-10 | 布里格姆妇女医院 | 诱导血管生成的组合物和方法 |
| US8556854B2 (en) | 2010-07-22 | 2013-10-15 | Becton, Dickinson And Company | Dual chamber syringe with retractable needle |
| CN103764071B (zh) * | 2011-07-11 | 2017-02-15 | 澳大利亚耳科学研究所 | 鼓室修补器械 |
| US9821118B2 (en) | 2011-09-02 | 2017-11-21 | Unl Holdings Llc | Automatic reconstitution for dual chamber syringe |
| AU2013284453A1 (en) * | 2012-06-28 | 2015-01-22 | The Administrators Of The Tulane Educational Fund | Selectively polymerizable compositions and methods of use in Vivo |
| HK1221639A1 (zh) | 2013-04-09 | 2017-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | 交联的壳聚糖-丙交酯水凝胶 |
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2014
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