RU2017123262A - Иммуногенные композиции для применения в пневмококковых вакцинах - Google Patents
Иммуногенные композиции для применения в пневмококковых вакцинах Download PDFInfo
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- RU2017123262A RU2017123262A RU2017123262A RU2017123262A RU2017123262A RU 2017123262 A RU2017123262 A RU 2017123262A RU 2017123262 A RU2017123262 A RU 2017123262A RU 2017123262 A RU2017123262 A RU 2017123262A RU 2017123262 A RU2017123262 A RU 2017123262A
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- 239000000203 mixture Substances 0.000 title claims 19
- 230000002163 immunogen Effects 0.000 title claims 17
- 229960005486 vaccine Drugs 0.000 title 1
- 238000000034 method Methods 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 4
- 238000002965 ELISA Methods 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000000625 opsonophagocytic effect Effects 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (18)
1. Иммуногенная композиция, содержащая по меньшей мере один гликоконъюгат из S. pneumoniae серотипа 9V, для применения в способе иммунизации субъекта против инфекции S. pneumoniae серотипа 9N, 9А и/или 9L.
2. Иммуногенная композиция по п. 1, которая не содержит капсульный сахарид из S. pneumoniae серотипов 9N, 9А и 9L.
3. Иммуногенная композиция по любому из пп. 1-2, дополнительно содержащая гликоконъюгаты из S. pneumoniae серотипов 4, 6 В, 14, 18С, 19F и 23F.
4. Иммуногенная композиция по любому из пп. 1-3, дополнительно содержащая по меньшей мере один гликоконъюгат из S. pneumoniae серотипов 1, 3, 5, 6А, 7F и 19А.
5. Иммуногенная композиция по любому из пп. 1-4, которая способна вызывать у человека выработку антител IgG, которые способны к связыванию с полисахаридом S. pneumoniae серотипа 9N в концентрации по меньшей мере 0,35 мкг/мл при определении посредством анализа ELISA (твердофазный иммуноферментый анализ).
6. Иммуногенная композиция по любому из пп. 1-5, которая способна вызывать у человека выработку функциональных антител, которые способны уничтожать S. pneumoniae серотипа 9N, 9А и/или 9L при определении посредством опсонофагоцитарного анализа in vitro (ОРА).
7. Иммуногенная композиция по любому из пп. 1-6, которая способна вызывать титр по меньшей мере 1:8 против S. pneumoniae серотипа 9N по меньшей мере у 50% субъектов при определении посредством анализа опсонофагоцитарного уничтожения in vitro (ОРА).
8. Иммуногенная композиция по любому из пп. 1-7 для применения в способе иммунизации субъекта против инфекции S. pneumoniae серотипа 9N, 9А и 9L.
9. Иммуногенная композиция по любому из пп. 1-7 для применения для предупреждения инфекции серотипами 9N, 9А и/или 9L S. pneumoniae у субъекта.
10. Способ предупреждения, лечения или уменьшения интенсивности инфекции, заболевания или состояния, ассоциированных с S. pneumoniae серотипов 9N, 9А и/или 9L, у субъекта, включающий введение субъекту иммунологически эффективного количества иммуногенной композиции по любому из пп. 1-7.
11. Набор, содержащий иммуногенную композицию по любому из пп. 1-7 и информационный листок.
12. Набор по п. 11, в котором в указанном информационном листке упоминается способность композиции вызывать выработку функциональных антител против S. pneumoniae серотипов 9А, 9L и/или 9N.
13. Способ получения набора, содержащего иммуногеную композицию и информационный листок, где указанный способ включает стадию:
получения иммуногенной композиции по любому из пп. 1-7;
печати информационного листка, где в указанном информационном листке упоминается способность указанной композиции вызывать выработку функциональных антител против S. pneumoniae серотипов 9А, 9L и/или 9N;
объединения в одном и том же наборе указанной иммуногенной композиции и указанного информационного листка.
14. Способ индуцирования иммунного ответа на S. pneumoniae серотипов 9N, 9А и/или 9L у субъекта, включающий введение субъекту иммунологически эффективного количества иммуногенной композиции по любому из пп. 1-7.
15. Применение иммуногенной композиции по любому из пп. 1-7 для изготовления лекарственного средства для предупреждения инфекции серотипами 9N, 9А и/или 9L S. pneumoniae у субъекта.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562103630P | 2015-01-15 | 2015-01-15 | |
| US62/103,630 | 2015-01-15 | ||
| PCT/IB2016/050036 WO2016113644A1 (en) | 2015-01-15 | 2016-01-05 | Immunogenic compositions for use in pneumococcal vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017123262A true RU2017123262A (ru) | 2019-02-15 |
| RU2017123262A3 RU2017123262A3 (ru) | 2019-02-15 |
| RU2712622C2 RU2712622C2 (ru) | 2020-01-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017123262A RU2712622C2 (ru) | 2015-01-15 | 2016-01-05 | Иммуногенные композиции для применения в пневмококковых вакцинах |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10653764B2 (ru) |
| EP (1) | EP3244917B1 (ru) |
| JP (3) | JP6857962B2 (ru) |
| KR (1) | KR102149760B1 (ru) |
| CN (1) | CN107427568B (ru) |
| AU (1) | AU2016207820B2 (ru) |
| BR (1) | BR112017013891B1 (ru) |
| CA (1) | CA2917331A1 (ru) |
| DK (1) | DK3244917T5 (ru) |
| ES (1) | ES2945312T3 (ru) |
| FI (1) | FI3244917T3 (ru) |
| HR (1) | HRP20230416T1 (ru) |
| HU (1) | HUE062499T2 (ru) |
| IL (1) | IL252915B2 (ru) |
| MX (1) | MX395525B (ru) |
| PL (1) | PL3244917T3 (ru) |
| PT (1) | PT3244917T (ru) |
| RU (1) | RU2712622C2 (ru) |
| SI (1) | SI3244917T1 (ru) |
| WO (1) | WO2016113644A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2827429C1 (ru) * | 2020-11-04 | 2024-09-26 | Пфайзер Инк. | Иммуногенные композиции для применения в пневмококковых вакцинах |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016015835B1 (pt) | 2014-01-21 | 2023-12-26 | Pfizer Inc | Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae |
| US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| FI3244917T3 (fi) | 2015-01-15 | 2023-05-25 | Pfizer | Immunogeenisiä koostumuksia pneumokokkirokotteissa käytettäväksi |
| KR102225282B1 (ko) | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| EP3493837B1 (en) | 2016-08-05 | 2022-08-31 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CA3031797A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| ES3024474T3 (en) | 2016-12-30 | 2025-06-04 | Vaxcyte Inc | Polypeptide-antigen conjugates with non-natural amino acids |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| SI3570879T1 (sl) * | 2017-01-20 | 2022-06-30 | Pfizer Inc. | Imunogenska kompozicija za uporabo v pnevmokoknih cepivih |
| KR20190108583A (ko) | 2017-01-31 | 2019-09-24 | 머크 샤프 앤드 돔 코포레이션 | 다당류-단백질 접합체 제조 방법 |
| US11246918B2 (en) | 2017-02-03 | 2022-02-15 | Eva Barbara Schadeck | Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof |
| EP3589314A4 (en) * | 2017-02-24 | 2021-04-21 | Merck Sharp & Dohme Corp. | INCREASED IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE PROTEIN CONJUGATES |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| CN117018172A (zh) | 2017-09-07 | 2023-11-10 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| BR112020004471A8 (pt) | 2017-09-07 | 2022-11-01 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| EP3691677A4 (en) | 2017-10-04 | 2021-07-07 | Pogona, Llc | COMPOSITIONS OF SACCHARIDE-POLYPEPTIDE CONJUGATES AND THEIR METHODS OF USE |
| US11116828B2 (en) | 2017-12-06 | 2021-09-14 | Merck Sharp & Dohme Corp. | Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| AU2019215216B2 (en) | 2018-02-05 | 2025-04-17 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| SG11202006387QA (en) | 2018-02-05 | 2020-07-29 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2019256218B2 (en) | 2018-04-18 | 2025-10-16 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharides and immunogenic conjugate thereof |
| US11896656B2 (en) | 2018-04-30 | 2024-02-13 | Merck Sharp & Dohme Llc | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| EP3787674A4 (en) | 2018-04-30 | 2022-01-26 | Merck Sharp & Dohme Corp. | PROCESS FOR THE PRODUCTION OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE CAPSULAR PROTEIN CONJUGATES FROM LYOSPHERES |
| CN120661645A (zh) | 2018-04-30 | 2025-09-19 | 默沙东有限责任公司 | 生产肺炎链球菌荚膜多糖载体蛋白缀合物的方法 |
| GEP20247633B (en) | 2018-12-19 | 2024-06-25 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| CN110302375A (zh) * | 2019-06-27 | 2019-10-08 | 康希诺生物股份公司 | 一种糖缀合物及其用途 |
| CN114324898B (zh) * | 2022-03-11 | 2022-05-31 | 南京岚煜生物科技有限公司 | 用于肝素结合蛋白hbp检测的结合垫处理液 |
| CN115434545B (zh) * | 2022-08-19 | 2023-12-29 | 三亚市中医院 | 中医医院防疫移动病房 |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
| US4950740A (en) | 1987-03-17 | 1990-08-21 | Cetus Corporation | Recombinant diphtheria vaccines |
| GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| EP0482068A1 (en) | 1989-07-14 | 1992-04-29 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
| ATE245446T1 (de) | 1992-02-11 | 2003-08-15 | Jackson H M Found Military Med | Dualer träger für immunogene konstrukte |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| CA2135052A1 (en) | 1992-05-06 | 1993-11-11 | R. John Collier | Diphtheria toxin receptor-binding region |
| NZ253137A (en) | 1992-06-25 | 1996-08-27 | Smithkline Beecham Biolog | Vaccine comprising antigen and/or antigenic composition, qs21 (quillaja saponaria molina extract) and 3 de-o-acylated monophosphoryl lipid a. |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| PT616034E (pt) | 1993-03-05 | 2005-02-28 | Wyeth Corp | Plasmideo para a producao de proteina crm e toxina da difteria |
| US5776468A (en) | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
| JP3828145B2 (ja) | 1993-09-22 | 2006-10-04 | ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン | 免疫原性構成物の製造のための新規シアン化試薬を使った可溶性炭水化物の活性化方法 |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
| JP3468773B2 (ja) | 1994-07-15 | 2003-11-17 | ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 免疫調節オリゴヌクレオチド |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| ATE241384T1 (de) | 1995-03-22 | 2003-06-15 | Jackson H M Found Military Med | Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| JP2001513776A (ja) | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| DE69838294T2 (de) | 1997-05-20 | 2009-08-13 | Ottawa Health Research Institute, Ottawa | Verfahren zur Herstellung von Nukleinsäurekonstrukten |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| EP1009382B1 (en) | 1997-09-05 | 2003-06-18 | GlaxoSmithKline Biologicals S.A. | Oil in water emulsions containing saponins |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| WO1999051259A2 (en) | 1998-04-03 | 1999-10-14 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| KR20010042573A (ko) | 1998-04-09 | 2001-05-25 | 장 스테판느 | 애쥬번트 조성물 |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| CN100406060C (zh) | 1998-10-16 | 2008-07-30 | 史密丝克莱恩比彻姆生物有限公司 | 一种佐剂组合物 |
| JP4689044B2 (ja) | 1998-12-21 | 2011-05-25 | メディミューン，インコーポレーテッド | ワクチン用の肺炎連鎖球菌タンパク質と免疫原断片 |
| CA2356836C (en) | 1998-12-23 | 2011-09-13 | Shire Biochem Inc. | Novel streptococcus antigens |
| AUPP807399A0 (en) | 1999-01-08 | 1999-02-04 | Csl Limited | Improved immunogenic lhrh composition and methods relating thereto |
| NZ513935A (en) | 1999-02-17 | 2004-02-27 | Csl Ltd | Immunogenic complexes and methods relating thereto |
| DE122009000054I1 (de) | 1999-03-19 | 2009-12-31 | Glaxosmithkline Biolog Sa | Impfstoff gegen bakterielle antigene |
| US6936258B1 (en) | 1999-03-19 | 2005-08-30 | Nabi Biopharmaceuticals | Staphylococcus antigen and vaccine |
| EP1165796A2 (en) | 1999-04-09 | 2002-01-02 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| CN1227030C (zh) | 1999-04-19 | 2005-11-16 | 史密丝克莱恩比彻姆生物有限公司 | 包含皂甙和免疫刺激寡核苷酸的佐剂组合物 |
| AU765824B2 (en) | 1999-09-24 | 2003-10-02 | Smithkline Beecham Biologicals (Sa) | Vaccines |
| CO5200838A1 (es) | 1999-09-24 | 2002-09-27 | Smithkline Beecham Corp | Vacunas |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| AU2001270381B2 (en) | 2000-06-20 | 2007-05-24 | Id Biomedical Corporation | Streptococcus antigens |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| US20030035806A1 (en) | 2001-05-11 | 2003-02-20 | D'ambra Anello J. | Novel meningitis conjugate vaccine |
| JP4360906B2 (ja) | 2001-09-14 | 2009-11-11 | サイトス バイオテクノロジー アーゲー | ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化 |
| EP1456231A2 (en) | 2001-12-20 | 2004-09-15 | Shire Biochem Inc. | Streptococcus antigens |
| KR101052996B1 (ko) | 2003-03-13 | 2011-07-29 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 박테리아 세포용해소에 대한 정제 공정 |
| CA2519511A1 (en) | 2003-03-17 | 2004-09-30 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| AU2005333126A1 (en) | 2004-07-18 | 2006-12-21 | Csl Limited | Methods and compositions for inducing innate immune responses |
| JP2008506789A (ja) | 2004-07-18 | 2008-03-06 | シーエスエル、リミテッド | インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物 |
| GB0421083D0 (en) | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
| US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| HUE050049T2 (hu) | 2005-04-08 | 2020-11-30 | Wyeth Llc | Szennyezõanyagok elválasztása streptococcus pneumoniae poliszacharidtól PH manipulációjával |
| CN104815327A (zh) | 2005-04-08 | 2015-08-05 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| WO2008045852A2 (en) | 2006-10-10 | 2008-04-17 | Wyeth | Purification of streptococcus pneumoniae type 3 polysaccharides |
| UA99278C2 (ru) | 2007-03-23 | 2012-08-10 | УАЙЕТ ЭлЭлСи | Способ получения существенно очищенных капсульных полисахаридов из лизата клеток streptococcus pneumoniae |
| AU2008267208B2 (en) | 2007-06-26 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
| US20090228380A1 (en) | 2008-03-10 | 2009-09-10 | Xerox Corporation | Centralized classification and retention of tax records |
| RU2536248C2 (ru) | 2009-04-30 | 2014-12-20 | Коули Фармасьютикал Груп, Инк. | Пневмококковая вакцина и ее применения |
| CN101590224A (zh) * | 2009-06-30 | 2009-12-02 | 广州精达医学科技有限公司 | 高效14价肺炎球菌结合疫苗 |
| US20150147356A1 (en) * | 2011-05-12 | 2015-05-28 | Alan Kimura | Antipyretics to enhance tolerability of vesicle-based vaccines |
| KR102057217B1 (ko) * | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| PT2885007T (pt) | 2012-08-16 | 2018-12-10 | Pfizer | Processos e composições de glicoconjugação |
| CN103656631B (zh) | 2012-09-24 | 2015-08-19 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法 |
| KR20140075196A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| HUE060718T2 (hu) | 2012-12-20 | 2023-04-28 | Pfizer | Glikokonjugációs eljárás |
| CN103469161B (zh) | 2013-09-24 | 2015-08-12 | 四川虹视显示技术有限公司 | 蒸发源 |
| CN103495161B (zh) | 2013-10-08 | 2019-06-18 | 江苏康泰生物医学技术有限公司 | 一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法 |
| EP3607966A1 (en) * | 2014-01-21 | 2020-02-12 | Pfizer Inc | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| FI3244917T3 (fi) * | 2015-01-15 | 2023-05-25 | Pfizer | Immunogeenisiä koostumuksia pneumokokkirokotteissa käytettäväksi |
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- 2016-01-05 FI FIEP16702585.7T patent/FI3244917T3/fi active
- 2016-01-05 IL IL252915A patent/IL252915B2/en unknown
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- 2016-01-05 AU AU2016207820A patent/AU2016207820B2/en active Active
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- 2016-01-05 CN CN201680015855.9A patent/CN107427568B/zh active Active
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- 2016-01-05 BR BR112017013891-3A patent/BR112017013891B1/pt active IP Right Grant
- 2016-01-05 HR HRP20230416TT patent/HRP20230416T1/hr unknown
- 2016-01-05 US US15/542,802 patent/US10653764B2/en active Active
- 2016-01-05 RU RU2017123262A patent/RU2712622C2/ru active
- 2016-01-05 WO PCT/IB2016/050036 patent/WO2016113644A1/en not_active Ceased
- 2016-01-05 SI SI201631694T patent/SI3244917T1/sl unknown
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- 2016-01-05 EP EP16702585.7A patent/EP3244917B1/en active Active
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2827429C1 (ru) * | 2020-11-04 | 2024-09-26 | Пфайзер Инк. | Иммуногенные композиции для применения в пневмококковых вакцинах |
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