RU2017108196A - Применение цистеамина в лечении инфекции, вызываемой дрожжевыми грибками/плесневыми грибками - Google Patents

Применение цистеамина в лечении инфекции, вызываемой дрожжевыми грибками/плесневыми грибками Download PDF

Info

Publication number: RU2017108196A
Authority: RU; Russia
Prior art keywords: species; composition according; infection; cysteamine; caused
Prior art date: 2014-09-22

Application number

RU2017108196A

Other languages

English (en)

Russian (ru)

Other versions

RU2017108196A3 (es

Inventor

Дебора Онил

Ванесса Дункан

Original Assignee

НоваБиотикс Лимитед

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-09-22

Filing date

2015-09-21

Publication date

2018-10-24

2015-09-21 Application filed by НоваБиотикс Лимитед filed Critical НоваБиотикс Лимитед

2018-10-24 Publication of RU2017108196A publication Critical patent/RU2017108196A/ru

2019-06-19 Publication of RU2017108196A3 publication Critical patent/RU2017108196A3/ru

Links

208000015181 infectious disease Diseases 0.000 title claims 6
UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 title claims 4
229960003151 mercaptamine Drugs 0.000 title claims 4
240000004808 Saccharomyces cerevisiae Species 0.000 title claims 3
238000011282 treatment Methods 0.000 title claims 3
239000000203 mixture Substances 0.000 claims 9
241000894007 species Species 0.000 claims 9
241000223682 Exophiala Species 0.000 claims 3
241000228212 Aspergillus Species 0.000 claims 2
206010006473 Bronchopulmonary aspergillosis Diseases 0.000 claims 2
241000222120 Candida <Saccharomycetales> Species 0.000 claims 2
241000222122 Candida albicans Species 0.000 claims 2
201000007336 Cryptococcosis Diseases 0.000 claims 2
241001527609 Cryptococcus Species 0.000 claims 2
241000221204 Cryptococcus neoformans Species 0.000 claims 2
208000004430 Pulmonary Aspergillosis Diseases 0.000 claims 2
208000002474 Tinea Diseases 0.000 claims 2
239000003429 antifungal agent Substances 0.000 claims 2
238000011321 prophylaxis Methods 0.000 claims 2
VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
241000235389 Absidia Species 0.000 claims 1
241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 claims 1
241000187362 Actinomadura Species 0.000 claims 1
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
241000293035 Apophysomyces Species 0.000 claims 1
241000985243 Arthrographis Species 0.000 claims 1
201000002909 Aspergillosis Diseases 0.000 claims 1
208000036641 Aspergillus infections Diseases 0.000 claims 1
241000235579 Basidiobolus Species 0.000 claims 1
241000223679 Beauveria Species 0.000 claims 1
241000335423 Blastomyces Species 0.000 claims 1
206010005098 Blastomycosis Diseases 0.000 claims 1
206010007134 Candida infections Diseases 0.000 claims 1
108010020326 Caspofungin Proteins 0.000 claims 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
241000123346 Chrysosporium Species 0.000 claims 1
241001633123 Cladophialophora Species 0.000 claims 1
241000223203 Coccidioides Species 0.000 claims 1
241000223205 Coccidioides immitis Species 0.000 claims 1
241001480517 Conidiobolus Species 0.000 claims 1
241000235555 Cunninghamella Species 0.000 claims 1
201000003883 Cystic fibrosis Diseases 0.000 claims 1
201000004624 Dermatitis Diseases 0.000 claims 1
208000007163 Dermatomycoses Diseases 0.000 claims 1
206010012504 Dermatophytosis Diseases 0.000 claims 1
241001123635 Dipodascus Species 0.000 claims 1
241001262659 Emmonsia Species 0.000 claims 1
206010014561 Emphysema Diseases 0.000 claims 1
241001480035 Epidermophyton Species 0.000 claims 1
206010017523 Fungaemia Diseases 0.000 claims 1
206010017533 Fungal infection Diseases 0.000 claims 1
241000223218 Fusarium Species 0.000 claims 1
241000159512 Geotrichum Species 0.000 claims 1
241000190550 Graphium <Microascales incertae sedis> Species 0.000 claims 1
241000228402 Histoplasma Species 0.000 claims 1
201000002563 Histoplasmosis Diseases 0.000 claims 1
241000526728 Lacazia Species 0.000 claims 1
241000228456 Leptosphaeria Species 0.000 claims 1
241000555676 Malassezia Species 0.000 claims 1
241000555688 Malassezia furfur Species 0.000 claims 1
201000009906 Meningitis Diseases 0.000 claims 1
206010027236 Meningitis fungal Diseases 0.000 claims 1
241001480037 Microsporum Species 0.000 claims 1
241001460074 Microsporum distortum Species 0.000 claims 1
241000235395 Mucor Species 0.000 claims 1
241000322230 Neotestudina Species 0.000 claims 1
241000187654 Nocardia Species 0.000 claims 1
241000203622 Nocardiopsis Species 0.000 claims 1
208000010195 Onychomycosis Diseases 0.000 claims 1
241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 claims 1
206010033767 Paracoccidioides infections Diseases 0.000 claims 1
201000000301 Paracoccidioidomycosis Diseases 0.000 claims 1
206010064458 Penicilliosis Diseases 0.000 claims 1
241001503951 Phoma Species 0.000 claims 1
241001326501 Piedraia Species 0.000 claims 1
241000233870 Pneumocystis Species 0.000 claims 1
208000005384 Pneumocystis Pneumonia Diseases 0.000 claims 1
206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 claims 1
241000223596 Pseudallescheria Species 0.000 claims 1
241000223252 Rhodotorula Species 0.000 claims 1
241000235070 Saccharomyces Species 0.000 claims 1
241000132889 Scedosporium Species 0.000 claims 1
241000122799 Scopulariopsis Species 0.000 claims 1
241000222068 Sporobolomyces <Sporidiobolaceae> Species 0.000 claims 1
206010041736 Sporotrichosis Diseases 0.000 claims 1
241000736854 Syncephalastrum Species 0.000 claims 1
241000130764 Tinea Species 0.000 claims 1
241000223259 Trichoderma Species 0.000 claims 1
241000223238 Trichophyton Species 0.000 claims 1
241001459572 Trichophyton interdigitale Species 0.000 claims 1
241000223229 Trichophyton rubrum Species 0.000 claims 1
241000223230 Trichosporon Species 0.000 claims 1
241000266300 Ulocladium Species 0.000 claims 1
241000221566 Ustilago Species 0.000 claims 1
241000082085 Verticillium <Phyllachorales> Species 0.000 claims 1
206010061418 Zygomycosis Diseases 0.000 claims 1
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
229960003942 amphotericin b Drugs 0.000 claims 1
239000003242 anti bacterial agent Substances 0.000 claims 1
201000010564 basidiobolomycosis Diseases 0.000 claims 1
230000003115 biocidal effect Effects 0.000 claims 1
201000003984 candidiasis Diseases 0.000 claims 1
JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 claims 1
229960003034 caspofungin Drugs 0.000 claims 1
230000001684 chronic effect Effects 0.000 claims 1
201000003486 coccidioidomycosis Diseases 0.000 claims 1
201000003929 dermatomycosis Diseases 0.000 claims 1
239000003085 diluting agent Substances 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 1
229960004884 fluconazole Drugs 0.000 claims 1
208000024386 fungal infectious disease Diseases 0.000 claims 1
201000010056 fungal meningitis Diseases 0.000 claims 1
229960004130 itraconazole Drugs 0.000 claims 1
238000000034 method Methods 0.000 claims 1
201000007524 mucormycosis Diseases 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
201000000317 pneumocystosis Diseases 0.000 claims 1
201000009800 pulmonary aspergilloma Diseases 0.000 claims 1
201000005882 tinea unguium Diseases 0.000 claims 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

RU2017108196A 2014-09-22 2015-09-21 Применение цистеамина в лечении инфекции, вызываемой дрожжевыми грибками/плесневыми грибками RU2017108196A (ru)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201462053523P	2014-09-22	2014-09-22
GB1416727.4		2014-09-22
GBGB1416727.4A GB201416727D0 (en)	2014-09-22	2014-09-22	Use
US62/053,523		2014-09-22
PCT/GB2015/052714 WO2016046524A1 (en)	2014-09-22	2015-09-21	Use of cysteamine in treating infections caused by yeasts/moulds

Publications (2)

Publication Number	Publication Date
RU2017108196A true RU2017108196A (ru)	2018-10-24
RU2017108196A3 RU2017108196A3 (es)	2019-06-19

Family

ID=51869299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU2017108196A RU2017108196A (ru)	2014-09-22	2015-09-21	Применение цистеамина в лечении инфекции, вызываемой дрожжевыми грибками/плесневыми грибками

Country Status (14)

Country	Link
EP (1)	EP3197476A1 (es)
JP (1)	JP2017532317A (es)
KR (1)	KR20170052613A (es)
CN (1)	CN106687140A (es)
AU (1)	AU2015323566B2 (es)
BR (1)	BR112017005272A2 (es)
CA (1)	CA2959003A1 (es)
GB (1)	GB201416727D0 (es)
MX (1)	MX2017003550A (es)
NZ (1)	NZ730092A (es)
RU (1)	RU2017108196A (es)
SG (1)	SG11201701648UA (es)
WO (1)	WO2016046524A1 (es)
ZA (1)	ZA201701330B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR112017028448A2 (pt)	2015-07-02	2018-08-28	Horizon Orphan Llc	análogos de cisteamina resistentes a ado e usos dos mesmos
EP3573994A4 (en) *	2017-01-25	2020-11-11	Adare Pharmaceuticals, Inc.	MEDICINES OF CYSTEAMINE
WO2018224813A1 (en) *	2017-06-06	2018-12-13	Novabiotics Limited	Use of cysteamine compositions
EP3866775B1 (en) *	2018-10-17	2025-03-19	Novabiotics Limited	Cysteamine for use in the treatment of lung diseases
CN110551637B (zh) *	2019-09-03	2020-11-27	黑龙江省农业科学院植物保护研究所	一种来自黄芪根部的高效抑制番茄灰霉病菌的棘壳孢菌及其应用
CN110859950B (zh) *	2019-11-25	2021-08-10	武汉大学	一种用于白念珠菌棘白菌素类药物耐药菌的药物组合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5696164A (en) *	1994-12-22	1997-12-09	Johnson & Johnson Consumer Products, Inc.	Antifungal treatment of nails
US6086921A (en) *	1995-04-25	2000-07-11	Wintrop-University Hospital	Metal/thiol biocides
EP1927597B1 (en) *	2004-08-18	2016-11-02	Novabiotics Limited	Antibacterial peptides
JP2006347990A (ja) *	2005-06-20	2006-12-28	Pola Chem Ind Inc	爪用の抗真菌医薬組成物
JP2006347989A (ja) *	2005-06-20	2006-12-28	Pola Chem Ind Inc	爪用の抗真菌医薬組成物
GB0905451D0 (en) *	2009-03-31	2009-05-13	Novabiotics Ltd	Biofilms
AU2010283031A1 (en) *	2009-08-13	2012-01-19	Moberg Derma Ab	Compositions and methods for treating fungal infection of the nail
GB201021186D0 (en) *	2010-12-14	2011-01-26	Novabiotics Ltd	Composition

2014
- 2014-09-22 GB GBGB1416727.4A patent/GB201416727D0/en not_active Ceased
2015
- 2015-09-21 JP JP2017515704A patent/JP2017532317A/ja active Pending
- 2015-09-21 CN CN201580051064.7A patent/CN106687140A/zh active Pending
- 2015-09-21 BR BR112017005272A patent/BR112017005272A2/pt not_active Application Discontinuation
- 2015-09-21 SG SG11201701648UA patent/SG11201701648UA/en unknown
- 2015-09-21 NZ NZ730092A patent/NZ730092A/en not_active IP Right Cessation
- 2015-09-21 CA CA2959003A patent/CA2959003A1/en not_active Abandoned
- 2015-09-21 EP EP15770619.3A patent/EP3197476A1/en not_active Withdrawn
- 2015-09-21 MX MX2017003550A patent/MX2017003550A/es unknown
- 2015-09-21 AU AU2015323566A patent/AU2015323566B2/en not_active Ceased
- 2015-09-21 RU RU2017108196A patent/RU2017108196A/ru not_active Application Discontinuation
- 2015-09-21 WO PCT/GB2015/052714 patent/WO2016046524A1/en not_active Ceased
- 2015-09-21 KR KR1020177008807A patent/KR20170052613A/ko not_active Withdrawn
2017
- 2017-02-22 ZA ZA2017/01330A patent/ZA201701330B/en unknown

Also Published As

Publication number	Publication date
AU2015323566B2 (en)	2018-03-22
WO2016046524A1 (en)	2016-03-31
NZ730092A (en)	2018-05-25
AU2015323566A1 (en)	2017-04-06
GB201416727D0 (en)	2014-11-05
CA2959003A1 (en)	2016-03-31
RU2017108196A3 (es)	2019-06-19
EP3197476A1 (en)	2017-08-02
MX2017003550A (es)	2017-07-28
CN106687140A (zh)	2017-05-17
KR20170052613A (ko)	2017-05-12
JP2017532317A (ja)	2017-11-02
ZA201701330B (en)	2018-04-25
SG11201701648UA (en)	2017-04-27
BR112017005272A2 (pt)	2017-12-12

Publication	Publication Date	Title
RU2017108196A (ru)	2018-10-24	Применение цистеамина в лечении инфекции, вызываемой дрожжевыми грибками/плесневыми грибками
Du et al.	2015	Phytophthora infestans RXLR effector AVR1 interacts with exocyst component Sec5 to manipulate plant immunity
Mackey et al.	2002	RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis
Domazakis et al.	2018	The ELR-SOBIR1 complex functions as a two-component receptor-like kinase to mount defense against Phytophthora infestans
Zvereva et al.	2016	Viral protein suppresses oxidative burst and salicylic acid-dependent autophagy and facilitates bacterial growth on virus-infected plants
Rehman et al.	2009	A secreted SPRY domain-containing protein (SPRYSEC) from the plant-parasitic nematode Globodera rostochiensis interacts with a CC-NB-LRR protein from a susceptible tomato
Kretschmer et al.	2009	Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea
DK2251348T3 (en)	2014-03-03	Peptides and use thereof
Wang et al.	2022	Verticillium dahliae CFEM proteins manipulate host immunity and differentially contribute to virulence
Nürnberger	1999	Signal perception in plant pathogen defense
Pant et al.	2014	S yntaxin 31 functions in Glycine max resistance to the plant parasitic nematode Heterodera glycines
JP2012120535A5 (es)	2013-04-25
Wang et al.	2014	Wheat TaNPSN SNARE homologues are involved in vesicle-mediated resistance to stripe rust (Puccinia striiformis f. sp. tritici)
Vetukuri et al.	2017	Phytophthora infestans effector Pi14054 is a novel candidate suppressor of host silencing mechanisms
Chen et al.	2018	StPOTHR1, a NDR1/HIN1-like gene in Solanum tuberosum, enhances resistance against Phytophthora infestans
RU2008129866A (ru)	2010-01-27	Циклические противомикробные пептиды
Park et al.	2009	Nicotiana benthamiana protein, NbPCIP1, interacting with Potato virus X coat protein plays a role as susceptible factor for viral infection
Yan	2011	Isolation and expression patterns of rice WRKY82 transcription factor gene responsive to both biotic and abiotic stresses
Wang et al.	2023	Systemic screening of Fusarium oxysporum candidate effectors reveals FoSSP17 that suppresses plant immunity and contributes to virulence
Chen et al.	2022	Fungal oxysterol-binding protein-related proteins promote pathogen virulence and activate plant immunity
Fei et al.	2022	PnSCR82, a small cysteine-rich secretory protein of Phytophthora nicotianae, can enhance defense responses in plants
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