RU2017143465A - Бактерия lactobacillus rhamnosus для лечения, например, бактериального вагиноза - Google Patents
Бактерия lactobacillus rhamnosus для лечения, например, бактериального вагиноза Download PDFInfo
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- RU2017143465A RU2017143465A RU2017143465A RU2017143465A RU2017143465A RU 2017143465 A RU2017143465 A RU 2017143465A RU 2017143465 A RU2017143465 A RU 2017143465A RU 2017143465 A RU2017143465 A RU 2017143465A RU 2017143465 A RU2017143465 A RU 2017143465A
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- food
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- lactic acid
- lactobacillus rhamnosus
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- 241000218588 Lactobacillus rhamnosus Species 0.000 title claims 6
- 208000004926 Bacterial Vaginosis Diseases 0.000 title claims 4
- 208000037009 Vaginitis bacterial Diseases 0.000 title claims 4
- 235000013305 food Nutrition 0.000 claims 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 235000014655 lactic acid Nutrition 0.000 claims 6
- 239000004310 lactic acid Substances 0.000 claims 6
- 241000894006 Bacteria Species 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 206010046914 Vaginal infection Diseases 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 230000001332 colony forming effect Effects 0.000 claims 2
- 235000021107 fermented food Nutrition 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- 208000019206 urinary tract infection Diseases 0.000 claims 2
- 208000004746 Atrophic Vaginitis Diseases 0.000 claims 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 206010048461 Genital infection Diseases 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000002577 cryoprotective agent Substances 0.000 claims 1
- 235000015140 cultured milk Nutrition 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 230000035622 drinking Effects 0.000 claims 1
- 235000019985 fermented beverage Nutrition 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 230000009245 menopause Effects 0.000 claims 1
- 244000005706 microflora Species 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- -1 sachets Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 235000008924 yoghurt drink Nutrition 0.000 claims 1
- 235000013618 yogurt Nutrition 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
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- A—HUMAN NECESSITIES
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- A23K10/00—Animal feeding-stuffs
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- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/02—Separating microorganisms from their culture media
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
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- Reproductive Health (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
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- Communicable Diseases (AREA)
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- Tropical Medicine & Parasitology (AREA)
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- General Engineering & Computer Science (AREA)
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Claims (17)
1. Молочнокислая бактерия Lactobacillus rhamnosus с регистрационным номером СЕСТ 8800.
2. Пищевая или фармацевтическая композиция, включающая бактерию по п. 1.
3. Пищевая или фармацевтическая композиция по п. 2, где концентрация жизнеспособных клеток в композиции находится в диапазоне от 104 до 1014 КОЕ (колониеобразующих единиц) на грамм композиции, предпочтительно, где концентрация жизнеспособных клеток находится в диапазоне от 116 до 1013 КОЕ (колониеобразующих единиц) на грамм композиции.
4. Пищевая или фармацевтическая композиция по любому из пп. 1-3, причем композиция содержит бактерии в замороженном виде, высушенном виде или лиофилизированном виде.
5. Пищевая или фармацевтическая композиция по п. 4, причем композиция содержит бактерии в лиофилизированном виде, и композиция дополнительно содержит подходящие криопротекторные средства (например, мальтодекстрин).
6. Пищевая или фармацевтическая композиция по пп. 1-5, где композиция подходит для перорального приема или вагинального введения.
7. Пищевая или фармацевтическая композиция по п. 6, причем композиция имеет форму суппозиториев, вагинальных капсул для вагинального введения или капсул с покрытием, таблеток, саше, пилюль, ампул, флаконов для перорального приема, йогурта, йогуртовых напитков, ферментированного молока, соков и других ферментированных напитков и продуктов.
8. Пищевая или фармацевтическая композиция по любому из предшествующих пунктов, где композиция представляет собой фармацевтическую композицию, которая дополнительно включает фармацевтически приемлемые адъюванты и/или вспомогательные вещества.
9. Пищевая или фармацевтическая композиция по любому из пп. 2-8 для применения в лечении нарушения у женщины, где нарушение представляет собой дисбаланс естественной бактериальной микрофлоры влагалища, вагинальную инфекцию, женскую половую инфекцию, урогенитальную инфекцию или инфекцию мочевыводящих путей.
10. Пищевая или фармацевтическая композиция по п. 9, где нарушение представляет собой вагиноз, вагинит, хронический бактериальный вагиноз, хроническую дрожжевую инфекцию, хроническую инфекцию мочевыводящих путей в период менопаузы, атрофический вагинит, вагиноз или бактериальный вагиноз.
11. Пищевая или фармацевтическая композиция по п. 10, где инфекция представляет собой бактериальный вагиноз.
12. Молочный продукт, питьевой продукт, пищевой продукт для питания человека и/или кормовой продукт для кормления животных, характеризующийся тем, что продукт содержит композицию по любому из пп. 2-8.
13. Способ получения ферментированного пищевого продукта или ферментированного кормового продукта, включающий добавление молочнокислой бактерии Lactobacillus rhamnosus по п. 1 к исходному материалу пищевого или кормового продукта и хранение инокулированного таким образом исходного материала в условиях, в которых молочнокислые бактерии являются метаболически активными.
14. Способ получения мутантного штамма молочнокислой бактерии Lactobacillus rhamnosus с регистрационным номером СЕСТ 8800, включающий следующие стадии:
(i): получение мутантов молочнокислой бактерии Lactobacillus rhamnosus с регистрационным номером СЕСТ 8800;
(ii): исследование мутантов, полученных на стадии (i) и идентификация мутантного штамма, который сохранил или дополнительно улучшил способность СЕСТ 8800 снижать уровень рН; и
(iii) выделение мутантного штамма, идентифицированного на стадии (ii), с получением, таким образом, молочнокислой бактерии Lactobacillus rhamnosus с регистрационным номером СЕСТ 8800, причем мутантный штамм сохранил или дополнительно улучшил способность СЕСТ 8800 снижать уровень рН.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPEP15174222.8 | 2015-06-29 | ||
| EP15174222 | 2015-06-29 | ||
| PCT/EP2016/065074 WO2017001440A1 (en) | 2015-06-29 | 2016-06-29 | Lactobacillus rhamnosus bacterium for treatment of e.g. bacterial vaginosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017143465A true RU2017143465A (ru) | 2019-08-01 |
| RU2017143465A3 RU2017143465A3 (ru) | 2019-11-20 |
| RU2758109C2 RU2758109C2 (ru) | 2021-10-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017143465A RU2758109C2 (ru) | 2015-06-29 | 2016-06-29 | Бактерия lactobacillus rhamnosus для лечения, например, бактериального вагиноза |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10588926B2 (ru) |
| JP (1) | JP6837015B2 (ru) |
| KR (1) | KR102713511B1 (ru) |
| CN (2) | CN113564075A (ru) |
| AU (1) | AU2016287200B2 (ru) |
| CA (1) | CA2989977A1 (ru) |
| MX (1) | MX383921B (ru) |
| RU (1) | RU2758109C2 (ru) |
| WO (1) | WO2017001440A1 (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2989977A1 (en) | 2015-06-29 | 2017-01-05 | Ferring B.V. | Lactobacillus rhamnosus bacterium for treatment of e.g. bacterial vaginosis |
| EP3427745A1 (en) | 2017-07-12 | 2019-01-16 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | New probiotic composition for prevention of bacterial vaginosis |
| CN108004188B (zh) * | 2018-01-11 | 2020-02-14 | 广东龙创基药业有限公司 | 一种鼠李糖乳杆菌及其用于制备阴道抑菌药物的应用 |
| RU2703708C1 (ru) * | 2018-10-08 | 2019-10-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ прогнозирования степени риска нарушения микробиоты влагалища |
| CA3179613A1 (en) | 2020-06-01 | 2021-12-09 | Dana M. WALSH | Vaginal microbiota compositions |
| ES2984142T3 (es) * | 2020-06-11 | 2024-10-29 | Adm Denmark As | Composición probiótica y usos de la misma contra infecciones por Candida |
| DK3939602T3 (da) * | 2020-07-14 | 2024-06-17 | Probisearch S L U | Stamme af Lactobacillus salivarius PS1 1610 og anvendelse deraf i forebyggelse og behandling af urogenital traktdysbiose. |
| KR102546934B1 (ko) | 2021-04-02 | 2023-06-23 | 대한민국 | 락토바실러스 람노서스 kcc-51 균주 및 이를 포함하는 조성물 |
| CN113287753A (zh) * | 2021-05-24 | 2021-08-24 | 国珍健康科技（北京）有限公司 | 一种用于改善女性阴道炎症的益生菌组合物 |
| CN115252655B (zh) * | 2022-07-14 | 2023-06-16 | 金华银河生物科技有限公司 | 用于改善阴道炎症的益生菌后生元制品及制备方法和应用 |
| CN115569154B (zh) * | 2022-09-21 | 2024-06-11 | 微康益生菌(苏州)股份有限公司 | 防治念珠菌阴道炎的鼠李糖乳杆菌LRa05及其应用 |
| CN118077903B (zh) * | 2024-03-27 | 2024-09-17 | 瀚天生物(北京)科技有限公司 | 一种用于女性改善阴道紧致和水润环境的口服益生菌复合制剂及其制备方法与应用 |
| WO2025210272A1 (en) * | 2024-04-05 | 2025-10-09 | Ferring B.V. | Composition comprising lactobacillus species for vaginal therapies |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8603338D0 (sv) | 1986-08-07 | 1986-08-07 | Bjorn Andersch | Medel for behandling av tillstand i slidan |
| FR2672300B1 (fr) * | 1991-02-01 | 1994-09-23 | Agronomique Inst Nat Rech | Xylanase, souches de bacillus productrices de xylanase et leurs utilisations. |
| US5733568A (en) * | 1993-12-03 | 1998-03-31 | Lafor Laboratories Limited | Micro-encapsulated lactobacilli for medical applications |
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| US6461607B1 (en) * | 1998-08-24 | 2002-10-08 | Ganeden Biotech, Inc. | Probiotic, lactic acid-producing bacteria and uses thereof |
| PL348973A1 (en) * | 1998-12-11 | 2002-06-17 | Urex Biotech Inc | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
| US20020044926A1 (en) * | 1999-12-10 | 2002-04-18 | Gregor Reid | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
| SE521022C2 (sv) * | 2001-09-20 | 2003-09-23 | Ellen Ab | Mjölksyraproducerande bakterier för användning som probiotiska organismer i vaginan hos människa |
| US20040022775A1 (en) * | 2002-04-15 | 2004-02-05 | Gregor Reid | Methods of treating viral infections in mammals |
| US20090028839A1 (en) * | 2004-12-23 | 2009-01-29 | Tchikindas Mikhail L | Compositions and methods for the prophylaxis and treatment of vaginal infections |
| WO2006088923A2 (en) * | 2005-02-15 | 2006-08-24 | Gorbach Sherwood L | A food containing a probiotic and an isolated beta-glucan and methods of use thereof |
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| EP2428214A1 (en) * | 2010-09-14 | 2012-03-14 | HSO Health Care GmbH | Compositions for the vaginal and oral administration of lactobacillus and uses thereof |
| IT1403661B1 (it) * | 2011-01-28 | 2013-10-31 | Probiotical Spa | Composizione effervescente in forma solida per uso in applicazioni vaginali per il trattamento di infezioni vaginali. |
| CN102835657B (zh) * | 2011-06-20 | 2014-08-20 | 丰华生物科技股份有限公司 | 用以抑制发炎反应及抗阴道炎的含乳酸菌食品组合物及医药组合物 |
| PL2836587T3 (pl) * | 2012-04-09 | 2017-08-31 | Chr. Hansen A/S | Bioprotekcja z zastosowaniem szczepów Lactobacillus rhamnosus |
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| CN103409334B (zh) * | 2013-01-16 | 2018-07-20 | 生合生物科技股份有限公司 | 抑制阴道炎病原菌之乳酸杆菌及其用途 |
| JP6110240B2 (ja) * | 2013-04-10 | 2017-04-05 | 国立大学法人広島大学 | 乳酸菌の菌体等、並びにこれらを含有する口腔内疾患の予防材等及び食品 |
| RU2570622C2 (ru) * | 2013-10-24 | 2015-12-10 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | ШТАММ Lactobacillus rhamnosus, ОБЛАДАЮЩИЙ АНТИБАКТЕРИАЛЬНОЙ И АНТИГРИБКОВОЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ ПАТОГЕННОЙ И УСЛОВНО-ПАТОГЕННОЙ ВАГИНАЛЬНОЙ МИКРОФЛОРЫ |
| CA2989977A1 (en) | 2015-06-29 | 2017-01-05 | Ferring B.V. | Lactobacillus rhamnosus bacterium for treatment of e.g. bacterial vaginosis |
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2016
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- 2016-06-29 CN CN202110848314.7A patent/CN113564075A/zh active Pending
- 2016-06-29 JP JP2017567804A patent/JP6837015B2/ja active Active
- 2016-06-29 US US15/740,807 patent/US10588926B2/en active Active
- 2016-06-29 RU RU2017143465A patent/RU2758109C2/ru active
- 2016-06-29 WO PCT/EP2016/065074 patent/WO2017001440A1/en not_active Ceased
- 2016-06-29 AU AU2016287200A patent/AU2016287200B2/en active Active
- 2016-06-29 CN CN201680036708.XA patent/CN108076643B/zh active Active
- 2016-06-29 KR KR1020187000096A patent/KR102713511B1/ko active Active
- 2016-06-29 MX MX2017016748A patent/MX383921B/es unknown
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2020
- 2020-03-03 US US16/808,242 patent/US11202813B2/en active Active
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| WO2017001440A1 (en) | 2017-01-05 |
| US20180228850A1 (en) | 2018-08-16 |
| RU2017143465A3 (ru) | 2019-11-20 |
| AU2016287200A1 (en) | 2018-01-18 |
| KR102713511B1 (ko) | 2024-10-04 |
| RU2758109C2 (ru) | 2021-10-26 |
| US10588926B2 (en) | 2020-03-17 |
| JP6837015B2 (ja) | 2021-03-03 |
| CN108076643A (zh) | 2018-05-25 |
| US11202813B2 (en) | 2021-12-21 |
| CA2989977A1 (en) | 2017-01-05 |
| AU2016287200B2 (en) | 2020-09-17 |
| MX2017016748A (es) | 2018-11-09 |
| JP2018520677A (ja) | 2018-08-02 |
| CN108076643B (zh) | 2021-09-21 |
| US20200268815A1 (en) | 2020-08-27 |
| MX383921B (es) | 2025-03-14 |
| CN113564075A (zh) | 2021-10-29 |
| KR20180021777A (ko) | 2018-03-05 |
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