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RU2016129070A - Способы получения биополимеров с заданной средней молекулярной массой - Google Patents

Способы получения биополимеров с заданной средней молекулярной массой Download PDF

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RU2016129070A
RU2016129070A RU2016129070A RU2016129070A RU2016129070A RU 2016129070 A RU2016129070 A RU 2016129070A RU 2016129070 A RU2016129070 A RU 2016129070A RU 2016129070 A RU2016129070 A RU 2016129070A RU 2016129070 A RU2016129070 A RU 2016129070A
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biopolymer
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composition
lyophilization
molecular weight
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RU2016129070A
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RU2700420C2 (ru
RU2016129070A3 (ru
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Михаэль КУНЦ
Фабиан КУЛЬМАНН
Клаудиа ЭЛЬСИНГОРСТ
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Медскин Солюшнз Др.Сувелак Аг
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    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61K8/35—Ketones, e.g. benzophenone
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
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    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
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    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
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    • C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
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  • General Chemical & Material Sciences (AREA)
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  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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Claims (30)

1. Способ получения биополимера, причем биополимер имеет заданную среднюю молекулярную массу, включающий:
лиофилизацию композиции, содержащей биополимер,
факультативно, очистку и/или выделение биополимера;
причем максимальную температуру в ходе лиофилизации выбирают так, чтобы способствовать управляемому и заданному расщеплению указанного биополимера.
2. Способ по п. 1, отличающийся тем, что композиция, содержащая биополимер, представляет собой водный раствор или эмульсию.
3. Способ по п. 1, отличающийся тем, что композиция, содержащая биополимер, имеет заданную величину pH.
4. Способ по п. 3, отличающийся тем, что заданная величина pH выбрана из диапазона между 1,5 и 8,5, предпочтительно, между 2,5 и 6.
5. Способ по любому из пп. 1-4, отличающийся тем, что температура в ходе сублимации выбрана из диапазона между -40°С и 150°С.
6. Способ по любому из пп. 1-4, отличающийся тем, что давление в ходе сублимации выбрано из диапазона между 50 мкбар и 800 мкбар.
7. Способ по любому из пп. 1-4, отличающийся тем, что указанный биополимер выбран из группы, содержащей гиалуроновую кислоту, коллаген, глюкозаминогликаны, полисахариды и фукоиданы, предпочтительно указанный биополимер представляет собой гиалуроновую кислоту.
8. Способ получения композиций, содержащих биополимер, причем биополимер имеет заданную среднюю молекулярную массу, включающий:
(i) обеспечение базовой композиции, содержащей биополимер с природной высокой молекулярной массой,
(ii) лиофилизацию указанной композиции;
причем максимальную температуру в ходе лиофилизации выбирают так, чтобы способствовать управляемому и заданному расщеплению указанного биополимера.
9. Способ по п. 8, отличающийся тем, что базовая композиция представляет собой эмульсию или водный раствор.
10. Способ по п. 9, отличающийся тем, что указанная базовая композиция представляет собой эмульсию, содержащую:
(i) биополимер,
(ii) воду,
(iii) факультативно, фармацевтически, дерматологически или косметически приемлемое масло,
(iv) факультативно, эмульгирующий агент и
(v) факультативно, смягчители.
11. Способ по п. 10, отличающийся тем, что базовая композиция дополнительно содержит дерматологические, фармацевтические или косметические добавки.
12. Способ по любому из пп. 8-11, отличающийся тем, что базовая композиция содержит дополнительные компоненты, так что полученный лиофилизированный продукт является легко растворимым или легко образует эмульсию.
13. Способ по любому из пп. 8-11, отличающийся тем, что базовую композицию получают в соответствующем контейнере, подходящем для способа лиофилизации, который может также служить первичной упаковкой.
14. Способ по любому из пп. 8-11, отличающийся тем, что указанный биополимер выбран из группы, содержащей гиалуроновую кислоту, коллаген, глюкозаминогликаны, полисахариды и фукоиданы, предпочтительно указанный биополимер представляет собой гиалуроновую кислоту.
15. Применение способа по любому из пп. 1-7 для получения фармацевтически, дерматологически или косметически приемлемого биополимера.
16. Применение способа по любому из пп. 8-14 для получения фармацевтически, дерматологически или косметически приемлемых композиций, содержащих биополимер.
17. Композиция, полученная по любому из пп. 8-14.
18. Применение композиции по п. 17 в качестве фармацевтического, дерматологического или косметического продукта.
19. Применение биополимера, полученного посредством способа по любому из пп. 1-7, или композиции по п. 17 для получения фармацевтического, дерматологического или косметического продукта.
RU2016129070A 2014-02-19 2015-02-06 Способы получения биополимеров с заданной средней молекулярной массой RU2700420C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14155840.3 2014-02-19
EP14155840.3A EP2910255A1 (en) 2014-02-19 2014-02-19 Methods for the production of biopolymers with defined average molecular weight
PCT/EP2015/052540 WO2015124445A1 (en) 2014-02-19 2015-02-06 Methods for the production of biopolymers with defined average molecular weight

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RU2016129070A true RU2016129070A (ru) 2018-03-22
RU2016129070A3 RU2016129070A3 (ru) 2018-03-22
RU2700420C2 RU2700420C2 (ru) 2019-09-17

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AU2015221066A1 (en) 2016-08-11
KR20160147254A (ko) 2016-12-22
SG10202102316RA (en) 2021-04-29
EP3107579A1 (en) 2016-12-28
CN106456790A (zh) 2017-02-22
CA2937052C (en) 2019-03-19
EP3107579B1 (en) 2022-11-30
SG11201606260XA (en) 2016-09-29
EP2910255A1 (en) 2015-08-26
RU2700420C2 (ru) 2019-09-17
CA2937052A1 (en) 2015-08-27
US11091566B2 (en) 2021-08-17
JP2018076340A (ja) 2018-05-17
ES2939011T3 (es) 2023-04-18
AU2015221066B2 (en) 2018-07-19
CN112694545A (zh) 2021-04-23
JP2017508040A (ja) 2017-03-23
JP2020183544A (ja) 2020-11-12
RU2016129070A3 (ru) 2018-03-22
JP7250351B2 (ja) 2023-04-03
US20160355611A1 (en) 2016-12-08
WO2015124445A1 (en) 2015-08-27

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