RU2016150706A - Применение алленоксидсинтазы для сохранения спермы и вспомогательной репродукции - Google Patents
Применение алленоксидсинтазы для сохранения спермы и вспомогательной репродукции Download PDFInfo
- Publication number
- RU2016150706A RU2016150706A RU2016150706A RU2016150706A RU2016150706A RU 2016150706 A RU2016150706 A RU 2016150706A RU 2016150706 A RU2016150706 A RU 2016150706A RU 2016150706 A RU2016150706 A RU 2016150706A RU 2016150706 A RU2016150706 A RU 2016150706A
- Authority
- RU
- Russia
- Prior art keywords
- sperm
- allenoxide synthase
- allenoxide
- synthase
- paragraphs
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003879 sperm preservation Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims 9
- 230000009027 insemination Effects 0.000 claims 3
- 241001495453 Parthenium argentatum Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 244000309464 bull Species 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000006174 pH buffer Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/52—Sperm; Prostate; Seminal fluid; Leydig cells of testes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/16—Physical preservation processes
- A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/061—Sperm cells, spermatogonia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01092—Hydroperoxide dehydratase (4.2.1.92)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Biophysics (AREA)
- Physiology (AREA)
Claims (19)
1. Применение алленоксидсинтазы в качестве консерванта для спермы.
2. Применение по п. 1, отличающееся тем, что указанная алленоксидсинтаза представляет собой алленоксидсинтазу Parthenium argentatum или была клонирована из нее, или указанная алленоксидсинтаза представляет собой функционально эквивалентный вариант алленоксидсинтазы Parthenium argentatum.
3. Применение по п. 1 или 2, отличающееся тем, что указанная алленоксидсинтаза имеет аминокислотную последовательность SEQ ID NO: 1 или представляет собой ее функционально эквивалентный вариант.
4. Применение по любому из пп. 1-3, отличающееся тем, что указанная алленоксидсинтаза находится в водной среде с буфером рН.
5. Применение по п. 4, отличающееся тем, что указанная алленоксидсинтаза присутствует в среде в концентрации, находящейся в диапазоне от 1 до 10 мкг/мл.
6. Применение по любому из пп. 1-5, отличающееся тем, что указанная сперма представляет собой сперму быка.
7. Применение по любому из пп. 1-5, отличающееся тем, что указанная сперма представляет собой сперму человека.
8. Способ продления жизнеспособности спермы, включающий приведение указанной спермы в контакт с алленоксидсинтазой.
9. Способ по п. 8, отличающийся тем, что указанную сперму хранят в присутствии алленоксидсинтазы.
10. Способ по п. 8 или 9, отличающийся тем, что указанную алленоксидсинтазу добавляют к сперме, после чего указанную сперму замораживают.
11. Способ по п. 10, отличающийся тем, что указанную замороженную сперму размораживают перед использованием.
12. Способ по п. 9, отличающийся тем, что указанная сперма представляет собой свежую сперму.
13. Способ по п. 12, отличающийся тем, что по меньшей мере 50% сперматозоидов в указанной сперме жизнеспособны через 4 дня после эякуляции.
14. Сперма, содержащая алленоксидсинтазу.
15. Сперма по п. 14, которая представляет собой замороженную сперму.
16. Сперма по п. 14, которая представляет собой свежую сперму.
17. Применение спермы по любому из пп. 14-16 в процессе искусственного осеменения, процессе экстракорпорального оплодотворения или в процессе сортировки спермы.
18. Применение по п. 17, отличающееся тем, что указанный процесс искусственного осеменения включает стадию искусственного осеменения женщины, коровы, лошади, свиньи, овцы или птицы.
19. Композиция для сохранения спермы, содержащая алленоксидсинтазу.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462004527P | 2014-05-29 | 2014-05-29 | |
| US62/004,527 | 2014-05-29 | ||
| PCT/NZ2015/050067 WO2015183106A1 (en) | 2014-05-29 | 2015-05-27 | Use of allene oxide synthase for semen preservation and assisted reproduction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016150706A true RU2016150706A (ru) | 2018-07-02 |
| RU2016150706A3 RU2016150706A3 (ru) | 2018-11-28 |
Family
ID=54699330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016150706A RU2016150706A (ru) | 2014-05-29 | 2015-05-27 | Применение алленоксидсинтазы для сохранения спермы и вспомогательной репродукции |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20170196219A1 (ru) |
| EP (1) | EP3148557A4 (ru) |
| KR (1) | KR20170031667A (ru) |
| CN (1) | CN106714825A (ru) |
| AU (2) | AU2015268170A1 (ru) |
| BR (1) | BR112016027998A2 (ru) |
| CA (1) | CA2953320A1 (ru) |
| CL (2) | CL2016003067A1 (ru) |
| RU (1) | RU2016150706A (ru) |
| WO (1) | WO2015183106A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019093909A1 (en) * | 2017-11-13 | 2019-05-16 | Synthase Biotech Limited | Allene oxide synthase for restoring or improving sperm viability |
| WO2020046144A1 (en) * | 2018-08-28 | 2020-03-05 | Synthase Biotech Limited | Novel enzymes |
| CN111088221B (zh) * | 2020-01-14 | 2022-08-16 | 成都艾伟孚生物科技有限公司 | 促进精子激活的组合物和一种精子激活液及其制备方法 |
| EP4291027A4 (en) * | 2021-02-11 | 2025-02-19 | Synthase Biotech Limited | IMPROVED BIRTH RATES |
| WO2025116748A1 (en) * | 2023-11-30 | 2025-06-05 | Lipoxagen Limited | Novel compositions and uses |
| WO2025116746A1 (en) * | 2023-11-30 | 2025-06-05 | Lipoxagen Limited | Compositions and methods for treating central nervous system degeneration |
| WO2025116747A1 (en) * | 2023-11-30 | 2025-06-05 | Lipoxagen Limited | Treatment of central nervous system injury |
| WO2025153843A1 (en) * | 2024-01-19 | 2025-07-24 | Fujairah Research Center | Camel semen extender |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6132711A (en) * | 1991-04-17 | 2000-10-17 | Arizona Board Of Regents | Enzymatic antioxidant of allene oxide for lipid peroxidation in biological systems |
| US5633433A (en) * | 1991-04-17 | 1997-05-27 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Rubber particle protein gene from guayule |
| JP4177320B2 (ja) * | 2004-11-25 | 2008-11-05 | 株式会社資生堂 | 新規物質のα−ケトール不飽和脂肪酸誘導体及びそれを利用する植物成長調整剤 |
| US8771934B2 (en) * | 2011-12-09 | 2014-07-08 | The Curators Of The University Of Missouri | Inorganic pyrophosphate and uses thereof |
-
2015
- 2015-05-27 CN CN201580036626.0A patent/CN106714825A/zh active Pending
- 2015-05-27 KR KR1020167036651A patent/KR20170031667A/ko not_active Withdrawn
- 2015-05-27 AU AU2015268170A patent/AU2015268170A1/en not_active Abandoned
- 2015-05-27 WO PCT/NZ2015/050067 patent/WO2015183106A1/en not_active Ceased
- 2015-05-27 RU RU2016150706A patent/RU2016150706A/ru not_active Application Discontinuation
- 2015-05-27 EP EP15799445.0A patent/EP3148557A4/en not_active Withdrawn
- 2015-05-27 BR BR112016027998A patent/BR112016027998A2/pt not_active Application Discontinuation
- 2015-05-27 US US15/314,428 patent/US20170196219A1/en not_active Abandoned
- 2015-05-27 CA CA2953320A patent/CA2953320A1/en not_active Abandoned
-
2016
- 2016-11-29 CL CL2016003067A patent/CL2016003067A1/es unknown
-
2019
- 2019-01-04 CL CL2019000032A patent/CL2019000032A1/es unknown
-
2020
- 2020-09-10 AU AU2020230287A patent/AU2020230287A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3148557A4 (en) | 2017-12-27 |
| CL2016003067A1 (es) | 2017-11-10 |
| CA2953320A1 (en) | 2015-12-03 |
| US20170196219A1 (en) | 2017-07-13 |
| CN106714825A (zh) | 2017-05-24 |
| BR112016027998A2 (pt) | 2017-08-22 |
| AU2020230287A1 (en) | 2020-10-01 |
| WO2015183106A1 (en) | 2015-12-03 |
| KR20170031667A (ko) | 2017-03-21 |
| EP3148557A1 (en) | 2017-04-05 |
| CL2019000032A1 (es) | 2019-05-10 |
| RU2016150706A3 (ru) | 2018-11-28 |
| AU2015268170A1 (en) | 2017-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200210 |