RU2016150687A - Способ получения стволовых клеток с индуцированной плюрипотентностью из мезенхимальных стволовых клеток путем использования фракции флоротаннина - Google Patents
Способ получения стволовых клеток с индуцированной плюрипотентностью из мезенхимальных стволовых клеток путем использования фракции флоротаннина Download PDFInfo
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- RU2016150687A RU2016150687A RU2016150687A RU2016150687A RU2016150687A RU 2016150687 A RU2016150687 A RU 2016150687A RU 2016150687 A RU2016150687 A RU 2016150687A RU 2016150687 A RU2016150687 A RU 2016150687A RU 2016150687 A RU2016150687 A RU 2016150687A
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- florotannin
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- 238000000034 method Methods 0.000 title claims 4
- 210000000130 stem cell Anatomy 0.000 title claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 title claims 3
- 239000002609 medium Substances 0.000 claims 12
- 239000013028 medium composition Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 241000199923 Dictyota dichotoma Species 0.000 claims 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 2
- 241001512722 Ecklonia cava Species 0.000 claims 2
- 241000631640 Ishige okamurae Species 0.000 claims 2
- 241000199919 Phaeophyceae Species 0.000 claims 2
- 241001260874 Sargassum horneri Species 0.000 claims 2
- 241000593524 Sargassum patens Species 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000032459 dedifferentiation Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 claims 1
- 241000031729 Dictyopteris prolifera Species 0.000 claims 1
- 239000012980 RPMI-1640 medium Substances 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1392—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from mesenchymal stem cells from other natural sources
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Claims (13)
1. Композиция среды для дедифференцировки мезенхимальных стволовых клеток в стволовые клетки с индуцированной плюрипотентностью, содержащая фракцию флоротаннина.
2. Композиция среды по п. 1, где фракция флоротаннина представляет собой биэкольное соединение, представленное следующей химической формулой 1, или его соли.
[Химическая формула 1]
3. Композиция среды по п. 1, где фракция флоротаннина экстрагирована и выделена из одного из видов бурых водорослей, выбранных из группы, состоящей из Ecklonia cava, Dictyopteris prolifera Okamura, Dictyota dichotoma Lamouroux, Sargassum horneri C. Agardh, Sargassum patens C. Agardh и Ishige okamurae Yendo, или искусственно синтезирована.
4. Композиция среды по п. 1, где фракция флоротаннина включена в среду, выбранную из группы, состоящей из DMEM (среда Игла, модифицированная Дульбекко), MEM (минимальная поддерживающая среда), ВМЕ (базальная среда Игла), RPMI 1640, F-10, F-12, DMEM F-12, α-МЕМ (α-минимальная поддерживающая среда), G-MEM (минимальная поддерживающая среда Глазго), IMDM (среда Дульбекко, модифицированная по способу Исков), среды MacCoy's 5А, полной среды AminoMax II и среды MesenCult-XF.
5. Композиция среды по п. 1, где фракция флоротаннина включена в количестве от 10 до 500 мкг/мл относительно композиции среды.
6. Композиция среды по п. 1, дополнительно содержащая от 1 до 10% об./об. энергетической воды.
7. Способ получения стволовых клеток с индуцированной плюрипотентностью, включающий: добавление фракции флоротаннина в клеточную культуральную среду и дедифференцировку мезенхимальных стволовых клеток в стволовые клетки с индуцированной плюрипотентностью в этой среде.
8. Способ по п. 7, где фракция флоротаннина представляет собой биэкольное соединение, представленное следующей химической формулой 1, или его соли.
[Химическая формула 1]
9. Способ по п. 7, где фракция флоротаннина экстрагирована и выделена из одного из видов бурых водорослей, выбранных из группы, состоящей из Ecklonia cava, Dictyoptehs prolifera Okamura, Dictyota dichotoma Lamouroux, Sargassum horneri C. Agardh, Sargassum patens C. Agardh и Ishige okamurae Yendo, или искусственно синтезирована.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140062526 | 2014-05-23 | ||
| KR10-2014-0062526 | 2014-05-23 | ||
| KR10-2015-0071240 | 2015-05-21 | ||
| KR1020150071240A KR101699761B1 (ko) | 2014-05-23 | 2015-05-21 | 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 |
| PCT/KR2015/005183 WO2015178728A1 (ko) | 2014-05-23 | 2015-05-22 | 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016150687A3 RU2016150687A3 (ru) | 2018-06-25 |
| RU2016150687A true RU2016150687A (ru) | 2018-06-25 |
| RU2668803C2 RU2668803C2 (ru) | 2018-10-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016150687A RU2668803C2 (ru) | 2014-05-23 | 2015-05-22 | Способ получения стволовых клеток с индуцированной плюрипотентностью из мезенхимальных стволовых клеток путем использования фракции флоротаннина |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10131881B2 (ru) |
| EP (1) | EP3147352B1 (ru) |
| JP (1) | JP6839982B2 (ru) |
| KR (1) | KR101699761B1 (ru) |
| CN (1) | CN105960452B (ru) |
| AU (1) | AU2015262123B2 (ru) |
| CA (1) | CA2949949C (ru) |
| CY (1) | CY1123348T1 (ru) |
| DK (1) | DK3147352T3 (ru) |
| ES (1) | ES2820577T3 (ru) |
| HR (1) | HRP20201525T1 (ru) |
| HU (1) | HUE050877T2 (ru) |
| IL (1) | IL249170A0 (ru) |
| LT (1) | LT3147352T (ru) |
| MX (1) | MX380687B (ru) |
| MY (1) | MY179152A (ru) |
| PH (1) | PH12016502330A1 (ru) |
| PL (1) | PL3147352T3 (ru) |
| PT (1) | PT3147352T (ru) |
| RS (1) | RS60817B1 (ru) |
| RU (1) | RU2668803C2 (ru) |
| SG (1) | SG11201609804RA (ru) |
| SI (1) | SI3147352T1 (ru) |
| SM (1) | SMT202000487T1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105264066B (zh) | 2013-11-01 | 2021-06-11 | 株式会社美合康生 | 由间充质干细胞生产诱导性多能干细胞的方法以及由该方法生产的诱导性多能干细胞 |
| KR101966315B1 (ko) * | 2017-04-26 | 2019-04-08 | 제주대학교 산학협력단 | 감태 추출물과 괭생이모자반 추출물을 이용한 면역억제용 조성물 |
| CN113194743A (zh) * | 2018-12-05 | 2021-07-30 | 博塔医疗株式会社 | 包含褐藻多酚作为有效成分的用于改善食物香味的组合物 |
| WO2021145742A1 (ko) * | 2020-01-17 | 2021-07-22 | 주식회사 만나스 | 플로로탄닌을 유효성분으로 포함하는 운동 기능 개선용 조성물 |
| CN111557869A (zh) * | 2020-06-19 | 2020-08-21 | 湖北楚天香妆生物科技有限公司 | 昆布提取物的应用 |
| CN114438037B (zh) * | 2022-01-25 | 2024-06-04 | 深圳市乐土生物医药有限公司 | 一种制备诱导性间充质干细胞的方法 |
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| JPS5818874A (ja) * | 1981-07-28 | 1983-02-03 | Shin Kobe Electric Mach Co Ltd | 鉛蓄電池の製造法 |
| JP2932660B2 (ja) | 1990-10-09 | 1999-08-09 | 松下電器産業株式会社 | スクリーン印刷用スキージ装置 |
| JP4146146B2 (ja) | 2002-03-25 | 2008-09-03 | 熊本県 | フロロタンニン類を主成分とする抗菌剤 |
| US7910755B2 (en) * | 2004-09-29 | 2011-03-22 | Harbor Biosciences, Inc. | Stem cell expansion and uses |
| CA2842964A1 (en) * | 2006-09-13 | 2008-03-20 | Abbvie Inc. | Cell culture improvements |
| WO2009157610A1 (en) * | 2008-06-26 | 2009-12-30 | Pusan National University Industry-University Cooperation Foundation | Selenium dedifferentiated cell, preparation method and usage thereof |
| JP2010030917A (ja) * | 2008-07-25 | 2010-02-12 | Guraiko Materials:Kk | 肝炎予防剤又は肝炎治療剤 |
| CN101748096B (zh) * | 2008-12-17 | 2013-03-13 | 北京汉氏联合生物技术有限公司 | 亚全能干细胞、其制备方法及其用途 |
| KR101166257B1 (ko) | 2009-06-16 | 2012-07-19 | 한국생명공학연구원 | 미분화 다능성줄기세포의 제작, 유지 및 증식을 위한 뉴로펩타이드 ｙ를 포함하는 배지 조성물 및 이를 이용한 다능성줄기세포의 배양 방법 |
| EP2616539A1 (en) * | 2010-09-15 | 2013-07-24 | Ramot at Tel-Aviv University Ltd. | Methods of expanding and redifferentiating islet beta cells |
| KR101807704B1 (ko) | 2011-04-12 | 2017-12-13 | 차의과학대학교 산학협력단 | 역분화-증진제를 이용한 역분화 만능 줄기세포의 제조방법 |
| US20150072416A1 (en) | 2012-05-29 | 2015-03-12 | Korea Research Institute Of Bioscience And Biotech | Metabolite for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and method of culturing pluripotent stem cell using the same |
| KR101542850B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 지방세포로 분화시키는 방법 |
| KR101544195B1 (ko) | 2013-11-01 | 2015-08-12 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 및 그 방법에 의해 제조된 유도만능 줄기세포 |
| KR101542847B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 신경세포로 분화시키는 방법 |
| KR101542848B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 골아세포로 분화시키는 방법 |
| KR101542849B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 간세포로 분화시키는 방법 |
| KR101542846B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 연골세포로 분화시키는 방법 |
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2016
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- 2016-11-23 IL IL249170A patent/IL249170A0/en active IP Right Grant
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2020
- 2020-09-21 CY CY20201100887T patent/CY1123348T1/el unknown
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