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RU2015143409A - COMPOSITIONS FOR LOCAL APPLICATION CONTAINING BIMATOPROST AND METHODS FOR STIMULATING HAIR GROWTH WITH THEIR HELP - Google Patents

COMPOSITIONS FOR LOCAL APPLICATION CONTAINING BIMATOPROST AND METHODS FOR STIMULATING HAIR GROWTH WITH THEIR HELP Download PDF

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RU2015143409A
RU2015143409A RU2015143409A RU2015143409A RU2015143409A RU 2015143409 A RU2015143409 A RU 2015143409A RU 2015143409 A RU2015143409 A RU 2015143409A RU 2015143409 A RU2015143409 A RU 2015143409A RU 2015143409 A RU2015143409 A RU 2015143409A
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amount
bimatoprost
mass
composition
composition according
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RU2015143409A
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Russian (ru)
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RU2703713C2 (en
Inventor
Кевин УОРНЕР
Кристин ПРИНН
Четан П. ПУДЖАРА
Прамод САРПОТДАР
Джон Т. ТРОГДЕН
Аднан К. САЛАМЕХ
Гуанг Вэй ЛУ
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Аллерган, Инк.
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Priority claimed from US14/163,954 external-priority patent/US9138480B2/en
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Publication of RU2015143409A publication Critical patent/RU2015143409A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)

Claims (28)

1. Композиция для роста волос для местного нанесения, содержащая:1. Composition for hair growth for local application, containing: биматопрост в несвязанной форме или в форме его фармацевтически приемлемой соли, при этом биматопрост содержится в количестве, составляющем от 0,3до 4% масс.;bimatoprost in unbound form or in the form of its pharmaceutically acceptable salt, while bimatoprost is contained in an amount of from 0.3 to 4% by weight .; этанол,ethanol пропиленгликоль,propylene glycol простой моноэтиловый эфир диэтиленгликоля, бензиловый спирт, иdiethylene glycol monoethyl ether, benzyl alcohol, and по меньшей мере одно соединение, выбранное из группы, состоящей из глицерилмоноолеата и олеиновой кислотыat least one compound selected from the group consisting of glyceryl monooleate and oleic acid при этом указанную композицию изготавливают для местного нанесения на кожу.wherein said composition is formulated for topical application to the skin. 2. Композиция по п. 1, отличающаяся тем, что содержит биматопрост в количестве, составляющем от 1до 4% масс.2. The composition according to p. 1, characterized in that it contains bimatoprost in an amount of from 1 to 4% of the mass. 3. Композиция по п. 2, отличающаяся тем, что содержит биматопрост в количестве, составляющем от 2,5до 3,5% масс.3. The composition according to p. 2, characterized in that it contains bimatoprost in an amount of from 2.5 to 3.5% of the mass. 4. Композиция по п. 3, отличающаяся тем, что содержит биматопрост в количестве, составляющем 3% масс.4. The composition according to p. 3, characterized in that it contains bimatoprost in an amount of 3% of the mass. 5. Композиция по п. 1, отличающаяся тем, что существует в одной из форм, выбранных из группы, состоящей из растворов, гелей, мазей, пен, пленок, линиментов, кремов, шампуней, лосьонов, паст, желе, спреев и аэрозолей.5. The composition according to p. 1, characterized in that it exists in one of the forms selected from the group consisting of solutions, gels, ointments, foams, films, liniment, creams, shampoos, lotions, pastes, jellies, sprays and aerosols. 6. Композиция по п. 1, отличающаяся тем, что упакована в набор с аппликатором для нанесения на кожу.6. The composition according to p. 1, characterized in that it is packaged in a kit with an applicator for application to the skin. 7. Способ стимуляции роста волос, включающий введение в кожу пациента эффективного количества композиции биматопроста по любому из п.п. 1-6, при этом введение приводит к усиленному росту волос.7. A method of stimulating hair growth, comprising introducing into the patient's skin an effective amount of a bimatoprost composition according to any one of paragraphs. 1-6, while the introduction leads to enhanced hair growth. 8. Способ по п. 7, отличающийся тем, что композицию наносят на волосистую часть кожи головы.8. The method according to p. 7, characterized in that the composition is applied to the scalp. 9. Способ по п. 7, отличающийся тем, что композицию наносят по меньшей мере один раз в день.9. The method according to p. 7, characterized in that the composition is applied at least once a day. 10. Способ по п. 7, отличающийся тем, что композицию наносят на волосистую часть кожи головы для лечения состояния, выбранного из группы, состоящей из очаговой алопеции, телогеновой алопеции, анагеновой алопеции, рубцовой алопеции, шрамовой алопеции; нарушений волосяного стержня, узловатого трихорексиса, синдрома ослабленных анагенных волос, трихотилломании, тракционной алопеции; инфекционных поражений волос, стригущего лишая, себорейного дерматита, фолликулита волосистой части кожи головы и андрогенной алопеции.10. The method according to p. 7, characterized in that the composition is applied to the scalp for treating a condition selected from the group consisting of focal alopecia, telogen alopecia, anagen alopecia, cicatricial alopecia, scar alopecia; disturbances of the hair shaft, nodular trichorexis, a syndrome of weakened anagen hair, trichotillomania, traction alopecia; infectious lesions of hair, ringworm, seborrheic dermatitis, folliculitis of the scalp and androgenic alopecia. 11. Способ по п. 7, отличающийся тем, что композицию наносят на одну или обе из волосистой части кожи головы и бровей у пациентов, страдающих от выпадения волос вследствие химиотерапии, гормонального дисбаланса, грибковой инфекции волосистой части кожи головы, приема антикоагулянтов, препаратов для лечения подагры, депрессии, высокого артериального давления и заболеваний сердечно-сосудистой системы.11. The method according to p. 7, characterized in that the composition is applied to one or both of the scalp and eyebrow in patients suffering from hair loss due to chemotherapy, hormonal imbalance, fungal infection of the scalp, taking anticoagulants, drugs for treating gout, depression, high blood pressure and diseases of the cardiovascular system. 12. Композиция для стимуляции роста волос, содержащая:12. A composition for stimulating hair growth, comprising: по меньшей мере одно вещество, способствующее проникновению; включающее комбинацию:at least one penetration enhancer; comprising a combination of: первой группы веществ, способствующих проникновению, включающей этанол, пропиленгликоль и простой моноэтиловый эфир диэтиленгликоля, иa first group of penetration enhancers including ethanol, propylene glycol and diethylene glycol monoethyl ether, and второй группы веществ, способствующих проникновению, включающей эффективное количество по меньшей мере двух соединений, выбранных из выбранных из группы, состоящей из глицерилмоноолеата, олеиновой кислоты и бензилового спирта, иa second group of penetration enhancing substances comprising an effective amount of at least two compounds selected from the group consisting of glyceryl monooleate, oleic acid and benzyl alcohol, and биматопрост в свободной форме или в форме его фармацевтически приемлемой соли, при этом биматопрост содержится в количестве, составляющем 1-4% масс.;bimatoprost in free form or in the form of its pharmaceutically acceptable salt, while bimatoprost is contained in an amount of 1-4% of the mass .; при этом указанную композицию изготавливают для местного нанесения на кожу.wherein said composition is formulated for topical application to the skin. 13. Композиция по п. 12, включающая этанол в количестве 70% масс., простой моноэтиловый эфир диэтиленгликоля в количестве 10% масс., пропиленгликоль в количестве 10% масс., глицерилмоноолеат в количестве 2% масс., олеиновая кислота в количестве 2% масс., бензиловый спирт в количестве 1% масс.13. The composition according to p. 12, comprising ethanol in an amount of 70 wt.%, Diethylene glycol monoethyl ether in an amount of 10 wt.%, Propylene glycol in an amount of 10 wt.%, Glyceryl monooleate in an amount of 2 wt.%, Oleic acid in an amount of 2% mass., benzyl alcohol in an amount of 1% of the mass. 14. Композиция по п. 12, включающая этанол в количестве 67% масс., простой моноэтиловый эфир диэтиленгликоля в количестве 10% масс., пропиленгликоль в количестве 10% масс., глицерилмоноолеат в количестве 2% масс., олеиновая кислота в количестве 2% масс., бензиловый спирт в количестве 1% масс.14. The composition according to p. 12, comprising ethanol in an amount of 67% by weight, diethylene glycol monoethyl ether in an amount of 10% by weight, propylene glycol in an amount of 10% by weight, glyceryl monooleate in an amount of 2% by weight, oleic acid in an amount of 2% mass., benzyl alcohol in an amount of 1% of the mass. 15. Композиция по любому из п.п. 13 или 14, где биматопрост содержится в количестве 1% масс.15. The composition according to any one of paragraphs. 13 or 14, where bimatoprost is contained in an amount of 1% of the mass. 16. Композиция по любому из п.п. 13 или 14, где биматопрост содержится в количестве 3% масс.16. The composition according to any one of paragraphs. 13 or 14, where bimatoprost is contained in an amount of 3% of the mass. 17. Композиция по п. 2, содержащая биматопрост в количестве 1% масс.17. The composition according to p. 2, containing bimatoprost in an amount of 1% of the mass.
RU2015143409A 2013-03-14 2014-02-07 Compositions for local application containing bimatoprost, and methods for hair growth stimulation with help thereof RU2703713C2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361783962P 2013-03-14 2013-03-14
US61/783,962 2013-03-14
US14/163,954 2014-01-24
US14/163,954 US9138480B2 (en) 2009-11-09 2014-01-24 Compositions and methods for stimulating hair growth
PCT/US2014/015430 WO2014158373A1 (en) 2013-03-14 2014-02-07 Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith

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RU2015143409A true RU2015143409A (en) 2017-04-20
RU2703713C2 RU2703713C2 (en) 2019-10-22

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JP (1) JP6082158B2 (en)
KR (1) KR20150129733A (en)
CN (2) CN105263469B (en)
AU (1) AU2014242317B2 (en)
CA (1) CA2900285A1 (en)
HK (1) HK1220384A1 (en)
RU (1) RU2703713C2 (en)
WO (1) WO2014158373A1 (en)

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WO2014158373A1 (en) 2014-10-02
KR20150129733A (en) 2015-11-20
AU2014242317B2 (en) 2018-12-20
EP2968093A1 (en) 2016-01-20
CN105263469A (en) 2016-01-20
RU2703713C2 (en) 2019-10-22
JP2016512246A (en) 2016-04-25
CN109106606A (en) 2019-01-01
CN105263469B (en) 2018-11-02
JP6082158B2 (en) 2017-02-15
CA2900285A1 (en) 2014-10-02
HK1220384A1 (en) 2017-05-05
AU2014242317A1 (en) 2015-09-03

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