RU2015141767A - Композиции и способы для местной доставки простагландинов в подкожный жир - Google Patents
Композиции и способы для местной доставки простагландинов в подкожный жир Download PDFInfo
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- RU2015141767A RU2015141767A RU2015141767A RU2015141767A RU2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A
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- Prior art keywords
- composition according
- concentration
- prostaglandins
- compositions
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 23
- 238000000034 method Methods 0.000 title 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 210000004003 subcutaneous fat Anatomy 0.000 title 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 10
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 8
- 229960001160 latanoprost Drugs 0.000 claims 8
- 229940099259 vaseline Drugs 0.000 claims 4
- 235000019271 petrolatum Nutrition 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 239000004264 Petrolatum Substances 0.000 claims 1
- 229940074928 isopropyl myristate Drugs 0.000 claims 1
- 229940066842 petrolatum Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (20)
1. Композиция, содержащая латанопрост, изопропилмиристат и вазелин.
2. Композиция по п. 1, отличающаяся тем, что по существу состоит из латанопроста, изопропилмиристата и вазелина.
3. Композиция по п. 1, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.
4. Композиция по п. 3, отличающаяся тем, что концентрация латанопроста составляет от 0,03% до 0,1% мас./мас.
5. Композиция по п. 2, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.
6. Композиция по п. 5, отличающаяся тем, что концентрация латанопроста составляет от 0,03% до 0,1% мас./мас.
7. Композиция по п. 1, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 20% мас./мас.
8. Композиция по п. 7, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 10% мас./мас.
9. Композиция по п. 7, отличающаяся тем, что концентрация изопропилмиристата составляет от 5% до 15% мас./мас.
10. Композиция по п. 2, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 20% мас./мас.
11. Композиция по п. 10, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 10% мас./мас.
12. Композиция по п. 10, отличающаяся тем, что концентрация изопропилмиристата составляет от 5% до 15% мас./мас.
13. Композиция по п. 1, отличающаяся тем, что концентрация вазелина составляет от 70% до 99% мас./мас.
14. Композиция по п. 2, отличающаяся тем, что концентрация вазелина составляет от 70% до 99% мас./мас.
15. Композиция по п. 1, отличающаяся тем, что дополнительно содержит консервант.
16. Композиция по п. 2, отличающаяся тем, что дополнительно содержит консервант.
17. Композиция по п. 1, отличающаяся тем, что композиция является стерильной.
18. Композиция по п. 2, отличающаяся тем, что композиция является стерильной.
19. Композиция по п. 1, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.; концентрация изопропилмиристата составляет от 1% до 10% мас./мас. и концентрация вазелина составляет от 70% до 99% мас./мас.
20. Композиция по п. 2, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.; концентрация изопропилмиристата составляет от 1% до 10% мас./мас. и концентрация вазелина составляет от 70% до 99% мас./мас.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822139P | 2013-05-10 | 2013-05-10 | |
| US61/822,139 | 2013-05-10 | ||
| PCT/US2014/037512 WO2014183045A2 (en) | 2013-05-10 | 2014-05-09 | Compositions and methods for topical delivery of prostaglandins to subcutaneous fat |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017139109A Division RU2017139109A (ru) | 2014-05-09 | 2014-05-09 | Композиции и способы для местной доставки простагландинов в подкожный жир |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015141767A true RU2015141767A (ru) | 2017-04-06 |
| RU2635864C2 RU2635864C2 (ru) | 2017-11-16 |
Family
ID=50933526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015141767A RU2635864C2 (ru) | 2013-05-10 | 2014-05-09 | Композиции и способы для местной доставки простагландинов в подкожный жир |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9040584B2 (ru) |
| EP (3) | EP3124015B1 (ru) |
| JP (2) | JP5930568B1 (ru) |
| KR (4) | KR102098987B1 (ru) |
| CN (2) | CN109966240A (ru) |
| AU (3) | AU2014262495B9 (ru) |
| BR (1) | BR112015028290A2 (ru) |
| CA (1) | CA2907721C (ru) |
| CL (1) | CL2015003270A1 (ru) |
| CR (1) | CR20150652A (ru) |
| CY (1) | CY1118654T1 (ru) |
| DK (2) | DK2863886T3 (ru) |
| ES (2) | ES2604160T3 (ru) |
| HU (2) | HUE030977T2 (ru) |
| IL (2) | IL240807A (ru) |
| MX (2) | MX347969B (ru) |
| MY (1) | MY183193A (ru) |
| NO (1) | NO2753788T3 (ru) |
| NZ (1) | NZ712784A (ru) |
| PH (1) | PH12015502503A1 (ru) |
| PL (2) | PL2863886T3 (ru) |
| PT (2) | PT3124015T (ru) |
| RU (1) | RU2635864C2 (ru) |
| SG (2) | SG11201600068WA (ru) |
| SI (1) | SI2863886T1 (ru) |
| WO (1) | WO2014183045A2 (ru) |
| ZA (1) | ZA201507702B (ru) |
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| CA2681668C (en) | 2006-03-23 | 2014-04-01 | Michael S. Singer | Compositions comprising prostaglandin f2-alpha analogs and methods for reducing body fat |
| RU2567792C2 (ru) | 2009-11-09 | 2015-11-10 | Аллерган, Инк. | Композиции и способы стимулирования роста волос |
| US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| NO2753788T3 (ru) * | 2013-05-10 | 2018-06-16 | ||
| WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| US9795615B2 (en) * | 2015-04-30 | 2017-10-24 | Allergan, Inc. | Methods for fat reduction |
| EP3307325A1 (en) * | 2015-06-09 | 2018-04-18 | Thesan Pharmaceuticals, Inc. | Beta-naphthoisoflavones, compositions containing, and uses of, same |
| CA2990856A1 (en) * | 2015-06-23 | 2016-12-29 | Thesan Pharmaceuticals, Inc. | 12h-benzo[a]xanthen-12-ones, compositions containing, and uses of, same |
| US20180179174A1 (en) * | 2015-06-23 | 2018-06-28 | Thesan Pharmaceuticals, Inc. | 12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME |
| US10674746B2 (en) | 2015-10-27 | 2020-06-09 | Cytozyme Animal Nutrition, Inc. | Animal nutrition compositions and related methods |
| BR112018007434A2 (pt) | 2015-10-27 | 2018-10-23 | Cytozyme Animal Nutrition Inc | composições para nutrição animal, usos e métodos relacionados |
| CN107773758B (zh) * | 2016-08-31 | 2021-02-26 | 程辉 | 一种用于消除皮下脂肪沉积的组合物及其应用 |
| JP7640452B2 (ja) * | 2018-09-19 | 2025-03-05 | モデルナティエックス インコーポレイテッド | 高純度ｐｅｇ脂質及びそれらの使用 |
| EP3713551B1 (en) | 2018-10-16 | 2023-06-07 | Polithera, Inc. | Alcohol-based compositions and uses thereof |
| PL427837A1 (pl) * | 2018-11-22 | 2020-06-01 | Gbj Pharma Spółka Z Ograniczoną Odpowiedzialnością | Systemy do ciągłego obwodowego podawania latanoprostu dla obniżania ciśnienia śródgałkowego |
| EP3958835B1 (en) * | 2019-04-24 | 2023-05-24 | Follicum AB | Topical formulation |
| US11452703B2 (en) * | 2020-05-21 | 2022-09-27 | Peregrine Ophthalmic PTE LTD. | Methods and compositions for reducing adipocyte numbers |
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